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Your search keyword '"Taylor, Darien"' showing total 3 results
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3 results on '"Taylor, Darien"'

1. Willingness of Older Canadians with HIV to Participate in HIV Cure Research Near and After the End of Life: A Mixed-Method Study

Author

Lessard, David, Dubé, Karine, Bilodeau, Martin, Keeler, Patrick, Margolese, Shari, Rosenes, Ron, Sinyavskaya, Liliya, Durand, Madeleine, Benko, Erika, Kovacs, Colin, Guerlotté, Charlotte, Tharao, Wangari, Arnold, Keresa, Masching, Renée, Taylor, Darien, Sousa, José, Ostrowski, Mario, Taylor, Jeff, Kaytes, Andy, Smith, Davey, Gianella, Sara, Chomont, Nicolas, Angel, Jonathan B, Routy, Jean-Pierre, Cohen, Éric A, Lebouché, Bertrand, and Costiniuk, Cecilia T

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Behavioral and Social Science, Clinical Research, HIV/AIDS, Aging, Infectious Diseases, Sexually Transmitted Infections, Good Health and Well Being, Aged, Biological Specimen Banks, Canada, Death, HIV Infections, HIV-1, Humans, Qualitative Research, Virus Latency, HIV, HIV cure, end-of-life research, research autopsy, mixed-methods research, Virology, Clinical sciences
Abstract

HIV cure research requires interrogating latent HIV reservoirs in deep tissues, which necessitates autopsies to avoid risks to participants. An HIV autopsy biobank would facilitate this research, but such research raises ethical issues and requires participant engagement. This study explores the willingness to participate in HIV cure research at the end of life. Participants include Canadians with HIV [people with HIV (PWHIV)] aged 55 years or older. Following a mixed-method study design, all participants completed a phone or online survey, and a subset of participants participated in in-depth phone or videoconference interviews. We produced descriptive statistics of quantitative data and a thematic analysis of qualitative data. Barriers and facilitators were categorized under domains of the Theoretical Domains Framework. From April 2020 to August 2021, 37 participants completed the survey (mean age = 69.9 years old; mean duration of HIV infection = 28.5 years), including 15 interviewed participants. About three quarters of participants indicated being willing to participate in hypothetical medical studies toward the end of life (n = 30; 81.1%), in HIV biobanking (n = 30; 81.1%), and in a research autopsy (n = 28; 75.7%) to advance HIV cure research, mainly for altruistic benefits. The main perceived risks had to do with physical pain and confidentiality. Barriers and facilitators were distributed across five domains: social/professional role and identity, environmental context and resources, social influences, beliefs about consequences, and capabilities. Participants wanted more information about study objectives and procedures, possible accommodations with their last will, and rationale for studies or financial interests funding studies. Our results indicate that older PWHIV would be willing to participate in HIV cure research toward the end of life, HIV biobanking, and research autopsy. However, a dialogue should be initiated to inform participants thoroughly about HIV cure studies, address concerns, and accommodate their needs and preferences. Additional work is required, likely through increased community engagement, to address educational needs.

Published
2022

2. Blood Relatives

Author

Taylor, Darien

Subjects
Literature/writing
Abstract

In each issue, Broken Pencil asks an artist or curator to host Folio--a section bridging the printed page with unexpected media and materials. For this edition, activist and critic Darien [...]

Published
2019

3. Model based approach to leakage management for distribution systems with distinct pressure variability [A case study of Castle Grant, Barbados]

Author

Taylor, Darien M. G. and Taylor, Darien M. G.

Abstract

High physical losses in water supply networks (WSNs) can result in several socioeconomic issues like customer dissatisfaction, high operating costs, and poor network performance, which often also results in cyclical operational problems for water utilities in developing countries. While traditional non-revenue water and leakage reduction techniques have a track record of success in developed countries, developing ones typically experience challenges to successfully implement, especially small island developing states (SIDS). Pressure management and pipe replacement are two commonly applied leakage management strategies with a proven history of positively affecting leakage reduction. However, to implement an effective pressure management strategy or to plan a strategic pipe replacement project, some decision support tool or system should be used to inform which approaches should be taken, prioritized, or combined; to ensure that the most cost efficient and technically proficient options are selected without compromising the quality of service, or over expensing the utility. Against this background, the goal of this research was the development of a set of guidelines for approaching leakage reduction in WSNs with high pressure variations; modelling the application of pressure management and pipe replacement to do so. The guidelines are developed as a streamlined methodology to conduct leakage assessment modelling that utilities in developing countries can easily adapt. The research was focused on a case study using the Castle Grant DMA in the central region of Barbados’ water supply network, as it experiences significant variations in network pressures, with very low minimums and high maximums. Leakage was assessed in a sub-DMA of the larger DMA by evaluating the minimum night flow and validated via a top-down water balance assessment, comparing production and consumption data. A major component of the research was also to update, calibrate, and validate an existing m

Published
2023

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