Search

Your search keyword '"Tosh, Donna"' showing total 13 results
Start Over Author "Tosh, Donna" Publication Year Range Last 10 years
13 results on '"Tosh, Donna"'

1. An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria infection model

Author

Livezey, Jeffrey, Twomey, Patrick, Morrison, Meshell, Cicatelli, Susan, Duncan, Elizabeth H., Hamer, Melinda, Lee, Christine, Hutter, Jack, Mills, Kristin, DeLuca, Jesse, Poon, Lucas, Selig, Daniel, Vuong, Chau, Sousa, Jason, Oliver, Thomas, Bennett, Jason, Moon, James E., Sikaffy, April, Sedegah, Martha, Tosh, Donna, Kreishman-Deitrick, Mara, and Waterman, Paige

Published
2020
Full Text
View/download PDF

2. Additional file 3 of An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria infection model

Author

Livezey, Jeffrey, Twomey, Patrick, Meshell Morrison, Cicatelli, Susan, Duncan, Elizabeth H., Hamer, Melinda, Lee, Christine, Hutter, Jack, Mills, Kristin, DeLuca, Jesse, Poon, Lucas, Selig, Daniel, Vuong, Chau, Sousa, Jason, Oliver, Thomas, Bennett, Jason, Moon, James E., Sikaffy, April, Sedegah, Martha, Tosh, Donna, Kreishman-Deitrick, Mara, and Waterman, Paige

Abstract

Additional file 3. PK Data Points: Table of CQ, CQm and AZ exposure levels in the CQAZ cohort.

Published
2020
Full Text
View/download PDF

3. Additional file 1 of An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria infection model

Author

Livezey, Jeffrey, Twomey, Patrick, Meshell Morrison, Cicatelli, Susan, Duncan, Elizabeth H., Hamer, Melinda, Lee, Christine, Hutter, Jack, Mills, Kristin, DeLuca, Jesse, Poon, Lucas, Selig, Daniel, Vuong, Chau, Sousa, Jason, Oliver, Thomas, Bennett, Jason, Moon, James E., Sikaffy, April, Sedegah, Martha, Tosh, Donna, Kreishman-Deitrick, Mara, and Waterman, Paige

Abstract

Additional file 1. AE Listing: Listing of all adverse events in enrolled subjects.

Published
2020
Full Text
View/download PDF

4. Additional file 2 of An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria infection model

Author

Livezey, Jeffrey, Twomey, Patrick, Meshell Morrison, Cicatelli, Susan, Duncan, Elizabeth H., Hamer, Melinda, Lee, Christine, Hutter, Jack, Mills, Kristin, DeLuca, Jesse, Poon, Lucas, Selig, Daniel, Vuong, Chau, Sousa, Jason, Oliver, Thomas, Bennett, Jason, Moon, James E., Sikaffy, April, Sedegah, Martha, Tosh, Donna, Kreishman-Deitrick, Mara, and Waterman, Paige

Subjects
cardiovascular diseases
Abstract

Additional file 2. EKG Data: Lisitng of electrocardiogram values at baseline and Day 11 after challenge.

Published
2020
Full Text
View/download PDF

5. Corrigendum to: Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population

Author

Spring, Michele D, primary, Sousa, Jason C, primary, Li, Qigui, primary, Darko, Christian A, primary, Morrison, Meshell N, primary, Marcsisin, Sean R, primary, Mills, Kristin T, primary, Potter, Brittney M, primary, Paolino, Kristopher M, primary, Twomey, Patrick S, primary, Moon, James E, primary, Tosh, Donna M, primary, Cicatelli, Susan B, primary, Froude, Jeffrey W, primary, Pybus, Brandon S, primary, Oliver, Thomas G, primary, Mccarthy, William F, primary, Waters, Norman C, primary, Smith, Philip L, primary, Reichard, Gregory A, primary, and Bennett, Jason W, primary

Published
2019
Full Text
View/download PDF

6. Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population

Author

Spring, Michele D, primary, Sousa, Jason C, additional, Li, Qigui, additional, Darko, Christian A, additional, Morrison, Meshell N, additional, Marcsisin, Sean R, additional, Mills, Kristin T, additional, Potter, Brittney M, additional, Paolino, Kristopher M, additional, Twomey, Patrick S, additional, Moon, James E, additional, Tosh, Donna M, additional, Cicatelli, Susan B, additional, Froude, Jeffrey W, additional, Pybus, Brandon S, additional, Oliver, Thomas G, additional, McCarthy, William F, additional, Waters, Norman C, additional, Smith, Philip L, additional, Reichard, Gregory A, additional, and Bennett, Jason W, additional

