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2. Acute Vasoreactivity Testing and Outcomes in Pulmonary Arterial Hypertension: A Call for Increased Testing

Author

Chandrasekara, Sahan, Lau, Edmund M., Anderson, James, Collins, Nicholas, Cordina, Rachael, Corrigan, Carolyn, Dwyer, Nathan, Feenstra, John, Horrigan, Mark, Keogh, Anne, Kotlyar, Eugene, Lavender, Melanie, McWilliams, Tanya, Rhodes, Bronwen, Steele, Peter, Strange, Geoff, Thakkar, Vivek, Weintraub, Robert, Whitford, Helen, Whyte, Kenneth, Williams, Trevor, Wrobel, Jeremy, and Keating, Dominic T.

Published
2023
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4. Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Author

Caneva, Jorge, Tuhay, Graciela, Diez, Mirta, Talavera, Maria Lujan, Acosta, Adriana, Vulcano, Norberto, Bosio, Martin, Maldonado, Lorena, Deleo, Sabino, Melatini, Luciano, Keogh, Anne, Kotlyar, Eugene, Feenstra, John, Dwyer, Nathan, Adams, Heath, Stevens, Wendy, Steele, Peter, Proudman, Susanna, Minson, Robert, Reeves, Glenn, Lavender, Melanie, Ng, Benjamin, Mackenzie, Michele, Barry, Lisa, Gruenberger, Margarethe, Huber, Charlotte, Lang, Irene, Tilea, Ioana, Sadushi-Kolici, Roela, Löffler-Ragg, Judith, Feistmantl, Lisa-Theresa, Evrard, Patrick, Louis, Renaud, Guiot, Julien, Naldi, Marco, De Pauw, Michel, Mehta, Sanjay, Camacho, Rafael Conde, Tovar, Patricia Parada, Londoño, Alejandro, Campo, Felipe, Garcia, Paula, Lema, Camila, Orozco-Levi, Mauricio, Martinez, William, Gomez, Juan Esteban, Nielsen-Kudsk, Jens Erik, Mellemkjaer, Soren, Anton, Ly, Altraja, Alan, Vihinen, Tapani, Vasankari, Tuija, Sitbon, Olivier, Cottin, Vincent, Têtu, Laurent, Noël-Savina, Elise, Shearman, Nicole, Tayler, Susanne, Olzik, Ilona, Kulka, Christine, Grimminger, Jan, Simon, Marcel, Nolde, Anna, Oqueka, Tim, Harbaum, Lars, Egenlauf, Benjamin, Ewert, Ralf, Schulz, Christian, Regotta, Sabine, Kramer, Tilmann, Knoop-Busch, Susanne, Gerhardt, Felix, Konstantinides, Stavros, Pitsiou, Georgia, Stanopoulos, Ioannis, Sourla, Evdokia, Mouratoglou, Sofia, Karvounis, Haralambos, Pappas, Athanasios, Georgopoulos, Dimitrios, Fanaridis, Michail, Mitrouska, Ioanna, Michalis, Lampros, Pappas, Konstantinos, Kotsia, Anna, Gaine, Sean, Vizza, Carmine Dario, Manzi, Giovanna, Poscia, Roberto, Badagliacca, Roberto, Agostoni, Piergiuseppe, Bruno, Noemi, Farina, Stefania, D'Alto, Michele, Argiento, Paola, Correra, Anna, Di Marco, Giovanni Maria, Cresci, Chiara, Vannucchi, Vieri, Torricelli, Elena, Garcea, Alessio, Pesci, Alberto, Sardella, Luca, Paciocco, Giuseppe, Pane, Federico, D'Armini, Andrea Maria, Pin, Maurizio, Grazioli, Valentina, Massola, Giulia, Sciortino, Antonio, Prediletto, Renato, Bauleo, Carolina, Airò, Edoardo, Ndreu, Rudina, Pavlickova, Ivana, Lunardi, Claudio, Mulè, Massimiliano, Farruggio, Silvia, Costa, Serena, Galgano, Giuseppe, Petruzzi, Mario, De Luca, Anna, Lombardi, Francesco, Roncon, Loris, Conte, Luca, Picariello, Claudio, Wirtz, Gil, Alexandre, Myriam, Vonk-Noordegraaf, A., Boogaard, H., Mager, J., Reesink, H., van den Toorn, Leon M., Boomars, Karin, Andreassen, Arne K., Castro, Graça, Tania, Gonçalves, Baptista, Rui, Marinho, António, Shiang, Teresa, Oliveira, Ana, Coutinho, Daniel, Sousa, Joana, Loureiro, Maria José, Repolho, Débora, Martins Jesus, Susana Maria, Capinha, Marta, Agostinho, João, Cardoso, Tania, Rocha, Andreia, Espinha, Mafalda, Ivanov, Kyundyul Ivanovich, Alexeeva, Dalyana Eduardovna, Batalina, Marina Vadimovna, Hegya, Daria Viktorovna, Zvereva, Tatyana Nikolaevna, Avdeev, Sergey Nikolaevich, Tsareva, Natalia Anatolievna, Galyavich, Albert Sarvatovich, Nikolaevich, Bykov Aleksander, Filippov, Evgeny Vladimirovich, Yakovleva, Olga Eduardovna, Pavlova, Olga Borisovna, Skripkina, Elena Sergeevna, Martynyuk, Tamila Vitalievna, Bukatova, Irina Fedorovna, Tregubova, Anna Viktorovna, Platonov, Dmitry Yurievich, Kolomeytseva, Tatyana Mikhaylovna, Al Dalaan, Abdullah, Abdelsayed, Abeer Abeer, Weheba, Ihab, Saleemi, Sarferaz, Sakkijha, Hussam, Bohacekova, Marcela, Valkovicova, Tatiana, Farkasova, Iveta, Quezada, Carlos Andres, Piccari, Lucilla, Blanco, Isabel, Sebastian, Laura, Roman, Antonio, Lopez, Manuel, Otero, Remedios, Elias, Teresa, Jara, Luis, Asencio, Isabel, Arjona, Josefa Jiménez, Almagro, Raúl Menor, Cárdenas, Salvador López, García, Salvador Alcaraz, Rodríguez, Patricia Villanueva, Lopez, Raquel, Garcia, Alberto, Avilés, Francisco Fernandez, De La Pava, Sebastian, Yotti, Raquel, Peñate, Gregorio Pérez, Marrero, Fernando León, Cifrián Martínez, José Manuel, Martinez-Meñaca, Amaya, Alonso, Lecue Pilar, Rozas, Sonia Fernandez, Fernandez, David Iturbe, Cuesta, Victor Mora, Söderberg, Stefan, Bartfay, Sven-Erik, Rundqvist, Bengt, Alfetlawi, Monthir, Wodlin, Peter, Schwarz, Esther Irene, Speich, Rudolf, Lador, Frédéric, Rochat, Thierry, Gasche-Soccal, Paola, Hsu, Chih-Hsin, Lin, Tsung-Hsien, Su, Ho-Ming, Lai, Wen-Ter, Chu, Chun Yuan, Hsu, Po-Chao, Voon, Wen-Chol, Yen, Hsueh-Wei, Yih-Jer Wu, Jacob, Wu, Shu-Hao, Huang, Wen-Pin, Fong, Man-Cai, Huang, Chien-Lung, Kuo, Ping-Hung, Lin, Yen-Hung, Lin, Jiunn-Lee, Hung, Chi-Sheng, Wu, Cho-Kai, Sung, Shih-Hsien, Huang, Wei-Chun, Cheng, Chin-Chang, Kuo, Shu-Hung, Wang, Wen-Hwa, Ho, Wan-Jing, Hsu, Tsu-Shiu, Mutlu, Bülent, Atas, Halil, Ongen, Gul, Un, Zeynep, Okumus, Gulfer, Hanta, Ismail, Corris, Paul, Peacock, Andrew, Church, Colin, Toshner, Mark, Newnham, Michael, Ghofrani, Hossein-Ardeschir, Gomez Sanchez, Miguel-Angel, Humbert, Marc, Pittrow, David, Simonneau, Gérald, Gall, Henning, Grünig, Ekkehard, Klose, Hans, Halank, Michael, Langleben, David, Snijder, Repke J., Escribano Subias, Pilar, Mielniczuk, Lisa M., Lange, Tobias J., Vachiéry, Jean-Luc, Wirtz, Hubert, Helmersen, Douglas S., Tsangaris, Iraklis, Barberá, Joan A., Pepke-Zaba, Joanna, Boonstra, Anco, Rosenkranz, Stephan, Ulrich, Silvia, Steringer-Mascherbauer, Regina, Delcroix, Marion, Jansa, Pavel, Šimková, Iveta, Giannakoulas, George, Klotsche, Jens, Williams, Evgenia, Meier, Christian, and Hoeper, Marius M.

