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In 2013, Congress reaffirmed tribes' inherent authority to prosecute all persons who commit dating violence, domestic violence, or violate a protective order against Indian women on tribal land in the Violence Against Women Reauthorization Act (VAWA). Congress required tribes to comply with strict procedural safeguards to implement VAWA. Although VAWA was not designed to stimulate tribal economies, its due process provisions may be considered judicial improvements. Stronger judiciaries have been consistently linked to greater economic performance. Accordingly, we test whether implementing VAWA improved tribal economies. This analysis compares the income growth of VAWA-implementing tribes in Arizona to neighboring non-implementing tribes. Our findings show that incomes grew faster for VAWA-implementing tribes than for non-implementing tribes in Arizona. [ABSTRACT FROM AUTHOR]

Localities have often been quicker than states to respond to public health concerns related to tobacco use by implementing restrictive policies.[1] However, some states preempt localities from passing laws that are more stringent than states' tobacco control policies.[1] The tobacco industry has historically supported state preemption to reverse existing local tobacco control laws and prevent future enactment of such laws.[2] A US federal government prevention plan called to eliminate state laws that preempt stronger local tobacco control laws.[3] Despite a consensus among public health advocates that state preemption has an adverse impact on local tobacco control efforts, limited published research to date has quantified its effects.[2] We studied the effects of state preemption of local smoke-free restrictions in worksites, restaurants, and bars on county-level adult cigarette smoking prevalence between 1997 and 2017. We used difference-in-differences regressions to compare smoking prevalence in our exposed counties (with smoke-free restrictions previously and then subject to state preemption) with that in our control counties (with smoke-free restrictions and never subject to state preemption) before and after state preemption. [Extracted from the article]

Technological advancements and the increasingly large amounts spent for elections have made it easier for get-out-the-vote (GOTV) campaigns to contact potential voters many times prior to elections. However, the effects of repeated exposure to GOTV treatment have received little attention in the academic literature. Multiple treatments can increase the intensive margin of treatment—by increasing the number of times that treated individuals are exposed to the treatment—or the extensive margin of treatment—by increasing the number of people who are exposed to at least one treatment attempt. We analyze the differences between a treatment with one automated GOTV call and a treatment with three GOTV calls to isolate the effect of changes in the extensive and intensive margins of treatment on voting rates. On the intensive margin, we find that answering one additional call is associated with an approximately 0.6% point increased probability to vote. On the extensive margin, we find that answering one additional call is associated with an approximately one percentage point increased probability to vote. This evidence is consistent with the academic literature on commercial advertising, which finds that repeated exposures to commercial advertisements have diminishing marginal effects. [ABSTRACT FROM AUTHOR]

Abstract Committee membership in mixed-member systems presents an informative setting for studying legislators' behavior under majoritarian vs. proportional electoral incentives. Committee membership allows for a determination as to whether legislators sort themselves into committees that are more consistent with an objective to win the next election in their electoral district, or more consistent with gaining a more prestigious position in their party. Using data from three large German states, we find that legislators elected in the electoral system's majoritarian tier more often become members of "district committees," i.e., committees that might give politicians greater opportunity than others to obtain government funds for the benefit of their home districts. This effect is strongest for legislators who won district elections by narrow margins. Moreover, we find that districts that are better represented on "district committees" receive more government funds. [ABSTRACT FROM AUTHOR]

Adverse selection theory predicts people with a high risk of death are more likely to own life insurance. Using a unique data set merging administrative and survey records, we test this theory and find the opposite: people with high death risk are less likely to own life insurance. We postulate advantageous selection and price discrimination swamp adverse selection in individual life insurance markets. To determine which effect is more powerful, we analyze group life insurance markets, where insurance companies cannot price discriminate as well as in individual markets. Our data suggest that price discrimination has a stronger effect than advantageous selection. ( JEL D8, G1, I1) [ABSTRACT FROM AUTHOR]

