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464 results on '"Speicher, David W."'

6. Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy

Author

Tcyganov, Evgenii N., Sanseviero, Emilio, Marvel, Douglas, Beer, Thomas, Tang, Hsin-Yao, Hembach, Peter, Speicher, David W., Zhang, Qianfei, Donthireddy, Laxminarasimha R., Mostafa, Ali, Tsyganova, Sabina, Pisarev, Vladimir, Laufer, Terri, Ignatov, Dmitriy, Ferrone, Soldano, Meyer, Christiane, Maby-El Hajjami, Hélène, Speiser, Daniel E., Altiok, Sooner, Antonia, Scott, Xu, Xiaowei, Xu, Wei, Zheng, Cathy, Schuchter, Lynn M., Amaravadi, Ravi K., Mitchell, Tara C., Karakousis, Giorgos C., Yuan, Zhe, Montaner, Luis J., Celis, Esteban, and Gabrilovich, Dmitry I.

Published
2022
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7. Stromal changes in the aged lung induce an emergence from melanoma dormancy

Author

Fane, Mitchell E., Chhabra, Yash, Alicea, Gretchen M., Maranto, Devon A., Douglass, Stephen M., Webster, Marie R., Rebecca, Vito W., Marino, Gloria E., Almeida, Filipe, Ecker, Brett L., Zabransky, Daniel J., Hüser, Laura, Beer, Thomas, Tang, Hsin-Yao, Kossenkov, Andrew, Herlyn, Meenhard, Speicher, David W., Xu, Wei, Xu, Xiaowei, Jaffee, Elizabeth M., Aguirre-Ghiso, Julio A., and Weeraratna, Ashani T.

Published
2022
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9. Oxidation of Peroxiredoxin 6 in the Presence of GSH Increases its Phospholipase A₂ Activity at Cytoplasmic pH.

Author

Zhou, Suiping, Dodia, Chandra, Feinstein, Sheldon I, Harper, Sandra, Forman, Henry J, Speicher, David W, and Fisher, Aron B

Subjects
Prdx6 structure, mass spectroscopic analysis, substrate binding, sulfinic acid
Abstract

The expression of the phospholipase A₂ activity (aiPLA₂) of peroxiredoxin 6 (Prdx6) in the cell cytoplasm is physiologically relevant for the repair of peroxidized cell membranes, but aiPLA₂ assay in vitro indicates that, unlike assay at pH 4, activity at cytosolic pH is essentially absent with non-oxidized substrate. However, the addition of glutathione (GSH) to the assay medium significantly increased aiPLA₂ activity at cytosolic pH, while oxidized GSH (GSSG) and several other thiols had no effect. By mass spectroscopy (ESI MS), the addition of GSH to Prdx6 paradoxically led to oxidation of its conserved Cys47 residue to a sulfinic acid. The effect of GSH on PLA₂ activity was abolished by incubation under anaerobic conditions, confirming that auto-oxidation of the protein was the mechanism for the GSH effect. Analysis by circular dichroism (CD) and tryptophan fluorescence showed alterations of the protein structure in the presence of GSH. Independently of GSH, the oxidation of Prdx6 by exposure to H₂O₂ or the presence of oxidized phospholipid as substrate also significantly increased aiPLA₂ activity at pH 7. We conclude that the oxidation of the peroxidatically active Cys47 of Prdx6 results in an increase of aiPLA₂ activity at pH 7 without effect on the activity of the enzyme at pH 4.

Published
2018

10. HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors

Author

Guan, Lei, Wu, Bin, Li, Ting, Beer, Lynn A., Sharma, Gaurav, Li, Mingyue, Lee, Chin Nien, Liu, Shujing, Yang, Changsong, Huang, Lili, Frederick, Dennie T., Boland, Genevieve M., Shao, Guangcan, Svitkina, Tatyana M., Cai, Kathy Q., Chen, Fangping, Dong, Meng-Qiu, Mills, Gordon B., Schuchter, Lynn M., Karakousis, Giorgos C., Mitchell, Tara C., Flaherty, Keith T., Speicher, David W., Chen, Youhai H., Herlyn, Meenhard, Amaravadi, Ravi K., Xu, Xiaowei, and Guo, Wei

Published
2022
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12. Lysosomal lipid peroxidation regulates tumor immunity

Author

Bhardwaj, Monika, Lee, Jennifer J., Versace, Amanda M., Harper, Sandra L., Goldman, Aaron R., Crissey, Mary Ann S., Jain, Vaibhav, Singh, Mahendra Pal, Vernon, Megane, Aplin, Andrew E., Lee, Seokwoo, Morita, Masao, Winkler, Jeffrey D., Liu, Qin, Speicher, David W., and Amaravadi, Ravi K.

