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Human body motion segmentation plays a major role in many applications, ranging from computer vision to robotics. Among a variety of algorithms, graph-based approaches have demonstrated exciting potential in motion analysis owing to their power to capture the underlying correlations among joints. However, most existing works focus on simpler single-layer geometric structures, whereas multi-layer spatial-temporal graph structure can provide more informative results. To provide an interpretable analysis on multilayer spatial-temporal structures, we revisit the emerging field of multilayer graph signal processing (M-GSP), and propose novel approaches based on M-GSP to human motion segmentation. Specifically, we model the spatial-temporal relationships via multilayer graphs (MLG) and introduce M-GSP spectrum analysis for feature extraction. We present two different M-GSP based algorithms for unsupervised segmentation in the MLG spectrum and vertex domains, respectively. Our experimental results demonstrate the robustness and effectiveness of our proposed methods.

The CRISPR/Cas9 system is a powerful genome editing tool that has made enormous impacts on next-generation molecular diagnostics and therapeutics, especially for genetic disorders that traditional therapies cannot cure. Currently, CRISPR-based gene editing is widely applied in basic, preclinical, and clinical studies. In this review, we attempt to identify trends in clinical studies involving CRISPR techniques to gain insights into the improvement and contribution of CRISPR/Cas technologies compared to traditional modified modalities. The review of clinical trials is focused on the applications of the CRISPR/Cas systems in the treatment of cancer, hematological, endocrine, and immune system diseases, as well as in diagnostics. The scientific basis underlined is analyzed. In addition, the challenges of CRISPR application in disease therapies and recent advances that expand and improve CRISPR applications in precision medicine are discussed.

The proliferation of artificial intelligence (AI) has opened up new avenues for the modeling of power electronics with ultra-fast transient responses, such as wide-bandgap (WBG) devices. This article highlights the significance of ultra-fast transient device-level hardware emulation for the DC railway microgrid (DRM) in real-time. To this end, the proposed approach partitions the DRM power system by transmission line method (TLM) and employs gated recurrent unit (GRU) and electromagnetic transient (EMT) modeling techniques for system-level subsystems. Meanwhile, for WBG devices, gallium nitride (GaN) high electron mobility transistors (HEMT) and silicon carbide (SiC) insulated gate bipolar transistors (IGBT) are modeled using a novel physical feature neuron network (PFNN), which offers high flexibility with a variable time-step (as low as 1 ns), thereby improving the accuracy, efficiency and accelerating the emulation on the field-programmable gate array (FPGA). The effectiveness of the proposed approach is confirmed by comparing the emulation results with offline simulation results obtained from PSCAD/EMTDC for system-level and SaberRD for device-level transients. The proposed PFNN approach provides strong versatility, ultra-fast transient emulation capability, and significantly improved accuracy, which bodes well for the future of power electronics device-level emulation.