Published
2021
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5. Riociguat treatment in patients with pulmonary arterial hypertension: Final safety data from the EXPERT registry

Author

Caneva, Jorge, Tuhay, Graciela, Diez, Mirta, Talavera, Maria Lujan, Acosta, Adriana, Vulcano, Norberto, Bosio, Martin, Maldonado, Lorena, Deleo, Sabino, Melatini, Luciano, Keogh, Anne, Kotlyar, Eugene, Feenstra, John, Dwyer, Nathan, Adams, Heath, Stevens, Wendy, Steele, Peter, Proudman, Susanna, Minson, Robert, Reeves, Glenn, Lavender, Melanie, Ng, Benjamin, Mackenzie, Michele, Barry, Lisa, Gruenberger, Margarethe, Huber, Charlotte, Lang, Irene, Tilea, Ioana, Sadushi-Kolici, Roela, Löffler-Ragg, Judith, Feistmantl, Lisa-Theresa, Evrard, Patrick, Guiot, Julien, Naldi, Marco, De Pauw, Michel, Louis, Renaud, Mehta, Sanjay, Camacho, Rafael Conde, Tovar, Patricia Parada, Londoño, Alejandro, Campo, Felipe, Garcia, Paula, Lema, Camila, Orozco-Levi, Mauricio, Martinez, William, Gomez, Juan Esteban, Nielsen-Kudsk, Jens Erik, Mellemkjaer, Soren, Anton, Ly, Altraja, Alan, Vihinen, Tapani, Vasankari, Tuija, Sitbon, Olivier, Cottin, Vincent, Têtu, Laurent, Noël-Savina, Elise, Shearman, Nicole, Tayler, Susanne, Olzik, Ilona, Kulka, Christine, Grimminger, Jan, Simon, Marcel, Nolde, Anna, Oqueka, Tim, Harbaum, Lars, Egenlauf, Benjamin, Ewert, Ralf, Schulz, Christian, Regotta, Sabine, Kramer, Tilmann, Knoop-Busch, Susanne, Gerhardt, Felix, Konstantinides, Stavros, Pitsiou, Georgia, Stanopoulos, Ioannis, Sourla, Evdokia, Mouratoglou, Sofia, Karvounis, Haralambos, Pappas, Athanasios, Mitrouska, Ioanna, Georgopoulos, Dimitrios, Fanaridis, Michail, Michalis, Lampros, Pappas, Konstantinos, Kotsia, Anna, Gaine, Sean, Vizza, Carmine Dario, Manzi, Giovanna, Poscia, Roberto, Badagliacca, Roberto, Agostoni, Piergiuseppe, Bruno, Noemi, Farina, Stefania, D'Alto, Michele, Argiento, Paola, Correra, Anna, Di Marco, Giovanni Maria, Cresci, Chiara, Vannucchi, Vieri, Torricelli, Elena, Garcea, Alessio, Pesci, Alberto, Sardella, Luca, Paciocco, Giuseppe, Pane, Federico, D'Armini, Andrea Maria, Pin, Maurizio, Grazioli, Valentina, Massola, Giulia, Sciortino, Antonio, Prediletto, Renato, Bauleo, Carolina, Airò, Edoardo, Ndreu, Rudina, Pavlickova, Ivana, Lunardi, Claudio, Farruggio, Silvia, Costa, Serena, Mulè, Massimiliano, Galgano, Giuseppe, Petruzzi, Mario, De Luca, Anna, Lombardi, Francesco, Roncon, Loris, Conte, Luca, Picariello, Claudio, Wirtz, Gil, Alexandre, Myriam, Vonk-Noordegraaf, A., Boogaard, H., Mager, J., Reesink, H., van den Toorn, Leon M., Boomars, Karin, Andreassen, Arne K., Castro, Graça, Tania, Gonçalves, Baptista, Rui, Marinho, António, Shiang, Teresa, Oliveira, Ana, Coutinho, Daniel, Sousa, Joana, Loureiro, Maria José, Repolho, Débora, Martins Jesus, Susana Maria, Capinha, Marta, Agostinho, João, Cardoso, Tania, Rocha, Andreia, Espinha, Mafalda, Ivanov, Kyundyul Ivanovich, Alexeeva, Dalyana Eduardovna, Batalina, Marina Vadimovna, Hegya, Daria Viktorovna, Zvereva, Tatyana Nikolaevna, Avdeev, Sergey Nikolaevich, Tsareva, Natalia Anatolievna, Galyavich, Albert Sarvatovich, Nikolaevich, Bykov Aleksander, Filippov, Evgeny Vladimirovich, Yakovleva, Olga Eduardovna, Pavlova, Olga Borisovna, Skripkina, Elena Sergeevna, Martynyuk, Tamila Vitalievna, Bukatova, Irina Fedorovna, Tregubova, Anna Viktorovna, Platonov, Dmitry Yurievich, Kolomeytseva, Tatyana Mikhaylovna, Al Dalaan, Abdullah, Abdelsayed, Abeer Abeer, Weheba, Ihab, Saleemi, Sarferaz, Sakkijha, Hussam, Bohacekova, Marcela, Valkovicova, Tatiana, Farkasova, Iveta, Quezada, Carlos Andres, Piccari, Lucilla, Blanco, Isabel, Sebastian, Laura, Roman, Antonio, Lopez, Manuel, Otero, Remedios, Elias, Teresa, Jara, Luis, Asencio, Isabel, Arjona, Josefa Jiménez, Almagro, Raúl Menor, Cárdenas, Salvador López, García, Salvador Alcaraz, Rodríguez, Patricia Villanueva, Lopez, Raquel, Garcia, Alberto, Avilés, Francisco Fernandez, De La Pava, Sebastian, Yotti, Raquel, Peñate, Gregorio Pérez, Marrero, Fernando León, Cifrián Martínez, José Manuel, Martinez-Meñaca, Amaya, Alonso, Lecue Pilar, Rozas, Sonia Fernandez, Fernandez, David Iturbe, Cuesta, Victor Mora, Söderberg, Stefan, Bartfay, Sven-Erik, Rundqvist, Bengt, Alfetlawi, Monthir, Wodlin, Peter, Schwarz, Esther Irene, Speich, Rudolf, Lador, Frédéric, Rochat, Thierry, Gasche-Soccal, Paola, Hsu, Chih-Hsin, Lin, Tsung-Hsien, Su, Ho-Ming, Lai, Wen-Ter, Chu, Chun Yuan, Hsu, Po-Chao, Voon, Wen-Chol, Yen, Hsueh-Wei, Yih-Jer Wu, Jacob, Wu, Shu-Hao, Huang, Wen-Pin, Fong, Man-Cai, Huang, Chien-Lung, Kuo, Ping-Hung, Lin, Yen-Hung, Lin, Jiunn-Lee, Hung, Chi-Sheng, Wu, Cho-Kai, Sung, Shih-Hsien, Huang, Wei-Chun, Cheng, Chin-Chang, Kuo, Shu-Hung, Wang, Wen-Hwa, Ho, Wan-Jing, Hsu, Tsu-Shiu, Mutlu, Bülent, Atas, Halil, Ongen, Gul, Un, Zeynep, Okumus, Gulfer, Hanta, Ismail, Corris, Paul, Peacock, Andrew, Church, Colin, Toshner, Mark, Newnham, Michael, Hoeper, Marius M., Gomez Sanchez, Miguel-Angel, Humbert, Marc, Pittrow, David, Simonneau, Gérald, Gall, Henning, Grünig, Ekkehard, Klose, Hans, Halank, Michael, Langleben, David, Snijder, Repke J., Escribano Subias, Pilar, Mielniczuk, Lisa M., Lange, Tobias J., Vachiéry, Jean-Luc, Wirtz, Hubert, Helmersen, Douglas S., Tsangaris, Iraklis, Barberà, Joan A., Pepke-Zaba, Joanna, Boonstra, Anco, Rosenkranz, Stephan, Ulrich, Silvia, Steringer-Mascherbauer, Regina, Delcroix, Marion, Jansa, Pavel, Šimková, Iveta, Giannakoulas, George, Klotsche, Jens, Williams, Evgenia, Meier, Christian, and Ghofrani, Hossein-Ardeschir