Subjects
Oncology, Experimental, Lipid peroxidation -- Research, Cell death -- Research, Tumors -- Development and progression, Immunity -- Research, Cancer -- Research, Lysosomes -- Physiological aspects -- Health aspects, Health care industry
Abstract

Lysosomal inhibition elicited by palmitoyl-protein thioesterase 1 (PPT1) inhibitors such as DC661 can produce cell death, but the mechanism for this is not completely understood. Programmed cell death pathways (autophagy, apoptosis, necroptosis, ferroptosis, and pyroptosis) were not required to achieve the cytotoxic effect of DC661. Inhibition of cathepsins, or iron or calcium chelation, did not rescue DC661-induced cytotoxicity. PPT1 inhibition induced lysosomal lipid peroxidation (LLP), which led to lysosomal membrane permeabilization and cell death that could be reversed by the antioxidant N-acetylcysteine (NAC) but not by other lipid peroxidation antioxidants. The lysosomal cysteine transporter MFSD12 was required for intralysosomal transport of NAC and rescue of LLP. PPT1 inhibition produced cell-intrinsic immunogenicity with surface expression of calreticulin that could only be reversed with NAC. DC661-treated cells primed naive T cells and enhanced T cell-mediated toxicity. Mice vaccinated with DC661-treated cells engendered adaptive immunity and tumor rejection in 'immune hot' tumors but not in 'immune cold' tumors. These findings demonstrate that LLP drives lysosomal cell death, a unique immunogenic form of cell death, pointing the way to rational combinations of immunotherapy and lysosomal inhibition that can be tested in clinical trials., Introduction With encouraging activity in clinical trials that involve the lysosomal inhibitor hydroxychloroquine (HCQ) (1), the identification of palmitoyl-protein thioesterase 1 (PPT1) as the molecular target of chloroquine derivatives (2), [...]

Published
2023
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13. Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma

Author

Wu, Shuai, Fukumoto, Takeshi, Lin, Jianhuang, Nacarelli, Timothy, Wang, Yemin, Ong, Dionzie, Liu, Heng, Fatkhutdinov, Nail, Zundell, Joseph A., Karakashev, Sergey, Zhou, Wei, Schwartz, Lauren E., Tang, Hsin-Yao, Drapkin, Ronny, Liu, Qin, Huntsman, David G., Kossenkov, Andrew V., Speicher, David W., Schug, Zachary T., Van Dang, Chi, and Zhang, Rugang

Published
2021
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15. sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Author

Kaur, Amanpreet, Webster, Marie R, Marchbank, Katie, Behera, Reeti, Ndoye, Abibatou, Kugel, Curtis H, Dang, Vanessa M, Appleton, Jessica, O’Connell, Michael P, Cheng, Phil, Valiga, Alexander A, Morissette, Rachel, McDonnell, Nazli B, Ferrucci, Luigi, Kossenkov, Andrew V, Meeth, Katrina, Tang, Hsin-Yao, Yin, Xiangfan, Wood, William H, Lehrmann, Elin, Becker, Kevin G, Flaherty, Keith T, Frederick, Dennie T, Wargo, Jennifer A, Cooper, Zachary A, Tetzlaff, Michael T, Hudgens, Courtney, Aird, Katherine M, Zhang, Rugang, Xu, Xiaowei, Liu, Qin, Bartlett, Edmund, Karakousis, Giorgos, Eroglu, Zeynep, Lo, Roger S, Chan, Matthew, Menzies, Alexander M, Long, Georgina V, Johnson, Douglas B, Sosman, Jeffrey, Schilling, Bastian, Schadendorf, Dirk, Speicher, David W, Bosenberg, Marcus, Ribas, Antoni, and Weeraratna, Ashani T

