Search

Your search keyword '"Tullis, D. Elizabeth"' showing total 16 results
Start Over Author "Tullis, D. Elizabeth" Publication Year Range Last 10 years
16 results on '"Tullis, D. Elizabeth"'

5. Triaging Access to Critical Care Resources in Patients with Chronic Respiratory Diseases in the Event of a Major COVID-19Surge: Key highlights from the Canadian Thoracic Society (CTS) Position Statement

Author

Gupta, Samir, Batt, Jane, Bourbeau, Jean, Chapman, Kenneth R., Gershon, Andrea, Granton, John, Hambly, Nathan, Hernandez, Paul, Kolb, Martin, Mehta, Sanjay, Mielniczuk, Lisa, Provencher, Steeve, Stephenson, Anne L., Swiston, John, Tullis, D. Elizabeth, Vozoris, Nicholas T., Wald, Joshua, Weatherald, Jason, and Bhutani, Mohit

Subjects
Canada, CFS, clinical frailty score, Critical Care, Cystic Fibrosis, Pulmonary Fibrosis, Respiratory Tract Diseases, PH, pulmonary hypertension, Article, Health Services Accessibility, Pulmonary Disease, Chronic Obstructive, Forced Expiratory Volume, PaO2, partial pressure of oxygen, Pulmonary Medicine, AE, acute exacerbation, IPF, idiopathic pulmonary fibrosis, Humans, COVID-19, 2019 novel coronavirus, Mortality, mMRC, modified Medical Research Council dyspnea scale, PaCO2, partial pressure of carbon dioxide, Societies, Medical, Pulmonary Arterial Hypertension, DLCO, diffusing capacity of the lungs for carbon monoxide, Health Care Rationing, Frailty, CTS, Canadian Thoracic Society, Patient Selection, Oxygen Inhalation Therapy, Surge Capacity, COVID-19, Prognosis, FEV1, forced expiratory volume in the first second, Respiratory Function Tests, REVEAL, Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management, Intensive Care Units, FVC, forced vital capacity, Chronic Disease, ILD, interstitial lung disease, Health Resources, Pulmonary Diffusing Capacity, Triage, RV, right ventricular
Published
2020

6. Triaging Access to Critical Care Resources in Patients With Chronic Respiratory Diseases in the Event of a Major COVID-19 Surge

Author

Gupta, Samir, primary, Batt, Jane, additional, Bourbeau, Jean, additional, Chapman, Kenneth R., additional, Gershon, Andrea, additional, Granton, John, additional, Hambly, Nathan, additional, Hernandez, Paul, additional, Kolb, Martin, additional, Mehta, Sanjay, additional, Mielniczuk, Lisa, additional, Provencher, Steeve, additional, Stephenson, Anne L., additional, Swiston, John, additional, Tullis, D. Elizabeth, additional, Vozoris, Nicholas T., additional, Wald, Joshua, additional, Weatherald, Jason, additional, and Bhutani, Mohit, additional

Published
2020
Full Text
View/download PDF

7. Position statement from the Canadian Thoracic Society (CTS) on clinical triage thresholds in respiratory disease patients in the event of a major surge during the COVID-19 pandemic

Author

Gupta, Samir, primary, Batt, Jane, additional, Bourbeau, Jean, additional, Chapman, Kenneth R., additional, Gershon, Andrea, additional, Granton, John, additional, Hambly, Nathan, additional, Hernandez, Paul, additional, Kolb, Martin, additional, Mehta, Sanjay, additional, Mielniczuk, Lisa, additional, Provencher, Steeve, additional, Stephenson, Anne L., additional, Swiston, John, additional, Tullis, D. Elizabeth, additional, Vozoris, Nicholas T., additional, Wald, Joshua, additional, Weatherald, Jason, additional, and Bhutani, Mohit, additional

Published
2020
Full Text
View/download PDF

8. A genome-wide association analysis reveals a potential role for recombination in the evolution of antimicrobial resistance in Burkholderia multivorans

Author

Diaz Caballero, Julio, primary, Clark, Shawn T., additional, Wang, Pauline W., additional, Donaldson, Sylva L., additional, Coburn, Bryan, additional, Tullis, D. Elizabeth, additional, Yau, Yvonne C. W., additional, Waters, Valerie J., additional, Hwang, David M., additional, and Guttman, David S., additional

Published
2018
Full Text
View/download PDF

9. A Genome-Wide Association Analysis Reveals a Role for Recombination in the Evolution of Antimicrobial Resistance in Burkholderia multivorans

