47 results on '"Verboom, Diana"'
Search Results
2. Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis
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van Vught, Lonneke A., Uhel, Fabrice, Ding, Chao, van‘t Veer, Cees, Scicluna, Brendon P., Peters‐Sengers, Hessel, Klein Klouwenberg, Peter M.C., Nürnberg, Peter, Cremer, Olaf L., Schultz, Marcus J., van der Poll, Tom, de Beer, Friso M., Bos, Lieuwe D.J., Glas, Gerie J., Hoogendijk, Arie J., van Hooijdonk, Roosmarijn T.M., Horn, Janneke, Huson, Mischa A., Schouten, Laura R.A., Straat, Marleen, Wieske, Luuk, Wiewel, Maryse A., Witteveen, Esther, Bonten, Marc J.M., Cremer, Olaf M., Ong, David S.Y., Frencken, Jos F., Koster‐Brouwer, Maria E., van de Groep, Kirsten, and Verboom, Diana M.
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- 2021
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3. A pilot study of a novel molecular host response assay to diagnose infection in patients after high-risk gastro-intestinal surgery
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Verboom, Diana M., Koster-Brouwer, Maria E., Ruurda, Jelle P., van Hillegersberg, Richard, van Berge Henegouwen, Mark I., Gisbertz, Suzanne S., Scicluna, Brendon P., Bonten, Marc J.M., and Cremer, Olaf L.
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- 2019
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4. Epidemiology and outcomes of source control procedures in critically ill patients with intra-abdominal infection
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van de Groep, Kirsten, Verhoeff, Tessa L., Verboom, Diana M., Bos, Lieuwe D., Schultz, Marcus J., Bonten, Marc J.M., and Cremer, Olaf L.
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- 2019
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5. The Diagnostic Yield of Routine Admission Blood Cultures in Critically Ill Patients
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Verboom, Diana M., van de Groep, Kirsten, Boel, C. H. Edwin, Haas, Pieter Jan A., Derde, Lennie P. G., Cremer, Olaf L., and Bonten, Marc J. M.
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- 2021
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6. Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study
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de Beer, Friso M., Bos, Lieuwe D.J., Frencken, Jos F., Koster-Brouwer, Maria E., van de Groep, Kirsten, Verboom, Diana M., Glas, Gerie J., van Hooijdonk, Roosmarijn T.M., Hoogendijk, Arie J., Huson, Mischa A., Klouwenberg, Peter M. Klein, Ong, David S.Y., Schouten, Laura R.A., Straat, Marleen, Witteveen, Esther, Wieske, Luuk, Scicluna, Brendon P, van Vught, Lonneke A, Zwinderman, Aeilko H, Wiewel, Maryse A, Davenport, Emma E, Burnham, Katie L, Nürnberg, Peter, Schultz, Marcus J, Horn, Janneke, Cremer, Olaf L, Bonten, Marc J, Hinds, Charles J, Wong, Hector R, Knight, Julian C, and van der Poll, Tom
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- 2017
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7. Robustness of sepsis-3 criteria in critically ill patients
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Verboom, Diana M., Frencken, Jos F., Ong, David S. Y., Horn, Janneke, van der Poll, Tom, Bonten, Marc J. M., Cremer, Olaf L., and Klein Klouwenberg, Peter M. C.
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- 2019
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8. Association between age and the host response in critically ill patients with sepsis
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Michels, Erik H. A., Butler, Joe M., Reijnders, Tom D. Y., Cremer, Olaf L., Scicluna, Brendon P., Uhel, Fabrice, Peters-Sengers, Hessel, Schultz, Marcus J., Knight, Julian C., van Vught, Lonneke A., van der Poll, Tom, de Beer, Friso M., Bos, Lieuwe D. J., Glas, Gerie J., Hoogendijk, Arie J., van Hooijdonk, Roosmarijn T. M., Horn, Janneke, Huson, Mischa A., Schouten, Laura R. A., Straat, Marleen, Wieske, Luuk, Wiewel, Maryse A., Witteveen, Esther, Bonten, Marc J. M., Cremer, Olaf M., Ong, David S. Y., Frencken, Jos F., Klouwenberg, Peter M. C. Klein, Koster‐Brouwer, Maria E., van de Groep, Kirsten, Verboom, Diana M., Center of Experimental and Molecular Medicine, Graduate School, AII - Infectious diseases, Epidemiology and Data Science, Intensive Care Medicine, ACS - Pulmonary hypertension & thrombosis, ACS - Diabetes & metabolism, ACS - Microcirculation, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Infectious diseases, ACS - Heart failure & arrhythmias, AII - Inflammatory diseases, ANS - Neuroinfection & -inflammation, General Paediatrics, Neurology, VU University medical center, Pulmonary medicine, Internal medicine, Intensive care medicine, and MARS consortium
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Inflammation ,Coagulation ,Aging -- Immunological aspects ,Critical Care and Intensive Care Medicine ,Ageing ,Immune system ,Septicemia -- Immunological aspects ,Sepsis ,Cytokines ,Endothelium ,Biochemical markers -- Diagnostic use ,Inflammation -- Immunological aspects ,Transcriptome ,Cytokines -- Immunology ,Biomarkers - Abstract
Background: The association of ageing with increased sepsis mortality is well established. Nonetheless, current investigations on the influence of age on host response aberrations are largely limited to plasma cytokine levels while neglecting other pathophysiological sepsis domains like endothelial cell activation and function, and coagulation activation. The primary objective of this study was to gain insight into the association of ageing with aberrations in key host response pathways and blood transcriptomes in sepsis., Methods: We analysed the clinical outcome (n=1952), 16 plasma biomarkers providing insight in deregulation of specific pathophysiological domains (n=899), and blood leukocyte transcriptomes (n=488) of sepsis patients stratified according to age decades. Blood transcriptome results were validated in an independent sepsis cohort and compared with healthy individuals. se., Results: Older age was associated with increased mortality independent of comorbidities and disease severity. Ageing was associated with lower endothelial cell activation and dysfunction, and similar inflammation and coagulation activation, despite higher disease severity scores. Blood leukocytes of patients≥70 years, compared to patients, Conclusions: This study provides novel evidence that older age is associated with relatively mitigated sepsis-induced endothelial cell activation and dysfunction, and a blood leukocyte transcriptome signature indicating impaired innate immune and cytokine signaling. These data suggest that age should be considered in patient selection in future sepsis trials targeting the immune system and/or the endothelial cell response., peer-reviewed
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- 2022
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9. The authors reply
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Koster-Brouwer, Maria E., Verboom, Diana M., Bonten, Marc J. M., and Cremer, Olaf L.
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- 2018
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10. Validation of a Novel Molecular Host Response Assay to Diagnose Infection in Hospitalized Patients Admitted to the ICU With Acute Respiratory Failure
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Koster-Brouwer, Maria E., Verboom, Diana M., Scicluna, Brendon P., van de Groep, Kirsten, Frencken, Jos F., Janssen, Davy, Schuurman, Rob, Schultz, Marcus J., van der Poll, Tom, Bonten, Marc J.M., and Cremer, Olaf L.
