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6 results on '"Våge, Jorn"'

1. Classical BSE dismissed as the cause of CWD in Norwegian red deer despite strain similarities between both prion agents

Author

Marín-Moreno, Alba, Benestad, Sylvie L., Barrio, Tomas, Pirisinu, Laura, Espinosa, Juan Carlos, Tran, Linh, Huor, Alvina, Di Bari, Michele Angelo, Eraña, Hasier, Maddison, Ben C., D’Agostino, Claudia, Fernández-Borges, Natalia, Canoyra, Sara, Jerez-Garrido, Nuria, Castilla, Joaquín, Spiropoulos, John, Bishop, Keith, Gough, Kevin C., Nonno, Romolo, Våge, Jorn, Andréoletti, Olivier, and Torres, Juan María

Published
2024
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3. Classical BSE dismissed as the cause of CWD in Norwegian red deer despite strain similarities between both prion agents

Author

Conferencia de Rectores de las Universidades Españolas, Consejo Superior de Investigaciones Científicas (España), European Commission, Agencia Estatal de Investigación (España), Istituto Superiore di Sanità, Ministerio de Ciencia, Innovación y Universidades (España), Marín-Moreno, Alba [0000-0002-4023-6398], Benestad, Sylvie L. [0000-0002-3011-0484], Barrio, Tomás [0000-0002-7037-6316], Pirisinu, Laura [0000-0002-6548-8225], Espinosa, Juan Carlos [0000-0002-6719-9902], di Bari, Michele [0000-0003-0943-6823], Eraña, Hasier [0000-0001-8776-4211], Maddison, Ben C. [0000-0001-5453-5359], Canoyra, Sara [0000-0001-6371-8122], Castilla, Joaquín [0000-0002-2216-1361], Spiropoulos, J. [0000-0003-0119-8920], Bishop, Keith [0009-0009-8486-9486], Nonno, Romolo [0000-0001-7556-1564], Våge, Jorn [0000-0002-2016-0111], Andréoletti, Olivier [0000-0002-7369-6016], Torres, Juan María [0000-0003-0443-9232], Marín-Moreno, Alba, Benestad, Sylvie L., Barrio, Tomás, Pirisinu, Laura, Espinosa, Juan Carlos, Tran, Linh, Huor, Alvina, di Bari, Michele, Eraña, Hasier, Maddison, Ben C., D'Agostino, Claudia, Fernández-Borges, N., Canoyra, Sara, Jerez-Garrido, Nuria, Castilla, Joaquín, Spiropoulos, J., Bishop, Keith, Gough, Kevin C., Nonno, Romolo, Våge, Jorn, Andréoletti, Olivier, Torres, Juan María, Conferencia de Rectores de las Universidades Españolas, Consejo Superior de Investigaciones Científicas (España), European Commission, Agencia Estatal de Investigación (España), Istituto Superiore di Sanità, Ministerio de Ciencia, Innovación y Universidades (España), Marín-Moreno, Alba [0000-0002-4023-6398], Benestad, Sylvie L. [0000-0002-3011-0484], Barrio, Tomás [0000-0002-7037-6316], Pirisinu, Laura [0000-0002-6548-8225], Espinosa, Juan Carlos [0000-0002-6719-9902], di Bari, Michele [0000-0003-0943-6823], Eraña, Hasier [0000-0001-8776-4211], Maddison, Ben C. [0000-0001-5453-5359], Canoyra, Sara [0000-0001-6371-8122], Castilla, Joaquín [0000-0002-2216-1361], Spiropoulos, J. [0000-0003-0119-8920], Bishop, Keith [0009-0009-8486-9486], Nonno, Romolo [0000-0001-7556-1564], Våge, Jorn [0000-0002-2016-0111], Andréoletti, Olivier [0000-0002-7369-6016], Torres, Juan María [0000-0003-0443-9232], Marín-Moreno, Alba, Benestad, Sylvie L., Barrio, Tomás, Pirisinu, Laura, Espinosa, Juan Carlos, Tran, Linh, Huor, Alvina, di Bari, Michele, Eraña, Hasier, Maddison, Ben C., D'Agostino, Claudia, Fernández-Borges, N., Canoyra, Sara, Jerez-Garrido, Nuria, Castilla, Joaquín, Spiropoulos, J., Bishop, Keith, Gough, Kevin C., Nonno, Romolo, Våge, Jorn, Andréoletti, Olivier, and Torres, Juan María

Abstract

The first case of CWD in a Norwegian red deer was detected by a routine ELISA test and confirmed by western blotting and immunohistochemistry in the brain stem of the animal. Two different western blotting tests were conducted independently in two different laboratories, showing that the red deer glycoprofile was different from the Norwegian CWD reindeer and CWD moose and from North American CWD. The isolate showed nevertheless features similar to the classical BSE (BSE-C) strain. Furthermore, BSE-C could not be excluded based on the PrPSc immunohistochemistry staining in the brainstem and the absence of detectable PrPSc in the lymphoid tissues. Because of the known ability of BSE-C to cross species barriers as well as its zoonotic potential, the CWD red deer isolate was submitted to the EURL Strain Typing Expert Group (STEG) as a BSE-C suspect for further investigation. In addition, different strain typing in vivo and in vitro strategies aiming at identifying the BSE-C strain in the red deer isolate were performed independently in three research groups and BSE-C was not found in it. These results suggest that the Norwegian CWD red deer case was infected with a previously unknown CWD type and further investigation is needed to determine the characteristics of this potential new CWD strain.

Published
2024

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