Published
2019
Full Text
View/download PDF

7. Mosquito Bite-Induced Controlled Human Malaria Infection with Plasmodium vivax or P. falciparum Generates Immune Responses to Homologous and Heterologous Preerythrocytic and Erythrocytic Antigens

Author

Hall, Cysha E., primary, Hagan, Lisa M., additional, Bergmann-Leitner, Elke, additional, Tosh, Donna M., additional, Bennett, Jason W., additional, Regules, Jason A., additional, Chuang, Ilin, additional, Angov, Evelina, additional, Dutta, Sheetij, additional, Chattopadhyay, Debasish, additional, and Yadava, Anjali, additional

Published
2019
Full Text
View/download PDF

8. Protection against Plasmodium falciparum malaria by PfSPZ Vaccine

Author

Epstein, Judith E., primary, Paolino, Kristopher M., additional, Richie, Thomas L., additional, Sedegah, Martha, additional, Singer, Alexandra, additional, Ruben, Adam J., additional, Chakravarty, Sumana, additional, Stafford, April, additional, Ruck, Richard C., additional, Eappen, Abraham G., additional, Li, Tao, additional, Billingsley, Peter F., additional, Manoj, Anita, additional, Silva, Joana C., additional, Moser, Kara, additional, Nielsen, Robin, additional, Tosh, Donna, additional, Cicatelli, Susan, additional, Ganeshan, Harini, additional, Case, Jessica, additional, Padilla, Debbie, additional, Davidson, Silas, additional, Garver, Lindsey, additional, Saverino, Elizabeth, additional, Murshedkar, Tooba, additional, Gunasekera, Anusha, additional, Twomey, Patrick S., additional, Reyes, Sharina, additional, Moon, James E., additional, James, Eric R., additional, KC, Natasha, additional, Li, Minglin, additional, Abot, Esteban, additional, Belmonte, Arnel, additional, Hauns, Kevin, additional, Belmonte, Maria, additional, Huang, Jun, additional, Vasquez, Carlos, additional, Remich, Shon, additional, Carrington, Mary, additional, Abebe, Yonas, additional, Tillman, Amy, additional, Hickey, Bradley, additional, Regules, Jason, additional, Villasante, Eileen, additional, Sim, B. Kim Lee, additional, and Hoffman, Stephen L., additional

Published
2017
Full Text
View/download PDF

9. Phase 1/2a Trial of Plasmodium vivax Malaria Vaccine Candidate VMP001/AS01B in Malaria-Naive Adults: Safety, Immunogenicity, and Efficacy

Author

Bennett, Jason W., primary, Yadava, Anjali, additional, Tosh, Donna, additional, Sattabongkot, Jetsumon, additional, Komisar, Jack, additional, Ware, Lisa A., additional, McCarthy, William F., additional, Cowden, Jessica J., additional, Regules, Jason, additional, Spring, Michele D., additional, Paolino, Kristopher, additional, Hartzell, Joshua D., additional, Cummings, James F., additional, Richie, Thomas L., additional, Lumsden, Joanne, additional, Kamau, Edwin, additional, Murphy, Jittawadee, additional, Lee, Cynthia, additional, Parekh, Falgunee, additional, Birkett, Ashley, additional, Cohen, Joe, additional, Ballou, W. Ripley, additional, Polhemus, Mark E., additional, Vanloubbeeck, Yannick F., additional, Vekemans, Johan, additional, and Ockenhouse, Christian F., additional

Published
2016
Full Text
View/download PDF

10. Ad35.CS.01 - RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve Adults

Author

Ockenhouse, Christian F., primary, Regules, Jason, additional, Tosh, Donna, additional, Cowden, Jessica, additional, Kathcart, April, additional, Cummings, James, additional, Paolino, Kristopher, additional, Moon, James, additional, Komisar, Jack, additional, Kamau, Edwin, additional, Oliver, Thomas, additional, Chhoeu, Austin, additional, Murphy, Jitta, additional, Lyke, Kirsten, additional, Laurens, Matthew, additional, Birkett, Ashley, additional, Lee, Cynthia, additional, Weltzin, Rich, additional, Wille-Reece, Ulrike, additional, Sedegah, Martha, additional, Hendriks, Jenny, additional, Versteege, Isabella, additional, Pau, Maria Grazia, additional, Sadoff, Jerold, additional, Vanloubbeeck, Yannick, additional, Lievens, Marc, additional, Heerwegh, Dirk, additional, Moris, Philippe, additional, Guerra Mendoza, Yolanda, additional, Jongert, Erik, additional, Cohen, Joe, additional, Voss, Gerald, additional, Ballou, W. Ripley, additional, and Vekemans, Johan, additional

Published
2015
Full Text
View/download PDF

11. Phase 1/2a Trial of Plasmodium vivax Malaria Vaccine Candidate VMP001/AS01B in Malaria-Naive Adults: Safety, Immunogenicity, and Efficacy.

