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237 results on '"Smith, Lori A."'

1. Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study

Author

Aizenstein, Howard J, Andrews, Howard F, Bell, Karen, Birn, Rasmus M, Bulova, Peter, Cheema, Amrita, Chen, Kewei, Clare, Isabel, Clark, Lorraine, Cohen, Ann D, Constantino, John N, Doran, Eric W, Feingold, Eleanor, Foroud, Tatiana M, Hartley, Sigan L, Hom, Christy, Honig, Lawrence, Ikonomovic, Milos D, Johnson, Sterling C, Jordan, Courtney, Kamboh, M Ilyas, Keator, David, Klunk MD, William E, Kofler, Julia K, Kreisl, William C, Krinsky- McHale, Sharon J, Lao, Patrick, Laymon, Charles, Lott, Ira T, Lupson, Victoria, Mathis, Chester A, Minhas, Davneet S, Nadkarni, Neelesh, Pang, Deborah, Petersen, Melissa, Price, Julie C, Pulsifer, Margaret, Reiman, Eric, Rizvi, Batool, Sabbagh, Marwan N, Schupf, Nicole, Tudorascu, Dana L, Tumuluru, Rameshwari, Tycko, Benjamin, Varadarajan, Badri, White, Desiree A, Yassa, Michael A, Zaman, Shahid, Zhang, Fan, Adams, Sarah, Allegri, Ricardo, Araki, Aki, Barthelemy, Nicolas, Bechara, Jacob, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William, Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Mendez, Patricio C, Chua, Jasmin, Chui, Helena, Courtney, Laura, Day, Gregory, DeLaCruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Fox, Nick, Franklin, Erin, Joseph-Mathurin, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Gonzalez, Alyssa, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Haass, Christian, Häslerc, Lisa, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Johnson, Erik, Jucker, Mathias, Karch, Celeste, Käser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William, Koeppe, Robert, Koudelis, Deb, Kuder-Buletta, Elke, Laske, Christoph, Levey, Allan, Levin, Johannes, Li, Yan, Lopez, Oscar, Marsh, Jacob, Martins, Ralph, Mason, Neal S, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, Mejia, Arlene, Morenas-Rodriguez, Estrella, Morris, John C, Mountz, James, Mummery, Catherine, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Obermüller, Ulricke, O'Connor, Antoinette, Patira, Riddhi, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Seyfried, Nicholas T, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, Vöglein, Jonathan, Wang, Peter, Wang, Qing, Weamer, Elise, Xu, Jinbin, Xu, Xiong, Boerwinkle, Anna H, Gordon, Brian A, Wisch, Julie, Flores, Shaney, Henson, Rachel L, Butt, Omar H, McKay, Nicole, Chen, Charles D, Benzinger, Tammie L S, Fagan, Anne M, Handen, Benjamin L, Christian, Bradley T, Head, Elizabeth, Mapstone, Mark, Rafii, Michael S, O'Bryant, Sid, Lai, Florence, Rosas, H Diana, Lee, Joseph H, Silverman, Wayne, Brickman, Adam M, Chhatwal, Jasmeer P, Cruchaga, Carlos, Perrin, Richard J, Xiong, Chengjie, Hassenstab, Jason, McDade, Eric, Bateman, Randall J, and Ances, Beau M

Published
2023
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2. Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease

Author

Adams, Sarah, Allegri, Ricardo, Araki, Aki, Barthelemy, Nicolas, Bateman, Randall, Bechara, Jacob, Benzinger, Tammie, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William (Bill), Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Mendez, Patricio Chrem, Chua, Jasmin, Chui, Helena, Courtney, Laura, Cruchaga, Carlos, Day, Gregory S, DeLaCruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Fagan, Anne, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Flores, Shaney, Fox, Nick, Franklin, Erin, Joseph-Mathurin, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Gonzalez, Alyssa, Gordon, Brian, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Haass, Christian, Häsler, Lisa, Hassenstab, Jason, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Johnson, Erik, Jucker, Mathias, Karch, Celeste, Käser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William, Koeppe, Robert, Koudelis, Deb, Kuder-Buletta, Elke, Laske, Christoph, Levey, Allan, Levin, Johannes, Li, Yan, Lopez, Oscar, Marsh, Jacob, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, McDade, Eric, Mejia, Arlene, Morenas-Rodriguez, Estrella, Morris, John, Mountz, James, Mummery, Cath, Nadkarni, N eelesh, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Obermüller, Ulricke, O'Connor, Antoinette, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Seyfried, Nicholas T, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, Vöglein, Jonathan, Wang, Peter, Wang, Qing, Weamer, Elise, Xiong, Chengjie, Xu, Jinbin, Xu, Xiong, Millar, Peter R., Luckett, Patrick H., Gordon, Brian A., Benzinger, Tammie L.S., Schindler, Suzanne E., Fagan, Anne M., Bateman, Randall J., Lee, Jae-Hong, Mori, Hiroshi, Salloway, Stephen P, Yakushev, Igor, Morris, John C., and Ances, Beau M.

Published
2022
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3. Unique North American isolates of severe metastatic hypervirulent Klebsiella pneumoniae strain infections with hepatic abscesses seen in young patients within Texas.

Author

Alam, Junaid M., Riha, Eric N., Ahmed, Haris, Thai, Hong M., Garnepudi, Kevin, Kesavan, Ramesh B., Jayaraman, Gnananandh, Sangster, Anna, Curry, Dylan, Butz, Heidi A., Smith, Lori, Vowles, Maureen, Oakeson, Kelly F., Young, Erin L., and Sarva, Siva T.

Subjects
WHOLE genome sequencing, KLEBSIELLA pneumoniae, SEPTIC shock, SYMPTOMS, SEQUENCE analysis
Abstract

Rationale: Hypervirulent Klebsiella pneumoniae (hvKp) infections have principally been identified in Asia. Within a two-month period, two patients between the ages of 30 to 50 years old presented to a tertiary referral hospital in Texas with septic shock, hepatic abscess, and septic thrombophlebitis. Blood cultures were positive for Klebsiella pneumoniae (isolates 2020CK-00441 and 2021CK-00720 respectively). The first patient survived after a prolonged hospital course while the second patient expired. Objectives: Describe the clinical presentation of these two patients. Perform whole genome sequencing and bioinformatic analysis to evaluate potential outbreak of specific hvKp bacteria isolates. Methods: Whole genome sequencing was performed using both paired-end Illumina MiSeq and nanopore sequencing to obtain a Completed genome for both isolates. Main results: 2020CK-00441 belonged to ST23 type while 2021CK-00720 was a ST65 type isolate. Kleborate analyses predicted with high confidence both isolates were hvKp. Phylogenetic analyses showed the two strains are not closely related to each other nor to any known hvKp isolates reported. Both isolates had yersiniabactin, colibactin, aerobactin and salmochelin producing loci which likely confer these isolates hvKp phenotype. 2020CK-00441 and 2021CK-00720 had a unique pK2044 like plasmid. Conclusions: HvKp strains capable of causing devastating metastatic septic infections have emerged in Texas. These isolates are unique compared to other hvKp strains globally. Country-wide surveillance and whole genome sequencing of these strains is essential to prevent a major public health emergency in the USA. [ABSTRACT FROM AUTHOR]