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- 2018
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11. Myocardial Injury in Patients With Sepsis and Its Association With Long-Term Outcome
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Frencken, Jos F., Donker, Dirk W., Spitoni, Cristian, Koster-Brouwer, Marlies E., Soliman, Ivo W., Ong, David S.Y., Horn, Janneke, van der Poll, Tom, van Klei, Wilton A., Bonten, Marc J.M., Cremer, Olaf L., de Beer, Friso M., Bos, Lieuwe D.J., Glas, Gerie J., van Hooijdonk, Roosmarijn T.M., Schouten, Laura R.A., Straat, Marleen, Witteveen, Esther, Wieske, Luuk, van Vught, Lonneke A., Wiewel, Maryse, Hoogendijk, Arie J., Huson, Mischa A., Scicluna, Brendon, Schultz, Marcus J., Klein Klouwenberg, Peter M.C., van de Groep, Kirsten, and Verboom, Diana
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- 2018
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12. Patients with hypothermic sepsis have a unique gene expression profile compared to patients with fever and sepsis
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Harmon, Matthew B. A., Scicluna, Brendon P., Wiewel, Maryse A., Schultz, Marcus J., Horn, Janneke, Cremer, Olaf L., van der Poll, Tom, Joost Wiersinga, W., Juffermans, Nicole P., de Beer, Friso M., Bos, Lieuwe D., Glas, Gerie J., Hoogendijk, Arie J., van Hooijdonk, Roosmarijn T., Huson, Mischa A., Scicluna, Brendon, Schouten, Laura R., Straat, Marleen, van Vught, Lonneke A., Wieske, Luuk, Witteveen, Esther, Bonten, Marc J., Frencken, Jos F., van de Groep, Kirsten, Klein Klouwenberg, Peter M., Koster–Brouwer, Maria E., Ong, David S., Varkila, Meri R., Verboom, Diana M., VU University medical center, Pulmonary medicine, Internal medicine, Intensive care medicine, ACS - Heart failure & arrhythmias, Intensive Care Medicine, Center of Experimental and Molecular Medicine, AII - Infectious diseases, ACS - Pulmonary hypertension & thrombosis, ACS - Diabetes & metabolism, ACS - Microcirculation, ANS - Neuroinfection & -inflammation, Infectious diseases, Anesthesiology, General Paediatrics, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Neurology, and MARS Consortium
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Septicemia -- Diagnosis ,fever ,Fever ,Protein microarrays ,RNA-Binding Proteins ,Hypothermia ,Cell Biology ,Tryptophan -- Metabolism ,sepsis ,Humans ,biomarker ,Molecular Medicine ,tryptophan ,Biochemical markers -- Diagnostic use ,Transcriptome ,hypothermia ,microarray - Abstract
The pathophysiology of hypothermia during sepsis is unclear. Using genomic profiling of blood leukocytes, we aimed to determine if hypothermia is associated with a different gene expression profile compared to fever during sepsis. Patients with sepsis and either hypothermia or fever within 24 hours after ICU admission were included in the study (n = 168). Hypothermia was defined as body temperature below 36 °C. Fever was defined as body temperature equal to or above 38.3°C. We compared blood gene expression (whole-genome transcriptome in leukocytes) in hypothermic septic compared to febrile septic patients in an unmatched analysis and matched for APACHE IV score and the presence of shock. In total, 67 septic patients were hypothermic and 101 patients were febrile. Hypothermia was associated with a distinct gene expression profile in both unmatched and matched analyses. There were significant differences related to the up- and downregulation of canonical signalling pathways. In the matched analysis, the top upregulated gene was cold-inducible mRNA binding protein (CIRBP) which plays a role in cold-induced suppression of cell proliferation. In addition, we found three signalling pathways significantly upregulated in hypothermic patients compared to febrile patients; tryptophan degradation X, phenylalanine degradation IV and putrescine degradation III. In conclusion, there are distinct signalling pathways and genes associated with hypothermia, including tryptophan degradation and CIRBP expression, providing a possible link to the modulation of body temperature and early immunosuppression. Future studies may focus on the canonical signalling pathways presented in this paper to further investigate spontaneous hypothermia in sepsis., peer-reviewed
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- 2022
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13. Etiology of Myocardial Injury in Critically Ill Patients with Sepsis: A Cohort Study
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Frencken, Jos F., primary, van Smeden, Maarten, additional, van de Groep, Kirsten, additional, Ong, David S. Y., additional, Klein Klouwenberg, Peter M. C., additional, Juffermans, Nicole, additional, Bonten, Marc J. M., additional, van der Poll, Tom, additional, Cremer, Olaf L., additional, de Beer, Friso M., additional, Bos, Lieuwe D. J., additional, Glas, Gerie J., additional, van Hooijdonk, Roosmarijn T. M., additional, Schouten, Laura R. A., additional, Straat, Marleen, additional, Witteveen, Esther, additional, Wieske, Luuk, additional, van Vught, Lonneke A., additional, Wiewel, Maryse, additional, Hoogendijk, Arie J., additional, Huson, Mischa A., additional, Scicluna, Brendon, additional, Schultz, Marcus J., additional, Verboom, Diana, additional, and Koster-Brouwer, Maria E., additional
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- 2022
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14. Effect of erythromycin on mortality and the host response in critically ill patients with sepsis: a target trial emulation
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Reijnders, Tom D. Y., Peters-Sengers, Hessel, van Vught, Lonneke A., Uhel, Fabrice, Bonten, Marc J. M., Cremer, Olaf L., Schultz, Marcus J., Stuiver, Martijn M., van der Poll, Tom, de Beer, Friso M., Bos, Lieuwe D. J., Glas, Gerie J., van Hooijdonk, Roosmarijn T. M., Horn, Janneke, Schouten, Laura R. A., Straat, Marleen, Wieske, Luuk, Witteveen, Esther, Schuurman, Alex R., van Engelen, Tjitske S. R., Pereverzeva, Liza, Hoogendijk, Arie J., Huson, Mischa A., Wiewel, Maryse A., Klouwenberg, Peter M. C. Klein, Ong, David S. Y., Frencken, Jos F., Koster-Brouwer, Maria E., van de Groep, Kirsten, Verboom, Diana M., Graduate School, Center of Experimental and Molecular Medicine, Epidemiology and Data Science, AII - Infectious diseases, Intensive Care Medicine, ACS - Diabetes & metabolism, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, ACS - Pulmonary hypertension & thrombosis, ACS - Microcirculation, APH - Quality of Care, Master Evidence Based Practice, Infectious diseases, VU University medical center, and ACS - Heart failure & arrhythmias
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Clinical Trials as Topic ,Propensity score ,Critical Illness ,Critical Care and Intensive Care Medicine ,Target trial ,Erythromycin ,Immunomodulation ,Intensive Care Units ,Sepsis ,Humans ,Macrolides ,Mortality ,Critically ill ,Biomarkers - Abstract
Background Immunomodulatory therapies that improve the outcome of sepsis are not available. We sought to determine whether treatment of critically ill patients with sepsis with low-dose erythromycin—a macrolide antibiotic with broad immunomodulatory effects—decreased mortality and ameliorated underlying disease pathophysiology. Methods We conducted a target trial emulation, comparing patients with sepsis admitted to two intensive care units (ICU) in the Netherlands for at least 72 h, who were either exposed or not exposed during this period to treatment with low-dose erythromycin (up to 600 mg per day, administered as a prokinetic agent) but no other macrolides. We used two common propensity score methods (matching and inverse probability of treatment weighting) to deal with confounding by indication and subsequently used Cox regression models to estimate the treatment effect on the primary outcome of mortality rate up to day 90. Secondary clinical outcomes included change in SOFA, duration of mechanical ventilation and the incidence of ICU-acquired infections. We used linear mixed models to assess differences in 15 host response biomarkers reflective of key pathophysiological processes from admission to day 4. Results In total, 235 patients started low-dose erythromycin treatment, 470 patients served as controls. Treatment started at a median of 38 [IQR 25–52] hours after ICU admission for a median of 5 [IQR 3–8] total doses in the first course. Matching and weighting resulted in populations well balanced for proposed confounders. We found no differences between patients treated with low-dose erythromycin and control subjects in mortality rate up to day 90: matching HR 0.89 (95% CI 0.64–1.24), weighting HR 0.95 (95% CI 0.66–1.36). There were no differences in secondary clinical outcomes. The change in host response biomarker levels from admission to day 4 was similar between erythromycin-treated and control subjects. Conclusion In this target trial emulation in critically ill patients with sepsis, we could not demonstrate an effect of treatment with low-dose erythromycin on mortality, secondary clinical outcomes or host response biomarkers.