Published
2021
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8. Retrospective Validation of the REVEAL 2.0 Risk Score With the Australian and New Zealand Pulmonary Hypertension Registry Cohort

Author

Anderson, James J., Lau, Edmund M., Lavender, Melanie, Benza, Raymond, Celermajer, David S., Collins, Nicholas, Corrigan, Carolyn, Dwyer, Nathan, Feenstra, John, Horrigan, Mark, Keating, Dominic, Kermeen, Fiona, Kotlyar, Eugene, McWilliams, Tanya, Rhodes, Bronwen, Steele, Peter, Thakkar, Vivek, Williams, Trevor, Whitford, Helen, Whyte, Kenneth, Weintraub, Robert, Wrobel, Jeremy P., Keogh, Anne, and Strange, Geoff

Published
2020
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11. The contours of exile: The poetry of Derek Walcott: ARTS AND CULTURE.

Author

Steele, Peter

Subjects
*SEPSIS, *EXILE (Punishment), *HUMANISM, *PROSE poems, *CONSCIOUSNESS
Abstract

This article discusses the poetry of Derek Walcott, a Nobel Prize-winning poet. The author reflects on the changing perception of poets and the challenges they face in today's society. Walcott's work is described as being rooted in the condition of exile, which has often been a source of inspiration for great poetry throughout history. The article also highlights the metaphysical and questioning nature of Walcott's poetry, as well as his ability to capture the essence of human experience. The author concludes by praising Walcott's work and acknowledging the difficulties faced by poets in the contemporary world. [Extracted from the article]

Published
2024

12. Survival of Idiopathic Pulmonary Arterial Hypertension Patients in the Modern Era in Australia and New Zealand

Author

Strange, Geoff, Lau, Edmund M., Giannoulatou, Eleni, Corrigan, Carolyn, Kotlyar, Eugene, Kermeen, Fiona, Williams, Trevor, Celermajer, David S., Dwyer, Nathan, Whitford, Helen, Wrobel, Jeremy P., Feenstra, John, Lavender, Melanie, Whyte, Kenneth, Collins, Nicholas, Steele, Peter, Proudman, Susanna, Thakkar, Vivek, Keating, Dominic, and Keogh, Anne

Published
2018
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14. Computational Construction of Toxicant Signaling Networks

Author

Law, Jeffrey N., Orbach, Sophia M., Weston, Bronson R., Steele, Peter A., Rajagopalan, Padmavathy, and Murali, T. M.

Abstract

This repository contains the code and datasets for building and evaluating toxicant signaling networks: https://github.com/Murali-group/tox_signaling_networks. This is a snapshot of the code and datasets at the time of publication (07/14/2023). See the README for adescription of the Supplementary Files that support the publication. In addition, each of the toxicant signalingnetworksare available for visualization and download on GraphSpace at http://graphspace.org/graphs/?query=tags:2023-toxicant-signaling-networks.