Published
2025
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4. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study

Author

Adams, Sarah, Allegri, Ricardo, Araki, Aki, Barthelemy, Nicolas, Bechara, Jacob, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William (Bill), Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Chrem, Patricio, Chua, Jasmin, Chui, Helena, Cruchaga, Carlos, Day, Gregory S, De La Cruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Flores, Shaney, Fox, Nick, Franklin, Erin, Friedrichsen, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Gonzalez, Alyssa, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Häsler, Lisa, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Johnson, Erik, Käser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William (Bill), Koeppe, Robert, Koudelis, Deb, Kuder-Buletta, Elke, Laske, Christoph, Levey, Allan, Lopez, Oscar, Marsh, Jacob, Martinez, Rita, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, Mejia, Arlene, MountzMD, James, Mummery, Cath, Nadkarni, Neelesh, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, O'Connor, Antoinette, Obermüller, Ulricke, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Seyfried, Nick, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, Wang, Peter, Wang, Qing, Weamer, Elise, Xu, Jinbin, Xu, Xiong, Morenas-Rodríguez, Estrella, Li, Yan, Franzmeier, Nicolai, Xiong, Chengjie, Suárez-Calvet, Marc, Fagan, Anne M, Schultz, Stephanie, Gordon, Brian A, Benzinger, Tammie L S, Hassenstab, Jason, McDade, Eric, Feederle, Regina, Karch, Celeste M, Schlepckow, Kai, Morris, John C, Kleinberger, Gernot, Nellgard, Bengt, Vöglein, Jonathan, Blennow, Kaj, Zetterberg, Henrik, Ewers, Michael, Jucker, Mathias, Levin, Johannes, Bateman, Randall J, and Haass, Christian

Published
2022
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9. An Eye in the Sky: Developing a Novel Framework for Visual Airport Traffic Control Tower Tasks

Author

Kinsella, Amelia, Smith, Lori, Collins, Rebecca, Berry, Katherine, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, and Stanton, Neville, editor

Published
2020
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10. Descriptive analysis of targeted carbapenemase genes and antibiotic susceptibility profiles among carbapenem-resistant Acinetobacter baumannii tested in the Antimicrobial Resistance Laboratory Network—United States, 2017–2020

Author

Sabour, Sarah, primary, Bantle, Katie, additional, Bhatnagar, Amelia, additional, Huang, Jennifer Y., additional, Biggs, Angela, additional, Bodnar, Janine, additional, Dale, Jennifer L., additional, Gleason, Rachel, additional, Klein, Liore, additional, Lasure, Megan, additional, Lee, Rachel, additional, Nazarian, Elizabeth, additional, Schneider, Emily, additional, Smith, Lori, additional, Snippes Vagnone, Paula, additional, Therrien, Michelle, additional, Tran, Michael, additional, Valley, Ann, additional, Wang, Chun, additional, Young, Erin L., additional, Lutgring, Joseph D., additional, and Brown, Allison C., additional

Published
2024
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12. Outbreak of E. coli O157:H7 Infections Associated with Exposure to Animal Manure in a Rural Community — Arizona and Utah, June–July 2017

Author

Luna, Sarah, Krishnasamy, Vikram, Saw, Louise, Smith, Lori, Wagner, Jennifer, Weigand, Jenna, Tewell, Mackenzie, Kellis, Marilee, Penev, Roumen, McCullough, Laine, Eason, Jeffrey, McCaffrey, Keegan, Burnett, Cindy, Oakeson, Kelly, Dimond, Melissa, Nakashima, Allyn, Barlow, Deidre, Scherzer, Anna, Sarino, Melanie, Schroeder, Morgan, Hassan, Rashida, Basler, Colin, Wise, Matthew, and Gieraltowski, Laura

Published
2018

19. Imperfect detection and misidentification affect inferences from data informing water operation decisions.

Author

Kirsch, Joseph E., Peterson, James T., Duarte, Adam, Goodman, Denise, Goodman, Andrew, Hugentobler, Sara, Meek, Mariah, Perry, Russell W., Phillis, Corey, Smith, Lori, and Stuart, Jeffrey

Subjects
CHINOOK salmon, FISH population estimates, IDENTIFICATION of fishes, STREAMFLOW, WATER management
Abstract

Objective: Managers can modify river flow regimes using fish monitoring data to minimize impacts from water management infrastructure. For example, operation of the gate-controlled Delta Cross Channel (DCC) in California can negatively affect the endangered Sacramento River winter-run Chinook Salmon Oncorhynchus tshawytscha. Although guidelines have been developed for DCC operations by using real-time juvenile fish sampling count data, there is uncertainty about how environmental conditions influence fish occupancy and the extent to which those relationships are affected by sampling and identification error. Methods: We evaluated the effect of environmental conditions, imperfect detection, and misidentification error on salmon occupancy by analyzing data using hierarchical multistate occupancy models. A total of 14,147 trawl tows and beach seine hauls were conducted on 1058 sampling days between October and December from 1996 to 2019. During these surveys, 2803 juvenile winter-run Chinook Salmon were identified, and approximately 29% of the sampling days had at least one winter-run juvenile detected. Result: The probability of misidentifying an individual juvenile winter-run Chinook Salmon in the field was estimated to be 0.056 based on fish identification examinations and genetic sampling. Occupancy varied considerably and was related to flow characteristics, water clarity, weather, time of year, and whether occupancy was detected during the previous sampling day. However, these relationships and their significance changed considerably when accounting for imperfect detection and the probability of misidentifying individual juvenile salmon. Detection was <0.3 under average sampling conditions during a single sample and was influenced by flow, water clarity, site, and volume sampled. Conclusion: Our modeling results indicate that DCC gate closure decisions could occur on fewer days when imperfect detection and misidentification error are not accounted for. These findings demonstrate the need to account for identification and detection error while using monitoring data to assess factors influencing fish occupancy and inform future management decisions. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Supplementary Table S2 from A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside

Author

Chiang, Cheryl Lai-Lai, primary, Kandalaft, Lana E., primary, Tanyi, Janos, primary, Hagemann, Andrea R., primary, Motz, Gregory T., primary, Svoronos, Nikolaos, primary, Montone, Kathleen, primary, Mantia-Smaldone, Gina M., primary, Smith, Lori, primary, Nisenbaum, Harvey L., primary, Levine, Bruce L., primary, Kalos, Michael, primary, Czerniecki, Brian J., primary, Torigian, Drew A., primary, Powell, Daniel J., primary, Mick, Rosemarie, primary, and Coukos, George, primary