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- 2022
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15. Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study
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Peters-Sengers, Hessel, Butler, Joe M., Uhel, Fabrice, Schultz, Marcus J., Bonten, Marc J., Cremer, Olaf L., Scicluna, Brendon P., van Vught, Lonneke A., van der Poll, Tom, de Beer, Friso M., Bos, Lieuwe D. J., Glas, Gerie J., van Hooijdonk, Roosmarijn T. M., Horn, Janneke, Schouten, Laura R. A., Straat, Marleen, Wieske, Luuk, Witteveen, Esther, Reijnders, Tom D. Y., Schuurman, Alex R., van Engelen, Tjitske S. R., Pereverzeva, Liza, Hoogendijk, Arie J., Huson, Mischa A., Wiewel, Maryse A., Klouwenberg, Peter M. C. Klein, Ong, David S. Y., Frencken, Jos F., Koster-Brouwer, Maria E., van de Groep, Kirsten, Verboom, Diana M., MARS Consortium, Center of Experimental and Molecular Medicine, Epidemiology and Data Science, Nephrology, Intensive Care Medicine, ACS - Pulmonary hypertension & thrombosis, ACS - Diabetes & metabolism, ACS - Microcirculation, AII - Infectious diseases, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Infectious diseases, Pulmonology, ACS - Heart failure & arrhythmias, Anesthesiology, Graduate School, APH - Quality of Care, ANS - Neuroinfection & -inflammation, General Paediatrics, Neurology, VU University medical center, Pulmonary medicine, Internal medicine, Pediatric surgery, Intensive care medicine, and consortium, MARS
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Septicemia -- Diagnosis ,Intensive care units ,Original ,Critical Illness ,Infection -- Immunological aspects ,Critical Care and Intensive Care Medicine ,Host-virus relationships ,Cohort Studies ,Source of infection ,Intensive Care Units ,Site of infection ,Sepsis ,Host response ,Humans ,Intensive care unit ,Prospective Studies ,Biomarkers - Abstract
Purpose: There is limited knowledge on how the source of infection impacts the host response to sepsis. We aimed to compare the host response in sepsis patients with a single, known source at admission (< 24 h) to the intensive care unit., Methods: From the molecular diagnosis and risk stratification of sepsis (MARS) prospective cohort, we measured 16 plasma host response biomarkers reflective of key host response pathways in 621 sepsis patients. In a subgroup (n = 335), blood leukocyte transcriptomes were compared between the sources. Differences in clinical patient profiles and survival were compared in the whole sepsis cohort (n = 2019)., Results: The plasma biomarker cohort was categorized into sepsis originating from the respiratory tract (n = 334, 53.8%), abdomen (n = 159, 25.6%), urinary tract (n = 44, 7.1%), cardiovascular (n = 41, 6.6%), central nervous system (CNS) (n = 18, 2.9%), or skin (n = 25, 4%). This analysis revealed stronger inflammatory and cytokine responses, loss of vascular integrity and coagulation activation in abdominal sepsis relative to respiratory. Endothelial cell activation was prominent in urinary, cardiovascular and skin infections, while CNS infection was associated with the least host response aberrations. The leukocyte transcriptional response showed the largest overlap between abdominal and pulmonary infections (76% in common); notable differences between the sources were detected regarding hemostasis, cytokine signaling, innate and adaptive immune, and metabolic transcriptional pathways. After adjustment for confounders, the source of infection remained an independent contributor to 30-day mortality (unadjusted p = 0.001, adjusted p = 0.028)., Conclusion: Sepsis heterogeneity is partly explained by source-specific host response dysregulations and should be considered when selecting patients for trials testing immune modulatory drugs., peer-reviewed
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- 2021
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16. Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis
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van de Groep, Kirsten, Bos, Martine P., Varkila, Meri R. J., Savelkoul, Paul H. M., Ong, David S. Y., Derde, Lennie P. G., Juffermans, Nicole P., Bonten, Marc J. M., Cremer, Olaf L., de Beer, Friso M., Bos, Lieuwe D. J., Glas, Gerie J., Hoogendijk, Arie J., van Hooijdonk, Roosmarijn T. M., Horn, Janneke, Huson, Mischa A., van der Poll, Tom, Schouten, Laura R. A., Scicluna, Brendon, Schultz, Marcus J., Straat, Marleen, van Vught, Lonneke A., Wieske, Luuk, Wiewel, Maryse A., Witteveen, Esther, Frencken, Jos F., Klouwenberg, Peter M. C. Klein, Koster-Brouwer, Maria E., Verboom, Diana M., MUMC+: DA Medische Microbiologie en Infectieziekten (5), Med Microbiol, Infect Dis & Infect Prev, RS: NUTRIM - R2 - Liver and digestive health, RS: CAPHRI - R4 - Health Inequities and Societal Participation, Medical Microbiology and Infection Prevention, AGEM - Digestive immunity, AII - Infectious diseases, Amsterdam Reproduction & Development (AR&D), Division 1, Intensive Care Medicine, Center of Experimental and Molecular Medicine, Infectious diseases, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, and ACS - Microcirculation
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Male ,0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,Diagnostic research ,Multiplex real-time PCR ,Critical Illness ,030106 microbiology ,Pathogen detection ,Real-Time Polymerase Chain Reaction ,law.invention ,Sepsis ,03 medical and health sciences ,0302 clinical medicine ,Medical microbiology ,Predictive Value of Tests ,law ,Intensive care ,Internal medicine ,Journal Article ,medicine ,Humans ,Multiplex ,Prospective Studies ,030212 general & internal medicine ,Aged ,Whole blood ,Critically ill ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Intensive care unit ,Blood ,Infectious Diseases ,Real-time polymerase chain reaction ,INFECTIONS ,Female ,Original Article ,business ,Multiplex Polymerase Chain Reaction - Abstract
A novel multiplex real-time PCR for bloodstream infections (BSI-PCR) detects pathogens directly in blood. This study aimed at determining the positive predictive value (PPV) of BSI-PCR in critically ill patients with sepsis. We included consecutive patients with presumed sepsis upon admission to the intensive care unit (ICU). The multiplexed BSI-PCR included 17 individual PCRs for a broad panel of species- and genus-specific DNA targets. BSI-PCR results were compared with a reference diagnosis for which plausibility of infection and causative pathogen(s) had been prospectively assessed by trained observers, based on available clinical and microbiological evidence. PPV and false positive proportion (FPP) were calculated. Clinical plausibility of discordant positive results was adjudicated by an expert panel. Among 325 patients, infection likelihood was categorized as confirmed, uncertain, and ruled out in 210 (65%), 88 (27%), and 27 (8%) subjects, respectively. BSI-PCR identified one or more microorganisms in 169 (52%) patients, of whom 104 (61%) had at least one detection in accordance with the reference diagnosis. Discordant positive PCR results were observed in 95 patients, including 30 subjects categorized as having an “unknown” pathogen. Based on 5525 individual PCRs yielding 295 positive results, PPV was 167/295 (57%) and FPP was 128/5525 (2%). Expert adjudication of the 128 discordant PCR findings resulted in an adjusted PPV of 68% and FPP of 2%. BSI-PCR was all-negative in 156 patients, including 79 (51%) patients in whom infection was considered ruled out. BSI-PCR may complement conventional cultures and expedite the microbiological diagnosis of sepsis in ICU patients, but improvements in positive predictive value of the test are warranted before its implementation in clinical practice can be considered. Electronic supplementary material The online version of this article (10.1007/s10096-019-03616-w) contains supplementary material, which is available to authorized users.
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- 2019
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17. Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study
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Schouten, Laura R., van Kaam, Anton H., Kohse, Franziska, Veltkamp, Floor, Bos, Lieuwe D., de Beer, Friso M., van Hooijdonk, Roosmarijn T., Horn, Janneke, Straat, Marleen, Witteveen, Esther, Glas, Gerie J., Wieske, Luuk, van Vught, Lonneke A., Wiewel, Maryse A., Ingelse, Sarah A., Cortjens, Bart, van Woensel, Job B., Bos, Albert P., Walther, Thomas, Schultz, Marcus J., Wösten-van Asperen, Roelie M., Hoogendijk, Arie J., Huson, Mischa A., van der Poll, Tom, Scicluna, Brendon, Bonten, Marc J., Cremer, Olaf L., Frencken, Jos F., van de Groep, Kirsten, Klein Klouwenberg, Peter M., Koster-Brouwer, Maria E., Ong, David S., Verboom, Diana M., Amsterdam Reproduction & Development (AR&D), Internal medicine, Division 1, Pediatric surgery, Amsterdam Neuroscience - Brain Imaging, Neurology, Neonatology, ARD - Amsterdam Reproduction and Development, Graduate School, AII - Inflammatory diseases, Intensive Care Medicine, ACS - Heart failure & arrhythmias, ANS - Neuroinfection & -inflammation, Anesthesiology, ANS - Amsterdam Neuroscience, APH - Quality of Care, ACS - Diabetes & metabolism, APH - Health Behaviors & Chronic Diseases, Center of Experimental and Molecular Medicine, Medical Microbiology and Infection Prevention, Paediatric Intensive Care, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, General Paediatrics, Infectious diseases, Epidemiology and Data Science, APH - Personalized Medicine, ACS - Pulmonary hypertension & thrombosis, and ACS - Microcirculation
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medicine.medical_specialty ,ARDS ,Aging ,Critical Care and Intensive Care Medicine ,Gastroenterology ,Pathophysiology ,Endothelial activation ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Epidemiology ,medicine ,Journal Article ,Host response ,medicine.diagnostic_test ,biology ,business.industry ,Research ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,Interleukin ,030208 emergency & critical care medicine ,Angiotensin-converting enzyme ,lcsh:RC86-88.9 ,medicine.disease ,3. Good health ,Bronchoalveolar lavage ,030228 respiratory system ,biology.protein ,business ,Angiotensin converting enzyme ,Biomarkers ,Cohort study - Abstract
Background Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respiratory distress syndrome (ARDS) between children and adults. The present study compares biomarkers of host defense and RAS in bronchoalveolar lavage (BAL) fluid from neonates, children, adults, and older adults with ARDS. Methods In this prospective observational study, we enrolled mechanical ventilated ARDS patients categorized into four age groups: 20 neonates ( 65 years of age). All patients underwent a nondirected BAL within 72 h after intubation. Activities of the two main enzymes of RAS, angiotensin converting enzyme (ACE) and ACE2, and levels of biomarkers of inflammation, endothelial activation, and epithelial damage were determined in BAL fluid. Results Levels of myeloperoxidase, interleukin (IL)-6, IL-10, and p-selectin were higher with increasing age, whereas intercellular adhesion molecule-1 was higher in neonates. No differences in activity of ACE and ACE2 were seen between the four age groups. Conclusions Age-dependent differences in the levels of biomarkers in lungs of ARDS patients are present. Especially, higher levels of markers involved in the neutrophil response were found with increasing age. In contrast to preclinical studies, age is not associated with changes in the pulmonary RAS. Electronic supplementary material The online version of this article (10.1186/s13613-019-0529-4) contains supplementary material, which is available to authorized users.
