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Saccadic eye movements are preceded by profound changes in visual perception. These changes have been linked to the phenomenon of 'forward remapping', in which cells begin to respond to stimuli that appear in their post-saccadic receptive field before the eye has moved. Few studies have examined the perceptual consequences of remapping of areas of impaired sensory acuity, such as the blindspot. Understanding the perceptual consequences of remapping of scotomas may produce important insights into why some neurovisual deficits, such as hemianopia are so intractable for rehabilitation. The current study took advantage of a naturally occurring scotoma in healthy participants (the blindspot) to examine pre-saccadic perception at the upcoming location of the blindspot. Participants viewed stimuli monocularly and were required to make stimulus-driven vertical eye-movements. At a variable latency between the onset of saccade target (ST) and saccade execution a discrimination target (DT) was presented at one of 4 possible locations; within the blindspot, contralateral to the blindspot, in post-saccadic location of the blindspot and contralateral to the post-saccadic location of the blindspot. There was a significant perceptual impairment at the post-saccadic location of the blindspot relative to the contralateral post-saccadic location of the blindspot and the post-saccadic location of the blindspot in a no-saccade control condition. These data are consistent with the idea that the visual system includes a representation of the blindspot which is remapped prior to saccade onset. [ABSTRACT FROM AUTHOR]

The ability to interpret and follow the gaze of our social partners is an integral skill in human communication. Recent research has demonstrated that gaze following behaviour is influenced by theory of mind (ToM) processes. However, it has yet to be determined whether the modulation of gaze cueing by ToM is affected by individual differences, such as autistic traits. The aim of this experiment was to establish whether autistic traits in neurotypical populations affect the mediation of gaze cueing by ToM processes. This study used a gaze cueing paradigm within a change detection task. Participants' perception of a gaze cue was manipulated such that they only believed the cue to be able to 'see' in one condition. The results revealed that participants in the Low Autistic Traits group were significantly influenced by the mental state of the gaze cue and were more accurate on valid trials when they believed the cue could 'see'. By contrast, participants in the High Autistic Traits group were also more accurate on valid trials, but this was not influenced by the mental state of the gaze cue. This study therefore provides evidence that autistic traits influence the extent to which mental state attributions modulate social attention in neurotypical adults. [ABSTRACT FROM AUTHOR]

Visual perception and saccadic eye-movements are more precise when directed at isoeccentric locations along the horizontal compared to vertical meridian. This effect is known as horizontal-vertical anisotropy (HVA). Given that the eye-movement system plays an important role in spatial short-term memory (STM) it was hypothesized that spatial STM would also show a horizontal-vertical anisotropy. Consistent with this hypothesis an online experiment revealed a significant HVA in spatial STM (Experiment 1). This effect persisted even when eye-movements were precluded by using very short display durations (Experiment 2). However, there was no HVA in a colour span or orientation change detection task. It is argued that the HVA in spatial STM may result from greater imprecision in the representation of spatial locations along the vertical meridian relative to the horizontal meridian in the spatial maps underpinning spatial STM, a bilateral field advantage, or some combination of these mechanisms. [ABSTRACT FROM AUTHOR]

Ultrarunning requires extraordinary endurance but the psychological factors involved in successful ultrarunning are not well understood. One widely held view is that fluctuations in mood play a pivotal role in performance during endurance events. However, this view is primarily based on comparisons of mood before and after marathons and shorter running events. Indeed, to date no study has explicitly examined mood changes during a competive ultramarathon. To address this issue, we measured mood fluctuations in athletes competing in the Hardmoors 60, a 100 km, single day continuous trail-ultramarathon, and examined how variation in mood related to performance, as measured by completion time. The key finding was that the variability of athletes Total Mood Disturbance (TMD) score was significantly and positively correlated with completion time, consistent with the idea that mood is an important factor in determining race performance. Athletes also experienced a significant increase in tension immediately prior to race onset. This effect was more pronounced in less experienced athletes and significantly attenuated by measurement stage 1 at 35.4 km, which suggests the effect was driven by the release of pre-competition anxiety. Depression, anger and TMD were significantly lower at the pre-race measurement compared to the baseline measurement taken the week before. Consistent with previous studies, there were also significant increases in fatigue, anger and TMD during the race. The data are interpreted in terms of the Psychobiological model of endurance and may have broader implications for the understanding of endurance performance in other domains. [ABSTRACT FROM AUTHOR]