Published
2023
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28. Supplementary Figure S4 from A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside

Author

Chiang, Cheryl Lai-Lai, primary, Kandalaft, Lana E., primary, Tanyi, Janos, primary, Hagemann, Andrea R., primary, Motz, Gregory T., primary, Svoronos, Nikolaos, primary, Montone, Kathleen, primary, Mantia-Smaldone, Gina M., primary, Smith, Lori, primary, Nisenbaum, Harvey L., primary, Levine, Bruce L., primary, Kalos, Michael, primary, Czerniecki, Brian J., primary, Torigian, Drew A., primary, Powell, Daniel J., primary, Mick, Rosemarie, primary, and Coukos, George, primary

Published
2023
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29. Supplementary Materials, Methods, Figures and Table legends from A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside

Author

Chiang, Cheryl Lai-Lai, primary, Kandalaft, Lana E., primary, Tanyi, Janos, primary, Hagemann, Andrea R., primary, Motz, Gregory T., primary, Svoronos, Nikolaos, primary, Montone, Kathleen, primary, Mantia-Smaldone, Gina M., primary, Smith, Lori, primary, Nisenbaum, Harvey L., primary, Levine, Bruce L., primary, Kalos, Michael, primary, Czerniecki, Brian J., primary, Torigian, Drew A., primary, Powell, Daniel J., primary, Mick, Rosemarie, primary, and Coukos, George, primary

Published
2023
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30. Data from MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer

Author

Yang, Nuo, primary, Kaur, Sippy, primary, Volinia, Stefano, primary, Greshock, Joel, primary, Lassus, Heini, primary, Hasegawa, Kosei, primary, Liang, Shun, primary, Leminen, Arto, primary, Deng, Shan, primary, Smith, Lori, primary, Johnstone, Cameron N., primary, Chen, Xian-Ming, primary, Liu, Chang-Gong, primary, Huang, Qihong, primary, Katsaros, Dionyssios, primary, Calin, George Adrian, primary, Weber, Barbara L., primary, Bützow, Ralf, primary, Croce, Carlo M., primary, Coukos, George, primary, and Zhang, Lin, primary

Published
2023
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31. Supplementary References from MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer

Author

Yang, Nuo, primary, Kaur, Sippy, primary, Volinia, Stefano, primary, Greshock, Joel, primary, Lassus, Heini, primary, Hasegawa, Kosei, primary, Liang, Shun, primary, Leminen, Arto, primary, Deng, Shan, primary, Smith, Lori, primary, Johnstone, Cameron N., primary, Chen, Xian-Ming, primary, Liu, Chang-Gong, primary, Huang, Qihong, primary, Katsaros, Dionyssios, primary, Calin, George Adrian, primary, Weber, Barbara L., primary, Bützow, Ralf, primary, Croce, Carlo M., primary, Coukos, George, primary, and Zhang, Lin, primary

Published
2023
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32. Supplementary Figure 1 from MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer

Author

Yang, Nuo, primary, Kaur, Sippy, primary, Volinia, Stefano, primary, Greshock, Joel, primary, Lassus, Heini, primary, Hasegawa, Kosei, primary, Liang, Shun, primary, Leminen, Arto, primary, Deng, Shan, primary, Smith, Lori, primary, Johnstone, Cameron N., primary, Chen, Xian-Ming, primary, Liu, Chang-Gong, primary, Huang, Qihong, primary, Katsaros, Dionyssios, primary, Calin, George Adrian, primary, Weber, Barbara L., primary, Bützow, Ralf, primary, Croce, Carlo M., primary, Coukos, George, primary, and Zhang, Lin, primary

Published
2023
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33. Supplementary Table 2 from MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer

Author

Yang, Nuo, primary, Kaur, Sippy, primary, Volinia, Stefano, primary, Greshock, Joel, primary, Lassus, Heini, primary, Hasegawa, Kosei, primary, Liang, Shun, primary, Leminen, Arto, primary, Deng, Shan, primary, Smith, Lori, primary, Johnstone, Cameron N., primary, Chen, Xian-Ming, primary, Liu, Chang-Gong, primary, Huang, Qihong, primary, Katsaros, Dionyssios, primary, Calin, George Adrian, primary, Weber, Barbara L., primary, Bützow, Ralf, primary, Croce, Carlo M., primary, Coukos, George, primary, and Zhang, Lin, primary

Published
2023
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34. Supplementary Table 1 from MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer

Author

Yang, Nuo, primary, Kaur, Sippy, primary, Volinia, Stefano, primary, Greshock, Joel, primary, Lassus, Heini, primary, Hasegawa, Kosei, primary, Liang, Shun, primary, Leminen, Arto, primary, Deng, Shan, primary, Smith, Lori, primary, Johnstone, Cameron N., primary, Chen, Xian-Ming, primary, Liu, Chang-Gong, primary, Huang, Qihong, primary, Katsaros, Dionyssios, primary, Calin, George Adrian, primary, Weber, Barbara L., primary, Bützow, Ralf, primary, Croce, Carlo M., primary, Coukos, George, primary, and Zhang, Lin, primary

Published
2023
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36. sj-pdf-1-vdi-10.1177_10406387231178558 – Supplemental material for Validation and interlaboratory comparison of anticoagulant rodenticide analysis in animal livers using ultra-performance liquid chromatography–mass spectrometry

Author

Chen, Yang, Lopez, Salvador, Reddy, Ravinder M., Wan, Jason, Tkachenko, Andriy, Nemser, Sarah M., Smith, Lori, and Reimschessel, Renate

Subjects
70706 Veterinary Medicine, FOS: Clinical medicine, FOS: Veterinary sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-vdi-10.1177_10406387231178558 for Validation and interlaboratory comparison of anticoagulant rodenticide analysis in animal livers using ultra-performance liquid chromatography–mass spectrometry by Yang Chen, Salvador Lopez, Ravinder M. Reddy, Jason Wan, Andriy Tkachenko, Sarah M. Nemser, Lori Smith and Renate Reimschessel in Journal of Veterinary Diagnostic Investigation

Published
2023
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37. Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study