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Adult, Aging, Animals, Cell Line, Tumor, Culture Media, Conditioned, DNA Damage, DNA-(Apurinic or Apyrimidinic Site) Lyase, Disease Progression, Drug Resistance, Neoplasm, Fibroblasts, Humans, Indoles, Male, Melanoma, Membrane Proteins, Mice, Microphthalmia-Associated Transcription Factor, Middle Aged, Molecular Targeted Therapy, Neoplasm Metastasis, Neovascularization, Pathologic, Oxidative Stress, Phenotype, Reactive Oxygen Species, Sulfonamides, Tumor Microenvironment, Vemurafenib, Wnt Signaling Pathway, Wnt1 Protein, beta Catenin, General Science & Technology
Abstract

Cancer is a disease of ageing. Clinically, aged cancer patients tend to have a poorer prognosis than young. This may be due to accumulated cellular damage, decreases in adaptive immunity, and chronic inflammation. However, the effects of the aged microenvironment on tumour progression have been largely unexplored. Since dermal fibroblasts can have profound impacts on melanoma progression, we examined whether age-related changes in dermal fibroblasts could drive melanoma metastasis and response to targeted therapy. Here we find that aged fibroblasts secrete a Wnt antagonist, sFRP2, which activates a multi-step signalling cascade in melanoma cells that results in a decrease in β-catenin and microphthalmia-associated transcription factor (MITF), and ultimately the loss of a key redox effector, APE1. Loss of APE1 attenuates the response of melanoma cells to DNA damage induced by reactive oxygen species, rendering the cells more resistant to targeted therapy (vemurafenib). Age-related increases in sFRP2 also augment both angiogenesis and metastasis of melanoma cells. These data provide an integrated view of how fibroblasts in the aged microenvironment contribute to tumour progression, offering new possibilities for the design of therapy for the elderly.

Published
2016

16. MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer

Author

Casciano, Jessica C., Perry, Caroline, Cohen-Nowak, Adam J., Miller, Katelyn D., Vande Voorde, Johan, Zhang, Qifeng, Chalmers, Susan, Sandison, Mairi E., Liu, Qin, Hedley, Ann, McBryan, Tony, Tang, Hsin-Yao, Gorman, Nicole, Beer, Thomas, Speicher, David W., Adams, Peter D., Liu, Xuefeng, Schlegel, Richard, McCarron, John G., Wakelam, Michael J. O., Gottlieb, Eyal, Kossenkov, Andrew V., and Schug, Zachary T.

Published
2020
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23. Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer

Author

Lu, Huimin, Bowler, Nicholas, Harshyne, Larry A., Craig Hooper, D., Krishn, Shiv Ram, Kurtoglu, Senem, Fedele, Carmine, Liu, Qin, Tang, Hsin-Yao, Kossenkov, Andrew V., Kelly, William K., Wang, Kerith, Kean, Rhonda B., Weinreb, Paul H., Yu, Lei, Dutta, Anindita, Fortina, Paolo, Ertel, Adam, Stanczak, Maria, Forsberg, Flemming, Gabrilovich, Dmitry I., Speicher, David W., Altieri, Dario C., and Languino, Lucia R.

Published
2018
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25. Aberrant splicing contributes to severe [alpha]-spectrin-linked congenital hemolytic anemia

Author

Gallagher, Patrick G., Maksimova, Yelena, Lezon-Geyda, Kimberly, Newburger, Peter E., Medeiros, Desiree, Hanson, Robin D., Rothman, Jennifer, Israels, Sara, Wall, Donna A., Sidonio, Robert F., Jr., Sieff, Colin, Gowans, L. Kate, Mittal, Nupur, Rivera-Santiago, Roland, Speicher, David W., Baserga, Susan J., and Schulz, Vincent P.