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- 2019
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18. The Diagnostic Yield of Routine Admission Blood Cultures in Critically Ill Patients
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Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB onderwijs, MMB Medische Staf, Medische Staf Intensive Care, DVF Medisch, Epi Infectieziekten, MMB, Verboom, Diana M, van de Groep, Kirsten, Boel, C H Edwin, Haas, Pieter Jan A, Derde, Lennie P G, Cremer, Olaf L, Bonten, Marc J M, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB onderwijs, MMB Medische Staf, Medische Staf Intensive Care, DVF Medisch, Epi Infectieziekten, MMB, Verboom, Diana M, van de Groep, Kirsten, Boel, C H Edwin, Haas, Pieter Jan A, Derde, Lennie P G, Cremer, Olaf L, and Bonten, Marc J M
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- 2021
19. Biological Subphenotypes of Acute Respiratory Distress Syndrome Show Prognostic Enrichment in Mechanically Ventilated Patients without Acute Respiratory Distress Syndrome
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Heijnen, Nanon F. L., primary, Hagens, Laura A., additional, Smit, Marry R., additional, Cremer, Olaf L., additional, Ong, David S. Y., additional, van der Poll, Tom, additional, van Vught, Lonneke A., additional, Scicluna, Brendon P., additional, Schnabel, Ronny M., additional, van der Horst, Iwan C. C., additional, Schultz, Marcus J., additional, Bergmans, Dennis C. J. J., additional, Bos, Lieuwe D. J., additional, de Beer, Friso M., additional, Bos, Lieuwe D., additional, Glas, Gerie J., additional, Horn, Janneke, additional, Hoogendijk, Arie J., additional, van Hooijdonk, Roosmarijn T., additional, Huson, Mischa A., additional, Scicluna, Brendon, additional, Schouten, Laura R., additional, Straat, Marleen, additional, Wieske, Luuk, additional, Wievel, Maryse A., additional, Witteveen, Esther, additional, Bonten, Marc J., additional, Frencken, Jos F., additional, van de Groep, Kirsten, additional, Klein Klouwenberg, Peter M., additional, Koster-Brouwer, Maria E., additional, Ong, David S., additional, Varkila, Meri R., additional, and Verboom, Diana M., additional
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- 2021
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20. Novel Approaches for Diagnosing Sepsis in the Critically Ill
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Cremer, O.L., Bonten, M.J.M., Verboom, Diana Milena, Cremer, O.L., Bonten, M.J.M., and Verboom, Diana Milena
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- 2020
21. The Diagnostic Yield of Routine Admission Blood Cultures in Critically Ill Patients
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Verboom, Diana M., primary, van de Groep, Kirsten, additional, Boel, C. H. Edwin, additional, Haas, Pieter Jan A., additional, Derde, Lennie P. G., additional, Cremer, Olaf L., additional, and Bonten, Marc J. M., additional
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- 2020
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22. Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS
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Morales-Quinteros, Luis, Schultz, Marcus J., Bringué, Josep, Calfee, Carolyn S., Camprubí, Marta, Cremer, Olaf L., Horn, Janneke, van der Poll, Tom, Sinha, Pratik, Artigas, Antonio, Bos, Lieuwe D., de Beer, Friso M., Glas, Gerie J., Hoogendijk, Arie J., van Hooijdonk, Roosmarijn T., Huson, Mischa A., Scicluna, Brendon, Schouten, Laura R., Straat, Marleen, van Vught, Lonneke A., Wieske, Luuk, Wiewel, Maryse A., Witteveen, Esther, Bonten, Marc J., Frencken, Jos F., van de Groep, Kirsten, Klein Klouwenberg, Peter M., Koster-Brouwer, Maria E., Ong, David S., Varkila, Meri R., Verboom, Diana M., Intensive Care Medicine, ANS - Neuroinfection & -inflammation, Center of Experimental and Molecular Medicine, Infectious diseases, ACS - Heart failure & arrhythmias, Anesthesiology, Graduate School, ACS - Diabetes & metabolism, APH - Quality of Care, Epidemiology and Data Science, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, Medical Microbiology and Infection Prevention, AII - Inflammatory diseases, ARD - Amsterdam Reproduction and Development, ACS - Pulmonary hypertension & thrombosis, and ACS - Microcirculation
- Subjects
medicine.medical_specialty ,ARDS ,medicine.medical_treatment ,Dead space ,Respiratory Dead Space ,Prognostication ,Critical Care and Intensive Care Medicine ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Internal medicine ,Journal Article ,medicine ,Acute respiratory distress syndrome (ARDS) ,Intensive care unit ,Mortality ,Respiratory dead space ,Mechanical ventilation ,Acute respiratory distress syndrome ,business.industry ,Research ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,Ventilatory ratio ,030208 emergency & critical care medicine ,lcsh:RC86-88.9 ,Odds ratio ,medicine.disease ,030228 respiratory system ,Breathing ,Cardiology ,Prediction ,business ,Cohort study - Abstract
Background Indirect indices for measuring impaired ventilation, such as the estimated dead space fraction and the ventilatory ratio, have been shown to be independently associated with an increased risk of mortality. This study aimed to compare various methods for dead space estimation and the ventilatory ratio in patients with acute respiratory distress syndrome (ARDS) and to determine their independent values for predicting death at day 30. The present study is a post hoc analysis of a prospective observational cohort study of ICUs of two tertiary care hospitals in the Netherlands. Results Individual patient data from 940 ARDS patients were analyzed. Estimated dead space fraction and the ventilatory ratio at days 1 and 2 were significantly higher among non-survivors (p VD/VT phys] and the ventilatory ratio at day 2 showed independent association with mortality at 30 days (odds ratio 1.28 [95% CI 1.02–1.61], p p VD/VT HB] and Penn State [VD/VT PS] estimations were not associated with mortality. The predicted validity of the estimated dead space fraction and the ventilatory ratio improved the baseline model based on PEEP, PaO2/FiO2, driving pressure and compliance of the respiratory system at day 2 (AUROCC 0.72 vs. 0.69, p Conclusions Estimated methods for dead space calculation and the ventilatory ratio during the early course of ARDS are associated with mortality at day 30 and add statistically significant but limited improvement in the predictive accuracy to indices of oxygenation and respiratory system mechanics at the second day of mechanical ventilation.