Key message: High-throughput phenotyping (HTP) is in its infancy for deployment in large-scale breeding programmes. With the ability to measure correlated traits associated with physiological ideotypes, in-field phenotyping methods are available for screening of abiotic stress responses. As cropping environments become more hostile and unpredictable due to the effects of climate change, the need to characterise variability across spatial and temporal scales will become increasingly important. The sensor technologies that have enabled HTP from macroscopic through to satellite sensors may also be utilised here to complement spatial characterisation using envirotyping, which can improve estimations of genotypic performance across environments by better accounting for variation at the plot, trial and inter-trial levels. Climate change is leading to increased variation at all physical and temporal scales in the cropping environment. Maintaining yield stability under circumstances with greater levels of abiotic stress while capitalising upon yield potential in good years, requires approaches to plant breeding that target the physiological limitations to crop performance in specific environments. This requires dynamic modelling of conditions within target populations of environments, GxExM predictions, clustering of environments so breeding trajectories can be defined, and the development of screens that enable selection for genetic gain to occur. High-throughput phenotyping (HTP), combined with related technologies used for envirotyping, can help to address these challenges. Non-destructive analysis of the morphological, biochemical and physiological qualities of plant canopies using HTP has great potential to complement whole-genome selection, which is becoming increasingly common in breeding programmes. A range of novel analytic techniques, such as machine learning and deep learning, combined with a widening range of sensors, allow rapid assessment of large breeding populations that are repeatable and objective. Secondary traits underlying radiation use efficiency and water use efficiency can be screened with HTP for selection at the early stages of a breeding programme. HTP and envirotyping technologies can also characterise spatial variability at trial and within-plot levels, which can be used to correct for spatial variations that confound measurements of genotypic values. This review explores HTP for abiotic stress selection through a physiological trait lens and additionally investigates the use of envirotyping and EC to characterise spatial variability at all physical scales in METs. [ABSTRACT FROM AUTHOR]

It has been proposed that covert visual search can be fast, efficient, and stimulus driven, particularly when the target is defined by a salient single feature, or slow, inefficient, and effortful when the target is defined by a nonsalient conjunction of features. This distinction between fast, stimulus-driven orienting and slow, effortful orienting can be related to the distinction between exogenous spatial attention and endogenous spatial attention. Several studies have shown that exogenous, covert orienting is limited to the range of saccadic eye movements, whereas covert endogenous orienting is independent of the range of saccadic eye movements. The current study examined whether covert visual search is affected in a similar way. Experiment 1 showed that covert visual search for feature singletons was impaired when stimuli were presented beyond the range of saccadic eye movements, whereas conjunction search was unaffected by array position. Experiment 2 replicated and extended this effect by measuring search times at 6 eccentricities. The impairment in covert feature search emerged only when stimuli crossed the effective oculomotor range and remained stable for locations further into the periphery, ruling out the possibility that the results of Experiment 1 were due to a failure to fully compensate for the effects of cortical magnification. The findings are interpreted in terms of biased competition and oculomotor theories of spatial attention. It is concluded that, as with covert exogenous orienting, biological constraints on overt orienting in the oculomotor system constrain covert, preattentive search. [ABSTRACT FROM AUTHOR]