Published
2023
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24. Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Author

Ghofrani, Hossein-Ardeschir, primary, Gomez Sanchez, Miguel-Angel, additional, Humbert, Marc, additional, Pittrow, David, additional, Simonneau, Gérald, additional, Gall, Henning, additional, Grünig, Ekkehard, additional, Klose, Hans, additional, Halank, Michael, additional, Langleben, David, additional, Snijder, Repke J., additional, Escribano Subias, Pilar, additional, Mielniczuk, Lisa M., additional, Lange, Tobias J., additional, Vachiéry, Jean-Luc, additional, Wirtz, Hubert, additional, Helmersen, Douglas S., additional, Tsangaris, Iraklis, additional, Barberá, Joan A., additional, Pepke-Zaba, Joanna, additional, Boonstra, Anco, additional, Rosenkranz, Stephan, additional, Ulrich, Silvia, additional, Steringer-Mascherbauer, Regina, additional, Delcroix, Marion, additional, Jansa, Pavel, additional, Šimková, Iveta, additional, Giannakoulas, George, additional, Klotsche, Jens, additional, Williams, Evgenia, additional, Meier, Christian, additional, Hoeper, Marius M., additional, Caneva, Jorge, additional, Tuhay, Graciela, additional, Diez, Mirta, additional, Talavera, Maria Lujan, additional, Acosta, Adriana, additional, Vulcano, Norberto, additional, Bosio, Martin, additional, Maldonado, Lorena, additional, Deleo, Sabino, additional, Melatini, Luciano, additional, Keogh, Anne, additional, Kotlyar, Eugene, additional, Feenstra, John, additional, Dwyer, Nathan, additional, Adams, Heath, additional, Stevens, Wendy, additional, Steele, Peter, additional, Proudman, Susanna, additional, Minson, Robert, additional, Reeves, Glenn, additional, Lavender, Melanie, additional, Ng, Benjamin, additional, Mackenzie, Michele, additional, Barry, Lisa, additional, Gruenberger, Margarethe, additional, Huber, Charlotte, additional, Lang, Irene, additional, Tilea, Ioana, additional, Sadushi-Kolici, Roela, additional, Löffler-Ragg, Judith, additional, Feistmantl, Lisa-Theresa, additional, Evrard, Patrick, additional, Louis, Renaud, additional, Guiot, Julien, additional, Naldi, Marco, additional, De Pauw, Michel, additional, Mehta, Sanjay, additional, Camacho, Rafael Conde, additional, Tovar, Patricia Parada, additional, Londoño, Alejandro, additional, Campo, Felipe, additional, Garcia, Paula, additional, Lema, Camila, additional, Orozco-Levi, Mauricio, additional, Martinez, William, additional, Gomez, Juan Esteban, additional, Nielsen-Kudsk, Jens Erik, additional, Mellemkjaer, Soren, additional, Anton, Ly, additional, Altraja, Alan, additional, Vihinen, Tapani, additional, Vasankari, Tuija, additional, Sitbon, Olivier, additional, Cottin, Vincent, additional, Têtu, Laurent, additional, Noël-Savina, Elise, additional, Shearman, Nicole, additional, Tayler, Susanne, additional, Olzik, Ilona, additional, Kulka, Christine, additional, Grimminger, Jan, additional, Simon, Marcel, additional, Nolde, Anna, additional, Oqueka, Tim, additional, Harbaum, Lars, additional, Egenlauf, Benjamin, additional, Ewert, Ralf, additional, Schulz, Christian, additional, Regotta, Sabine, additional, Kramer, Tilmann, additional, Knoop-Busch, Susanne, additional, Gerhardt, Felix, additional, Konstantinides, Stavros, additional, Pitsiou, Georgia, additional, Stanopoulos, Ioannis, additional, Sourla, Evdokia, additional, Mouratoglou, Sofia, additional, Karvounis, Haralambos, additional, Pappas, Athanasios, additional, Georgopoulos, Dimitrios, additional, Fanaridis, Michail, additional, Mitrouska, Ioanna, additional, Michalis, Lampros, additional, Pappas, Konstantinos, additional, Kotsia, Anna, additional, Gaine, Sean, additional, Vizza, Carmine Dario, additional, Manzi, Giovanna, additional, Poscia, Roberto, additional, Badagliacca, Roberto, additional, Agostoni, Piergiuseppe, additional, Bruno, Noemi, additional, Farina, Stefania, additional, D'Alto, Michele, additional, Argiento, Paola, additional, Correra, Anna, additional, Di Marco, Giovanni Maria, additional, Cresci, Chiara, additional, Vannucchi, Vieri, additional, Torricelli, Elena, additional, Garcea, Alessio, additional, Pesci, Alberto, additional, Sardella, Luca, additional, Paciocco, Giuseppe, additional, Pane, Federico, additional, D'Armini, Andrea Maria, additional, Pin, Maurizio, additional, Grazioli, Valentina, additional, Massola, Giulia, additional, Sciortino, Antonio, additional, Prediletto, Renato, additional, Bauleo, Carolina, additional, Airò, Edoardo, additional, Ndreu, Rudina, additional, Pavlickova, Ivana, additional, Lunardi, Claudio, additional, Mulè, Massimiliano, additional, Farruggio, Silvia, additional, Costa, Serena, additional, Galgano, Giuseppe, additional, Petruzzi, Mario, additional, De Luca, Anna, additional, Lombardi, Francesco, additional, Roncon, Loris, additional, Conte, Luca, additional, Picariello, Claudio, additional, Wirtz, Gil, additional, Alexandre, Myriam, additional, Vonk-Noordegraaf, A., additional, Boogaard, H., additional, Mager, J., additional, Reesink, H., additional, van den Toorn, Leon M., additional, Boomars, Karin, additional, Andreassen, Arne K., additional, Castro, Graça, additional, Tania, Gonçalves, additional, Baptista, Rui, additional, Marinho, António, additional, Shiang, Teresa, additional, Oliveira, Ana, additional, Coutinho, Daniel, additional, Sousa, Joana, additional, Loureiro, Maria José, additional, Repolho, Débora, additional, Martins Jesus, Susana Maria, additional, Capinha, Marta, additional, Agostinho, João, additional, Cardoso, Tania, additional, Rocha, Andreia, additional, Espinha, Mafalda, additional, Ivanov, Kyundyul Ivanovich, additional, Alexeeva, Dalyana Eduardovna, additional, Batalina, Marina Vadimovna, additional, Hegya, Daria Viktorovna, additional, Zvereva, Tatyana Nikolaevna, additional, Avdeev, Sergey Nikolaevich, additional, Tsareva, Natalia Anatolievna, additional, Galyavich, Albert Sarvatovich, additional, Nikolaevich, Bykov Aleksander, additional, Filippov, Evgeny Vladimirovich, additional, Yakovleva, Olga Eduardovna, additional, Pavlova, Olga Borisovna, additional, Skripkina, Elena Sergeevna, additional, Martynyuk, Tamila Vitalievna, additional, Bukatova, Irina Fedorovna, additional, Tregubova, Anna Viktorovna, additional, Platonov, Dmitry Yurievich, additional, Kolomeytseva, Tatyana Mikhaylovna, additional, Al Dalaan, Abdullah, additional, Abdelsayed, Abeer Abeer, additional, Weheba, Ihab, additional, Saleemi, Sarferaz, additional, Sakkijha, Hussam, additional, Bohacekova, Marcela, additional, Valkovicova, Tatiana, additional, Farkasova, Iveta, additional, Quezada, Carlos Andres, additional, Piccari, Lucilla, additional, Blanco, Isabel, additional, Sebastian, Laura, additional, Roman, Antonio, additional, Lopez, Manuel, additional, Otero, Remedios, additional, Elias, Teresa, additional, Jara, Luis, additional, Asencio, Isabel, additional, Arjona, Josefa Jiménez, additional, Almagro, Raúl Menor, additional, Cárdenas, Salvador López, additional, García, Salvador Alcaraz, additional, Rodríguez, Patricia Villanueva, additional, Lopez, Raquel, additional, Garcia, Alberto, additional, Avilés, Francisco Fernandez, additional, De La Pava, Sebastian, additional, Yotti, Raquel, additional, Peñate, Gregorio Pérez, additional, Marrero, Fernando León, additional, Cifrián Martínez, José Manuel, additional, Martinez-Meñaca, Amaya, additional, Alonso, Lecue Pilar, additional, Rozas, Sonia Fernandez, additional, Fernandez, David Iturbe, additional, Cuesta, Victor Mora, additional, Söderberg, Stefan, additional, Bartfay, Sven-Erik, additional, Rundqvist, Bengt, additional, Alfetlawi, Monthir, additional, Wodlin, Peter, additional, Schwarz, Esther Irene, additional, Speich, Rudolf, additional, Lador, Frédéric, additional, Rochat, Thierry, additional, Gasche-Soccal, Paola, additional, Hsu, Chih-Hsin, additional, Lin, Tsung-Hsien, additional, Su, Ho-Ming, additional, Lai, Wen-Ter, additional, Chu, Chun Yuan, additional, Hsu, Po-Chao, additional, Voon, Wen-Chol, additional, Yen, Hsueh-Wei, additional, Yih-Jer Wu, Jacob, additional, Wu, Shu-Hao, additional, Huang, Wen-Pin, additional, Fong, Man-Cai, additional, Huang, Chien-Lung, additional, Kuo, Ping-Hung, additional, Lin, Yen-Hung, additional, Lin, Jiunn-Lee, additional, Hung, Chi-Sheng, additional, Wu, Cho-Kai, additional, Sung, Shih-Hsien, additional, Huang, Wei-Chun, additional, Cheng, Chin-Chang, additional, Kuo, Shu-Hung, additional, Wang, Wen-Hwa, additional, Ho, Wan-Jing, additional, Hsu, Tsu-Shiu, additional, Mutlu, Bülent, additional, Atas, Halil, additional, Ongen, Gul, additional, Un, Zeynep, additional, Okumus, Gulfer, additional, Hanta, Ismail, additional, Corris, Paul, additional, Peacock, Andrew, additional, Church, Colin, additional, Toshner, Mark, additional, and Newnham, Michael, additional

