Search

Chronic wounds are defined as wounds that fail to heal through normal phases of healing. Chronic wounds are becoming challenge for medical science due to its psychological and economic burdens. In Ayurveda, chronic wounds have close resemblance with Dustha-vrana. Various herbs, minerals-metals and formulations were described in classics for management of wounds. Gojihva [Launaea nudicaulis (L.) Hook.f.] herb is one of them. An eight year, old female child with parents visited Shalya Tantra OPD with complaint of wound at right foot with other associated complaints foul smell, discharge, swelling, loss of pain and touch sensations since five to six years. She was diagnosed at various higher centers as chronic non healing wound of right foot with tibial artery thrombosis and chronic osteomyelitis. The patient has taken various treatments with dressings but didn’t get relief. Lastly she was advised for amputation. Parents of the patient were not willing for surgery and they visited OPD for Ayurvedic treatment. On the basis of signs and symptoms it was diagnosed Dustha-vrana. The treatment was planned the topical application of Gojihva kwatha (decoction). The patient was completely cured within 21 days and regain the sensations. No re-occurrence was noted after 2 months of follow up.

SARS-CoV-2 is a global public-health concern. Interventions to prevent infection are urgently needed. The anti-inflammatory and antiviral effects of neem make it a potential agent for COVID-19 prophylaxis.The study intended to evaluate the prophylactic effects of neem capsules for persons at high risk of COVID-19 infection due to contact with COVID-19 positive patients.The research team designed a prospective, randomized, double-blind, placebo-controlled, parallel-design study.The study was conducted at a single center in India.Participants were 190 healthcare workers at the hospital or relatives of patients with COVID-19 infection.Of the 190 participants, 95 were in the intervention group and 95 in the control group. Participants received 50 mg of a proprietary, patent-pending, neem-leaf extract or a placebo orally in capsules, twice a day for 28 days.The number of individuals positive for COVID-19 between baseline and follow-up on day 56 was the primary outcome measure. Secondary measures included an evaluation of neem's safety and its effects on quality of life (QOL) and changes in biomarkers.The mean age of participants was 36.97 years, and 68.42% were male. Total 13 subjects tested positive during the study. All were asymptomatic. Of the 154 participants who completed the study per-protocol, 11 tested positive, 3 in the intervention group and 8 in the control group. The probability of COVID-19 infection in participants receiving the intervention was 0.45 times that of participants receiving the placebo, a relative risk of 0.45, with the effectiveness of the intervention being around 55%. Treatment-emergent adverse events (TEAEs) in both groups were minimal and were of grade 1 or 2 in severity. Biomarkers and QOL remained stable in both groups.The study found a reduced risk of COVID-19 infection in participants receiving neem capsules, which demonstrates its potential as a prophylactic treatment for the prevention of COVID-19 infection. The findings warrant further investigation in clinical trials.

Introduction Laghupanchamula is a compound formulation prepared by combinations of roots of five herbs. Two variants of Laghupanchamula have been described in Ayurvedic classics where beside four common herbs fifth one is either Gokshura (Tribulus terrestris L.) or Eranda (Ricinus communis L.). The objective of the study is to make comparison between two variants of Laghupanchmula with respect to important group of phytochemicals and antioxidant activity to corroborate the science behind their therapeutic utility. Materials and methods Standard methods have been followed for quantitative determination of total quantity of phenols, tannins, flavonoids, and flavonols, and in vitro antioxidant activity in variants of Laghupanchmula formulations. Qualitative high-performance liquid chromatography (HPLC) analysis has also been performed to establish presence/absence of important chemical constituents in formulations. Results Additional quantity of phenols, tannins, flavonoids, and flavonols has been observed in Laghupanchamula variant containing Eranda than the variant containing Gokshura. Greater antioxidant activity has also been found in formulation containing Eranda. The HPLC analysis revealed the presence of shikimic acid, gallic acid, catechin in both formulations, but rutin has been found only in formulation containing Eranda. Conclusion From the results of experiments it has been observed that the formulation containing Eranda has more antioxidant activity as it contains more quantities of phenol, tannins, flavonoids, and flavonols than the formulation containing Gokshura. How to cite this article Ghildiyal S, Joshi A, Joshi VK. Comparative Study on Two Variants of Laghupanchamula (A Compound Ayurvedic Formulation) for Important Groups of Phytochemicals and Antioxidant Activity. J Drug Res Ayurvedic Sci 2017;2(3):157-163.