Salient peripheral events trigger fast, "exogenous" covert orienting. The influential premotor theory of attention argues that covert orienting of attention depends upon planned but unexecuted eye-movements. One problem with this theory is that salient peripheral events, such as offsets, appear to summon attention when used to measure covert attention (e.g., the Posner cueing task) but appear not to elicit oculomotor preparation in tasks that require overt orienting (e.g., the remote distractor paradigm). Here, we examined the effects of peripheral offsets on covert attention and saccade preparation. Experiment 1 suggested that transient offsets summoned attention in a manual detection task without triggering motor preparation planning in a saccadic localisation task, although there were a high proportion of saccadic capture errors on "no-target" trials, where a cue was presented but no target appeared. In Experiment 2, "no-target" trials were removed. Here, transient offsets produced both attentional facilitation and faster saccadic responses on valid cue trials. A third experiment showed that the permanent disappearance of an object also elicited attentional facilitation and faster saccadic reaction times. These experiments demonstrate that offsets trigger both saccade programming and covert attentional orienting, consistent with the idea that exogenous, covert orienting is tightly coupled with oculomotor activation. The finding that no-go trials attenuates oculomotor priming effects offers a way to reconcile the current findings with previous claims of a dissociation between covert attention and oculomotor control in paradigms that utilise a high proportion of catch trials. [ABSTRACT FROM AUTHOR]

It is well established that alcoholics and heavy social drinkers show a bias of attention towards alcohol-related items. Previous research suggests that there is a shared foundation of attentional bias, which is linked to attentional control settings. Specifically, attentional bias relates to a persistent selection of a Feature Search Mode which prioritises attentional bias-related information for selection and processing. However, no research has yet examined the effect of pre-existing biases on the development of an additional attentional bias. This paper seeks to discover how pre-existing biases affect the formation of a new, additional attentional bias. Twenty-five heavy and 25 light social drinkers, with and without a pre-existing bias to alcohol-related items, respectively, had an attentional bias towards the colour green induced via an information sheet. They then completed a series of one-shot change detection tasks. In the critical task, green items were present but task-irrelevant. Irrelevant green items caused significantly more interference for light than heavy social drinkers. This somewhat counter intuitive result is likely due to heavy drinkers having more experience in exerting cognitive control over attentional biases, something not previously observed in investigations of the effects of holding an attentional bias. Our findings demonstrate for the first time that an established attentional bias significantly modulates future behaviour. [ABSTRACT FROM AUTHOR]

Visual perception can be influenced by the content of working memory. Previous studies have shown this influence can be enough to improve unconscious visual discrimination in healthy participants and conscious visual discrimination in neuropsychological patients with extinction. Here, these findings are extended by examining the effects of holding an object in working memory on unconscious visual perception in a person with hemianopia. The results revealed significantly enhanced detection accuracy when there was an exact match between the colour and orientation of the discrimination target and the item in working memory. However, the facilitatory effect was greatly reduced when only colour or orientation was matched with the item being held in memory. A control experiment confirmed these effects were not due to visual priming. These results are consistent with the proposal that working memory guided perceptual facilitation is driven by signal enhancement. More broadly, the data are interpreted in terms of a biased competition account of visual perception. [ABSTRACT FROM AUTHOR]

Salient peripheral cues produce a transient shift of attention which is superseded by a sustained inhibitory effect. Cueing part of an object produces an inhibitory cueing effect (ICE) that spreads throughout the object. In dynamic scenes the ICE stays with objects as they move. We examined object-centred attentional facilitation and inhibition in a patient with visual form agnosia. There was no evidence of object-centred attentional facilitation. In contrast, object-centred ICE was observed in 3 out of 4 tasks. These inhibitory effects were strongest where cues to objecthood were highly salient. These data are evidence of a neuropsychological dissociation between the facilitatory and inhibitory effects of attentional cueing. From a theoretical perspective the findings suggest that ‘grouped arrays’ are sufficient for object-based inhibition, but insufficient to generate object-centred attentional facilitation. [ABSTRACT FROM AUTHOR]

