1. Nr4a3 : A key nuclear receptor in vascular biology, cardiovascular remodeling and beyond
- Author
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Martínez-González, José, Cañes Esteve, Laia, Alonso Nieto, Judith, Ballester-Servera, Carme, Rodríguez-Sinovas, Antonio, Corrales Insa, Irene, Rodríguez, Cristina, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Martínez-González J, Cañes L, Alonso J, Ballester-Servera C] Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas (IIBB-CSIC), Barcelona, Spain. CIBER de Enfermedades Cardiovasculares, ISCIII, Madrid, Spain. Instituto de Investigación Biomédica Sant Pau, Barcelona, Spain. [Rodríguez-Sinovas A] CIBER de Enfermedades Cardiovasculares, ISCIII, Madrid, Spain. Grup de Recerca en Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Corrales I] Laboratorio de Coagulopatías Congénitas, Banc de Sang i Teixits (BST), Barcelona, Spain. Grup de Recerca en Medicina Transfusional, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Rodríguez C] CIBER de Enfermedades Cardiovasculares, ISCIII, Madrid, Spain. Instituto de Investigación Biomédica Sant Pau, Barcelona, Spain. Institut de Recerca Hospital de la Santa Creu i Sant Pau (IRHSCSP), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Generalitat de Catalunya, and European Commission
- Subjects
Receptors, Steroid ,Review ,Bioinformatics ,Sistema cardiovascular - Malalties ,Cardiovascular System ,Extracellular matrix ,Medicine ,Biology (General) ,Spectroscopy ,Orphan receptor ,Pulmonary Arterial Hypertension ,Receptors, Thyroid Hormone ,Cardiovascular Diseases [DISEASES] ,Vascular biology ,General Medicine ,Computer Science Applications ,aminoácidos, péptidos y proteínas::proteínas::receptores citoplásmicos y nucleares [COMPUESTOS QUÍMICOS Y DROGAS] ,DNA-Binding Proteins ,Chemistry ,Cardiovascular Diseases ,Cardiovascular remodeling ,medicine.symptom ,Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Vascular Remodeling [PHENOMENA AND PROCESSES] ,QH301-705.5 ,Inflammation ,Nerve Tissue Proteins ,Catalysis ,Inorganic Chemistry ,Immune system ,abdominal aortic aneurysm ,Sistema cardiovascular - Fisiologia ,Animals ,Humans ,Physical and Theoretical Chemistry ,QD1-999 ,Molecular Biology ,Transcription factor ,enfermedades cardiovasculares [ENFERMEDADES] ,fenómenos fisiológicos respiratorios y circulatorios::fenómenos fisiológicos cardiovasculares::remodelación vascular [FENÓMENOS Y PROCESOS] ,cardiovascular remodeling ,business.industry ,Organic Chemistry ,Atrial Remodeling ,Atherosclerosis ,Amino Acids, Peptides, and Proteins::Proteins::Receptors, Cytoplasmic and Nuclear [CHEMICALS AND DRUGS] ,NOR-1 ,Nuclear receptor ,Apoptosis ,Abdominal aortic aneurysm ,Receptors cel·lulars ,business - Abstract
The mechanisms committed in the activation and response of vascular and inflammatory immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such as atherosclerosis, pulmonary arterial hypertension, and abdominal aortic aneurysm. Cardiovascular remodeling entails interrelated cellular processes (proliferation, survival/apoptosis, inflammation, extracellular matrix (ECM) synthesis/degradation, redox homeostasis, etc.) coordinately regulated by a reduced number of transcription factors. Nuclear receptors of the subfamily 4 group A (NR4A) have recently emerged as key master genes in multiple cellular processes and vital functions of different organs, and have been involved in a variety of high‐incidence human pathologies including atherosclerosis and other CVDs. This paper reviews the major findings involving NR4A3 (Neuron‐derived Orphan Receptor 1, NOR‐1) in the cardiovascular remodeling operating in these diseases., This research was funded by the Spanish Ministerio de Ciencia e Innovación (RTI2018- 094727-B-100), Instituto de Salud Carlos III (ISCIII; PI18/0919 and PI20/01649), the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR; 2017-SGR-00333). The study was cofounded by Fondo Europeo de Desarrollo Regional (FEDER), a way to make Europe. C.B.-S. is supported by a FPU fellowship (Ministerio de Ciencia, Innovación y Universidades).
- Published
- 2021