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Your search keyword '"Sparling, David"' showing total 14 results
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14 results on '"Sparling, David"'

8. 1277-P: Diabetes Management Supplies in Youth with Type 1 Diabetes: Don’t Leave Home Without Them!

Author

QUINN, MARYANNE, primary, BAILEY, RYAN, additional, FOSTER, NICOLE C., additional, SIMMONS, JILL, additional, EYTH, EMILY, additional, RODRIGUEZ, HENRY, additional, CORATHERS, SARAH, additional, LEVY, CAROL J., additional, SHEANON, NICOLE M., additional, WASSERMAN, RACHEL M., additional, SPARLING, DAVID, additional, ADKINS, DEANNA, additional, ALBANESE-O'NEILL, ANASTASIA, additional, and DESALVO, DANIEL J., additional

Published
2019
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9. Continuous Glucose Monitoring Profiles in Healthy Nondiabetic Participants: A Multicenter Prospective Study

Author

Shah, Viral N, primary, DuBose, Stephanie N, primary, Li, Zoey, primary, Beck, Roy W, primary, Peters, Anne L, primary, Weinstock, Ruth S, primary, Kruger, Davida, primary, Tansey, Michael, primary, Sparling, David, primary, Woerner, Stephanie, primary, Vendrame, Francesco, primary, Bergenstal, Richard, primary, Tamborlane, William V, primary, Watson, Sara E, primary, and Sherr, Jennifer, primary

Published
2019
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13. Farm Support Payments and Risk Balancing: Implications for Financial Riskiness of Canadian Farms.

Author

Uzea, Nicoleta, Poon, Kenneth, Sparling, David, and Weersink, Alfons

Subjects
AGRICULTURAL economics, AGRICULTURE costs, AGRICULTURE finance, RISK assessment, AGRICULTURE, BEEF industry, GOVERNMENT policy
Abstract

Copyright of Canadian Journal of Agricultural Economics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2014
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14. Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity.

Author

Sparling DP, Yu J, Kim K, Zhu C, Brachs S, Birkenfeld AL, and Pajvani UB

Abstract

Objective: As the obesity pandemic continues to expand, novel molecular targets to reduce obesity-related insulin resistance and Type 2 Diabetes (T2D) continue to be needed. We have recently shown that obesity is associated with reactivated liver Notch signaling, which, in turn, increases hepatic insulin resistance, opening up therapeutic avenues for Notch inhibitors to be repurposed for T2D. Herein, we tested the systemic effects of γ-secretase inhibitors (GSIs), which prevent endogenous Notch activation, and confirmed these effects through creation and characterization of two different adipocyte-specific Notch loss-of-function mouse models through genetic ablation of the Notch transcriptional effector Rbp-Jk (A-Rbpj) and the obligate γ-secretase component Nicastrin (A-Nicastrin)., Methods: Glucose homeostasis and both local adipose and systemic insulin sensitivity were examined in GSI-treated, A-Rbpj and A-Nicastrin mice, as well as vehicle-treated or control littermates, with complementary in vitro studies in primary hepatocytes and 3T3-L1 adipocytes., Results: GSI-treatment increases hepatic insulin sensitivity in obese mice but leads to reciprocal lowering of adipose glucose disposal. While A-Rbpj mice show normal body weight, adipose development and mass and unchanged adipose insulin sensitivity as control littermates, A-Nicastrin mice are relatively insulin-resistant, mirroring the GSI effect on adipose insulin action., Conclusions: Notch signaling is dispensable for normal adipocyte function, but adipocyte-specific γ-secretase blockade reduces adipose insulin sensitivity, suggesting that specific Notch inhibitors would be preferable to GSIs for application in T2D.

Published
2015
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