Salient peripheral cues produce a transient shift of attention which is superseded by a sustained inhibitory effect. Cueing part of an object produces an inhibitory cueing effect (ICE) that spreads throughout the object. In dynamic scenes the ICE stays with objects as they move. We examined object-centred attentional facilitation and inhibition in a patient with visual form agnosia. There was no evidence of object-centred attentional facilitation. In contrast, object-centred ICE was observed in 3 out of 4 tasks. These inhibitory effects were strongest where cues to objecthood were highly salient. These data are evidence of a neuropsychological dissociation between the facilitatory and inhibitory effects of attentional cueing. From a theoretical perspective the findings suggest that ‘grouped arrays’ are sufficient for object-based inhibition, but insufficient to generate object-centred attentional facilitation. [ABSTRACT FROM AUTHOR]

Attentional control settings have an important role in guiding visual behaviour. Previous work within cognitive psychology has found that the deployment of general attentional control settings can be modulated by training. However, research has not yet established whether long-term modifications of one particular type of attentional control setting can be induced. To address this, we investigated persistent alterations to feature search mode, also known as an attentional bias, towards an arbitrary stimulus in healthy participants. Subjects were biased towards the colour green by an information sheet. Attentional bias was assessed using a change detection task. After an interval of either 1 or 2 weeks, participants were then retested on the same change detection task, tested on a different change detection task where colour was irrelevant, or were biased towards an alternative colour. One experiment included trials in which the distractor stimuli (but never the target stimuli) were green. The key finding was that green stimuli in the second task attracted attention, despite this impairing task performance. Furthermore, inducing a second attentional bias did not override the initial bias toward green objects. The attentional bias also persisted for at least two weeks. It is argued that this persistent attentional bias is mediated by a chronic change to participants’ attentional control settings, which is aided by long-term representations involving contextual cueing. We speculate that similar changes to attentional control settings and continuous cueing may relate to attentional biases observed in psychopathologies. Targeting these biases may be a productive approach to treatment. [ABSTRACT FROM AUTHOR]

The neural and cognitive mechanisms of spatial working memory are tightly coupled with the systems that control eye movements, but the precise nature of this coupling is not well understood. It has been argued that the oculomotor system is selectively involved in rehearsal of spatial but not visual material in visuospatial working memory. However, few studies have directly compared the effect of saccadic interference on visual and spatial memory, and there is little consensus on how the underlying working memory representation is affected by saccadic interference. In this study we aimed to examine how working memory for visual and spatial features is affected by overt and covert attentional interference across two experiments. Participants were shown a memory array, then asked to either maintain fixation or to overtly or covertly shift attention in a detection task during the delay period. Using the continuous report task we directly examined the precision of visual and spatial working memory representations and fit psychophysical functions to investigate the sources of recall error associated with different types of interference. These data were interpreted in terms of embodied theories of attention and memory and provide new insights into the nature of the interactions between cognitive and motor systems. [ABSTRACT FROM AUTHOR]

Introduction: Situational judgement tests (SJTs) have been widely adopted, internationally, into medical selection. It was hoped that such assessments could identify candidates likely to exhibit future professional behaviours. Understanding how performance on such tests may predict the risk of disciplinary action during medical school would provide evidence for the validity of such SJTs within student selection. It would also inform the implementation of such tests within student recruitment. Methods: This cohort study used data for 6910 medical students from 36 UK medical schools who sat the University Clinical Aptitude Test (UCAT) SJT in 2013. The relationship between SJT scores at application and the risk of subsequent disciplinary action during their studies was modelled. The incremental ability of the SJT scores to predict the risk of disciplinary action, above that already provided by UCAT cognitive test scores and secondary (high) school achievement, was also evaluated in 5535 of the students with information available on this latter metric. Results: Two hundred and ten (3.05%) of the students in the cohort experienced disciplinary action. The risk of disciplinary action reduced with increasing performance on the admissions SJT (odds ratio (OR) 0.80, 95% confidence interval (CI) 0.69 to 0.92, p = 0.002). This effect remained similar after adjusting for cognitive performance and prior academic attainment (OR 0.77, 95% CI 0.65 to 0.92, p = 0.004). The overall estimated effect‐size was small (Cohen's d = 0.08) and no evidence of 'threshold' effects were observed for the SJT scores and risk of disciplinary action. Conclusions: Performance on admissions SJTs can, at least modestly, incrementally predict the risk of subsequent disciplinary action, supporting their use in this context. However, for this SJT and outcome, there did not seem a distinct threshold score above which the risk of disciplinary action disproportionately increased. This should be considered when using the scores within medical selection. Performance on an admissions Situational Judgment Test is reported to predict risk of formal disciplinary action in medical students with implications for how such tests should be used to improve medical professionalism. [ABSTRACT FROM AUTHOR]