The effectiveness of cancer screening is a salient health policy issue that remains unresolved. This article sheds new light on the benefits of population-wide cancer screening. We investigate changes in mortality after the introduction of screening guidelines for breast and prostate cancers in the USA and UK. We use differences in the timing of guideline adoption, differences in ages recommended for screening, and differences in which cancers are detectable by screening to identify the effect of cancer screening guidelines. Our quadruple-differencing strategy finds a moderately sized mortality benefit from mammography and prostate-specific antigen (PSA) screening guidelines among recommended age groups and little change in mortality rates among age groups not recommended to receive screening. As a falsification test, we verify that prostate cancer rates among men did not fall after the introduction of mammography screening and breast cancer rates among women did not fall after the introduction of the PSA test. [ABSTRACT FROM AUTHOR]

Did the nuclear catastrophe at Fukushima in March 2011 cause individuals to reappraise the risks they attach to nuclear power plants? We investigate the change in home prices in the U.S. after the Fukushima event to test the hypothesis that home prices in the proximity of power plants fell due to an updated nuclear risk perception. Using a difference-in-differences approach, we do not find evidence in support of the hypothesis that individuals reappraised the risks associated with nuclear power plants. According to our results home prices close to nuclear reactor sites did not fall relative to home prices at other locations in the U.S. [ABSTRACT FROM AUTHOR]

In states with Certificate of Need (CON) laws, medical services providers must file an application and demonstrate community need before being permitted to start or expand a service. We examine CON laws for magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) scanners to test the hypothesis that the approval process favors established incumbent hospitals over new hospital entrants and nonhospital providers. Using Medicare claims data in 2013, we find that states with CON laws have 20 to 33% fewer providers, depending on the type of scanners to which the laws apply. As a result, residents of CON law states are 3.4–5.3 percentage points more likely to travel outside their home county to obtain imaging services than residents of non-CON states. In addition, there is a notable shift in the type of provider: CON laws are associated with 27–53% fewer scans by nonhospital providers per beneficiary, 23 to 70% fewer by new hospitals, but 6 to 21% more scans in older hospitals. • States requiring imaging services certificate-of-need (CON) laws have affected the provider type composition of the market. • CON laws are correlated with reductions in services provided by new hospitals and non-hospitals but not by pre-existing hospitals. • CON state residency is related to a higher likelihood of traveling outside one's home county to obtaining imaging services. [ABSTRACT FROM AUTHOR]

Swine influenza viruses (SIVs), the causal agents of swine influenza, are not only important to control due to the economic losses in the swine industry, but also can be pandemic pathogens. Vaccination is one of the most relevant strategies to control and prevent influenza infection. Current human vaccines against influenza induce strain-specific immunity and annual update is required due to the virus antigenic shift phenomena. Previously, our group has reported the use of conserved hemagglutinin peptides (HA-peptides) derived from H1-influenza virus as a potential multivalent vaccine candidate. Immunization of swine with these HA-peptides elicited antibodies that recognized and neutralized heterologous influenza viruses in vitro and demonstrated strong hemagglutination-inhibiting activity. In the present work, we cloned one HA-peptide (named NG34) into a plasmid fused with cytotoxic T lymphocyte-associated antigen (CTLA4) which is a molecule that modifies T cell activation and with an adjuvant activity interfering with the adaptive immune response. The resulting plasmid, named pCMV-CTLA4-Ig-NG34, was administered twice to animals employing a needle-free delivery approach. Two studies were carried out to test the efficacy of pCMV-CTLA4-Ig-NG34 as a potential swine influenza vaccine, one in seronegative and another in seropositive pigs against SIV. The second one was aimed to evaluate whether pCMV-CTLA4-Ig-NG34 vaccination would overcome maternally derived antibodies (MDA). After immunization, all animals were intranasally challenged with an H3N2 influenza strain. A complete elimination or significant reduction in the viral shedding was observed within the first week after the challenge in the vaccinated animals from both studies. In addition, no challenged heterologous virus load was detected in the airways of vaccinated pigs. Overall, it is suggested that the pCMV-CTLA4-Ig-NG34 vaccine formulation could potentially be used as a multivalent vaccine against influenza viruses. [ABSTRACT FROM AUTHOR]