Subjects
Hemolytic anemia -- Genetic aspects -- Development and progression -- Analysis, Genetic disorders -- Genetic aspects -- Development and progression -- Analysis, Membrane proteins -- Analysis, Messenger RNA -- Analysis, Codons -- Analysis, DNA, Etiology (Medicine), Alleles, RNA, Anemia, Novels, Health care industry
Abstract

The etiology of severe hemolytic anemia in most patients with recessive hereditary spherocytosis (rHS) and the related disorder hereditary pyropoikilocytosis (HPP) is unknown. Whole-exome sequencing of DNA from probands of 24 rHS or HPP kindreds identified numerous mutations in erythrocyte membrane [alpha]- spectrin (SPTA1). Twenty-eight mutations were novel, with null alleles frequently found in trans to missense mutations. No mutations were identified in a third of SPTA1 alleles (17/48). WGS revealed linkage disequilibrium between the common rHS- linked [[alpha].sup.BH] polymorphism and a rare intron 30 variant in all 17 mutation-negative alleles. In vitro minigene studies and in vivo splicing analyses revealed the intron 30 variant changes a weak alternate branch point (BP) to a strong BP. This change leads to increased utilization of an alternate 3' splice acceptor site, perturbing normal [alpha]-spectrin mRNA splicing and creating an elongated mRNA transcript. In vivo mRNA stability studies revealed the newly created termination codon in the elongated transcript activates nonsense-mediated decay leading to spectrin deficiency. These results demonstrate that a unique mechanism of human genetic disease contributes to the etiology of a third of rHS cases, facilitating diagnosis and treatment of severe anemia and identifying a new target for therapeutic manipulation., Introduction Hereditary spherocytosis (HS), the most common inherited hemolytic anemia in Northern Europeans, affects people of every ethnic background worldwide. A quarter of HS cases exhibit recessive inheritance (rHS) (1-5). [...]

Published
2019
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28. Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors

Author

Kumar, Vinit, Donthireddy, Laxminarasimha, Marvel, Douglas, Condamine, Thomas, Wang, Fang, Lavilla-Alonso, Sergio, Hashimoto, Ayumi, Vonteddu, Prashanthi, Behera, Reeti, Goins, Marlee A., Mulligan, Charles, Nam, Brian, Hockstein, Neil, Denstman, Fred, Shakamuri, Shanti, Speicher, David W., Weeraratna, Ashani T., Chao, Timothy, Vonderheide, Robert H., Languino, Lucia R., Ordentlich, Peter, Liu, Qin, Xu, Xiaowei, Lo, Albert, Puré, Ellen, Zhang, Chunsheng, Loboda, Andrey, Sepulveda, Manuel A., Snyder, Linda A., and Gabrilovich, Dmitry I.

Published
2017
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32. Supplementary Data from Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2

Author

Alicea, Gretchen M., primary, Rebecca, Vito W., primary, Goldman, Aaron R., primary, Fane, Mitchell E., primary, Douglass, Stephen M., primary, Behera, Reeti, primary, Webster, Marie R., primary, Kugel, Curtis H., primary, Ecker, Brett L., primary, Caino, M. Cecilia, primary, Kossenkov, Andrew V., primary, Tang, Hsin-Yao, primary, Frederick, Dennie T., primary, Flaherty, Keith T., primary, Xu, Xiaowei, primary, Liu, Qin, primary, Gabrilovich, Dmitry I., primary, Herlyn, Meenhard, primary, Blair, Ian A., primary, Schug, Zachary T., primary, Speicher, David W., primary, and Weeraratna, Ashani T., primary

Published
2023
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33. Supplementary Movie 1 from Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2

Author

Alicea, Gretchen M., primary, Rebecca, Vito W., primary, Goldman, Aaron R., primary, Fane, Mitchell E., primary, Douglass, Stephen M., primary, Behera, Reeti, primary, Webster, Marie R., primary, Kugel, Curtis H., primary, Ecker, Brett L., primary, Caino, M. Cecilia, primary, Kossenkov, Andrew V., primary, Tang, Hsin-Yao, primary, Frederick, Dennie T., primary, Flaherty, Keith T., primary, Xu, Xiaowei, primary, Liu, Qin, primary, Gabrilovich, Dmitry I., primary, Herlyn, Meenhard, primary, Blair, Ian A., primary, Schug, Zachary T., primary, Speicher, David W., primary, and Weeraratna, Ashani T., primary

Published
2023
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34. Supplementary Movie 2 from Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2