The capacity of visuospatial working memory (VSWM) is limited. However, there is continued debate surrounding the nature of this capacity limitation. The resource model (Bays et al., 2009) proposes that VSWM capacity is limited by the precision with which visuospatial features can be retained. In one of the few studies of spatial working memory, Schneegans and Bays (2016) report that memory guided pointing responses show a monotonic decrease in precision as set size increases, consistent with resource models. Here we report two conceptual replications of this study that use mouse responses rather than pointing responses. Overall results are consistent with the resource model, as there was an exponential increase in localisation error and monotonic increases in the probability of misbinding and guessing with increases in set size. However, an unexpected result of Experiment One was that, unlike Schneegans and Bays (2016) , imprecision did not increase between set sizes of 2 and 8. Experiment Two replicated this effect and ruled out the possibility that the invariance of imprecision at set sizes greater than 2 was a product of oculomotor strategies during recall. We speculate that differences in imprecision are related to additional visuomotor transformations required for memory-guided mouse localisation compared to memory-guided manual pointing localisation. These data demonstrate the importance of considering the nature of the response modality when interpreting VSWM data. [ABSTRACT FROM AUTHOR]

The DLPFC is thought to be critically involved in maintaining attention away from behaviourally irrelevant information, and in the establishment of attentional control settings. These play an important role in the phenomenon of top-down bias to features in the visual field – also known as attentional bias. This paper probes the involvement of the left DLPFC in attentional bias by manipulating its cortical excitability via tDCS and then analysing these effects following an induced attentional bias towards the colour green. Although both anodal and cathodal tDCS over the left DLPFC decrease distractibility caused by biased but irrelevant objects, further interrogation of our data reveals theoretically differential mechanisms for each type of stimulation. Anodal tDCS appears to increase cognitive control over attentional bias-related items that are behaviourally irrelevant, allowing for their efficient disregard. In contrast, cathodal tDCS appears to lessen the overall effect of the induced attentional bias, potentially by reducing the influence of top-down modulated attentional control settings thus preventing the implementation of the control setting favouring green items. These results suggest a potential causal role of the left DLPFC in the cognitive mechanism underlying attentional bias. • tDCS over left DLPFC decreases distractions caused by biased but irrelevant objects. • Anodal tDCS likely increases cognitive control over irrelevant attentional bias-related items. • Cathodal tDCS likely reduces the influence of top-down attentional control settings. • These results suggest a potential causal role of the left DLPFC in mechanisms underlying attentional bias. [ABSTRACT FROM AUTHOR]