Published
2021
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26. Riociguat treatment in patients with pulmonary arterial hypertension: Final safety data from the EXPERT registry

Author

Hoeper, Marius M., primary, Gomez Sanchez, Miguel-Angel, additional, Humbert, Marc, additional, Pittrow, David, additional, Simonneau, Gérald, additional, Gall, Henning, additional, Grünig, Ekkehard, additional, Klose, Hans, additional, Halank, Michael, additional, Langleben, David, additional, Snijder, Repke J., additional, Escribano Subias, Pilar, additional, Mielniczuk, Lisa M., additional, Lange, Tobias J., additional, Vachiéry, Jean-Luc, additional, Wirtz, Hubert, additional, Helmersen, Douglas S., additional, Tsangaris, Iraklis, additional, Barberà, Joan A., additional, Pepke-Zaba, Joanna, additional, Boonstra, Anco, additional, Rosenkranz, Stephan, additional, Ulrich, Silvia, additional, Steringer-Mascherbauer, Regina, additional, Delcroix, Marion, additional, Jansa, Pavel, additional, Šimková, Iveta, additional, Giannakoulas, George, additional, Klotsche, Jens, additional, Williams, Evgenia, additional, Meier, Christian, additional, Ghofrani, Hossein-Ardeschir, additional, Caneva, Jorge, additional, Tuhay, Graciela, additional, Diez, Mirta, additional, Talavera, Maria Lujan, additional, Acosta, Adriana, additional, Vulcano, Norberto, additional, Bosio, Martin, additional, Maldonado, Lorena, additional, Deleo, Sabino, additional, Melatini, Luciano, additional, Keogh, Anne, additional, Kotlyar, Eugene, additional, Feenstra, John, additional, Dwyer, Nathan, additional, Adams, Heath, additional, Stevens, Wendy, additional, Steele, Peter, additional, Proudman, Susanna, additional, Minson, Robert, additional, Reeves, Glenn, additional, Lavender, Melanie, additional, Ng, Benjamin, additional, Mackenzie, Michele, additional, Barry, Lisa, additional, Gruenberger, Margarethe, additional, Huber, Charlotte, additional, Lang, Irene, additional, Tilea, Ioana, additional, Sadushi-Kolici, Roela, additional, Löffler-Ragg, Judith, additional, Feistmantl, Lisa-Theresa, additional, Evrard, Patrick, additional, Guiot, Julien, additional, Naldi, Marco, additional, De Pauw, Michel, additional, Louis, Renaud, additional, Mehta, Sanjay, additional, Camacho, Rafael Conde, additional, Tovar, Patricia Parada, additional, Londoño, Alejandro, additional, Campo, Felipe, additional, Garcia, Paula, additional, Lema, Camila, additional, Orozco-Levi, Mauricio, additional, Martinez, William, additional, Gomez, Juan Esteban, additional, Nielsen-Kudsk, Jens Erik, additional, Mellemkjaer, Soren, additional, Anton, Ly, additional, Altraja, Alan, additional, Vihinen, Tapani, additional, Vasankari, Tuija, additional, Sitbon, Olivier, additional, Cottin, Vincent, additional, Têtu, Laurent, additional, Noël-Savina, Elise, additional, Shearman, Nicole, additional, Tayler, Susanne, additional, Olzik, Ilona, additional, Kulka, Christine, additional, Grimminger, Jan, additional, Simon, Marcel, additional, Nolde, Anna, additional, Oqueka, Tim, additional, Harbaum, Lars, additional, Egenlauf, Benjamin, additional, Ewert, Ralf, additional, Schulz, Christian, additional, Regotta, Sabine, additional, Kramer, Tilmann, additional, Knoop-Busch, Susanne, additional, Gerhardt, Felix, additional, Konstantinides, Stavros, additional, Pitsiou, Georgia, additional, Stanopoulos, Ioannis, additional, Sourla, Evdokia, additional, Mouratoglou, Sofia, additional, Karvounis, Haralambos, additional, Pappas, Athanasios, additional, Mitrouska, Ioanna, additional, Georgopoulos, Dimitrios, additional, Fanaridis, Michail, additional, Michalis, Lampros, additional, Pappas, Konstantinos, additional, Kotsia, Anna, additional, Gaine, Sean, additional, Vizza, Carmine Dario, additional, Manzi, Giovanna, additional, Poscia, Roberto, additional, Badagliacca, Roberto, additional, Agostoni, Piergiuseppe, additional, Bruno, Noemi, additional, Farina, Stefania, additional, D'Alto, Michele, additional, Argiento, Paola, additional, Correra, Anna, additional, Di Marco, Giovanni Maria, additional, Cresci, Chiara, additional, Vannucchi, Vieri, additional, Torricelli, Elena, additional, Garcea, Alessio, additional, Pesci, Alberto, additional, Sardella, Luca, additional, Paciocco, Giuseppe, additional, Pane, Federico, additional, D'Armini, Andrea