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1. Aortic valve versus root surgery after failed transcatheter aortic valve replacement

Author

Saha, Shekhar, Hagl, Christian, Kiefer, Philipp, Holzhey, David, Noack, Thilo, Borger, Michael A., Desai, Nimesh D., Bavaria, Joseph E., Voisine, MDPierre, Mohammadi, Siamak, Rodés-Cabau, Josep, Harrington, Katherine B., Squiers, John J., Szerlip, Molly I., DiMaio, J. Michael, Mack, Michael J., Rovin, Joshua, Gennari, Marco, Fukuhara, Shinichi, Deeb, G. Michael, Sengupta, Aditya, Demers, Philippe, Ibrahim, Reda, Wyler von Ballmoos, Moritz, Atkins, Marvin D., Kleiman, Neal S., Reardon, Michael J., Maisano, Francesco, Bhadra, Oliver D., Conradi, Lenard, Shults, Christian, Satler, Lowell F., Waksman, Ron, Pirelli, Luigi, Brinster, Derek R., Algadheeb, Muhanad, Chu, Michael W.A., Bagur, Rodrigo, Ramlawi, Basel, Grubb, Kendra J., Robinson, Newell B., Wang, Lin, Petrossian, George A., Leroux, Lionel, Doty, John R., Whisenant, Brian K., Kempfert, Joerg, Unbehaun, Axel, Rahim, Hussein, Nazif, Tamim M., George, Isaac, Geirsson, Arnar, Forrest, John K., Vincent, Flavien, Van Belle, Eric, Koussa, Mohamad, Goldberg, Joshua B., Ahmad, Hasan A., Ben Ali, Walid, Andreas, Martin, Werner, Paul, Goel, Kashish, Shah, Ashish S., Gelpi, Guido, Ruel, Marc, Al-Atassi, Talal, Van Mieghem, Nicholas M., Hokken, Thijmen W., D'Onofrio, Augusto, Tessari, Chiara, Hirji, Sameer, Shah, Pinak B., Belluschi, Igor, Garatti, Andrea, Bruschi, Giuseppe, Ouzounian, Maral, Pizano, Alejandro, Di Eusanio, Marco, Capestro, Filippo, Taramasso, Maurizio, Colli, Andrea, Estevez-Loureiro, Rodrigo, Pinon, Miguel A., Salinger, Michael H., Di Virgilio, Antonio, Nguyen, Tom C., Lange, Rudiger, Vitanova, Keti, Zaid, Syed, Tang, Gilbert H.L., Kaneko, Tsuyoshi, Bapat, Vinayak N., Modine, Thomas, and Denti, Paolo

Published
2023
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2. Surgical Explantation of Failed Transcatheter Aortic Valve Replacement

Author

Saha, Shekhar, Kiefer, Philipp, Holzhey, David, Noack, Thilo, Voisine, Pierre, Mohammadi, Siamak, Harrington, Katherine B., Squiers, John J., Fukuhara, Shinichi, von Ballmoos, Moritz Wyler, Goel, Sachin S., Atkins, Marvin D., Bhadra, Oliver D., Conradi, Lenard, Shults, Christian, Satler, Lowell F., Pirelli, Luigi, Brinster, Derek R., Algadheeb, Muhanad, Chu, Michael W.A., Bagur, Rodrigo, Ramlawi, Basel, Grubb, Kendra J., Desai, Nimesh D., Robinson, Newell B., Wang, Lin, Petrossian, George A., Leroux, Lionel, Doty, John R., Kempfert, Joerg, Unbehaun, Axel, Rahim, Hussein, Geirsson, Arnar, Forrest, John K., Vincent, Flavien, Van Belle, Eric, Koussa, Mohamad, Goldberg, Joshua B., Ahmad, Hasan A., Ben Ali, Walid, Demers, Philippe, Ibrahim, Reda, Andreas, Martin, Werner, Paul, Goel, Kashish, Shah, Ashish S., Gelpi, Guido, Ruel, Marc, Al-Atassi, Talal, Van Mieghem, Nicholas M., Hokken, Thijmen W., D'Onofrio, Augusto, Tessari, Chiara, Shah, Pinak B., Belluschi, Igor, Garatti, Andrea, Bruschi, Giuseppe, Ouzounian, Maral, Pizano, Alejandro, Di Eusanio, Marco, Capestro, Filippo, Rovin, Joshua, Taramasso, Maurizio, Gennari, Marco, Colli, Andrea, Estevez-Loureiro, Rodrigo, Pinon, Miguel A., Salinger, Michael H., Di Virgilio, Antonio, Whisenant, Brian K., Nazif, Tamim M., Kleiman, Neal S., Szerlip, Molly I., Waksman, Ron, Rodés-Cabau, Josep, George, Isaac, DiMaio, J. Michael, Maisano, Francesco, Deeb, G. Michael, Vitanova, Keti, Lange, Rudiger, Borger, Michael A., Hagl, Christian, Bavaria, Joseph E., Zaid, Syed, Hirji, Sameer A., Bapat, Vinayak N., Denti, Paolo, Modine, Thomas, Nguyen, Tom C., Mack, Michael J., Reardon, Michael J., Kaneko, Tsuyoshi, and Tang, Gilbert H.L.