Altruistic punishment is a fundamental driver for cooperation in human interactions. In this paper, we expand our understanding of this form of pro-social behavior to help explain a puzzle of voting: why do individuals who are indifferent between two potential policy outcomes of an election participate when voting is costly? Using a simple voting experiment, we provide robust evidence that many voters are willing to engage in voting as a form of punishment, even when voting is costly and the voter has no monetary stake in the election outcome. In our sample, and in a robustness check through Monte Carlo simulation, we show that at least fourteen percent of individuals are willing to incur a cost to vote against candidates who broke their electoral promises, even when they have no pecuniary interest in the election outcome. [ABSTRACT FROM AUTHOR]

We model two-candidate elections in which (1) voters are uncertain about candidates' attributes; and (2) candidates can inform voters of their attributes by sending advertisements. We compare between political campaigns with truthful advertising and campaigns in which there is a small chance of deceptive advertising. Our model predicts that voters should vote in-line with an advertisement's information. We test our model's predictions using laboratory elections. We find, in the presence of even a small probability that an advertisement is deceptive, voters become substantially more likely to elect a 'low-quality' candidate. We discuss implications of this for existing models of voting decisions. ( JEL C92, D72, D82) [ABSTRACT FROM AUTHOR]

While the autoimmune destruction of pancreatic ß-cells underlying type 1 diabetes (1D) development is ultimately mediated by T-cells in NOD mice and also likely humans, B-lymphocytes play an additional key pathogenic role. It appears expression of plasma membrane bound immunoglobulin (Ig) molecules that efficiently capture ß-cell antigens allows autoreactive B-lymphocytes bypassing normal tolerance induction processes to be the subset of antigen presenting cells most efficiently activating diabetogenic T-cells. NOD mice transgenically expressing Ig molecules recognizing antigens that are (insulin) or not (hen egg lysozyme; HEL) expressed by ß-cells have proven useful in dissecting the developmental basis of diabetogenic B-lymphocytes. However, these transgenic Ig specificities were originally selected for their ability to recognize insulin or HEL as foreign, rather than autoantigens. Thus, we generated and characterized NOD mice transgenically expressing an Ig molecule representative of a large proportion of naturally occurring islet-infiltrating B-lymphocytes in NOD mice recognizing the neuronal antigen peripherin. Transgenic peripherin autoreactive B-lymphocytes infiltrate NOD pancreatic islets, acquire an activated proliferative phenotype, and potently support accelerated T1D development. These results support the concept of neuronal autoimmunity as a pathogenic feature of T1D, and targeting such responses could ultimately provide an effective disease intervention approach. [ABSTRACT FROM AUTHOR]

Introduction: The development of new therapies to induce self-tolerance has been an important medical health challenge in type 1 diabetes. An ideal immunotherapy should inhibit the autoimmune attack, avoid systemic side effects and allow β-cell regeneration. Based on the immunomodulatory effects of apoptosis, we hypothesized that apoptotic mimicry can help to restore tolerance lost in autoimmune diabetes. Objective: To generate a synthetic antigen-specific immunotherapy based on apoptosis features to specifically reestablish tolerance to β-cells in type 1 diabetes. Methods: A central event on the surface of apoptotic cells is the exposure of phosphatidylserine, which provides the main signal for efferocytosis. Therefore, phosphatidylserine-liposomes loaded with insulin peptides were generated to simulate apoptotic cells recognition by antigen presenting cells. The effect of antigen-specific phosphatidylserine-liposomes in the reestablishment of peripheral tolerance was assessed in NOD mice, the spontaneous model of autoimmune diabetes. MHC class II-peptide tetramers were used to analyze the T cell specific response after treatment with phosphatidylserine-liposomes loaded with peptides. Results: We have shown that phosphatidylserine-liposomes loaded with insulin peptides induce tolerogenic dendritic cells and impair autoreactive T cell proliferation. When administered to NOD mice, liposome signal was detected in the pancreas and draining lymph nodes. This immunotherapy arrests the autoimmune aggression, reduces the severity of insulitis and prevents type 1 diabetes by apoptotic mimicry. MHC class II tetramer analysis showed that peptide-loaded phosphatidylserine-liposomes expand antigen-specific CD4+ T cells in vivo. The administration of phosphatidylserine-free liposomes emphasizes the importance of phosphatidylserine in the modulation of antigen-specific CD4+ T cell expansion. Conclusions: We conclude that this innovative immunotherapy based on the use of liposomes constitutes a promising strategy for autoimmune diseases. [ABSTRACT FROM AUTHOR]