Maria, additional, Pin, Maurizio, additional, Grazioli, Valentina, additional, Massola, Giulia, additional, Sciortino, Antonio, additional, Prediletto, Renato, additional, Bauleo, Carolina, additional, Airò, Edoardo, additional, Ndreu, Rudina, additional, Pavlickova, Ivana, additional, Lunardi, Claudio, additional, Farruggio, Silvia, additional, Costa, Serena, additional, Mulè, Massimiliano, additional, Galgano, Giuseppe, additional, Petruzzi, Mario, additional, De Luca, Anna, additional, Lombardi, Francesco, additional, Roncon, Loris, additional, Conte, Luca, additional, Picariello, Claudio, additional, Wirtz, Gil, additional, Alexandre, Myriam, additional, Vonk-Noordegraaf, A., additional, Boogaard, H., additional, Mager, J., additional, Reesink, H., additional, van den Toorn, Leon M., additional, Boomars, Karin, additional, Andreassen, Arne K., additional, Castro, Graça, additional, Tania, Gonçalves, additional, Baptista, Rui, additional, Marinho, António, additional, Shiang, Teresa, additional, Oliveira, Ana, additional, Coutinho, Daniel, additional, Sousa, Joana, additional, Loureiro, Maria José, additional, Repolho, Débora, additional, Martins Jesus, Susana Maria, additional, Capinha, Marta, additional, Agostinho, João, additional, Cardoso, Tania, additional, Rocha, Andreia, additional, Espinha, Mafalda, additional, Ivanov, Kyundyul Ivanovich, additional, Alexeeva, Dalyana Eduardovna, additional, Batalina, Marina Vadimovna, additional, Hegya, Daria Viktorovna, additional, Zvereva, Tatyana Nikolaevna, additional, Avdeev, Sergey Nikolaevich, additional, Tsareva, Natalia Anatolievna, additional, Galyavich, Albert Sarvatovich, additional, Nikolaevich, Bykov Aleksander, additional, Filippov, Evgeny Vladimirovich, additional, Yakovleva, Olga Eduardovna, additional, Pavlova, Olga Borisovna, additional, Skripkina, Elena Sergeevna, additional, Martynyuk, Tamila Vitalievna, additional, Bukatova, Irina Fedorovna, additional, Tregubova, Anna Viktorovna, additional, Platonov, Dmitry Yurievich, additional, Kolomeytseva, Tatyana Mikhaylovna, additional, Al Dalaan, Abdullah, additional, Abdelsayed, Abeer Abeer, additional, Weheba, Ihab, additional, Saleemi, Sarferaz, additional, Sakkijha, Hussam, additional, Bohacekova, Marcela, additional, Valkovicova, Tatiana, additional, Farkasova, Iveta, additional, Quezada, Carlos Andres, additional, Piccari, Lucilla, additional, Blanco, Isabel, additional, Sebastian, Laura, additional, Roman, Antonio, additional, Lopez, Manuel, additional, Otero, Remedios, additional, Elias, Teresa, additional, Jara, Luis, additional, Asencio, Isabel, additional, Arjona, Josefa Jiménez, additional, Almagro, Raúl Menor, additional, Cárdenas, Salvador López, additional, García, Salvador Alcaraz, additional, Rodríguez, Patricia Villanueva, additional, Lopez, Raquel, additional, Garcia, Alberto, additional, Avilés, Francisco Fernandez, additional, De La Pava, Sebastian, additional, Yotti, Raquel, additional, Peñate, Gregorio Pérez, additional, Marrero, Fernando León, additional, Cifrián Martínez, José Manuel, additional, Martinez-Meñaca, Amaya, additional, Alonso, Lecue Pilar, additional, Rozas, Sonia Fernandez, additional, Fernandez, David Iturbe, additional, Cuesta, Victor Mora, additional, Söderberg, Stefan, additional, Bartfay, Sven-Erik, additional, Rundqvist, Bengt, additional, Alfetlawi, Monthir, additional, Wodlin, Peter, additional, Schwarz, Esther Irene, additional, Speich, Rudolf, additional, Lador, Frédéric, additional, Rochat, Thierry, additional, Gasche-Soccal, Paola, additional, Hsu, Chih-Hsin, additional, Lin, Tsung-Hsien, additional, Su, Ho-Ming, additional, Lai, Wen-Ter, additional, Chu, Chun Yuan, additional, Hsu, Po-Chao, additional, Voon, Wen-Chol, additional, Yen, Hsueh-Wei, additional, Yih-Jer Wu, Jacob, additional, Wu, Shu-Hao, additional, Huang, Wen-Pin, additional, Fong, Man-Cai, additional, Huang, Chien-Lung, additional, Kuo, Ping-Hung, additional, Lin, Yen-Hung, additional, Lin, Jiunn-Lee, additional, Hung, Chi-Sheng, additional, Wu, Cho-Kai, additional, Sung, Shih-Hsien, additional, Huang, Wei-Chun, additional, Cheng, Chin-Chang, additional, Kuo, Shu-Hung, additional, Wang, Wen-Hwa, additional, Ho, Wan-Jing, additional, Hsu, Tsu-Shiu, additional, Mutlu, Bülent, additional, Atas, Halil, additional, Ongen, Gul, additional, Un, Zeynep, additional, Okumus, Gulfer, additional, Hanta, Ismail, additional, Corris, Paul, additional, Peacock, Andrew, additional, Church, Colin, additional, Toshner, Mark, additional, and Newnham, Michael, additional

Published
2021
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28. Geologic Carbon Storage of Anthropogenic CO 2 under the Colorado Plateau in Emery County, Utah.