We typically move attention around the environment with overt eye-movements. However, it is also possible to orient attention covertly, such that the 'spotlight' of attention is moved independently of the locus of gaze. While there is enduring debate about the relationship between the mechanisms controlling covert and overt attention, one influential view is that shifts of covert attention are achieved by planning (but not executing) and overt eye movement. We have previously shown that placing stimuli at locations beyond the effective oculomotor range (EOMR) interfered with covert, exogenous orienting to peripheral cues but not covert endogenous orienting driven by symbolic cues (e.g. Smith et al., 2012; Smith & Casteau 2019). Here, we examined whether the association between exogenous attention and the EOMR observed in cueing tasks generalised to visual search tasks. We first measured the EOMR for each participant, then presented search arrays that were either within or beyond their EOMR. Feature search was significantly slower when stimuli were presented beyond the range of eye-movements whereas conjunction search was unaffected. In a second study we parametrically varied the location of the array to better establish how well changes in search performance mapped onto the range of eye-movements. The results confirmed that preattentive search was restricted to the locations within the range of eye-movement. We conclude that optimal covert, exogenous orienting of attention depends on the oculomotor system, consistent with an Oculomotor Readiness hypothesis of Exogenous Orienting. [ABSTRACT FROM AUTHOR]

Eye-tracking—the process of capturing and measuring human eye movement—is becoming an increasingly prevalent tool in the cultural heritage sector to understand visual processing and audience behaviours. Yet, most applications to date have focused on individual artworks and distinctions between representative/non-representative topics, with little prior work on the effects of differing written interpretations on the visual exploration of collections of artworks, particularly with devotional themes. This article reports on an eye-tracking study that explored responses to the unique collection of Francisco de Zurbarán paintings in County Durham. Using eye-tracking technology in a laboratory setting, we evaluated the viewing behaviour of three participant groups to determine whether the accompanying written context influences how digital reproductions are experienced. In addition to demonstrating statistically significant variations in aesthetic appreciation, the experiments showed that the gaze can be redirected towards areas of conceptual significance. Most importantly, we were able to challenge the assumption that viewers always look at faces (Bindemann et al. , 2005). Our findings make an important new contribution to the scholarly understanding of how audiences view, appreciate, and understand artworks and to museum and heritage practices relevant to the display of art. [ABSTRACT FROM AUTHOR]

4-Aminopyridine (4-AP) blocks voltage gated potassium channels, restoring conduction to demyelinated axons and improving function in demyelinating conditions, but its use is associated with adverse effects and benefit in spinal cord injury is limited. Derivatives of 4-AP have been developed to improve clinical efficacy while reducing toxicity. We compared the therapeutic effects of orally administered 4-AP and its t-butyl carbamate derivative (t-butyl) with placebo in dogs that had suffered an acute spinal cord injury that left them chronically paralyzed. Nineteen dogs were entered into the trial, conducted in two-week treatment blocks starting with placebo, followed by random assignment to 4-AP or t-butyl, a washout and then the opposite medication followed by placebo. Investigators and owners were blinded to treatment group. Primary outcome measures included open field gait score (OFS), and treadmill based stepping score and regularity index, with additional secondary measures also considered. Thirteen of 19 dogs completed the protocol. Two were euthanized due to unrelated heath problems, two developed side effects and two were unable to complete for unrelated reasons. Dogs showed significant improvement in supported stepping score (from 17.39 to 37.24% with 4-AP; 16.85 to 29.18% with t-butyl p<0.0001) and OFS (from 3.63 to 4.73 with 4-AP; 3.78 to 4.45 with t-butyl, p = 0.005). Response was individually variable and most dramatic in three dogs that were able to walk without support with treatment. No significant difference was found between 4-AP and t-butyl. No adverse effects were reported with t-butyl but gastrointestinal upset and seizures were observed in two dogs with 4-AP. In conclusion, both 4-AP and t-butyl significantly improved supported stepping ability in dogs with chronic spinal cord injury with no adverse effects noted with t-butyl. Drug response varied widely between individuals, highlighting the need to understand the factors that influence canine and human patients' response to therapy. [ABSTRACT FROM AUTHOR]