Author

Alicea, Gretchen M., primary, Rebecca, Vito W., primary, Goldman, Aaron R., primary, Fane, Mitchell E., primary, Douglass, Stephen M., primary, Behera, Reeti, primary, Webster, Marie R., primary, Kugel, Curtis H., primary, Ecker, Brett L., primary, Caino, M. Cecilia, primary, Kossenkov, Andrew V., primary, Tang, Hsin-Yao, primary, Frederick, Dennie T., primary, Flaherty, Keith T., primary, Xu, Xiaowei, primary, Liu, Qin, primary, Gabrilovich, Dmitry I., primary, Herlyn, Meenhard, primary, Blair, Ian A., primary, Schug, Zachary T., primary, Speicher, David W., primary, and Weeraratna, Ashani T., primary

Published
2023
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35. Data from Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2

Author

Alicea, Gretchen M., primary, Rebecca, Vito W., primary, Goldman, Aaron R., primary, Fane, Mitchell E., primary, Douglass, Stephen M., primary, Behera, Reeti, primary, Webster, Marie R., primary, Kugel, Curtis H., primary, Ecker, Brett L., primary, Caino, M. Cecilia, primary, Kossenkov, Andrew V., primary, Tang, Hsin-Yao, primary, Frederick, Dennie T., primary, Flaherty, Keith T., primary, Xu, Xiaowei, primary, Liu, Qin, primary, Gabrilovich, Dmitry I., primary, Herlyn, Meenhard, primary, Blair, Ian A., primary, Schug, Zachary T., primary, Speicher, David W., primary, and Weeraratna, Ashani T., primary

Published
2023
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36. Data from Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition

Author

Jain, Vaibhav, primary, Harper, Sandra L., primary, Versace, Amanda M., primary, Fingerman, Dylan, primary, Brown, Gregory Schuyler, primary, Bhardwaj, Monika, primary, Crissey, Mary Ann S., primary, Goldman, Aaron R., primary, Ruthel, Gordon, primary, Liu, Qin, primary, Zivkovic, Aleksandra, primary, Stark, Holgar, primary, Herlyn, Meenhard, primary, Gimotty, Phyllis A., primary, Speicher, David W., primary, and Amaravadi, Ravi K., primary

Published
2023
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37. Supplementary Data Figures S1-S5 from Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition

Author

Jain, Vaibhav, primary, Harper, Sandra L., primary, Versace, Amanda M., primary, Fingerman, Dylan, primary, Brown, Gregory Schuyler, primary, Bhardwaj, Monika, primary, Crissey, Mary Ann S., primary, Goldman, Aaron R., primary, Ruthel, Gordon, primary, Liu, Qin, primary, Zivkovic, Aleksandra, primary, Stark, Holgar, primary, Herlyn, Meenhard, primary, Gimotty, Phyllis A., primary, Speicher, David W., primary, and Amaravadi, Ravi K., primary

Published
2023
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38. Supplementary Data Tables S1-S2 from Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition

Author

Jain, Vaibhav, primary, Harper, Sandra L., primary, Versace, Amanda M., primary, Fingerman, Dylan, primary, Brown, Gregory Schuyler, primary, Bhardwaj, Monika, primary, Crissey, Mary Ann S., primary, Goldman, Aaron R., primary, Ruthel, Gordon, primary, Liu, Qin, primary, Zivkovic, Aleksandra, primary, Stark, Holgar, primary, Herlyn, Meenhard, primary, Gimotty, Phyllis A., primary, Speicher, David W., primary, and Amaravadi, Ravi K., primary

Published
2023
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39. Supplementary Movie 6 from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

Author

Kaur, Amanpreet, primary, Ecker, Brett L., primary, Douglass, Stephen M., primary, Kugel, Curtis H., primary, Webster, Marie R., primary, Almeida, Filipe V., primary, Somasundaram, Rajasekharan, primary, Hayden, James, primary, Ban, Ehsan, primary, Ahmadzadeh, Hossein, primary, Franco-Barraza, Janusz, primary, Shah, Neelima, primary, Mellis, Ian A., primary, Keeney, Frederick, primary, Kossenkov, Andrew, primary, Tang, Hsin-Yao, primary, Yin, Xiangfan, primary, Liu, Qin, primary, Xu, Xiaowei, primary, Fane, Mitchell, primary, Brafford, Patricia, primary, Herlyn, Meenhard, primary, Speicher, David W., primary, Wargo, Jennifer A., primary, Tetzlaff, Michael T., primary, Haydu, Lauren E., primary, Raj, Arjun, primary, Shenoy, Vivek, primary, Cukierman, Edna, primary, and Weeraratna, Ashani T., primary

