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This paper examines the Chicago sociologist William F. Ogburn's (1886–1959) views about technological unemployment, which were intimately connected to his analysis of the social impacts of technological developments and resulting social problems due to cultural lag. We trace the development of his views as seen through his well‐known 1922 book, Social Change with Respect to Culture and Original Nature, his important contributions to the President's Research Committee on Social Trends (1933), and his lesser‐known pamphlets designed for a broader audience—Living with Machines (1933), You and Machines (1934), and Machines and Tomorrow's World (1938). He used these pamphlets to educate the public about the dangers of new machines and technological unemployment. In doing so, he drew upon sociological analysis in his professional scholarly writings and his long‐standing personal interests in social betterment and social reform. Our analysis also calls into question the adequacy of existing scholarship on Ogburn that has emphasized his commitment to a statistical, dispassionate, and "objectivist" approach to social science research. We call for a revised, richer, and more complex view of Ogburn's work and legacy as one of the nation's leading social scientists during the first half of the 20th century. [ABSTRACT FROM AUTHOR]

An introduction is presented in which the editors discuss articles in the issue on topics including human well-being, social change and modernization.

Nodamura Virus (NoV) is a nodavirus originally isolated from insects that can replicate in a wide variety of hosts, including mammals. Because of their simplicity and ability to replicate in many diverse hosts, NoV, and the Nodaviridae in general, provide a unique window into the evolution of viruses and host-virus interactions. Here we show that the C-terminus of the viral polymerase exhibits extreme structural and evolutionary flexibility. Indeed, fewer than 10 positively charged residues from the 110 amino acid-long C-terminal region of protein A are required to support RNA1 replication. Strikingly, this region can be replaced by completely unrelated protein sequences, yet still produce a functional replicase. Structure predictions, as well as evolutionary and mutational analyses, indicate that the C-terminal region is structurally disordered and evolves faster than the rest of the viral proteome. Thus, the function of an intrinsically unstructured protein region can be independent of most of its primary sequence, conferring both functional robustness and sequence plasticity on the protein. Our results provide an experimental explanation for rapid evolution of unstructured regions, which enables an effective exploration of the sequence space, and likely function space, available to the virus. [ABSTRACT FROM AUTHOR]