1. Field and laboratory perspectives on fentanyl and carfentanil decontamination.
- Author
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Lindén, Pernilla, Mörén, Lina, Qvarnström, Johanna, Forsgren, Nina, Engdahl, Cecilia Springer, Engqvist, Magnus, Henych, Jiri, Tengel, Tobias, Österlund, Lars, Thors, Lina, Larsson, Andreas, and Johansson, Susanne
- Subjects
WOOD floors ,LIVER microsomes ,FENTANYL ,LIQUID chromatography ,PUBLIC health ,OPIOID receptors - Abstract
Abuse of the highly toxic compound fentanyl and its analogues is increasing, raising serious public health concerns due to their potency and availability. Therefore, there is a need for decontamination methodologies to safely remove fentanyl to avoid harmful exposure. In this study, the efficacy of commercial and in-house synthesized decontamination agents (Dahlgren Decon, RSDL (Reactive Skin Decontamination Lotion), FAST-ACT (First applied sorbent treatment against chemical threats), GDS2000, alldecont MED, bleach, Domestos Spray Bleach, Effekt Klor, MgO, TiO
2 -nanodiamond, and CeO2 ) were evaluated for the degradation of fentanyl and carfentanil under controlled laboratory conditions and on wooden floor surfaces. Liquid chromatography/mass spectrometry analysis showed that oxidative decontamination agents were the most effective, with N-oxides identified as major degradation products. The physiological effects of these N-oxides were also investigated regarding their ability to activate the µ-opioid receptor and their metabolism in human liver microsomes. The results provide empirical evidence that complements prior research findings on the degradation of fentanyl and carfentanil using a variety of decontamination agents. [ABSTRACT FROM AUTHOR]- Published
- 2024
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