There is little consensus regarding the specific processes responsible for encoding, maintenance, and retrieval of information in visuo-spatial working memory (VSWM). One influential theory is that VSWM may involve activation of the eye-movement (oculomotor) system. In this study we experimentally prevented healthy participants from planning or executing saccadic eye-movements during the encoding, maintenance, and retrieval stages of visual and spatial working memory tasks. Participants experienced a significant reduction in spatial memory span only when oculomotor preparation was prevented during encoding or maintenance. In contrast there was no reduction when oculomotor preparation was prevented only during retrieval. These results show that (a) involvement of the oculomotor system is necessary for optimal maintenance of directly-indicated locations in spatial working memory and (b) oculomotor preparation is not necessary during retrieval from spatial working memory. We propose that this study is the first to unambiguously demonstrate that the oculomotor system contributes to the maintenance of spatial locations in working memory independently from the involvement of covert attention. [ABSTRACT FROM AUTHOR]

Bedaquiline is one of two important new drugs for the treatment of drug-resistant tuberculosis (TB). It is marketed in the US as its fumarate salt, but only a few salts of bedaquiline have been structurally described so far. We present here five crystal structures of bedaquilinium maleate {systematic name: [4-(6-bromo-2-methoxyquinolin-3-yl)-3-hydroxy-3-(naphthalen-1-yl)-4-phenylbutyl]di-methylazanium 3-carboxyprop-2-enoate}, C32H32BrN2O2+⋅C4H3O4-, namely, a hemihydrate, a tetrahydrofuran (THF) solvate, a mixed acetone/hexane solvate, an ethyl acetate solvate, and a solvate-free structure obtained from the acetone/hexane solvate by in situ single-crystal-to-single-crystal desolvation. All salts exhibit a 1:1 cation-to-anion ratio, with the anion present as monoanionic hydro-maleate and a singly protonated bedaquilinium cation. The maleate exhibits the strong intramolecular hydrogen bond typical for cis-di-carboxylic acid anions. The conformations of the cations and packing interactions in the maleate salts are compared to those of free base bedaquiline and other bedaquilinium salts. [ABSTRACT FROM AUTHOR]

Background: Medical schools differ, particularly in their teaching, but it is unclear whether such differences matter, although influential claims are often made. The Medical School Differences (MedDifs) study brings together a wide range of measures of UK medical schools, including postgraduate performance, fitness to practise issues, specialty choice, preparedness, satisfaction, teaching styles, entry criteria and institutional factors.Method: Aggregated data were collected for 50 measures across 29 UK medical schools. Data include institutional history (e.g. rate of production of hospital and GP specialists in the past), curricular influences (e.g. PBL schools, spend per student, staff-student ratio), selection measures (e.g. entry grades), teaching and assessment (e.g. traditional vs PBL, specialty teaching, self-regulated learning), student satisfaction, Foundation selection scores, Foundation satisfaction, postgraduate examination performance and fitness to practise (postgraduate progression, GMC sanctions). Six specialties (General Practice, Psychiatry, Anaesthetics, Obstetrics and Gynaecology, Internal Medicine, Surgery) were examined in more detail.Results: Medical school differences are stable across time (median alpha = 0.835). The 50 measures were highly correlated, 395 (32.2%) of 1225 correlations being significant with p < 0.05, and 201 (16.4%) reached a Tukey-adjusted criterion of p < 0.0025. Problem-based learning (PBL) schools differ on many measures, including lower performance on postgraduate assessments. While these are in part explained by lower entry grades, a surprising finding is that schools such as PBL schools which reported greater student satisfaction with feedback also showed lower performance at postgraduate examinations. More medical school teaching of psychiatry, surgery and anaesthetics did not result in more specialist trainees. Schools that taught more general practice did have more graduates entering GP training, but those graduates performed less well in MRCGP examinations, the negative correlation resulting from numbers of GP trainees and exam outcomes being affected both by non-traditional teaching and by greater historical production of GPs. Postgraduate exam outcomes were also higher in schools with more self-regulated learning, but lower in larger medical schools. A path model for 29 measures found a complex causal nexus, most measures causing or being caused by other measures. Postgraduate exam performance was influenced by earlier attainment, at entry to Foundation and entry to medical school (the so-called academic backbone), and by self-regulated learning. Foundation measures of satisfaction, including preparedness, had no subsequent influence on outcomes. Fitness to practise issues were more frequent in schools producing more male graduates and more GPs.Conclusions: Medical schools differ in large numbers of ways that are causally interconnected. Differences between schools in postgraduate examination performance, training problems and GMC sanctions have important implications for the quality of patient care and patient safety. [ABSTRACT FROM AUTHOR]

