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Your search keyword '"Shrestha, Hira"' showing total 27 results
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27 results on '"Shrestha, Hira"'

4. Hair Cortisol Concentrations in Opioid-Exposed versus Nonexposed Mother–Infant Dyads.

Author

Morrison, Tierney M., Schiff, Davida M., Olson, Abigael, Hunter, Richard G., Agarwal, Joel, Work, Erin C., Muftu, Serra, Shrestha, Hira, Boateng, Jeffery, Werler, Martha M., Carter, Ginny, Jones, Hendree E., and Wachman, Elisha M.

Subjects
SUBSTANCE abuse, HAIR analysis, MATERNAL exposure, PILOT projects, HYDROCORTISONE, DESCRIPTIVE statistics, MOTHER-infant relationship, LONGITUDINAL method, PSYCHOLOGICAL stress, NARCOTICS, RESEARCH, PHYSIOLOGICAL stress, BIOMARKERS
Abstract

Objective To pilot measurement of hair cortisol concentration (HCC) in pregnant women with opioid use disorder and their infants over time and study the potential utility of hair cortisol as a biomarker of chronic stress in this population. Study Design In this pilot prospective cohort study of mother–infant dyads with and without prenatal opioid exposure, we obtained mother–infant HCCs at delivery and again within 1 to 3 months' postpartum. HCCs were compared between the opioid and control groups and between the two time points. Results There were no significant differences between opioid and control group maternal or infant HCCs at either time point. However, within the opioid-exposed group, there was a significant increase in infant HCCs across the two time points. Conclusion This pilot study describes our experience with the measurement of HCCs in opioid-exposed mother–infant dyads. Key Points Maternal stress impacts fetal and child health. Many stressors in pregnant women with opioid use disorder. Hair cortisol may be a useful stress biomarker. [ABSTRACT FROM AUTHOR]

Published
2024
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5. P-099 Phase II trial of daratumumab, bortezomib, lenalidomide and dexamethasone in high-risk smoldering multiple myeloma

Author

Nadeem, Omar, primary, Redd, Robert, additional, Mo, Clifton, additional, Laubach, Jacob, additional, Richardson, Paul G., additional, Prescott, Julia, additional, Marto, Marjorie, additional, Davie, Christine, additional, Ricciardi, Caroline, additional, Murphy, Elizabeth, additional, Bertoni, Meredith, additional, Choden, Dechen, additional, Magidson, Sophie, additional, Sheehan, Brian, additional, Shrestha, Hira, additional, Sperling, Adam S., additional, O'Donnell, Elizabeth K., additional, and Ghobrial, Irene M., additional

Published
2023
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13. Medication for Opioid Use Disorder During Pregnancy — Maternal and Infant Network to Understand Outcomes Associated with Use of Medication for Opioid Use Disorder During Pregnancy (MAT-LINK), 2014–2021

Author

Miele, Kathryn, primary, Kim, Shin Y., additional, Jones, Rachelle, additional, Rembert, Juneka H., additional, Wachman, Elisha M., additional, Shrestha, Hira, additional, Henninger, Michelle L., additional, Kimes, Teresa M., additional, Schneider, Patrick D., additional, Sivaloganathan, Vaseekaran, additional, Sward, Katherine A., additional, Deshmukh, Vikrant G., additional, Sanjuan, Pilar M., additional, Maxwell, Jessie R., additional, Seligman, Neil S., additional, Caveglia, Sarah, additional, Louis, Judette M., additional, Wright, Tanner, additional, Bennett, Carolyne Cody, additional, Green, Caitlin, additional, George, Nisha, additional, Gosdin, Lucas, additional, Tran, Emmy L., additional, Meaney-Delman, Dana, additional, and Gilboa, Suzanne M., additional

Published
2023
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14. Implementation of a pilot program of Reach Out and Read® in the neonatal intensive care unit: a quality improvement initiative

