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Using a photo-luminescent cholesteric liquid crystal (PL-CLC) cell, tri-stable electro-optic switching behaviour was demonstrated. Stable planar, uniformly lying helix (ULH), and focal conic states were obtained at an electric field of zero after applying proper electric signals corresponding to each state. When a PL-CLC cell was placed on a ultraviolet (UV) back-light, the cell emitted fluorescent light with different types of polarization corresponding to the liquid crystal (LC) state: the planar, ULH, and focal conic states emitted circularly polarized light, linearly polarized light, and un-polarized light, respectively. Hence, the proposed PL-CLC cell worked as a tri-stable polarization-switching light source. We also demonstrated that the PL-CLC cell can be used to fabricate a bistable fluorescent LC device. [ABSTRACT FROM AUTHOR]

Objectives: To evaluate the efficacy of tocilizumab (TCZ), a monoclonal antibody against the interleukin (IL)-6 receptor, for refractory adult-onset Still's disease (AOSD) in the Korean population., Methods: This retrospective study included 22 Korean patients with refractory AOSD who were given TCZ at one of seven university hospital-based clinics for rheumatic disease. Patients were subdivided into groups according to disease course: monocyclic, systemic polycyclic, and chronic articular. Modified Pouchot scores, including laboratory and clinical findings, were analysed at 6 months and 12 months., Results: TCZ was given at 4-8 mg/kg every 4-5 weeks (8 mg/kg every 4-5 weeks in 18 patients, 6 mg/kg every 4 weeks in 2, and 4 mg/kg every 4 weeks in 2) for 7.5 months (median, IQR: 4.0-12.3). A good response (measured as a decrease of >2 in the modified Pouchot score) was achieved in 50.0% of patients (11 of 22) at 6 months and in 64.3% (9 of 14) at 12 months. The dose of corticosteroid dose was reduced from 11.5 mg/day (median, IQR: 10.0-21.3) immediately before TCZ therapy to 7.5 mg/day (median, IQR: 5.0-10.0, p=0.002) at 6 months and finally to 6.3 mg/day (median, IQR: 5.0-7.5, p=0.002) at 12 months. Only one patient discontinued TCZ treatment due to facial swelling accompanied by high blood pressure. In all others, adverse events subsided with delayed TCZ therapy, and TCZ therapy was continued successfully without problems., Conclusions: TCZ was effective for treating Korean AOSD patients who were refractory to conventional therapy or other anti-cytokine biologics, showing a corticosteroid-sparing effect and an acceptable tolerance profile.