Author

Moodie, Nathan, Jia, Wei, Middleton, Richard, Yaw, Sean, Lee, Si-Yong, Xiao, Ting, Wheatley, David, Steele, Peter, Esser, Rich, and McPherson, Brian

Subjects
CARBON dioxide, GEOLOGICAL modeling, GREENHOUSE gas mitigation, STORAGE, CARBON
Abstract

Geologic Carbon Storage (GCS) is a promising technology for storing large volumes of anthropogenic CO2 effectively and permanently. Numerical simulations are an integral part of site selection and characterization for any potential GCS site. As part of the DOE-funded CarbonSAFE Rocky Mountains Phase I project, a regional GCS analysis was undertaken to understand the efficacy of storing CO2 emissions from the power generation and heavy industry in central Utah's favorable geology. In this study, the injection of CO2 for geologic storage was simulated in the Navajo Sandstone Formation in Emery County, Utah. Carbon dioxide was sourced from regional power generation stations and heavy industries throughout Utah, with an emphasis on emissions reduction at the Hunter Power Plant near Castle Dale, Utah. A simulation grid was extracted from the project's geological model encompassing an area around Price, Huntington, and Castle Dale in central Utah. The Navajo Sandstone Member of the Glen Canyon Group was the target of CO2 injection with the overlying Carmel formation providing the primary seal. A suite of simulations was performed assessing the viability of this area for permanent CO2 storage. Results indicate that the area can not only store 46 million metric tons of anthropogenic CO2, meeting the project goals, but this area has the capacity to securely store at least 1.3 billion tons of CO2, suggesting the injection site and surrounding geology are suitable locations for commercial-scale GCS. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Left ventricular ischemia in pre-capillary pulmonary hypertension: a cardiovascular magnetic resonance study

Author

Sree Raman, Karthigesh, primary, Shah, Ranjit, additional, Stokes, Michael, additional, Walls, Angela, additional, Woodman, Richard J., additional, Ananthakrishna, Rajiv, additional, Walker, Jennifer G., additional, Proudman, Susanna, additional, Steele, Peter M., additional, De Pasquale, Carmine G., additional, Celermajer, David S., additional, and Selvanayagam, Joseph B., additional

Published
2020
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32. Diagnostic delay in pulmonary arterial hypertension: Insights from the Australian and New Zealand pulmonary hypertension registry

Author

Khou, Victor, primary, Anderson, James J., additional, Strange, Geoff, additional, Corrigan, Carolyn, additional, Collins, Nicholas, additional, Celermajer, David S., additional, Dwyer, Nathan, additional, Feenstra, John, additional, Horrigan, Mark, additional, Keating, Dominic, additional, Kotlyar, Eugene, additional, Lavender, Melanie, additional, McWilliams, Tanya J., additional, Steele, Peter, additional, Weintraub, Robert, additional, Whitford, Helen, additional, Whyte, Ken, additional, Williams, Trevor J., additional, Wrobel, Jeremy P., additional, Keogh, Anne, additional, and Lau, Edmund M., additional

Published
2020
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33. Joycepoem.

Author

Steele, Peter

Subjects
*AWARDS, *SECONDARY schools, *POETRY writing, *CULTURE, *LAUGHTER, *PARADES
Abstract

This article, titled "Joycepoem," is a poem written by Fr Peter Steele SJ. The poem is about Belvedere College in Dublin, where James Joyce attended secondary school. The poem reflects on the city of Dublin, its landmarks, and its connection to Joyce. The author describes Joyce as a "moody harlequin" and a "oneman fugue," and explores themes of identity, perception, and the passage of time. Fr Peter Steele SJ was a poet and academic at the University of Melbourne, and a longtime contributor to Eureka Street. He passed away in June 2012. [Extracted from the article]

Published
2024

35. Late Breaking Abstract - Validation of the REVEAL 2.0 Risk Score with the Australian and New Zealand Pulmonary Hypertension Registry Cohort

Author

Anderson, James, primary, Lau, Edmund, additional, Lavender, Melanie, additional, Benza, Raymond, additional, Celermajer, David, additional, Collins, Nicholas, additional, Corrigan, Carolyn, additional, Dwyer, Nathan, additional, Feenstra, John, additional, Horrigan, Mark, additional, Keating, Dominic, additional, Kotlyar, Eugene, additional, Mcwilliams, Tanya, additional, Rhodes, Bronwen, additional, Steele, Peter, additional, Thakkar, Vivek, additional, Williams, Trevor, additional, Whitford, Helen, additional, Whyte, Kenneth, additional, Weintraub, Robert, additional, Wrobel, Jeremy, additional, Keogh, Anne, additional, and Strange, Geoff, additional

Published
2019
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39. The predictive capabilities of a novel cardiovascular magnetic resonance derived marker of cardiopulmonary reserve on established prognostic surrogate markers in patients with pulmonary vascular disease: results of a longitudinal pilot study

Author

Baillie, Timothy J., primary, Sidharta, Samuel, additional, Steele, Peter M., additional, Worthley, Stephen G., additional, Willoughby, Scott, additional, Teo, Karen, additional, Sanders, Prashanthan, additional, Nicholls, Stephen J., additional, and Worthley, Matthew I., additional

Published
2017
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40. Inbox.

Author

Larcombe, Ross and Steele, Peter

Subjects
SPORT utility vehicles
Published
2023

43. the Tribe.

Author

Power, Richard, Law, John, Sporry, Samuel, Ord, Cameron, Farquhar, Peter, Steele, Peter, Wans, Felix, and Scrivener, Peter

Subjects
INTERNAL combustion engines, TRIBES
Abstract

YOUR SEPTEMBER megaspread on the GT-R was enoughfor this fossil to buy a car mag for the first time in yonks. Electric vehicle (EV) emissions arefar from zero. It found thatfrom the point of extracting the rawmaterials, through to end-of-life vehicledisposal, the average EV contributed18 per cent less carbon emissions thanan equivalent ICE vehicle (or 273g CO2per km total lifetime emissions for theEV; versus 333g for the ICE). It's a lotof cost and change for 18 per cent,particularly as cars account for about10 per cent of Australia's greenhousegas emissions. [Extracted from the article]

Published
2019

44. the Tribe.

