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Your search keyword '"Shim, Ji‐yeon"' showing total 32 results
Start Over Author "Shim, Ji‐yeon" Publication Year Range Last 10 years
32 results on '"Shim, Ji‐yeon"'

5. Metformin Prevents Tumor Cell Growth and Invasion of Human Hormone Receptor-Positive Breast Cancer (HR+ BC) Cells via FOXA1 Inhibition.

Author

Song, Christine, Jung, Dawa, Kendi, Ayse Tuba, Rho, Jin Kyung, Kim, Eun-Joo, Horn, Ian, Curran, Geoffry L., Ghattamaneni, Sujala, Shim, Ji Yeon, Kang, Pil Soo, Kang, Daehun, Thakkar, Jay B., Dewan, Sannidhi, Lowe, Val J., and Lee, Seung Baek

Subjects
FORKHEAD transcription factors, HUMAN growth hormone, BREAST cancer, CELL growth, TUMOR growth, BRCA genes
Abstract

Women with type 2 diabetes (T2D) have a higher risk of being diagnosed with breast cancer and have worse survival than non-diabetic women if they do develop breast cancer. However, more research is needed to elucidate the biological underpinnings of these relationships. Here, we found that forkhead box A1 (FOXA1), a forkhead family transcription factor, and metformin (1,1-dimethylbiguanide hydrochloride), a medication used to treat T2D, may impact hormone-receptor-positive (HR+) breast cancer (BC) tumor cell growth and metastasis. Indeed, fourteen diabetes-associated genes are highly expressed in only three HR+ breast cancer cell lines but not the other subtypes utilizing a 53,805 gene database obtained from NCBI GEO. Among the diabetes-related genes, FOXA1, MTA3, PAK4, FGFR3, and KIF22 were highly expressed in HR+ breast cancer from 4032 breast cancer patient tissue samples using the Breast Cancer Gene Expression Omnibus. Notably, elevated FOXA1 expression correlated with poorer overall survival in patients with estrogen-receptor-positive/progesterone-receptor-positive (ER+/PR+) breast cancer. Furthermore, experiments demonstrated that loss of the FOXA1 gene inhibited tumor proliferation and invasion in vitro using MCF-7 and T47D HR+ breast cancer cell lines. Metformin, an anti-diabetic medication, significantly suppressed tumor cell growth in MCF-7 cells. Additionally, either metformin treatment or FOXA1 gene deletion enhanced tamoxifen-induced tumor growth inhibition in HR+ breast cancer cell lines within an ex vivo three-dimensional (3D) organoid model. Therefore, the diabetes-related medicine metformin and FOXA1 gene inhibition might be a new treatment for patients with HR+ breast cancer when combined with tamoxifen, an endocrine therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Graphene Oxide‐Supported Microwell Grids for Preparing Cryo‐EM Samples with Controlled Ice Thickness

Author

Kang, Min‐Ho, primary, Park, Junsun, additional, Kang, Sungsu, additional, Jeon, Sungho, additional, Lee, Minyoung, additional, Shim, Ji‐Yeon, additional, Lee, Jeeyoung, additional, Jeon, Tae Jin, additional, Ahn, Min Kyung, additional, Lee, Sung Mi, additional, Kwon, Ohkyung, additional, Kim, Byung Hyo, additional, Meyerson, Joel R., additional, Lee, Min Jae, additional, Lim, Kwang‐Il, additional, Roh, Soung‐Hun, additional, Lee, Won Chul, additional, and Park, Jungwon, additional

Published
2021
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32. Diagnostic Decision Points of Specific IgE Concentrations in Korean Children With Egg and Cow's Milk Allergies.

Author

Kim J, Kim HY, Park MR, Choi J, Shim JY, Kim MJ, Han Y, and Ahn K

Abstract

Purpose: The purpose of this study was to evaluate the utility of specific IgE (sIgE) concentrations for the diagnosis of immediate-type egg and cow's milk (CM) allergies in Korean children and to determine the optimal cutoff levels., Methods: In this prospective study, children ≥12 months of age with suspected egg or CM allergy were enrolled. Food allergy was diagnosed by an open oral food challenge (OFC) or through the presence of a convincing history after ingestion of egg or CM. The cutoff levels of sIgE for egg white (EW) and CM were determined by analyzing the receiver operating characteristic curves., Results: Out of 273 children, 52 (19.0%) were confirmed to have egg allergy. CM allergy was found in 52 (23.1%) of 225 children. The EW-sIgE concentration indicating a positive predictive value (PPV) of >90% was 28.1 kU/L in children <24 months of age and 22.9 kU/L in those ≥24 months of age. For CM-sIgE, the concentration of 31.4 kU/L in children <24 months of age and 10.1 kU/L in those ≥24 months of age indicated a >90% PPV. EW-sIgE levels of 3.45 kU/L presented a negative predictive value (NPV) of 93.6% in children <24 months of age, while 1.80 kU/L in those ≥24 months of age presented a NPV of 99.2%. The CM-sIgE levels of 0.59 kU/L in children <24 months of age and 0.94 kU/L in those ≥24 months of age showed NPVs of 100% and 96.9%., Conclusions: Our results indicate that different diagnostic decision points (DDPs) of sIgE levels should be used for the diagnosis of egg or CM allergy in Korean children. The data also suggest that DDPs with high PPV and high NPV are useful for determining whether OFC is required in children with suspected egg or CM allergy.

Published
2015
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