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- 2019
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23. Additional file 1: of Robustness of sepsis-3 criteria in critically ill patients
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Verboom, Diana, Frencken, Jos, Ong, David, Horn, Janneke, Poll, Tom, Bonten, Marc, Cremer, Olaf, and Klouwenberg, Peter Klein
- Abstract
Table S1. Missing data. Table S2. Incidence, organ failure, and mortality of sepsis-3 and MARS-sepsis. Table S3. Incidence, organ failure, and mortality of septic shock-3 and MARS-shock. (PDF 40 kb)
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- 2019
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24. Predicting the clinical trajectory in critically ill patients with sepsis: A cohort study
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Klein Klouwenberg, Peter M. C., Spitoni, Cristian, van der Poll, Tom, Bonten, Marc J., Cremer, Olaf L., Frencken, Jos F., van de Groep, Kirsten, Koster-Brouwer, Marlies E., Ong, David S. Y., Verboom, Diana, de Beer, Friso M., Bos, Lieuwe D. J., Glas, Gerie J., van Hooijdonk, Roosmarijn T. M., Schouten, Laura R. A., Straat, Marleen, Witteveen, Esther, Wieske, Luuk, Hoogendijk, Arie J., Huson, Mischa A., van Vught, Lonneke A., Schultz, Marcus, Center of Experimental and Molecular Medicine, Infectious diseases, AII - Infectious diseases, Anesthesiology, Graduate School, ACS - Heart failure & arrhythmias, ANS - Neuroinfection & -inflammation, Intensive Care Medicine, ACS - Diabetes & metabolism, APH - Quality of Care, Neurology, ANS - Amsterdam Neuroscience, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, ARD - Amsterdam Reproduction and Development, ACS - Pulmonary hypertension & thrombosis, and ACS - Microcirculation
- Subjects
medicine.medical_specialty ,Epidemiology ,Discharged alive ,Disease ,Research Support ,Critical Care and Intensive Care Medicine ,law.invention ,Sepsis ,03 medical and health sciences ,0302 clinical medicine ,law ,medicine ,Journal Article ,Organ failure ,Intensive care unit ,030212 general & internal medicine ,Non-U.S. Gov't ,Outcome ,Critically ill ,business.industry ,Research Support, Non-U.S. Gov't ,Organ dysfunction ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,030208 emergency & critical care medicine ,lcsh:RC86-88.9 ,medicine.disease ,Markov model ,Emergency medicine ,medicine.symptom ,business ,Cohort study - Abstract
Background To develop a mathematical model to estimate daily evolution of disease severity using routinely available parameters in patients admitted to the intensive care unit (ICU). Methods Over a 3-year period, we prospectively enrolled consecutive adults with sepsis and categorized patients as (1) being at risk for developing (more severe) organ dysfunction, (2) having (potentially still reversible) limited organ failure, or (3) having multiple-organ failure. Daily probabilities for transitions between these disease states, and to death or discharge, during the first 2 weeks in ICU were calculated using a multi-state model that was updated every 2 days using both baseline and time-varying information. The model was validated in independent patients. Results We studied 1371 sepsis admissions in 1251 patients. Upon presentation, 53 (4%) were classed at risk, 1151 (84%) had limited organ failure, and 167 (12%) had multiple-organ failure. Among patients with limited organ failure, 197 (17%) evolved to multiple-organ failure or died and 809 (70%) improved or were discharged alive within 14 days. Among patients with multiple-organ failure, 67 (40%) died and 91 (54%) improved or were discharged. Treatment response could be predicted with reasonable accuracy (c-statistic ranging from 0.55 to 0.81 for individual disease states, and 0.67 overall). Model performance in the validation cohort was similar. Conclusions This prediction model that estimates daily evolution of disease severity during sepsis may eventually support clinicians in making better informed treatment decisions and could be used to evaluate prognostic biomarkers or perform in silico modeling of novel sepsis therapies during trial design. Clinical trial registration ClinicalTrials.gov NCT01905033
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- 2019
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25. Predicting the clinical trajectory in critically ill patients with sepsis: A cohort study
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Klein Klouwenberg, Peter M.C., Spitoni, Cristian, Van Der Poll, Tom, Bonten, Marc J., Cremer, Olaf L., Frencken, Jos F., Van De Groep, Kirsten, Koster-Brouwer, Marlies E., Ong, David S.Y., Verboom, Diana, De Beer, Friso M., Bos, Lieuwe D.J., Glas, Gerie J., Van Hooijdonk, Roosmarijn T.M., Schouten, Laura R.A., Straat, Marleen, Witteveen, Esther, Wieske, Luuk, Hoogendijk, Arie J., Huson, Mischa A., Van Vught, Lonneke A., Klein Klouwenberg, Peter M.C., Spitoni, Cristian, Van Der Poll, Tom, Bonten, Marc J., Cremer, Olaf L., Frencken, Jos F., Van De Groep, Kirsten, Koster-Brouwer, Marlies E., Ong, David S.Y., Verboom, Diana, De Beer, Friso M., Bos, Lieuwe D.J., Glas, Gerie J., Van Hooijdonk, Roosmarijn T.M., Schouten, Laura R.A., Straat, Marleen, Witteveen, Esther, Wieske, Luuk, Hoogendijk, Arie J., Huson, Mischa A., and Van Vught, Lonneke A.
- Abstract
Background: To develop a mathematical model to estimate daily evolution of disease severity using routinely available parameters in patients admitted to the intensive care unit (ICU). Methods: Over a 3-year period, we prospectively enrolled consecutive adults with sepsis and categorized patients as (1) being at risk for developing (more severe) organ dysfunction, (2) having (potentially still reversible) limited organ failure, or (3) having multiple-organ failure. Daily probabilities for transitions between these disease states, and to death or discharge, during the first 2 weeks in ICU were calculated using a multi-state model that was updated every 2 days using both baseline and time-varying information. The model was validated in independent patients. Results: We studied 1371 sepsis admissions in 1251 patients. Upon presentation, 53 (4%) were classed at risk, 1151 (84%) had limited organ failure, and 167 (12%) had multiple-organ failure. Among patients with limited organ failure, 197 (17%) evolved to multiple-organ failure or died and 809 (70%) improved or were discharged alive within 14 days. Among patients with multiple-organ failure, 67 (40%) died and 91 (54%) improved or were discharged. Treatment response could be predicted with reasonable accuracy (c-statistic ranging from 0.55 to 0.81 for individual disease states, and 0.67 overall). Model performance in the validation cohort was similar. Conclusions: This prediction model that estimates daily evolution of disease severity during sepsis may eventually support clinicians in making better informed treatment decisions and could be used to evaluate prognostic biomarkers or perform in silico modeling of novel sepsis therapies during trial design.
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- 2019
26. Detection of Invasive Aspergillosis in Critically Ill Patients with Influenza : the Role of Plasma Galactomannan
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van de Groep, Kirsten, Verboom, Diana M, van de Veerdonk, Frank L, Haas, Pieter-Jan A, van der Poll, Tom, Schultz, Marcus J, Bonten, Marc J M, Cremer, Olaf L, van de Groep, Kirsten, Verboom, Diana M, van de Veerdonk, Frank L, Haas, Pieter-Jan A, van der Poll, Tom, Schultz, Marcus J, Bonten, Marc J M, and Cremer, Olaf L
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- 2019
27. A pilot study of a novel molecular host response assay to diagnose infection in patients after high-risk gastro-intestinal surgery
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Verboom, Diana M, Koster-Brouwer, Maria E, Ruurda, Jelle P, van Hillegersberg, Richard, van Berge Henegouwen, Mark I, Gisbertz, Suzanne S, Scicluna, Brendon P, Bonten, Marc J M, Cremer, Olaf L, Verboom, Diana M, Koster-Brouwer, Maria E, Ruurda, Jelle P, van Hillegersberg, Richard, van Berge Henegouwen, Mark I, Gisbertz, Suzanne S, Scicluna, Brendon P, Bonten, Marc J M, and Cremer, Olaf L
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- 2019
28. Robustness of sepsis-3 criteria in critically ill patients
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Verboom, Diana M, Frencken, Jos F, Ong, David S Y, Horn, Janneke, van der Poll, Tom, Bonten, Marc J M, Cremer, Olaf L, Klein Klouwenberg, Peter M C, Verboom, Diana M, Frencken, Jos F, Ong, David S Y, Horn, Janneke, van der Poll, Tom, Bonten, Marc J M, Cremer, Olaf L, and Klein Klouwenberg, Peter M C
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- 2019
29. Epidemiology and outcomes of source control procedures in critically ill patients with intra-abdominal infection