Published
2023
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40. Supplementary Figure Legends from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

Author

Kaur, Amanpreet, primary, Ecker, Brett L., primary, Douglass, Stephen M., primary, Kugel, Curtis H., primary, Webster, Marie R., primary, Almeida, Filipe V., primary, Somasundaram, Rajasekharan, primary, Hayden, James, primary, Ban, Ehsan, primary, Ahmadzadeh, Hossein, primary, Franco-Barraza, Janusz, primary, Shah, Neelima, primary, Mellis, Ian A., primary, Keeney, Frederick, primary, Kossenkov, Andrew, primary, Tang, Hsin-Yao, primary, Yin, Xiangfan, primary, Liu, Qin, primary, Xu, Xiaowei, primary, Fane, Mitchell, primary, Brafford, Patricia, primary, Herlyn, Meenhard, primary, Speicher, David W., primary, Wargo, Jennifer A., primary, Tetzlaff, Michael T., primary, Haydu, Lauren E., primary, Raj, Arjun, primary, Shenoy, Vivek, primary, Cukierman, Edna, primary, and Weeraratna, Ashani T., primary

Published
2023
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41. Supplementary Movie 5 from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

Author

Kaur, Amanpreet, primary, Ecker, Brett L., primary, Douglass, Stephen M., primary, Kugel, Curtis H., primary, Webster, Marie R., primary, Almeida, Filipe V., primary, Somasundaram, Rajasekharan, primary, Hayden, James, primary, Ban, Ehsan, primary, Ahmadzadeh, Hossein, primary, Franco-Barraza, Janusz, primary, Shah, Neelima, primary, Mellis, Ian A., primary, Keeney, Frederick, primary, Kossenkov, Andrew, primary, Tang, Hsin-Yao, primary, Yin, Xiangfan, primary, Liu, Qin, primary, Xu, Xiaowei, primary, Fane, Mitchell, primary, Brafford, Patricia, primary, Herlyn, Meenhard, primary, Speicher, David W., primary, Wargo, Jennifer A., primary, Tetzlaff, Michael T., primary, Haydu, Lauren E., primary, Raj, Arjun, primary, Shenoy, Vivek, primary, Cukierman, Edna, primary, and Weeraratna, Ashani T., primary

Published
2023
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42. Supplementary Figures from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

Author

Kaur, Amanpreet, primary, Ecker, Brett L., primary, Douglass, Stephen M., primary, Kugel, Curtis H., primary, Webster, Marie R., primary, Almeida, Filipe V., primary, Somasundaram, Rajasekharan, primary, Hayden, James, primary, Ban, Ehsan, primary, Ahmadzadeh, Hossein, primary, Franco-Barraza, Janusz, primary, Shah, Neelima, primary, Mellis, Ian A., primary, Keeney, Frederick, primary, Kossenkov, Andrew, primary, Tang, Hsin-Yao, primary, Yin, Xiangfan, primary, Liu, Qin, primary, Xu, Xiaowei, primary, Fane, Mitchell, primary, Brafford, Patricia, primary, Herlyn, Meenhard, primary, Speicher, David W., primary, Wargo, Jennifer A., primary, Tetzlaff, Michael T., primary, Haydu, Lauren E., primary, Raj, Arjun, primary, Shenoy, Vivek, primary, Cukierman, Edna, primary, and Weeraratna, Ashani T., primary

Published
2023
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43. Supplementary Movie 10 from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