Author

Boerwinkle, Anna H, primary, Gordon, Brian A, additional, Wisch, Julie, additional, Flores, Shaney, additional, Henson, Rachel L, additional, Butt, Omar H, additional, McKay, Nicole, additional, Chen, Charles D, additional, Benzinger, Tammie L S, additional, Fagan, Anne M, additional, Handen, Benjamin L, additional, Christian, Bradley T, additional, Head, Elizabeth, additional, Mapstone, Mark, additional, Rafii, Michael S, additional, O'Bryant, Sid, additional, Lai, Florence, additional, Rosas, H Diana, additional, Lee, Joseph H, additional, Silverman, Wayne, additional, Brickman, Adam M, additional, Chhatwal, Jasmeer P, additional, Cruchaga, Carlos, additional, Perrin, Richard J, additional, Xiong, Chengjie, additional, Hassenstab, Jason, additional, McDade, Eric, additional, Bateman, Randall J, additional, Ances, Beau M, additional, Aizenstein, Howard J, additional, Andrews, Howard F, additional, Bell, Karen, additional, Birn, Rasmus M, additional, Bulova, Peter, additional, Cheema, Amrita, additional, Chen, Kewei, additional, Clare, Isabel, additional, Clark, Lorraine, additional, Cohen, Ann D, additional, Constantino, John N, additional, Doran, Eric W, additional, Feingold, Eleanor, additional, Foroud, Tatiana M, additional, Hartley, Sigan L, additional, Hom, Christy, additional, Honig, Lawrence, additional, Ikonomovic, Milos D, additional, Johnson, Sterling C, additional, Jordan, Courtney, additional, Kamboh, M Ilyas, additional, Keator, David, additional, Klunk MD, William E, additional, Kofler, Julia K, additional, Kreisl, William C, additional, Krinsky- McHale, Sharon J, additional, Lao, Patrick, additional, Laymon, Charles, additional, Lott, Ira T, additional, Lupson, Victoria, additional, Mathis, Chester A, additional, Minhas, Davneet S, additional, Nadkarni, Neelesh, additional, Pang, Deborah, additional, Petersen, Melissa, additional, Price, Julie C, additional, Pulsifer, Margaret, additional, Reiman, Eric, additional, Rizvi, Batool, additional, Sabbagh, Marwan N, additional, Schupf, Nicole, additional, Tudorascu, Dana L, additional, Tumuluru, Rameshwari, additional, Tycko, Benjamin, additional, Varadarajan, Badri, additional, White, Desiree A, additional, Yassa, Michael A, additional, Zaman, Shahid, additional, Zhang, Fan, additional, Adams, Sarah, additional, Allegri, Ricardo, additional, Araki, Aki, additional, Barthelemy, Nicolas, additional, Bechara, Jacob, additional, Berman, Sarah, additional, Bodge, Courtney, additional, Brandon, Susan, additional, Brooks, William, additional, Brosch, Jared, additional, Buck, Jill, additional, Buckles, Virginia, additional, Carter, Kathleen, additional, Cash, Lisa, additional, Mendez, Patricio C, additional, Chua, Jasmin, additional, Chui, Helena, additional, Courtney, Laura, additional, Day, Gregory, additional, DeLaCruz, Chrismary, additional, Denner, Darcy, additional, Diffenbacher, Anna, additional, Dincer, Aylin, additional, Donahue, Tamara, additional, Douglas, Jane, additional, Duong, Duc, additional, Egido, Noelia, additional, Esposito, Bianca, additional, Farlow, Marty, additional, Feldman, Becca, additional, Fitzpatrick, Colleen, additional, Fox, Nick, additional, Franklin, Erin, additional, Joseph-Mathurin, Nelly, additional, Fujii, Hisako, additional, Gardener, Samantha, additional, Ghetti, Bernardino, additional, Goate, Alison, additional, Goldberg, Sarah, additional, Goldman, Jill, additional, Gonzalez, Alyssa, additional, Gräber-Sultan, Susanne, additional, Graff-Radford, Neill, additional, Graham, Morgan, additional, Gray, Julia, additional, Gremminger, Emily, additional, Grilo, Miguel, additional, Groves, Alex, additional, Haass, Christian, additional, Häslerc, Lisa, additional, Hellm, Cortaiga, additional, Herries, Elizabeth, additional, Hoechst-Swisher, Laura, additional, Hofmann, Anna, additional, Holtzman, David, additional, Hornbeck, Russ, additional, Igor, Yakushev, additional, Ihara, Ryoko, additional, Ikeuchi, Takeshi, additional, Ikonomovic, Snezana, additional, Ishii, Kenji, additional, Jack, Clifford, additional, Jerome, Gina, additional, Johnson, Erik, additional, Jucker, Mathias, additional, Karch, Celeste, additional, Käser, Stephan, additional, Kasuga, Kensaku, additional, Keefe, Sarah, additional, Klunk, William, additional, Koeppe, Robert, additional, Koudelis, Deb, additional, Kuder-Buletta, Elke, additional, Laske, Christoph, additional, Levey, Allan, additional, Levin, Johannes, additional, Li, Yan, additional, Lopez, Oscar, additional, Marsh, Jacob, additional, Martins, Ralph, additional, Mason, Neal S, additional, Masters, Colin, additional, Mawuenyega, Kwasi, additional, McCullough, Austin, additional, Mejia, Arlene, additional, Morenas-Rodriguez, Estrella, additional, Morris, John C, additional, Mountz, James, additional, Mummery, Catherine, additional, Nagamatsu, Akemi, additional, Neimeyer, Katie, additional, Niimi, Yoshiki, additional, Noble, James, additional, Norton, Joanne, additional, Nuscher, Brigitte, additional, Obermüller, Ulricke, additional, O'Connor, Antoinette, additional, Patira, Riddhi, additional, Ping, Lingyan, additional, Preische, Oliver, additional, Renton, Alan, additional, Ringman, John, additional, Salloway, Stephen, additional, Schofield, Peter, additional, Senda, Michio, additional, Seyfried, Nicholas T, additional, Shady, Kristine, additional, Shimada, Hiroyuki, additional, Sigurdson, Wendy, additional, Smith, Jennifer, additional, Smith, Lori, additional, Snitz, Beth, additional, Sohrabi, Hamid, additional, Stephens, Sochenda, additional, Taddei, Kevin, additional, Thompson, Sarah, additional, Vöglein, Jonathan, additional, Wang, Peter, additional, Wang, Qing, additional, Weamer, Elise, additional, Xu, Jinbin, additional, and Xu, Xiong, additional

Published
2023
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38. Validation and interlaboratory comparison of anticoagulant rodenticide analysis in animal livers using ultra-performance liquid chromatography–mass spectrometry.