Abstract The present research assessed the nature of endogenous shifts of attention based on internally generated expectations (i.e., target location probability) and involuntary attention shifts following eye-gaze cues from line-drawings of schematic faces (Experiment 1) and photographs of real neutral faces (Experiment 2) and fearful faces (Experiment 3). The time-course of these two forms of attention was explored by manipulating the gaze-target SOA (i.e., 100 ms, 200 ms, 300 ms). In all three experiments, target location probability influenced responding at each SOA with faster responses to high probability than low probability targets. However, the time-course of involuntary attention shifts was dependent on the gaze-cueing stimulus employed. For photographs of neutral gaze, endogenous orienting of attention was most efficient at the briefest SOA with involuntary attention shifts emerging later. However, both schematic and fearful gaze-cues influenced responding across all SOAs, which is indicative of stronger gaze-cueing effects from these cues. At 200 ms there was an additive effect as responses were slowest when the target had been invalidly cued by neutral gaze and also appeared in the low probability location. Taken together these findings suggest that these forms of involuntary and endogenous attention can operate in parallel and relatively independently, but can show potentially differing levels of influence, dependent on the time course in which they take to operate. Highlights • Target location probability influenced responding at each SOA. • Time-course of gaze-cueing was dependent on the gaze-cue stimulus employed. • Attention shifts to schematic and fearful gaze emerged earlier than to neutral gaze. • Endogenous attention and gaze-cueing operate in parallel and relatively independently. [ABSTRACT FROM AUTHOR]

A growing number of authors have argued that humans automatically compute the visual perspective of other individuals. Evidence for this has come from the dot perspective task in which observers are faster to judge the number of dots in a display when a human avatar has the same perspective as the observer compared to when their perspectives are different. The present experiment examined the ‘spontaneous perspective taking’ claim using a variant of the dot perspective paradigm in which we manipulated what the avatar could see via physical barriers that either allowed the targets to be seen by the avatar or occluded this view. We found a robust ‘perspective taking’ effect despite the avatar being unable to see the same stimuli as the participant. These findings do not support the notion that humans spontaneously take the perspective of others. [ABSTRACT FROM AUTHOR]

Biased competition theory assumes that shift of attention is biased towards visual stimuli that matched the content of the visual working memory (VWM) and this bias might be due to a competition between eye-movement motor plans and memory object location. Here, we measured the effect of holding an item in VWM on pre-saccadic shift of attention by measuring attention when the goal of an eye-movement is congruent or incongruent with the location of an object sharing properties with the VWM content. Participants performed an eye-movement towards a previously specified location (Saccade Target, ST) and make a discrimination decision (Discrimination Target, DT). They also had to retain a visual feature in VWM for the whole duration of the trial (Memory Target; MT). There were four different conditions: 1) MT congruent with ST and DT, 2) MT congruent with DT but incongruent with ST, 3) MT congruent with ST but incongruent with DT, 4) MT incongruent with ST and DT. As expected, pre-saccadic attentional facilitation was greatest when the VWM content, the saccade direction and the discrimination location were all congruent, and abolished when ST, DT and MT were at different locations. Critically, when the ST and DT were in the same location but the MT at a different location pre-saccadic attentional facilitation was significantly reduced, suggesting competition between the saccade goal and the MT. Our results suggest that, the attention bias linked to the content of VWM can be understand as a competition between different saccade goals in the oculomotor system. [ABSTRACT FROM AUTHOR]