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Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten, MMB, Medische Staf Intensive Care, van de Groep, Kirsten, Verhoeff, Tessa L, Verboom, Diana M, Bos, Lieuwe D, Schultz, Marcus J, Bonten, Marc J M, Cremer, Olaf L, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten, MMB, Medische Staf Intensive Care, van de Groep, Kirsten, Verhoeff, Tessa L, Verboom, Diana M, Bos, Lieuwe D, Schultz, Marcus J, Bonten, Marc J M, and Cremer, Olaf L
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- 2019
30. A pilot study of a novel molecular host response assay to diagnose infection in patients after high-risk gastro-intestinal surgery
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Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MS CGO, Cancer, Divisie Beeld & Oncologie, Epi Infectieziekten, MMB, Medische Staf Intensive Care, Verboom, Diana M, Koster-Brouwer, Maria E, Ruurda, Jelle P, van Hillegersberg, Richard, van Berge Henegouwen, Mark I, Gisbertz, Suzanne S, Scicluna, Brendon P, Bonten, Marc J M, Cremer, Olaf L, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MS CGO, Cancer, Divisie Beeld & Oncologie, Epi Infectieziekten, MMB, Medische Staf Intensive Care, Verboom, Diana M, Koster-Brouwer, Maria E, Ruurda, Jelle P, van Hillegersberg, Richard, van Berge Henegouwen, Mark I, Gisbertz, Suzanne S, Scicluna, Brendon P, Bonten, Marc J M, and Cremer, Olaf L
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- 2019
31. Detection of Invasive Aspergillosis in Critically Ill Patients with Influenza: the Role of Plasma Galactomannan
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Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB Medische Staf, Epi Infectieziekten, MMB, Medische Staf Intensive Care, van de Groep, Kirsten, Verboom, Diana M, van de Veerdonk, Frank L, Haas, Pieter-Jan A, van der Poll, Tom, Schultz, Marcus J, Bonten, Marc J M, Cremer, Olaf L, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB Medische Staf, Epi Infectieziekten, MMB, Medische Staf Intensive Care, van de Groep, Kirsten, Verboom, Diana M, van de Veerdonk, Frank L, Haas, Pieter-Jan A, van der Poll, Tom, Schultz, Marcus J, Bonten, Marc J M, and Cremer, Olaf L
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- 2019
32. Robustness of sepsis-3 criteria in critically ill patients
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Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten, MMB, Medische Staf Intensive Care, MMB opleiding Arts microbioloog, Verboom, Diana M, Frencken, Jos F, Ong, David S Y, Horn, Janneke, van der Poll, Tom, Bonten, Marc J M, Cremer, Olaf L, Klein Klouwenberg, Peter M C, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten, MMB, Medische Staf Intensive Care, MMB opleiding Arts microbioloog, Verboom, Diana M, Frencken, Jos F, Ong, David S Y, Horn, Janneke, van der Poll, Tom, Bonten, Marc J M, Cremer, Olaf L, and Klein Klouwenberg, Peter M C
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- 2019
33. Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study
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UMC Utrecht, Intensive care patientenzorg, Child Health, Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Medische Staf Intensive Care, Epi Infectieziekten Team 1, MMB opleiding Arts microbioloog, Schouten, Laura R., van Kaam, Anton H., Kohse, Franziska, Veltkamp, Floor, Bos, Lieuwe D., de Beer, Friso M., van Hooijdonk, Roosmarijn T., Horn, Janneke, Straat, Marleen, Witteveen, Esther, Glas, Gerie J., Wieske, Luuk, van Vught, Lonneke A., Wiewel, Maryse A., Ingelse, Sarah A., Cortjens, Bart, van Woensel, Job B., Bos, Albert P., Walther, Thomas, Schultz, Marcus J., Wösten-van Asperen, Roelie M., Hoogendijk, Arie J., Huson, Mischa A., van der Poll, Tom, Scicluna, Brendon, Bonten, Marc J., Cremer, Olaf L., Frencken, Jos F., van de Groep, Kirsten, Klein Klouwenberg, Peter M., Koster-Brouwer, Maria E., Ong, David S., Verboom, Diana M., for the MARS consortium, UMC Utrecht, Intensive care patientenzorg, Child Health, Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Medische Staf Intensive Care, Epi Infectieziekten Team 1, MMB opleiding Arts microbioloog, Schouten, Laura R., van Kaam, Anton H., Kohse, Franziska, Veltkamp, Floor, Bos, Lieuwe D., de Beer, Friso M., van Hooijdonk, Roosmarijn T., Horn, Janneke, Straat, Marleen, Witteveen, Esther, Glas, Gerie J., Wieske, Luuk, van Vught, Lonneke A., Wiewel, Maryse A., Ingelse, Sarah A., Cortjens, Bart, van Woensel, Job B., Bos, Albert P., Walther, Thomas, Schultz, Marcus J., Wösten-van Asperen, Roelie M., Hoogendijk, Arie J., Huson, Mischa A., van der Poll, Tom, Scicluna, Brendon, Bonten, Marc J., Cremer, Olaf L., Frencken, Jos F., van de Groep, Kirsten, Klein Klouwenberg, Peter M., Koster-Brouwer, Maria E., Ong, David S., Verboom, Diana M., and for the MARS consortium
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- 2019
34. Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis : A matched cohort study
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Van De Groep, K., Nierkens, Stefan, Cremer, Olaf L., Peelen, Linda M., Klein Klouwenberg, Peter M.C., Schultz, Marcus J., Hack, C. Erik, Van Der Poll, Tom, Bonten, Marc J.M., Ong, David S.Y., De Beer, Friso M., Bos, Lieuwe D.J., Glas, Gerie J., Hoogendijk, Arie J., Van Hooijdonk, Roosmarijn T.M., Horn, Janneke, Huson, Mischa A., Juffermans, Nicole P., Schouten, Laura R.A., Scicluna, Brendon, Straat, Marleen, Van Vught, Lonneke A., Wieske, Luuk, Wiewel, Maryse A., Witteveen, Esther, Frencken, Jos F., Koster-Brouwer, Maria E., Varkila, Meri R.J., Verboom, Diana M., Intensive Care Medicine, Center of Experimental and Molecular Medicine, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, and ACS - Microcirculation
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Male ,Critical Illness ,Congenital cytomegalovirus infection ,Cytomegalovirus ,Inflammation ,Viremia ,Critical Care and Intensive Care Medicine ,Cohort Studies ,Sepsis ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Clinical endpoint ,Host response ,Humans ,030212 general & internal medicine ,Critically ill ,Aged ,Chi-Square Distribution ,Interleukin-6 ,business.industry ,Research ,Elastase ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,virus diseases ,030208 emergency & critical care medicine ,lcsh:RC86-88.9 ,Middle Aged ,medicine.disease ,Reactivation ,Immunity, Humoral ,Interleukin-10 ,Chemokine CXCL10 ,Intensive Care Units ,Interleukin 1 Receptor Antagonist Protein ,Cytomegalovirus Infections ,Immunology ,Biomarker (medicine) ,Female ,Virus Activation ,medicine.symptom ,Serostatus ,business ,Biomarkers - Abstract
Background Cytomegalovirus (CMV) reactivation in previously immunocompetent critically ill patients is associated with increased mortality, which has been hypothesized to result from virus-induced immunomodulation. Therefore, we studied the effects of CMV reactivation on the temporal course of host response biomarkers in patients with sepsis. Methods In this matched cohort study, each sepsis patient developing CMV reactivation between day 3 and 17 (CMV+) was compared with one CMV seropositive patient without reactivation (CMVs+) and one CMV seronegative patient (CMVs−). CMV serostatus and plasma loads were determined by enzyme-linked immunoassays and real-time polymerase chain reaction, respectively. Systemic interleukin-6 (IL-6), IL-8, IL-18, interferon-gamma–induced protein-10 (IP-10), neutrophilic elastase, IL-1 receptor antagonist (RA), and IL-10 were measured at five time points by multiplex immunoassay. The effects of CMV reactivation on sequential concentrations of these biomarkers were assessed in multivariable mixed models. Results Among 64 CMV+ patients, 45 could be matched to CMVs+ or CMVs− controls or both. The two baseline characteristics and host response biomarker levels at viremia onset were similar between groups. CMV+ patients had increased IP-10 on day 7 after viremia onset (symmetric percentage difference +44% versus −15% when compared with CMVs+ and +37% versus +4% when compared with CMVs−) and decreased IL-1RA (−41% versus 0% and −49% versus +10%, respectively). However, multivariable analyses did not show an independent association between CMV reactivation and time trends of IL-6, IP-10, IL-10, or IL-1RA. Conclusion CMV reactivation was not independently associated with changes in the temporal trends of host response biomarkers in comparison with non-reactivating patients. Therefore, these markers should not be used as surrogate clinical endpoints for interventional studies evaluating anti-CMV therapy. Electronic supplementary material The online version of this article (10.1186/s13054-018-2261-0) contains supplementary material, which is available to authorized users.