Author

Chen, Yang, Lopez, Salvador, Reddy, Ravinder M., Wan, Jason, Tkachenko, Andriy, Nemser, Sarah M., Smith, Lori, and Reimschuessel, Renate

Subjects
LIVER analysis, LIQUID chromatography-mass spectrometry, RODENT populations, RODENT control, ANTICOAGULANTS
Abstract

Anticoagulant rodenticides (ARs) are used to control rodent populations. Poisoning of non-target species can occur by accidental consumption of commercial formulations used for rodent control. A robust method for determining ARs in animal tissues is important for animal postmortem diagnostic and forensic purposes. We evaluated an ultra-performance liquid chromatography coupled with mass spectrometry (UPLC-MS) method to quantify 8 ARs (brodifacoum, bromadiolone, chlorophacinone, coumachlor, dicoumarol, difethialone, diphacinone, warfarin) in a wide range of animal (bovine, canine, chicken, equine, porcine) liver samples, including incurred samples. We further evaluated UPLC-MS in 2 interlaboratory comparison (ILC) studies; one an ILC exercise (ICE), the other a proficiency test (PT). The limits of detection of UPLC-MS were 0.3–3.1 ng/g, and the limits of quantification were 0.8–9.4 ng/g. The recoveries obtained using UPLC-MS were 90–115%, and relative SDs were 1.2–13% for each of the 8 ARs for the 50, 500, and 2,000 ng/g spiked liver samples. The overall accuracy from the laboratories participating in the 2 ILC studies (4 and 11 laboratories for ICE and PT studies, respectively) were 86–118%, with relative repeatability SDs of 3.7–11%, relative reproducibility SDs of 7.8–31.2%, and Horwitz ratio values of 0.5–1.5. Via the ILC studies, we verified the accuracy of UPLC-MS for AR analysis in liver matrices and demonstrated that ILC can be utilized to evaluate performance characteristics of analytical methods. [ABSTRACT FROM AUTHOR]

Published
2023
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39. A Multiple-Serotype Outbreak of Salmonella Infections Linked to Kratom, United States, 2017–2018

Author

Schwensohn, Colin, primary, Nsubuga, Johnson, additional, Cronquist, Laura, additional, Jose, Gino, additional, Mastel, Laura, additional, McCullough, Laine, additional, Smith, Lori, additional, Powell, Melissa, additional, Booth, Hillary, additional, Allen, Krisandra, additional, Classon, Andrew, additional, and Gieraltowski, Laura, additional

Published
2022
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40. Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying the PSEN1 H163R mutation

Author

Adams, Sarah, Allegri, Ricardo, Araki, Aki, Barthelemy, Nicolas, Bateman, Randall, Bechara, Jacob, Benzinger, Tammie, Berman, Sarah, Bodge, Courtney, Brandon, Sus, (Bill) Brooks, William, Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Chrem Mendez, Patricio, Chua, Jasmin, Chui, Helena, Courtney, Laura, Cruchaga, Carlos, Day, Gregory S, DeLaCruz, Chrismary, Denner, Darcy, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Fagan, Anne, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Flores, Shaney, Fox, Nick, Franklin, Erin, Joseph-Mathurin, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Gonzalez, Alyssa, Gordon, Brian, Gr¨aber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Haass, Christian, H¨asler, Lisa, Hassenstab, Jason, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Jack, Clifford, Jerome, Gina, Johnson, Erik, Jucker, Mathias, Karch, Celeste, K¨aser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William, Koeppe, Robert, Koudelis, Deb, Kuder-Buletta, Elke, Laske, Christoph, Levey, Allan, Levin, Johannes, Li, Yan, Lopez, Oscar, Marsh, Jacob, Martins, Ralph, Scott Mason, Neal, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, McDade, Eric, Mejia, Arlene, Morenas-Rodriguez, Estrella, Morris, John, Mountz, James, Mummery, Cath, Nadkarni, Neelesh, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Obermüller, Ulricke, O’Connor, Antoinette, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Senda, Michio, Seyfried, Nicholas T, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Taddei, Kevin, Thompson, Sarah, V¨oglein, Jonathan, Wang, Peter, Wang, Qing, Weamer, Elise, Xiong, Chengjie, Xu, Jinbin, Xu, Xiong, Hernández, Damián, Morgan Schlicht, Stephanie, Elli Clarke, Jordan, Daniszewski, Maciej, Karch, Celeste M., Goate, Alison M., and Pébay, Alice

Published
2024
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41. Comprehensive Evaluation of an HPLC–MS-MS Method for Quantitation of Seven Anti-Coagulant Rodenticides and Dicoumarol in Animal Serum.

Author

Francis, Kyle A, Tkachenko, Andriy, Johnson, Joseph T, Smith, Lori L, Noonan, Robyn T, Filigenzi, Michael S, Gaskill, Cynthia L, and Romano, Megan C

Subjects
ELECTROSPRAY ionization mass spectrometry, LIQUID chromatography-mass spectrometry, RODENTICIDES, ANTICOAGULANTS, RODENT populations, EVALUATION methodology, ACETONE
Abstract

Anti-coagulant rodenticides (ARs) are commonly utilized for controlling rodent populations; however, non-target companion and wildlife animals are also exposed. A method was developed for quantitation of seven ARs (chlorophacinone, coumachlor, bromadiolone, brodifacoum, difethialone, diphacinone and warfarin) and dicoumarol (a naturally occurring anti-coagulant) in animal serum. Analytes were extracted with 10% (v/v) acetone in methanol and analyzed by reverse phase high-performance liquid chromatography–tandem mass spectrometry using electrospray ionization (negative mode) combined with multiple reaction monitoring. In-house method validation in the originating laboratory using non-blinded samples revealed method limits of quantitation at 2.5 ng/mL for all analytes. The inter-assay accuracy ranged from 99% to 104%, and the relative standard deviation ranged from 3.5% to 20.5%. Method performance was then verified in the originating laboratory during an exercise organized by an independent party using blinded samples. The method was successfully transferred to two naïve laboratories and further evaluated for reproducibility among three laboratories by means of Horwitz ratio (HorRat(R)) values. Such extensive validation provides a high degree of confidence that the method is rugged, robust, and will perform as expected if used by others in the future. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease

Author

Millar, Peter R., primary, Luckett, Patrick H., additional, Gordon, Brian A., additional, Benzinger, Tammie L.S., additional, Schindler, Suzanne E., additional, Fagan, Anne M., additional, Cruchaga, Carlos, additional, Bateman, Randall J., additional, Allegri, Ricardo, additional, Jucker, Mathias, additional, Lee, Jae-Hong, additional, Mori, Hiroshi, additional, Salloway, Stephen P, additional, Yakushev, Igor, additional, Morris, John C., additional, Ances, Beau M., additional, Adams, Sarah, additional, Araki, Aki, additional, Barthelemy, Nicolas, additional, Bateman, Randall, additional, Bechara, Jacob, additional, Benzinger, Tammie, additional, Berman, Sarah, additional, Bodge, Courtney, additional, Brandon, Susan, additional, Brooks, William (Bill), additional, Brosch, Jared, additional, Buck, Jill, additional, Buckles, Virginia, additional, Carter, Kathleen, additional, Cash, Lisa, additional, Chen, Charlie, additional, Chhatwal, Jasmeer, additional, Mendez, Patricio Chrem, additional, Chua, Jasmin, additional, Chui, Helena, additional, Courtney, Laura, additional, Day, Gregory S, additional, DeLaCruz, Chrismary, additional, Denner, Darcy, additional, Diffenbacher, Anna, additional, Dincer, Aylin, additional, Donahue, Tamara, additional, Douglas, Jane, additional, Duong, Duc, additional, Egido, Noelia, additional, Esposito, Bianca, additional, Fagan, Anne, additional, Farlow, Marty, additional, Feldman, Becca, additional, Fitzpatrick, Colleen, additional, Flores, Shaney, additional, Fox, Nick, additional, Franklin, Erin, additional, Joseph-Mathurin, Nelly, additional, Fujii, Hisako, additional, Gardener, Samantha, additional, Ghetti, Bernardino, additional, Goate, Alison, additional, Goldberg, Sarah, additional, Goldman, Jill, additional, Gonzalez, Alyssa, additional, Gordon, Brian, additional, Gräber-Sultan, Susanne, additional, Graff-Radford, Neill, additional, Graham, Morgan, additional, Gray, Julia, additional, Gremminger, Emily, additional, Grilo, Miguel, additional, Groves, Alex, additional, Haass, Christian, additional, Häsler, Lisa, additional, Hassenstab, Jason, additional, Hellm, Cortaiga, additional, Herries, Elizabeth, additional, Hoechst-Swisher, Laura, additional, Hofmann, Anna, additional, Holtzman, David, additional, Hornbeck, Russ, additional, Igor, Yakushev, additional, Ihara, Ryoko, additional, Ikeuchi, Takeshi, additional, Ikonomovic, Snezana, additional, Ishii, Kenji, additional, Jack, Clifford, additional, Jerome, Gina, additional, Johnson, Erik, additional, Karch, Celeste, additional, Käser, Stephan, additional, Kasuga, Kensaku, additional, Keefe, Sarah, additional, Klunk, William, additional, Koeppe, Robert, additional, Koudelis, Deb, additional, Kuder-Buletta, Elke, additional, Laske, Christoph, additional, Levey, Allan, additional, Levin, Johannes, additional, Li, Yan, additional, Lopez, Oscar, additional, Marsh, Jacob, additional, Martins, Ralph, additional, Mason, Neal Scott, additional, Masters, Colin, additional, Mawuenyega, Kwasi, additional, McCullough, Austin, additional, McDade, Eric, additional, Mejia, Arlene, additional, Morenas-Rodriguez, Estrella, additional, Morris, John, additional, Mountz, James, additional, Mummery, Cath, additional, Nadkarni, N eelesh, additional, Nagamatsu, Akemi, additional, Neimeyer, Katie, additional, Niimi, Yoshiki, additional, Noble, James, additional, Norton, Joanne, additional, Nuscher, Brigitte, additional, Obermüller, Ulricke, additional, O'Connor, Antoinette, additional, Patira, Riddhi, additional, Perrin, Richard, additional, Ping, Lingyan, additional, Preische, Oliver, additional, Renton, Alan, additional, Ringman, John, additional, Salloway, Stephen, additional, Schofield, Peter, additional, Senda, Michio, additional, Seyfried, Nicholas T, additional, Shady, Kristine, additional, Shimada, Hiroyuki, additional, Sigurdson, Wendy, additional, Smith, Jennifer, additional, Smith, Lori, additional, Snitz, Beth, additional, Sohrabi, Hamid, additional, Stephens, Sochenda, additional, Taddei, Kevin, additional, Thompson, Sarah, additional, Vöglein, Jonathan, additional, Wang, Peter, additional, Wang, Qing, additional, Weamer, Elise, additional, Xiong, Chengjie, additional, Xu, Jinbin, additional, and Xu, Xiong, additional

Published
2022
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43. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study

Author

Morenas-Rodríguez, Estrella, primary, Li, Yan, additional, Nuscher, Brigitte, additional, Franzmeier, Nicolai, additional, Xiong, Chengjie, additional, Suárez-Calvet, Marc, additional, Fagan, Anne M, additional, Schultz, Stephanie, additional, Gordon, Brian A, additional, Benzinger, Tammie L S, additional, Hassenstab, Jason, additional, McDade, Eric, additional, Feederle, Regina, additional, Karch, Celeste M, additional, Schlepckow, Kai, additional, Morris, John C, additional, Kleinberger, Gernot, additional, Nellgard, Bengt, additional, Vöglein, Jonathan, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Ewers, Michael, additional, Jucker, Mathias, additional, Levin, Johannes, additional, Bateman, Randall J, additional, Haass, Christian, additional, Adams, Sarah, additional, Allegri, Ricardo, additional, Araki, Aki, additional, Barthelemy, Nicolas, additional, Bechara, Jacob, additional, Berman, Sarah, additional, Bodge, Courtney, additional, Brandon, Susan, additional, Brooks, William (Bill), additional, Brosch, Jared, additional, Buck, Jill, additional, Buckles, Virginia, additional, Carter, Kathleen, additional, Cash, Lisa, additional, Chen, Charlie, additional, Chhatwal, Jasmeer, additional, Chrem, Patricio, additional, Chua, Jasmin, additional, Chui, Helena, additional, Cruchaga, Carlos, additional, Day, Gregory S, additional, De La Cruz, Chrismary, additional, Denner, Darcy, additional, Diffenbacher, Anna, additional, Dincer, Aylin, additional, Donahue, Tamara, additional, Douglas, Jane, additional, Duong, Duc, additional, Egido, Noelia, additional, Esposito, Bianca, additional, Farlow, Marty, additional, Feldman, Becca, additional, Fitzpatrick, Colleen, additional, Flores, Shaney, additional, Fox, Nick, additional, Franklin, Erin, additional, Friedrichsen, Nelly, additional, Fujii, Hisako, additional, Gardener, Samantha, additional, Ghetti, Bernardino, additional, Goate, Alison, additional, Goldberg, Sarah, additional, Goldman, Jill, additional, Gonzalez, Alyssa, additional, Gräber-Sultan, Susanne, additional, Graff-Radford, Neill, additional, Graham, Morgan, additional, Gray, Julia, additional, Gremminger, Emily, additional, Grilo, Miguel, additional, Groves, Alex, additional, Häsler, Lisa, additional, Hellm, Cortaiga, additional, Herries, Elizabeth, additional, Hoechst-Swisher, Laura, additional, Hofmann, Anna, additional, Holtzman, David, additional, Hornbeck, Russ, additional, Igor, Yakushev, additional, Ihara, Ryoko, additional, Ikeuchi, Takeshi, additional, Ikonomovic, Snezana, additional, Ishii, Kenji, additional, Jack, Clifford, additional, Jerome, Gina, additional, Johnson, Erik, additional, Käser, Stephan, additional, Kasuga, Kensaku, additional, Keefe, Sarah, additional, Klunk, William (Bill), additional, Koeppe, Robert, additional, Koudelis, Deb, additional, Kuder-Buletta, Elke, additional, Laske, Christoph, additional, Levey, Allan, additional, Lopez, Oscar, additional, Marsh, Jacob, additional, Martinez, Rita, additional, Martins, Ralph, additional, Mason, Neal Scott, additional, Masters, Colin, additional, Mawuenyega, Kwasi, additional, McCullough, Austin, additional, Mejia, Arlene, additional, MountzMD, James, additional, Mummery, Cath, additional, Nadkarni, Neelesh, additional, Nagamatsu, Akemi, additional, Neimeyer, Katie, additional, Niimi, Yoshiki, additional, Noble, James, additional, Norton, Joanne, additional, O'Connor, Antoinette, additional, Obermüller, Ulricke, additional, Patira, Riddhi, additional, Perrin, Richard, additional, Ping, Lingyan, additional, Preische, Oliver, additional, Renton, Alan, additional, Ringman, John, additional, Salloway, Stephen, additional, Schofield, Peter, additional, Senda, Michio, additional, Seyfried, Nick, additional, Shady, Kristine, additional, Shimada, Hiroyuki, additional, Sigurdson, Wendy, additional, Smith, Jennifer, additional, Smith, Lori, additional, Snitz, Beth, additional, Sohrabi, Hamid, additional, Stephens, Sochenda, additional, Taddei, Kevin, additional, Thompson, Sarah, additional, Wang, Peter, additional, Wang, Qing, additional, Weamer, Elise, additional, Xu, Jinbin, additional, and Xu, Xiong, additional