Author

Levesque, Bernadette, Tran, Anh, Levesque, Emily, Shrestha, Hira, Silva, Ramona, Adams, Marsha, Valles, Marilyn, Burke, Judith, Corning-Clarke, Alison, and Ferguson, Carole

Abstract

Language exposure is important for neurodevelopment, but is sparse in the neonatal intensive care unit (NICU). We introduced Reach Out and Read (ROR) in the NICU as a quality improvement initiative to increase language exposure. Measures included availability of books, accessibility of parents, and enrollment of infants, percent infants read to by their parents, and data from parental surveys. 98 infants were included (40 before, 58 after). We obtained books in the mother’s language for 95% of infants, 82% eligible infants were enrolled, and 70% read to their infants (mean of 0.45?±?0.35 times/day). Surveyed parents enjoyed reading, noted positive effect(s), and intended to read post-discharge. We launched a well-received pilot ROR program in the NICU and reached our goal of =50% infants being read to by their parents. Further study is needed to assess the impact of reading in the NICU on parents and infants.

Published
2024
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17. B-PRISM (Precision Intervention Smoldering Myeloma): A phase II trial of combination of daratumumab, bortezomib, lenalidomide, and dexamethasone in high-risk smoldering multiple myeloma.

Author

Nadeem, Omar, primary, Redd, Robert, additional, Mo, Clifton Craig, additional, Laubach, Jacob, additional, Prescott, Julia, additional, Metivier, Amada, additional, Davie, Christine, additional, Bertoni, Meredith, additional, Murphy, Elizabeth, additional, Sheehan, Brian, additional, Tague, Kelsey, additional, Shrestha, Hira, additional, Medina, Rebekah, additional, Distaso, Alexandra, additional, Leblebjian, Houry, additional, Richardson, Paul G., additional, and Ghobrial, Irene M., additional

Published
2022
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22. Standard Fixed-Schedule Methadone Taper Versus Symptom-Triggered Methadone Approach for Treatment of Neonatal Opioid Withdrawal Syndrome

Author

Wachman, Elisha M., primary, Minear, Susan, additional, Hirashima, Meshelle, additional, Hansbury, Aaron, additional, Hutton, Elizabeth, additional, Shrestha, Hira, additional, Combs, Ginny, additional, Barry, Karan, additional, Slater, Cheryl, additional, Stickney, Donna, additional, and Walley, Alexander Y., additional

Published
2019
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24. Maternal hair cortisol levels as a novel predictor of neonatal abstinence syndrome severity: A pilot feasibility study.

Author

Wachman, Elisha M., Hunter, Richard G., Shrestha, Hira, Lapp, Hannah E., Meyer, Jerrold, Alvarez, Crystal D., and Tronick, Edward

Abstract

Neonatal abstinence syndrome (NAS) after in‐utero opioid exposure remains a poorly understood condition with multiple factors contributing to severity. Exposure to maternal stress may be one contributing factor. Hair cortisol measurement represents a novel technique for assessing prenatal stress. In this pilot study, the association between maternal hair cortisol levels and NAS severity was examined in 70 postpartum women with opioid use disorder within 72 hr of delivery. Infants were monitored for NAS and treated according to institutional protocol. Forty‐four (63%) of the infants were pharmacologically treated for NAS, with a mean length of hospital stay (LOS) for all infants of 14.2 (SD 9.0) days. The mean cortisol level in the mothers was 131.8 pg/mg (SD 124.7). In bivariate analysis, higher maternal hair cortisol levels were associated with shorter infant LOS (R = −.26, p =.03) and fewer infant opioid treatment days (R = −.28, p =.02). Results were no longer statistically significant in regression models after adjusting for maternal opioid and smoking. In conclusion, we demonstrated the feasibility of hair cortisol assaying within the first few days after delivery in mothers with opioid use disorder as a novel marker for NAS. The findings suggest that maternal stress may impact the severity of infant opioid withdrawal. [ABSTRACT FROM AUTHOR]

Published
2020
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