504 results on '"Uno, Yasuhiro"'
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2. Identification of cytochrome P450 2C18 and 2C76 in tree shrews: P450 2C18 effectively oxidizes typical human P450 2C9/2C19 chiral substrates warfarin and omeprazole with less stereoselectivity
3. Investigation of Functional Cytochrome P450 4A Enzymes in Liver and Kidney of Pigs, Cats, Tree Shrews, and Dogs in Comparison with the Metabolic Capacity of Human P450 4A11
4. Novel Tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) Are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan
5. Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole
6. Molecular and functional characterization of flavin-containing monooxygenases (FMO1–6) in tree shrews
7. Involvement of beta3-adrenergic receptors in relaxation mediated by nitric oxide in chicken basilar artery
8. Novel Cytochrome P450 2C94 Functionally Metabolizes Diclofenac and Omeprazole in Dogs
9. Newly Identified Tree Shrew Cytochrome P450 2A13 is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog Cytochrome P450 2A13 and Pig Cytochrome P450 2A19
10. Newly identified cytochrome P450 3A genes of tree shrews and pigs are expressed and encode functional enzymes
11. Novel cytochrome P450 1 (CYP1) genes in tree shrews are expressed and encode functional drug-metabolizing enzymes
12. A Comprehensive Investigation of Dog Cytochrome P450 3A (CYP3A) Reveals a Functional Role of Newly Identified CYP3A98 in Small Intestine
13. Molecular and Functional Characterization of N-Acetyltransferases in Common Marmosets and Pigs
14. Cytochrome P450 2J Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes
15. Molecular and functional characterization of flavin-containing monooxygenases in pigs, dogs, and cats
16. Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans
17. Differences in Hydrolase Activities in the Liver and Small Intestine between Marmosets and Humans
18. Polymorphic cytochromes P450 in non-human primates
19. Expression of functional sulfotransferases (SULT) 1A1, 1A3, 1B1, 1C2, 1E1, and 2A1 in common marmosets
20. Genetic variants of N-acetyltransferases 1 and 2 (NAT1 and NAT2) in cynomolgus and rhesus macaques
21. Systematic characterization of glutathione S-transferases in common marmosets
22. Lessons learned from European and Japanese production of ITER toroidal field coils
23. Identification and Characterization of a New Carboxylesterase 2 Isozyme, mfCES2C, in the Small Intestine of Cynomolgus Monkeys
24. Molecular characterization of functional UDP-glucuronosyltransferases 1A and 2B in common marmosets
25. The marmoset cytochrome P450 superfamily: Sequence/phylogenetic analyses, genomic structure, and catalytic function
26. Molecular and functional characterization of cytosolic sulfotransferases in cynomolgus macaque
27. Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques
28. Electric Potential Profile with Distributed Degradation in the Terminal Joint for ITER TF Coil System
29. Novel tree shrewcytochrome P450 2Ds (CYP2D8a and CYP2D8b)are functional drug-metabolizing enzymes that metabolize bufuralol and dextromethorphan
30. Habu snakes (Protobothrops flavoviridis) show variation in thoracic aortic vasoreactivity between adjacent Japanese islands
31. Importance of cynomolgus monkeys in development of monoclonal antibody drugs
32. Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques
33. Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans
34. In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants
35. Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole
36. Characterization of Vasoreactivity in a Semi-Arboreal Snake, the Tokara Habu (Protobothrops tokarensis)
37. Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver
38. Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p -nitrophenol
39. Quinuclidine N-Oxygenation Mediated by Flavin-Containing Monooxygenases 1 and 3 in Kidney and Liver Microsomes from Humans, Monkeys, Dogs, and Pigs
40. Marmoset Cytochrome P450 3A4 Ortholog Expressed in Liver and Small-Intestine Tissues Efficiently Metabolizes Midazolam, Alprazolam, Nifedipine, and Testosterone
41. Transcript abundance of hepatic drug-metabolizing enzymes in two dog breeds compared with 14 species including humans
42. Sex- and age-dependent gene expression in human liver: An implication for drug-metabolizing enzymes
43. Reduced Nitric Oxide Synthase Involvement in Aigamo Duck Basilar Arterial Relaxation
44. Reduced Endothelial Nitric Oxide Involvement in Duck Basilar Arterial Relaxation
45. Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation
46. Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes
47. Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets
48. Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
49. A New Marmoset P450 4F12 Enzyme Expressed in Small Intestines and Livers Efficiently Metabolizes Antihistaminic Drug Ebastine
50. Molecular Cloning, Tissue Distribution, and Functional Characterization of Marmoset Cytochrome P450 1A1, 1A2, and 1B1
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