Author

Clarke, Ryan, Steele, Peter, Wilkie, Aaron, Davson-Galle, Peter, Luo, Antony, George, Chris, Basilou, Nick, and O'Brien, Cameron

Subjects
CAMARO automobile, MUSTANG automobile, SPEED limits
Published
2019

46. Inbox: GO AHEAD, TELL US WHAT YOU REALLY THINK.

Author

Parr, David, Wood, Brian, Steele, Peter, Scholz, Frank, Armstrong, Graeme, Dight, David, and East, Peter

Subjects
COMPACT cars, TECHNICAL drawing, SPEEDING violations, GRAPHIC arts
Published
2019

47. LETTER OF THE MONTH.

Author

Steele, Peter, Johnson, Steve, Mallos, Paul, Ludeke, Paul, Batt, Gordon, and Snowden, Tim

Subjects
GTI automobile, MUSTANG automobile, SPORT utility vehicles
Published
2017

49. Feasibility of oxygen sensitive cardiac magnetic resonance of the right ventricle in pulmonary artery hypertension

Author

Carmine G. De Pasquale, Rebecca Perry, P. Steele, David S. Celermajer, Karthigesh Sree Raman, C. Burdeniuk, Angela Walls, Joseph B. Selvanayagam, Michael B. Stokes, Raman, Karthigesh Sree, Stokes, Michael, Walls, Angela, Perry, Rebecca, Steele, Peter M, Burdeniuk, Christine, De Pasquale, Carmine G, Celermajer, David S, and Selvanayagam, Joseph B

Subjects
medicine.medical_specialty, oxygen-sensitive cardiac magnetic resonance, Ischemia, microcirculation, 030204 cardiovascular system & hematology, Microcirculation, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine.artery, medicine, cardiovascular diseases, medicine.diagnostic_test, business.industry, Myocardial oxygenation, Magnetic resonance imaging, medicine.disease, microvascular ischemia, medicine.anatomical_structure, Ventricle, Pulmonary artery, Right heart, Cardiology, Original Article, Cardiology and Cardiovascular Medicine, Cardiac magnetic resonance, business, cardiac magnetic resonance (CMR), pulmonary artery hypertension, 030215 immunology
Abstract

Background: Progressive right ventricular (RV) dysfunction in pulmonary arterial hypertension (PAH) which is contributed by RV ischemia leads to adverse clinical outcomes. Oxygen-sensitive (OS) cardiovascular magnetic resonance (CMR) has been used to determine the in vivo myocardial oxygenation of the left ventricle (LV). The aims of the present study were therefore to determine the feasibility of RV targeted rest/stress OS-CMR imaging in PAH patients and healthy volunteers. Methods: We prospectively recruited 20 patients with right heart catheter proven PAH and 9 healthy age matched controls (NC). The CMR examination involved standard functional imaging and OS-CMR imaging. An OS-CMR signal intensity (SI) index (stress/rest SI) was acquired at RV anterior, RV free-wall and RV inferior segments. In the LV, the OS-CMR SI index was acquired globally. Results: Reliable OS SI changes were only obtained from the RV inferior segment. As RV dysfunction in PAH is a global process, hence this segment was used in both patients and NC for further comparison. RV OS-CMR SI change between rest and stress in the NC was 17%±5% (mean ± SD). Nine of 20 (45%) of the PAH patients had a mean OS SI change of less than 9% (or ?2 SD different from the mean values in NC). Overall, RV OS SI index between the PAH patients and NC was 11%±9% vs. 17%±5% (P=0.045) in the RV inferior segment. In the LV, the global OS-CMR SI index between the PAH patients and NC was 11%±7% vs. 21%±9% (P=0.019). There was a strong correlation between RV Inf OS-CMR SI and LV OS-CMR SI (r=0.86, P

Published
2019

50. Ex vivo paracrine properties of cardiac tissue: Effects of chronic heart failure.

Author

JrBoucek, Robert J., Steele, Jasmine, Jacobs, Jeffery P., Steele, Peter, Asante-Korang, Alfred, Quintessenza, James, and Steele, Ann

Subjects
*PARACRINE mechanisms, *HEART failure, *CARDIAC regeneration, *CELLULAR signal transduction, *STEM cells, *MONOCLONAL antibodies
Abstract

Background Cardiac regenerative responses are responsive to paracrine factors. We hypothesize that chronic heart failure (HF) in pediatric patients affects cardiac paracrine signaling relevant to resident c-kit + cluster of differentiation (CD)34 – cardiac stem cells (CSCs). Methods Discarded atrial septum (huAS) and atrial appendages (huAA) from pediatric patients with HF (huAA-HF; n = 10) or without HF ( n = 3) were explanted and suspension explant cultured in media. Conditioned media were screened for 120 human factors using unedited monoclonal antibody-based arrays. Significantly expressed (relative chemiluminescence >30 of 100) factors are reported (secretome). Emigrated cells were immunoselected for c-kit and enumerated as CSCs. Results After culture Day 7, CSCs emigrate from huAA but not huAS. The huAA secretome during CSC emigration included hepatocyte growth factor (HGF), epithelial cell-derived neutrophil attractant-78 (ENA-78)/chemokine (C-X-C motif) ligand (CXCL) 5, growth-regulated oncogene-α (GRO-α)/CXCL1, and macrophage migration inhibitory factor (MIF), candidate pro-migratory factors not present in the huAS secretome. Survival/proliferation of emigrated CSCs required coculture with cardiac tissue or tissue-conditioned media. Removal of huAA (Day 14) resulted in the loss of all emigrated CSCs (Day 28) and in decreased expression of 13 factors, including HGF, ENA-78/CXCL5, urokinase-type plasminogen activator receptor (uPAR)/CD87, and neutrophil-activating protein-2 (NAP-2)/CXCL7 candidate pro-survival factors. Secretomes of atrial appendages from HF patients have lower expression of 14 factors, including HGF, ENA-78/CXCL5, GRO-α/CXCL1, MIF, NAP-2/CXCL7, uPAR/CD87, and macrophage inflammatory protein-1α compared with AA from patients without HF. Conclusions Suspension explant culturing models paracrine and innate CSC interactions in the heart. In pediatric patients, heart failure has an enduring effect on the ex vivo cardiac-derived secretome, with lower expression of candidate pro-migratory and pro-survival factors for CSCs. [ABSTRACT FROM AUTHOR]

Published
2015
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