Published
2022
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44. Multistate outbreak of Salmonella Mbandaka infections linked to sweetened puffed wheat cereal – United States, 2018

Author

Keaton, Amelia A., primary, Schwensohn, Colin A., additional, Brandenburg, Joshua M., additional, Pereira, Evelyn, additional, Adcock, Brandon, additional, Tecle, Selam, additional, Hinnenkamp, Rachel, additional, Havens, Jeff, additional, Bailey, Kim, additional, Applegate, Brad, additional, Whitney, Pamela, additional, Gibson, Deborah, additional, Manion, Kathy, additional, Griffin, Michelle, additional, Ritter, Joy, additional, Biskupiak, Carrie, additional, Ajileye, Kadri, additional, Golwalkar, Mugdha, additional, Gosciminski, Michael, additional, Viveiros, Brendalee, additional, Caron, Genevieve, additional, McCullough, Laine, additional, Smith, Lori, additional, Vidyaprakash, Eshaw, additional, Doyle, Matthew, additional, Hardy, Cerise, additional, Elliot, Elisa L., additional, and Gieraltowski, Laura B., additional

Published
2022
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46. Emergence of Severe Metastatic Hypervirulent Klebsiella pneumoniae infections in Texas

Author

Alam, Junaid M., primary, Ahmed, Haris, additional, Thai, Hong M., additional, Garnepudi, Kevin, additional, Kesavan, Ramesh B., additional, Jayaraman, Gnananandh, additional, Sangster, Anna, additional, Curry, Dylan, additional, Butz, Heidi A., additional, Smith, Lori, additional, Vowles, Maureen, additional, Oakeson, Kelly F., additional, Young, Erin L., additional, and Sarva, Siva T., additional

Published
2021
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47. Association ofBDNFVal66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease

Author

Lim, Yen Ying, Maruff, Paul, Levin, Johannes, Snitz, Beth, Thompson, Sarah, Weamer, Elise, Mason, Neal Scott, Chui, Helena, Ringman, John, Adams, Sarah, Barthelemy, Nicolas, Bateman, Randall, Benzinger, Tammie, Farlow, Martin R, Brandon, Susan, Buckles, Virginia, Cash, Lisa, Chen, Charlie, Chua, Jasmin, Cruchaga, Carlos, Denner, Darcy, Dincer, Aylin, Donahue, Tamara, Fagan, Anne, Graff-Radford, Neill R, Feldman, Becca, Flores, Shaney, Franklin, Erin, Friedrichsen, Nelly, Gonzalez, Alyssa, Gordon, Brian, Gray, Julia, Gremminger, Emily, Groves, Alex, Hassenstab, Jason, Laske, Christoph, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Holtzman, David, Hornbeck, Russ, Jerome, Gina, Karch, Celeste, Keefe, Sarah, Koudelis, Deb, Li, Yan, Masters, Colin L, Marsh, Jacob, Martinez, Rita, Mawuenyega, Kwasi, McCullough, Austin, McDade, Eric, Morris, John, Norton, Joanne, Perrin, Richard, Shady, Kristine, Sigurdson, Wendy, Salloway, Stephen, Smith, Jennifer, Wang, Peter, Wang, Qing, Xiong, Chengjie, Xu, Jinbin, Xu, Xiong, Schofield, Peter R, Morris, John C, Bateman, Randall J, Barthélemy, Nicolas R, Network, Dominantly Inherited Alzheimer, Chhatwal, Jasmeer, Fitzpatrick, Colleen, Bodge, Courtney, De La Cruz, Chrismary, Goldman, Jill, Mejia, Arlene, Neimeyer, Katie, Noble, James, Goate, Alison, Gardener, Samantha, Martins, Ralph, Sohrabi, Hamid, Taddei, Kevin, Carter, Kathleen, Duong, Duc, Johnson, Erik, Levey, Allan, Ping, Lingyan, Seyfried, Nick, Gräber-Sultan, Susanne, Häsler, Lisa, Hofmann, Anna, Jucker, Mathias, Kaeser, Stephan, Kuder-Buletta, Elke, Preische, Oliver, Diffenbacher, Anna, Igor, Yakushev, Sato, Chihiro, Vöglein, Jonathan, Obermüller, Ulricke, Esposito, Bianca, Renton, Alan, Brosch, Jared, Buck, Jill, Farlow, Marty, Ghetti, Bernardino, Fagan, Anne M, Allegri, Ricardo, Chrem, Patricio, Egido, Noelia, Haass, Christian, Morenas Rodriguez, Estrella, Nuscher, Brigitte, Day, Gregory S, Graff-Radford, Neill, Graham, Morgan, Stephens, Sochenda, Benzinger, Tammie L S, Jack, Clifford, Bechara, Jacob, Brooks, William Bill, Schofield, Peter, Araki, Aki, Ikeuchi, Takeshi, Kasuga, Kensaku, Ishii, Kenji, Fujii, Hisako, Senda, Michio, Shimada, Hiroyuki, Ihara, Ryoko, Nagamatsu, Akemi, Niimi, Yoshiki, Douglas, Jane, Fox, Nick, Grilo, Miguel, Mummery, Cath, O'Connor, Antoinette, Masters, Colin, Koeppe, Robert, Berman, Sarah, Goldberg, Sarah, Ikonomovic, Snezana, Klunk, William Bill, Lopez, Oscar, Mountz, James, Nadkarni, Neelesh, Patira, Riddhi, and Smith, Lori