Author

Bennett, Jason W., Yadava, Anjali, Tosh, Donna, Sattabongkot, Jetsumon, Komisar, Jack, Ware, Lisa A., McCarthy, William F., Cowden, Jessica J., Regules, Jason, Spring, Michele D., Paolino, Kristopher, Hartzell, Joshua D., Cummings, James F., Richie, Thomas L., Lumsden, Joanne, Kamau, Edwin, Murphy, Jittawadee, Lee, Cynthia, Parekh, Falgunee, and Birkett, Ashley

Subjects
MALARIA vaccines, PLASMODIUM vivax, MALARIA treatment, CIRCUMSPOROZOITE protein, IMMUNE response, PARASITEMIA
Abstract

Background: A vaccine to prevent infection and disease caused by Plasmodium vivax is needed both to reduce the morbidity caused by this parasite and as a key component in efforts to eradicate malaria worldwide. Vivax malaria protein 1 (VMP001), a novel chimeric protein that incorporates the amino- and carboxy- terminal regions of the circumsporozoite protein (CSP) and a truncated repeat region that contains repeat sequences from both the VK210 (type 1) and the VK247 (type 2) parasites, was developed as a vaccine candidate for global use. Methods: We conducted a first-in-human Phase 1 dose escalation vaccine study with controlled human malaria infection (CHMI) of VMP001 formulated in the GSK Adjuvant System AS01B. A total of 30 volunteers divided into 3 groups (10 per group) were given 3 intramuscular injections of 15μg, 30μg, or 60μg respectively of VMP001, all formulated in 500μL of AS01B at each immunization. All vaccinated volunteers participated in a P. vivax CHMI 14 days following the third immunization. Six non-vaccinated subjects served as infectivity controls. Results: The vaccine was shown to be well tolerated and immunogenic. All volunteers generated robust humoral and cellular immune responses to the vaccine antigen. Vaccination did not induce sterile protection; however, a small but significant delay in time to parasitemia was seen in 59% of vaccinated subjects compared to the control group. An association was identified between levels of anti-type 1 repeat antibodies and prepatent period. Significance: This trial was the first to assess the efficacy of a P. vivax CSP vaccine candidate by CHMI. The association of type 1 repeat-specific antibody responses with delay in the prepatency period suggests that augmenting the immune responses to this domain may improve strain-specific vaccine efficacy. The availability of a P. vivax CHMI model will accelerate the process of P. vivax vaccine development, allowing better selection of candidate vaccines for advancement to field trials. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

12. Corrigendum to: Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population.

Author

Spring, Michele D, Sousa, Jason C, Li, Qigui, Darko, Christian A, Morrison, Meshell N, Marcsisin, Sean R, Mills, Kristin T, Potter, Brittney M, Paolino, Kristopher M, Twomey, Patrick S, Moon, James E, Tosh, Donna M, Cicatelli, Susan B, Froude, Jeffrey W, Pybus, Brandon S, Oliver, Thomas G, Mccarthy, William F, Waters, Norman C, Smith, Philip L, and Reichard, Gregory A

Subjects
CYTOCHROME P-450, PRIMAQUINE, GENOTYPES, METABOLISM
Published
2020
Full Text
View/download PDF

13. Mosquito Bite-Induced Controlled Human Malaria Infection with Plasmodium vivaxor P. falciparumGenerates Immune Responses to Homologous and Heterologous Preerythrocytic and Erythrocytic Antigens

Author

Hall, Cysha E., Hagan, Lisa M., Bergmann-Leitner, Elke, Tosh, Donna M., Bennett, Jason W., Regules, Jason A., Chuang, Ilin, Angov, Evelina, Dutta, Sheetij, Chattopadhyay, Debasish, and Yadava, Anjali

Abstract

Seroepidemiological studies on the prevalence of antibodies to malaria antigens are primarily conducted on individuals from regions of endemicity. It is therefore difficult to accurately correlate the antibody responses to the timing and number of prior malaria infections.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results