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- 2018
35. Iron metabolism in critically ill patients developing anemia of inflammation : a case control study
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Boshuizen, Margit, Binnekade, Jan M., Nota, Benjamin, van de Groep, Kirsten, Cremer, Olaf L., Tuinman, Pieter R., Horn, Janneke, Schultz, Marcus J., van Bruggen, Robin, Juffermans, Nicole P., de Beer, Friso M., Bos, Lieuwe D.J., Glas, Gerie J., van Hooijdonk, Roosmarijn T.M., Schouten, Laura R.A., Straat, Marleen, Witteveen, Esther, Wieske, Luuk, Hoogendijk, Arie J., Huson, Mischa A., Scicluna, Brendon P., van der Poll, Tom, van Vught, Lonneke A., Wiewel, Maryse A., Bonten, Marc J.M., Frencken, Jos F., Klein Klouwenberg, Peter M.C., Koster-Brouwer, Maria E., Ong, David S.Y., Verboom, Diana M., and Molecular Diagnosis and Risk Stratification of Sepsis (MARS) Consortium
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Inflammation ,Critical care ,Iron ,Sepsis ,Hepcidin ,Anemia ,Critical Care and Intensive Care Medicine - Abstract
Background: Anemia occurring as a result of inflammatory processes (anemia of inflammation, AI) has a high prevalence in critically ill patients. Knowledge on changes in iron metabolism during the course of AI is limited, hampering the development of strategies to counteract AI. This case control study aimed to investigate iron metabolism during the development of AI in critically ill patients. Methods: Iron metabolism in 30 patients who developed AI during ICU stay was compared with 30 septic patients with a high Hb and 30 non-septic patients with a high Hb. Patients were matched on age and sex. Longitudinally collected plasma samples were analyzed for levels of parameters of iron metabolism. A linear mixed model was used to assess the predictive values of the parameters. Results: In patients with AI, levels of iron, transferrin and transferrin saturation showed an early decrease compared to controls with a high Hb, already prior to the development of anemia. Ferritin, hepcidin and IL-6 levels were increased in AI compared to controls. During AI development, erythroferrone decreased. Differences in iron metabolism between groups were not influenced by APACHE IV score. Conclusions: The results show that in critically ill patients with AI, iron metabolism is already altered prior to the development of anemia. Levels of iron regulators in AI differ from septic controls with a high Hb, irrespective of disease severity. AI is characterized by high levels of hepcidin, ferritin and IL-6 and low levels of iron, transferrin and erythroferrone.
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- 2018
36. Uncertainty in Diagnosis Leads to Underestimates of Performance Reply
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Koster-Brouwer, Maria E., Verboom, Diana M., Bonten, Marc J. M., and Cremer, Olaf L.
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- 2018
37. Detection of Invasive Aspergillosis in Critically Ill Patients with Influenza: The Role of Plasma Galactomannan
- Author
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van de Groep, Kirsten, primary, Verboom, Diana M., additional, van de Veerdonk, Frank L., additional, Haas, Pieter-Jan A., additional, van der Poll, Tom, additional, Schultz, Marcus J., additional, Bonten, Marc J. M., additional, and Cremer, Olaf L., additional
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- 2019
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38. Myocardial Injury in Critically Ill Patients with Community-acquired Pneumonia. A Cohort Study
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Frencken, Jos F., primary, van Baal, Lottie, additional, Kappen, Teus H., additional, Donker, Dirk W., additional, Horn, Janneke, additional, van der Poll, Tom, additional, van Klei, Wilton A., additional, Bonten, Marc J. M., additional, Cremer, Olaf L., additional, de Beer, Friso M., additional, Bos, Lieuwe D. J., additional, Glas, Gerie J., additional, van Hooijdonk, Roosmarijn T. M., additional, Schouten, Laura R. A., additional, Straat, Marleen, additional, Witteveen, Esther, additional, Wieske, Luuk, additional, van Vught, Lonneke A., additional, Wiewel, Maryse, additional, Hoogendijk, Arie J., additional, Huson, Mischa A., additional, Scicluna, Brendon, additional, Schultz, Marcus J., additional, Ong, David S. Y., additional, Klein Klouwenberg, Peter M. C., additional, van de Groep, Kirsten, additional, Verboom, Diana, additional, and Koster-Brouwer, Maria E., additional
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- 2019
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39. Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study
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Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, CDL Patiëntenzorg MI, Medische Staf Intensive Care, Epi Infectieziekten Team 2, JC onderzoeksprogramma Methodologie, MMB opleiding Arts microbioloog, CTI, Epi Infectieziekten, MMB, Van De Groep, K., Nierkens, Stefan, Cremer, Olaf L., Peelen, Linda M., Klein Klouwenberg, Peter M.C., Schultz, Marcus J., Hack, C. Erik, Van Der Poll, Tom, Bonten, Marc J.M., Ong, David S.Y., De Beer, Friso M., Bos, Lieuwe D.J., Glas, Gerie J., Hoogendijk, Arie J., Van Hooijdonk, Roosmarijn T.M., Horn, Janneke, Huson, Mischa A., Juffermans, Nicole P., Schouten, Laura R.A., Scicluna, Brendon, Straat, Marleen, Van Vught, Lonneke A., Wieske, Luuk, Wiewel, Maryse A., Witteveen, Esther, Frencken, Jos F., Koster-Brouwer, Maria E., Varkila, Meri R.J., Verboom, Diana M., Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, CDL Patiëntenzorg MI, Medische Staf Intensive Care, Epi Infectieziekten Team 2, JC onderzoeksprogramma Methodologie, MMB opleiding Arts microbioloog, CTI, Epi Infectieziekten, MMB, Van De Groep, K., Nierkens, Stefan, Cremer, Olaf L., Peelen, Linda M., Klein Klouwenberg, Peter M.C., Schultz, Marcus J., Hack, C. Erik, Van Der Poll, Tom, Bonten, Marc J.M., Ong, David S.Y., De Beer, Friso M., Bos, Lieuwe D.J., Glas, Gerie J., Hoogendijk, Arie J., Van Hooijdonk, Roosmarijn T.M., Horn, Janneke, Huson, Mischa A., Juffermans, Nicole P., Schouten, Laura R.A., Scicluna, Brendon, Straat, Marleen, Van Vught, Lonneke A., Wieske, Luuk, Wiewel, Maryse A., Witteveen, Esther, Frencken, Jos F., Koster-Brouwer, Maria E., Varkila, Meri R.J., and Verboom, Diana M.
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- 2018
40. Validation of a novel molecular host response assay to diagnose infection in hospitalized patients admitted to the ICU with acute respiratory failure
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Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB Staf diagnostiek, Epi Infectieziekten, MMB, Medische Staf Intensive Care, Koster-Brouwer, Maria E., Verboom, Diana M., Scicluna, Brendon P., Van De Groep, Kirsten, Frencken, Jos F., Janssen, Davy, Schuurman, Rob, Schultz, Marcus J., Van Der Poll, Tom, Bonten, Marc J.M., Cremer, Olaf L., Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB Staf diagnostiek, Epi Infectieziekten, MMB, Medische Staf Intensive Care, Koster-Brouwer, Maria E., Verboom, Diana M., Scicluna, Brendon P., Van De Groep, Kirsten, Frencken, Jos F., Janssen, Davy, Schuurman, Rob, Schultz, Marcus J., Van Der Poll, Tom, Bonten, Marc J.M., and Cremer, Olaf L.
- Published
- 2018
41. Uncertainty in Diagnosis Leads to Underestimates of Performance Reply
- Author
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Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten, MMB, Medische Staf Intensive Care, Koster-Brouwer, Maria E., Verboom, Diana M., Bonten, Marc J. M., Cremer, Olaf L., Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten, MMB, Medische Staf Intensive Care, Koster-Brouwer, Maria E., Verboom, Diana M., Bonten, Marc J. M., and Cremer, Olaf L.