Subjects
Adult, Male, Threonine, Memory Disorders, methods [Positron-Emission Tomography], cerebrospinal fluid [Amyloid beta-Peptides], Middle Aged, genetics [Brain-Derived Neurotrophic Factor], cerebrospinal fluid [Alzheimer Disease], Cognition, Cross-Sectional Studies, cerebrospinal fluid [tau Proteins], Humans, Female, ddc:610, Neurology (clinical), Biomarkers, Aged
Abstract

Allelic variation in the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism moderates increases in cerebrospinal fluid (CSF) levels of tau and phosphorylated tau 181 (p-tau181), measured using immunoassay, and cognitive decline in presymptomatic dominantly inherited Alzheimer disease (DIAD). Advances in mass spectrometry show that CSF tau phosphorylation occupancy at threonine 181 and 217 (p-tau181/tau181, p-tau217/tau217) increases with initial β-amyloid (Aβ) aggregation, while phosphorylation occupancy at threonine 205 (p-tau205/tau205) and level of total tau increase when brain atrophy and clinical symptoms become evident.To determine whether site-specific tau phosphorylation occupancy (ratio of phosphorylated to unphosphorylated tau) is associated with BDNF Val66Met in presymptomatic and symptomatic DIAD.This cross-sectional cohort study included participants from the Dominantly Inherited Alzheimer Network (DIAN) and Aβ-positive cognitively normal older adults in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Data were collected from 2009 through 2018 at multicenter clinical sites in the United States, United Kingdom, and Australia, with no follow-up. DIAN participants provided a CSF sample and completed clinical and cognitive assessments. Data analysis was conducted between March 2020 and March 2021.Mass spectrometry analysis was used to determine site-specific tau phosphorylation level; tau levels were also measured using immunoassay. Episodic memory and global cognitive composites were computed.Of 374 study participants, 144 were mutation noncarriers, 156 were presymptomatic mutation carriers, and 74 were symptomatic carriers. Of the 527 participants in the network, 153 were excluded because their CSF sample, BDNF status, or both were unavailable. Also included were 125 Aβ-positive cognitively normal older adults in the ADNI. The mean (SD) age of DIAD participants was 38.7 (10.9) years; 43% were women. The mean (SD) age of participants with preclinical sporadic AD was 74.8 (5.6) years; 52% were women. In presymptomatic mutation carriers, compared with Val66 homozygotes, Met66 carriers showed significantly poorer episodic memory (d = 0.62; 95% CI, 0.28-0.95), lower hippocampal volume (d = 0.40; 95% CI, 0.09-0.71), and higher p-tau217/tau217 (d = 0.64; 95% CI, 0.30-0.97), p-tau181/tau181 (d = 0.65; 95% CI, 0.32-0.99), and mass spectrometry total tau (d = 0.43; 95% CI, 0.10-0.76). In symptomatic mutation carriers, Met66 carriers showed significantly poorer global cognition (d = 1.17; 95% CI, 0.65-1.66) and higher p-tau217/tau217 (d = 0.53; 95% CI, 0.05-1.01), mass spectrometry total tau (d = 0.78; 95% CI, 0.28-1.25), and p-tau205/tau205 (d = 0.97; 95% CI, 0.46-1.45), when compared with Val66 homozygotes. In preclinical sporadic AD, Met66 carriers showed poorer episodic memory (d = 0.39; 95% CI, 0.00-0.77) and higher total tau (d = 0.45; 95% CI, 0.07-0.84) and p-tau181 (d = 0.46; 95% CI, 0.07-0.85).In DIAD, clinical disease stage and BDNF Met66 were associated with cognitive impairment and levels of site-specific tau phosphorylation. This suggests that pharmacological strategies designed to increase neurotrophic support in the presymptomatic stages of AD may be beneficial.

Published
2022
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48. Putting Indy on the cutting edge of health, science and tech

Author

Smith, Lori

Subjects
Biotechnology industry -- Growth -- Location, Health care industry -- Growth -- Location, Health care industry, Company growth, Business, Business, regional
Abstract

Central Indiana is attracting life sciences companies at an exceptional rate. For more than a century, our city has drawn people from around the world to work for some of [...]

Published
2021

49. Postnatal Effects of Gestational and Lactational Gavage Exposure to Boric Acid in the Developing Sprague Dawley Rat

Author

Watson, AtLee T D, primary, Sutherland, Vicki L, primary, Cunny, Helen, primary, Miller-Pinsler, Lutfiya, primary, Furr, Johnathan, primary, Hebert, Charles, primary, Collins, Brad, primary, Waidyanatha, Suramya, primary, Smith, Lori, primary, Vinke, Trey, primary, Aillon, Kristin, primary, Xie, Guanhua, primary, Shockley, Keith R, primary, and McIntyre, Barry S, primary

Published
2020
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50. A Multiple-Serotype Outbreak of SalmonellaInfections Linked to Kratom, United States, 2017–2018

Author

Schwensohn, Colin, Nsubuga, Johnson, Cronquist, Laura, Jose, Gino, Mastel, Laura, McCullough, Laine, Smith, Lori, Powell, Melissa, Booth, Hillary, Allen, Krisandra, Classon, Andrew, and Gieraltowski, Laura

Abstract

In early 2018, we investigated a large national multiple-serotype Salmonellaoutbreak linked to contaminated kratom, a raw minimally processed botanical substance. Kratom is a plant consumed for its stimulant effects and as an opioid substitute. A case was defined as a laboratory-confirmed Salmonellainfection with one of the outbreak strains (serotypes I 4,[5],12:b:-, Heidelberg, Javiana, Okatie, Weltevreden, or Thompson) with illnesses onset during January 11, 2017–May 8, 2018. State and local officials collected detailed information on product consumption and sources. Suspected products were tested for Salmonellaand traceback was conducted to determine product distribution chains and suppliers. We identified 199 cases from 41 states; 54 patients were hospitalized. Early interviews indicated kratom was an exposure of interest. Seventy-six (74%) of 103 people interviewed reported consuming kratom in pills, powders, or teas. Multiple serotypes of Salmonellawere detected in samples of kratom collected from the homes of the patients and from retail locations. Several companies issued recalls of kratom products due to Salmonellacontamination. To the authors' knowledge, this investigation is the first to establish kratom as a vehicle for Salmonellainfection. Our findings underscore the serious safety concerns regarding minimally processed botanical substances intended for oral consumption and the challenges in investigating outbreaks linked to novel outbreak vehicles.

Published
2022
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