Background: Wounds affect a large number of patients and seriously reduce the quality of life. The wound as a medical problem was first discussed by Maharshi Agnivesha in Agnivesha Samhita (later known as Charaka Samhita ) as Vrana . Laghupanchamula denotes a combination of the roots of five herbs. However, in Ayurvedic classics, besides four common herbs viz. Kantakari , Brihati , Shalaparni and Prinshniparni , the fifth one is either Gokshura (LPG) or Eranda (LPE), and both formulations have been documented to have wound healing ( Vrana ) activity. Objective: The present study was undertaken to determine the in vivo wound healing activity and in vitro antimicrobial activity of 50% ethanolic extract of Laghupanchamula containing Gokshura (LPGE) and Laghupanchamula containing Eranda (LPEE) in rats with acute toxicity in mice. Materials and Methods: LPGE and LPEE (1000 mg/kg) was administered orally, once daily for 10 days (incision wound model) or for 24 days (excision wound model) in rats. LPGE and LPEE was studied for its in vitro antimicrobial and in vivo wound breaking strength ( WBS) (incision model) and rate of contraction, period of epithelization and histology of skin (excision model). Results and Conclusion: LPGE and LPEE showed antimicrobial activity against skin pathogens, enhanced WBS, rate of contraction, skin collagen tissue formation and early epithelization period with low scar area indicating enhanced healing with histological evidence of more collagen formation in skin tissues. LPGE and LPEE also showed anti-bacterial activity and seemed to be safe, and use of both formulations in Laghupanchamula for their wound healing and anti-microbial activities is thus authenticated.

Chronic wounds are becoming challenge for scientific community due to their economical and psychological burden. Contemporary science tried hard to cop up with this difficult situation by the use of tissue engineering, cell-based therapy, plasma therapy along with various dressings, and surgical procedures, but the results are not very promising. Wounds are described under the heading of Vrana in Ayurveda along with various herbs and herbomineral preparations for their management. Gojihva (Launaea nudicaulis [L.] Hook.f.) is an herb mentioned to be useful in various diseases as well as for wounds. It is also practiced ethnomedicinally for wound management in various countries. A 60-year-old male having non-healing wound on his dorsal surface of the forearm for the past 45 days was treated with dressing of Gojihva kwatha (~ decoction) for 28 days. Bates–Jensen Wound Assessment Tool (BWAT), wound tracing and digital photography was used to asses wound healing on every week. BWAT score was 52 before treatment and 13 after the treatment. The surface area was 42.9 cm2 before treatment and nil after treatment. The wound was completely healed in 28 days without any complications.

Objective: Recently, we observed wound healing activity of 50% ethanol extract of Mallotus philippinensis Muell. Arg (MP) fruit hairs extract (MPE). In several intestinal infections, localized inflammation is of common occurrence and hence we evaluated the anti-inflammatory, analgesic and hypnotic activity of MPE in different rat experimental models. Materials and Methods: Anti-inflammatory activity was evaluated by carrageenan (acute) and turpentine oil induced formalin (subacute) induced paw edema and while granuloma pouch (subacute) in rats. Analgesic and hypnotic activity of MPE was undertaken by tail-flick, hot-plate, and acetic acid-induced writhing tests while pentobarbitone-induced hypnotic potentiation in rats. Results: MPE at a dose of 200 mg/kg at 3 h after their administration showed inhibition of formalin-induced paw edema by 41.60% (P < 0.001) and carrageenan-induced paw edema by 55.30% (P < 0.001). After 7 days of treatments, MPE showed 38.0% (P < 0.001) inhibition against formalin-induced paw edema and reduced weight of turpentine-induced granuloma pouch by 29.6% (P < 0.01) and volume of exudates by 26.1% (P < 0.01), respectively. MPE (200 mg/kg) showed dose-dependent elevation in pain threshold and peak analgesic effect at 120 min as evidenced by increased latency period in tail flick method and increased reaction time in the hot-plate test while the reduction in the number of acetic acid-induced writhes by 45.7% (P < 0.001). The pentobarbitone-induced hypnosis model showed potentiation, as defined by increased duration of sleep in treated group rats as compared to control. Conclusion: Thus, the study revealed MPE is effective in reducing acute and subacute inflammation and showed effective and similar analgesic activity. This seemed to be safe in the treatment of pain and inflammation.