Author

Kaur, Amanpreet, primary, Ecker, Brett L., primary, Douglass, Stephen M., primary, Kugel, Curtis H., primary, Webster, Marie R., primary, Almeida, Filipe V., primary, Somasundaram, Rajasekharan, primary, Hayden, James, primary, Ban, Ehsan, primary, Ahmadzadeh, Hossein, primary, Franco-Barraza, Janusz, primary, Shah, Neelima, primary, Mellis, Ian A., primary, Keeney, Frederick, primary, Kossenkov, Andrew, primary, Tang, Hsin-Yao, primary, Yin, Xiangfan, primary, Liu, Qin, primary, Xu, Xiaowei, primary, Fane, Mitchell, primary, Brafford, Patricia, primary, Herlyn, Meenhard, primary, Speicher, David W., primary, Wargo, Jennifer A., primary, Tetzlaff, Michael T., primary, Haydu, Lauren E., primary, Raj, Arjun, primary, Shenoy, Vivek, primary, Cukierman, Edna, primary, and Weeraratna, Ashani T., primary

Published
2023
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44. Data from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

Author

Kaur, Amanpreet, primary, Ecker, Brett L., primary, Douglass, Stephen M., primary, Kugel, Curtis H., primary, Webster, Marie R., primary, Almeida, Filipe V., primary, Somasundaram, Rajasekharan, primary, Hayden, James, primary, Ban, Ehsan, primary, Ahmadzadeh, Hossein, primary, Franco-Barraza, Janusz, primary, Shah, Neelima, primary, Mellis, Ian A., primary, Keeney, Frederick, primary, Kossenkov, Andrew, primary, Tang, Hsin-Yao, primary, Yin, Xiangfan, primary, Liu, Qin, primary, Xu, Xiaowei, primary, Fane, Mitchell, primary, Brafford, Patricia, primary, Herlyn, Meenhard, primary, Speicher, David W., primary, Wargo, Jennifer A., primary, Tetzlaff, Michael T., primary, Haydu, Lauren E., primary, Raj, Arjun, primary, Shenoy, Vivek, primary, Cukierman, Edna, primary, and Weeraratna, Ashani T., primary

Published
2023
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45. Supplementary Movie 2 (SM2) from Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2

Author

Alicea, Gretchen M., primary, Rebecca, Vito W., primary, Goldman, Aaron R., primary, Fane, Mitchell E., primary, Douglass, Stephen M., primary, Behera, Reeti, primary, Webster, Marie R., primary, Kugel, Curtis H., primary, Ecker, Brett L., primary, Caino, M. Cecilia, primary, Kossenkov, Andrew V., primary, Tang, Hsin-Yao, primary, Frederick, Dennie T., primary, Flaherty, Keith T., primary, Xu, Xiaowei, primary, Liu, Qin, primary, Gabrilovich, Dmitry I., primary, Herlyn, Meenhard, primary, Blair, Ian A., primary, Schug, Zachary T., primary, Speicher, David W., primary, and Weeraratna, Ashani T., primary

Published
2023
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46. Supplementary Movie 4 from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

Author

Kaur, Amanpreet, primary, Ecker, Brett L., primary, Douglass, Stephen M., primary, Kugel, Curtis H., primary, Webster, Marie R., primary, Almeida, Filipe V., primary, Somasundaram, Rajasekharan, primary, Hayden, James, primary, Ban, Ehsan, primary, Ahmadzadeh, Hossein, primary, Franco-Barraza, Janusz, primary, Shah, Neelima, primary, Mellis, Ian A., primary, Keeney, Frederick, primary, Kossenkov, Andrew, primary, Tang, Hsin-Yao, primary, Yin, Xiangfan, primary, Liu, Qin, primary, Xu, Xiaowei, primary, Fane, Mitchell, primary, Brafford, Patricia, primary, Herlyn, Meenhard, primary, Speicher, David W., primary, Wargo, Jennifer A., primary, Tetzlaff, Michael T., primary, Haydu, Lauren E., primary, Raj, Arjun, primary, Shenoy, Vivek, primary, Cukierman, Edna, primary, and Weeraratna, Ashani T., primary

Published
2023
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47. Supplementary Movie 7 from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