- Published
- 2018
42. Iron metabolism in critically ill patients developing anemia of inflammation: a case control study
- Author
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Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Medische Staf Intensive Care, Epi Infectieziekten, MMB opleiding Arts microbioloog, Boshuizen, Margit, Binnekade, Jan M., Nota, Benjamin, van de Groep, Kirsten, Cremer, Olaf L., Tuinman, Pieter R., Horn, Janneke, Schultz, Marcus J., van Bruggen, Robin, Juffermans, Nicole P., de Beer, Friso M., Bos, Lieuwe D.J., Glas, Gerie J., van Hooijdonk, Roosmarijn T.M., Schouten, Laura R.A., Straat, Marleen, Witteveen, Esther, Wieske, Luuk, Hoogendijk, Arie J., Huson, Mischa A., Scicluna, Brendon P., van der Poll, Tom, van Vught, Lonneke A., Wiewel, Maryse A., Bonten, Marc J.M., Frencken, Jos F., Klein Klouwenberg, Peter M.C., Koster-Brouwer, Maria E., Ong, David S.Y., Verboom, Diana M., Molecular Diagnosis and Risk Stratification of Sepsis (MARS) Consortium, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Medische Staf Intensive Care, Epi Infectieziekten, MMB opleiding Arts microbioloog, Boshuizen, Margit, Binnekade, Jan M., Nota, Benjamin, van de Groep, Kirsten, Cremer, Olaf L., Tuinman, Pieter R., Horn, Janneke, Schultz, Marcus J., van Bruggen, Robin, Juffermans, Nicole P., de Beer, Friso M., Bos, Lieuwe D.J., Glas, Gerie J., van Hooijdonk, Roosmarijn T.M., Schouten, Laura R.A., Straat, Marleen, Witteveen, Esther, Wieske, Luuk, Hoogendijk, Arie J., Huson, Mischa A., Scicluna, Brendon P., van der Poll, Tom, van Vught, Lonneke A., Wiewel, Maryse A., Bonten, Marc J.M., Frencken, Jos F., Klein Klouwenberg, Peter M.C., Koster-Brouwer, Maria E., Ong, David S.Y., Verboom, Diana M., and Molecular Diagnosis and Risk Stratification of Sepsis (MARS) Consortium
- Published
- 2018
43. A pilot study of a novel molecular host response assay to diagnose infection in patients after high-risk gastro-intestinal surgery
- Author
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Verboom, Diana, primary, Koster-Brouwer, Marlies, additional, Ruurda, Jelle, additional, Van Hillegersberg, Richard, additional, van Berge Henegouwen, Mark, additional, Gisbertz, Suzanne, additional, Scicluna, Brendon, additional, Bonten, Marc, additional, and Cremer, Olaf, additional
- Published
- 2018
- Full Text
- View/download PDF
44. Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis
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Vught, Lonneke A., Uhel, Fabrice, Ding, Chao, van‘t Veer, Cees, Scicluna, Brendon P., Peters‐Sengers, Hessel, Klein Klouwenberg, Peter M. C., Nürnberg, Peter, Cremer, Olaf L., Schultz, Marcus J., Poll, Tom, de Beer, Friso M., Bos, Lieuwe D. J., Glas, Gerie J., Hoogendijk, Arie J., van Hooijdonk, Roosmarijn T. M., Horn, Janneke, Huson, Mischa A., Schouten, Laura R. A., Schultz, Marcus J., Scicluna, Brendon P., Straat, Marleen, van Vught, Lonneke A., Wieske, Luuk, Wiewel, Maryse A., Witteveen, Esther, Bonten, Marc J.M., Cremer, Olaf M., Ong, David S.Y., Frencken, Jos F., Klein Klouwenberg, Peter M.C., Koster‐Brouwer, Maria E., van de Groep, Kirsten, and Verboom, Diana M.
- Abstract
A prolonged prothrombin time (PT) is a common feature in sepsis indicating consumptive coagulopathy. To determine the association between a prolonged PT and aberrations in other host response mechanisms in sepsis. Patients admitted to the intensive care unit with sepsis were divided in quartiles according to the highest PT value measured within 24 h after admission. The host response was evaluated by measuring 19 plasma biomarkers reflecting pathways implicated in sepsis pathogenesis and by blood leukocyte gene expression profiling. Of 1524 admissions for sepsis, 386 (25.3%) involved patients with a normal PT (≤12.7 s); the remaining quartiles entailed 379 (24.9%) patients with a slightly prolonged PT (12.8 ≤ PT ≤ 15.0 s), 383 (25.1%) with an intermediately prolonged PT (15.1 ≤ PT ≤ 17.2 s), and 376 (24.7%) with an extremely prolonged PT (≥17.3 s). While patients with an extremely prolonged PT showed an increased crude mortality up to 1 year after admission, none of the prolonged PT groups was independently associated with 30‐day adjusted mortality. Comparison of the host response between patients with a normal PT or an extremely prolonged PT matched for baseline characteristics including severity of disease showed that an extremely prolonged PT was associated with impaired anticoagulant mechanisms, a more disturbed endothelial barrier integrity and increased systemic inflammation, and blood leukocyte transcriptomes indicating more prominent metabolic reprogramming and protein catabolism. A prolonged PT is associated with stronger anomalies in pathways implicated in the pathogenesis of sepsis, suggesting that activation of coagulation impacts other host response mechanisms.
- Published
- 2021
- Full Text
- View/download PDF
45. Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study
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Scicluna, Brendon P, primary, van Vught, Lonneke A, additional, Zwinderman, Aeilko H, additional, Wiewel, Maryse A, additional, Davenport, Emma E, additional, Burnham, Katie L, additional, Nürnberg, Peter, additional, Schultz, Marcus J, additional, Horn, Janneke, additional, Cremer, Olaf L, additional, Bonten, Marc J, additional, Hinds, Charles J, additional, Wong, Hector R, additional, Knight, Julian C, additional, van der Poll, Tom, additional, de Beer, Friso M., additional, Bos, Lieuwe D.J., additional, Frencken, Jos F., additional, Koster-Brouwer, Maria E., additional, van de Groep, Kirsten, additional, Verboom, Diana M., additional, Glas, Gerie J., additional, van Hooijdonk, Roosmarijn T.M., additional, Hoogendijk, Arie J., additional, Huson, Mischa A., additional, Klouwenberg, Peter M. Klein, additional, Ong, David S.Y., additional, Schouten, Laura R.A., additional, Straat, Marleen, additional, Witteveen, Esther, additional, and Wieske, Luuk, additional
- Published
- 2017
- Full Text
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46. Correction to: Predicting the clinical trajectory in critically ill patients with sepsis: a cohort study.
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Klein Klouwenberg, Peter M. C., Spitoni, Cristian, van der Poll, Tom, Bonten, Marc J., Cremer, Olaf L., on behalf of the MARS consortium, Schultz, Marcus J., Horn, Janneke, Scicluna, Brendon, Wiewel, Maryse A., Frencken, Jos F., Groep, Kirsten van de, Koster-Brouwer, Marlies E., Ong, David S.Y., Verboom, Diana, de Beer, Friso M., Bos, Lieuwe D. J., Glas, Gerie J., van Hooijdonk, Roosmarijn T. M., and Schouten, Laura R. A.
- Abstract
In the publication of this article [1], there are 4 collaborating authors missing from the 'MARS consortium'. This has now been included in this correction article. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
47. Adalimumab provides long-lasting clinical improvement in refractory mucocutaneous Behçet's disease without formation of antidrug antibodies.
- Author
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Verboom DM, van der Houwen TB, Kappen JH, van Daele PLA, Dik WA, Schreurs MWJ, van Hagen PM, and van Laar JAM
- Subjects
- Drug Resistance, Humans, Tumor Necrosis Factor-alpha antagonists & inhibitors, Adalimumab therapeutic use, Behcet Syndrome drug therapy, Immunosuppressive Agents therapeutic use
- Abstract
Objectives: The TNF-blocker adalimumab can be effective in Behçet's disease (BD), a multisystem auto-inflammatory disorder. Unfortunately, the therapeutic efficacy of TNF-blockers can be hampered by the formation of anti-drug antibodies. We present an observational study of adalimumab in refractory BD with measurement of anti-drug antibodies., Methods: The effect of fortnightly 40mg adalimumab in nine patients with therapy refractory mucocutaneous, non-ocular or organ threatening BD was studied up to 60 months. Primary endpoint was a decrease in disease activity, measured by the BD Current Activity Form (BDCAF) within 6 months. Secondary endpoints included serum cytokines and the long-term formation of anti-adalimumab antibodies., Results: BDCAF improved significantly in all nine patients from 5.4 (SD=1.4) to 2.4 (SD=1.4) (p=0.007) within one month up to 6 months and after prolonged follow up of 5 years. All patients could either taper or stop concomitant therapy. Symptoms of mucocutaneous lesions, erythema nodosum and joint involvement decreased or disappeared. Serum TNF-alpha levels were elevates in five patients and decreased upon treatment (p=0.017). Adalimumab was save and none of the patients experienced therapy failure or antibodies against adalimumab., Conclusions: We present an observational study on patients with BD treated with adalimumab and provide a basis for long-term use in refractory mucocutaneous BD. These findings show that adalimumab can safely be administered yielding sustainable clinical effects in refractory BD patients with mucocutaneous disease without formation of anti-adalimumab antibodies, even after long follow up.
- Published
- 2019
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