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Aim: To assess the association of various clinical parameters and proinflammatory cytokines in the wound-healing process of dental implants with the presence or absence of antibiotic prophylaxis., Materials and Methods: The present study included evaluation of early wound-healing process in patients undergoing dental implant placement procedures with and without antibiotic prophylaxis. A total of 50 patients with partial edentulous arch were included in the present study. All the subjects were broadly divided into two study groups depending upon the presence or absence of prophylactic antibiotic therapy, with 25 patients in each group. One group consisted of subjects who were given prophylactic amoxicillin (2 gm), 1 hour before the starting of the surgery, followed by 500 mg 3 times a day for 1 week. Detection of interleukin (IL)-1β and -8 cytokine levels in the gingival crevicular fluid (GCF)/peri-implant crevicular fluid (PICF) was done immediately after the dental surgery. All the results were compiled and analyzed by Statistical Package for the Social Sciences (SPSS) software version 17.0., Results: A significant increase in the PICF IL-1β concentration at postoperative follow-up time was observed in the antibiotic group in comparison with the baseline values. A significant increase in the IL-8 concentration postoperatively in comparison with the baseline values in the antibiotic group was also observed. At the time of surgery, the IL-8 concentrations were statistically lower in the antibiotic group in comparison with the other study group. Concentration of amoxicillin, as observed by high-performance liquid chromatography (HPLC), was lower than the minimum detection levels., Conclusion: Detection of amoxicillin is not feasible within the GCF samples immediately after dental surgery procedure., Clinical Significance: Clinical usefulness of prophylactic use of amoxicillin is still doubtful.

Aim: The purpose of the study is to evaluate the bacterial micro-leakage of three different materials, mineral trioxide aggregate (MTA), resin-modified glass ionomer cement (RMGIC), and flowable composite, as a coronal barrier against Enterococcus faecalis., Materials and Methods: A total of 100 human extracted single-rooted teeth were selected. Access opening done, working length determined, and canals were cleaned and shaped with ProTaper F3 and obturated with AH26 and gutta-percha (GP) using lateral condensation technique. Samples were divided into three experimental and two control groups. Approximately 3 mm GP was removed from the coronal orifice and restored with one of the test materials. Teeth were suspended in glass tubes containing brain heart infusion (BHI) broth and equipped with microcaps, which were used to check bacterial leakage. A 24-hour broth of E. faecalis was placed in the pulp chamber. Tubes were incubated and checked for turbidity for 90 days. Data were analyzed using chi-squared test between the test and control groups and Fisher test between the test groups., Results: Significantly lesser number of samples turned turbid in the RMGIC group followed by MTA group and the maximum number of samples turned turbid in the flowable composite group., Conclusion: The RMGIC is a better coronal sealer, followed by MTA and flowable composite., Clinical Significance: Coronal sealing ability of RMGIC is more promising in comparison with the other agents.

Introduction: Dental implants form the mainstay of dental treatment involving rehabilitation of missing teeth. One of the major concerns for the clinicians doing dental implants is the postsurgical failure of dental implants. Success of dental implants is dependent upon the skills of the surgeon and the amount and quality of the bone remaining at the edentulous area where dental implant has to be placed. Myeloperoxidase (MPO) and nitrites are few of the enzymes and molecules which are said to be altered in inflammation. However, their exact role in the inflammatory processes around natural tooth and dental implant is still unclear. Hence we comparatively evaluated the levels of MPO and nitrites in the areas around the dental implants and natural teeth., Materials and Methods: The present study comprises 42 patients who underwent prosthetic rehabilitation by dental implants from 2011 to 2014. Depth of probing value (DP), score of plaque index (SPI), gingival index (GI), and index of gingival bleeding time (GBT) were evaluated for the assessment of the periimplant soft tissue changes. Assessment of inflammation around the dental implant surface and around natural tooth was done based on the readings of these parameters. For the measurement of the MPO levels, spectrophotometric MPO assay was used. All the results were analyzed by Statistical Package for the Social Sciences (SPSS) software., Results: The mean plaque index values were 1.56 and 0.97 in periodontitis cases of natural teeth and inflamed cases of dental implants respectively. While comparing mean plaque index, mean probing depth, and mean gingival bleeding index in between the two groups, significant difference was obtained. Mean MPO concentration in periodontitis and gingivitis cases in natural teeth were 0.683 and 0.875 U/μL, while in inflamed dental implant cases, the mean value was 0.622 U/μL. While comparing the total MPO levels, total nitrite levels, and total nitrite concentration in between two study groups, significant difference was obtained. On comparing the healthy and periodontitis cases in natural teeth, significant difference was obtained., Conclusion: In the inflammatory processes occurring around dental implant and natural teeth, MPO and NO make some amount of significant contribution., Clinical Significance: The present study enforces on the role of MPO and nitrite as diagnostic and prognostic marker.