Author

Kaur, Amanpreet, primary, Ecker, Brett L., primary, Douglass, Stephen M., primary, Kugel, Curtis H., primary, Webster, Marie R., primary, Almeida, Filipe V., primary, Somasundaram, Rajasekharan, primary, Hayden, James, primary, Ban, Ehsan, primary, Ahmadzadeh, Hossein, primary, Franco-Barraza, Janusz, primary, Shah, Neelima, primary, Mellis, Ian A., primary, Keeney, Frederick, primary, Kossenkov, Andrew, primary, Tang, Hsin-Yao, primary, Yin, Xiangfan, primary, Liu, Qin, primary, Xu, Xiaowei, primary, Fane, Mitchell, primary, Brafford, Patricia, primary, Herlyn, Meenhard, primary, Speicher, David W., primary, Wargo, Jennifer A., primary, Tetzlaff, Michael T., primary, Haydu, Lauren E., primary, Raj, Arjun, primary, Shenoy, Vivek, primary, Cukierman, Edna, primary, and Weeraratna, Ashani T., primary

Published
2023
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48. Supplemental Figures S1-S7 and Supplemental Table S1 from A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles

Author

Rebecca, Vito W., primary, Nicastri, Michael C., primary, McLaughlin, Noel, primary, Fennelly, Colin, primary, McAfee, Quentin, primary, Ronghe, Amruta, primary, Nofal, Michel, primary, Lim, Chun-Yan, primary, Witze, Eric, primary, Chude, Cynthia I., primary, Zhang, Gao, primary, Alicea, Gretchen M., primary, Piao, Shengfu, primary, Murugan, Sengottuvelan, primary, Ojha, Rani, primary, Levi, Samuel M., primary, Wei, Zhi, primary, Barber-Rotenberg, Julie S., primary, Murphy, Maureen E., primary, Mills, Gordon B., primary, Lu, Yiling, primary, Rabinowitz, Joshua, primary, Marmorstein, Ronen, primary, Liu, Qin, primary, Liu, Shujing, primary, Xu, Xiaowei, primary, Herlyn, Meenhard, primary, Zoncu, Roberto, primary, Brady, Donita C., primary, Speicher, David W., primary, Winkler, Jeffrey D., primary, and Amaravadi, Ravi K., primary

Published
2023
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49. Supplementary Figures S1-S4 from PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer

Author

Rebecca, Vito W., primary, Nicastri, Michael C., primary, Fennelly, Colin, primary, Chude, Cynthia I., primary, Barber-Rotenberg, Julie S., primary, Ronghe, Amruta, primary, McAfee, Quentin, primary, McLaughlin, Noel P., primary, Zhang, Gao, primary, Goldman, Aaron R., primary, Ojha, Rani, primary, Piao, Shengfu, primary, Noguera-Ortega, Estela, primary, Martorella, Alessandra, primary, Alicea, Gretchen M., primary, Lee, Jennifer J., primary, Schuchter, Lynn M., primary, Xu, Xiaowei, primary, Herlyn, Meenhard, primary, Marmorstein, Ronen, primary, Gimotty, Phyllis A., primary, Speicher, David W., primary, Winkler, Jeffrey D., primary, and Amaravadi, Ravi K., primary

Published
2023
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50. Data from A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles

Author

Rebecca, Vito W., primary, Nicastri, Michael C., primary, McLaughlin, Noel, primary, Fennelly, Colin, primary, McAfee, Quentin, primary, Ronghe, Amruta, primary, Nofal, Michel, primary, Lim, Chun-Yan, primary, Witze, Eric, primary, Chude, Cynthia I., primary, Zhang, Gao, primary, Alicea, Gretchen M., primary, Piao, Shengfu, primary, Murugan, Sengottuvelan, primary, Ojha, Rani, primary, Levi, Samuel M., primary, Wei, Zhi, primary, Barber-Rotenberg, Julie S., primary, Murphy, Maureen E., primary, Mills, Gordon B., primary, Lu, Yiling, primary, Rabinowitz, Joshua, primary, Marmorstein, Ronen, primary, Liu, Qin, primary, Liu, Shujing, primary, Xu, Xiaowei, primary, Herlyn, Meenhard, primary, Zoncu, Roberto, primary, Brady, Donita C., primary, Speicher, David W., primary, Winkler, Jeffrey D., primary, and Amaravadi, Ravi K., primary

Published
2023
Full Text
View/download PDF

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