Author

Diaz Caballero, Julio, primary, Clark, Shawn T., additional, Wang, Pauline W., additional, Donaldson, Sylva L., additional, Coburn, Bryan, additional, Tullis, D. Elizabeth, additional, Yau, Yvonne C.W., additional, Waters, Valerie J., additional, Hwang, David M., additional, and Guttman, David S., additional

Published
2018
Full Text
View/download PDF

12. Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation

Author

Kim, Sang Hu, primary, Clark, Shawn T., additional, Surendra, Anuradha, additional, Copeland, Julia K., additional, Wang, Pauline W., additional, Ammar, Ron, additional, Collins, Cathy, additional, Tullis, D. Elizabeth, additional, Nislow, Corey, additional, Hwang, David M., additional, Guttman, David S., additional, and Cowen, Leah E., additional

Published
2015
Full Text
View/download PDF

13. Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung

Author

Diaz Caballero, Julio, primary, Clark, Shawn T., additional, Coburn, Bryan, additional, Zhang, Yu, additional, Wang, Pauline W., additional, Donaldson, Sylva L., additional, Tullis, D. Elizabeth, additional, Yau, Yvonne C. W., additional, Waters, Valerie J., additional, Hwang, David M., additional, and Guttman, David S., additional

Published
2015
Full Text
View/download PDF

15. Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosaEvolution in the Cystic Fibrosis Lung

Author

Diaz Caballero, Julio, Clark, Shawn T., Coburn, Bryan, Zhang, Yu, Wang, Pauline W., Donaldson, Sylva L., Tullis, D. Elizabeth, Yau, Yvonne C. W., Waters, Valerie J., Hwang, David M., and Guttman, David S.

Abstract

ABSTRACTPulmonary infections caused by Pseudomonas aeruginosaare a recalcitrant problem in cystic fibrosis (CF) patients. While the clinical implications and long-term evolutionary patterns of these infections are well studied, we know little about the short-term population dynamics that enable this pathogen to persist despite aggressive antimicrobial therapy. Here, we describe a short-term population genomic analysis of 233 P. aeruginosaisolates collected from 12 sputum specimens obtained over a 1-year period from a single patient. Whole-genome sequencing and antimicrobial susceptibility profiling identified the expansion of two clonal lineages. The first lineage originated from the coalescence of the entire sample less than 3 years before the end of the study and gave rise to a high-diversity ancestral population. The second expansion occurred 2 years later and gave rise to a derived population with a strong signal of positive selection. These events show characteristics consistent with recurrent selective sweeps. While we cannot identify the specific mutations responsible for the origins of the clonal lineages, we find that the majority of mutations occur in loci previously associated with virulence and resistance. Additionally, approximately one-third of all mutations occur in loci that are mutated multiple times, highlighting the importance of parallel pathoadaptation. One such locus is the gene encoding penicillin-binding protein 3, which received three independent mutations. Our functional analysis of these alleles shows that they provide differential fitness benefits dependent on the antibiotic under selection. These data reveal that bacterial populations can undergo extensive and dramatic changes that are not revealed by lower-resolution analyses.IMPORTANCEPseudomonas aeruginosais a bacterial opportunistic pathogen responsible for significant morbidity and mortality in cystic fibrosis (CF) patients. Once it has colonized the lung in CF, it is highly resilient and rarely eradicated. This study presents a deep sampling examination of the fine-scale evolutionary dynamics of P. aeruginosain the lungs of a chronically infected CF patient. We show that diversity of P. aeruginosais driven by recurrent clonal emergence and expansion within this patient and identify potential adaptive variants associated with these events. This high-resolution sequencing strategy thus reveals important intraspecies dynamics that explain a clinically important phenomenon not evident at a lower-resolution analysis of community structure.

Published
2015
Full Text
View/download PDF

16. Conducting Effective Physician Performance Feedback: A Primer for Healthcare Leaders.

Author

Cheng AH, Manayathu J, Sinclair D, Tullis DE, and Bandiera G

Subjects
Canada, Humans, Leadership, Medical Audit, Patient Satisfaction, Patient Simulation, Physician-Patient Relations, Quality Indicators, Health Care, Clinical Competence, Feedback, Psychological, Physicians, Quality Improvement organization & administration
Abstract

Physician performance feedback (PPF) can help physicians gain insight into their practice, to identify areas for improvement, and to implement changes to improve care. There is increasing interest in the use of PPF in Canada. However, little is known about the different types of PPF methods and whether PPF can lead to improved physician performance and patient outcomes. We provide a primer for healthcare leaders interested in doing PPF by reviewing common PPF methods. We then describe our institution's experience with physician multi-source feedback and provide strategies to conduct meaningful PPF.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results