Published
2023
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4. The Variation in the Traits Ameliorated by Inhibitors of JAK1/2, TGF-β, P-Selectin, and CXCR1/CXCR2 in the Gata1 low Model Suggests That Myelofibrosis Should Be Treated by These Drugs in Combination.

Author

Gobbo, Francesca, Martelli, Fabrizio, Di Virgilio, Antonio, Demaria, Elena, Sarli, Giuseppe, and Migliaccio, Anna Rita

Subjects
TRANSFORMING growth factors-beta, MYELOFIBROSIS, HEMATOPOIETIC stem cells, MYELOPROLIFERATIVE neoplasms, THERAPEUTICS, THROMBOPOIETIN receptors
Abstract

Studies conducted on animal models have identified several therapeutic targets for myelofibrosis, the most severe of the myeloproliferative neoplasms. Unfortunately, many of the drugs which were effective in pre-clinical settings had modest efficacy when tested in the clinic. This discrepancy suggests that treatment for this disease requires combination therapies. To rationalize possible combinations, the efficacy in the Gata1low model of drugs currently used for these patients (the JAK1/2 inhibitor Ruxolitinib) was compared with that of drugs targeting other abnormalities, such as p27kip1 (Aplidin), TGF-β (SB431542, inhibiting ALK5 downstream to transforming growth factor beta (TGF-β) signaling and TGF-β trap AVID200), P-selectin (RB40.34), and CXCL1 (Reparixin, inhibiting the CXCL1 receptors CXCR1/2). The comparison was carried out by expressing the endpoints, which had either already been published or had been retrospectively obtained for this study, as the fold change of the values in the corresponding vehicles. In this model, only Ruxolitinib was found to decrease spleen size, only Aplidin and SB431542/AVID200 increased platelet counts, and with the exception of AVID200, all the inhibitors reduced fibrosis and microvessel density. The greatest effects were exerted by Reparixin, which also reduced TGF-β content. None of the drugs reduced osteopetrosis. These results suggest that future therapies for myelofibrosis should consider combining JAK1/2 inhibitors with drugs targeting hematopoietic stem cells (p27Kip1) or the pro-inflammatory milieu (TGF-β or CXCL1). [ABSTRACT FROM AUTHOR]

Published
2024
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6. Surgical Explantation of Failed Transcatheter Aortic Valve Replacement

Author

Zaid, Syed, primary, Hirji, Sameer A., additional, Bapat, Vinayak N., additional, Denti, Paolo, additional, Modine, Thomas, additional, Nguyen, Tom C., additional, Mack, Michael J., additional, Reardon, Michael J., additional, Kaneko, Tsuyoshi, additional, Tang, Gilbert H.L., additional, Saha, Shekhar, additional, Kiefer, Philipp, additional, Holzhey, David, additional, Noack, Thilo, additional, Voisine, Pierre, additional, Mohammadi, Siamak, additional, Harrington, Katherine B., additional, Squiers, John J., additional, Fukuhara, Shinichi, additional, von Ballmoos, Moritz Wyler, additional, Goel, Sachin S., additional, Atkins, Marvin D., additional, Bhadra, Oliver D., additional, Conradi, Lenard, additional, Shults, Christian, additional, Satler, Lowell F., additional, Pirelli, Luigi, additional, Brinster, Derek R., additional, Algadheeb, Muhanad, additional, Chu, Michael W.A., additional, Bagur, Rodrigo, additional, Ramlawi, Basel, additional, Grubb, Kendra J., additional, Desai, Nimesh D., additional, Robinson, Newell B., additional, Wang, Lin, additional, Petrossian, George A., additional, Leroux, Lionel, additional, Doty, John R., additional, Kempfert, Joerg, additional, Unbehaun, Axel, additional, Rahim, Hussein, additional, Geirsson, Arnar, additional, Forrest, John K., additional, Vincent, Flavien, additional, Van Belle, Eric, additional, Koussa, Mohamad, additional, Goldberg, Joshua B., additional, Ahmad, Hasan A., additional, Ben Ali, Walid, additional, Demers, Philippe, additional, Ibrahim, Reda, additional, Andreas, Martin, additional, Werner, Paul, additional, Goel, Kashish, additional, Shah, Ashish S., additional, Gelpi, Guido, additional, Ruel, Marc, additional, Al-Atassi, Talal, additional, Van Mieghem, Nicholas M., additional, Hokken, Thijmen W., additional, D'Onofrio, Augusto, additional, Tessari, Chiara, additional, Shah, Pinak B., additional, Belluschi, Igor, additional, Garatti, Andrea, additional, Bruschi, Giuseppe, additional, Ouzounian, Maral, additional, Pizano, Alejandro, additional, Di Eusanio, Marco, additional, Capestro, Filippo, additional, Rovin, Joshua, additional, Taramasso, Maurizio, additional, Gennari, Marco, additional, Colli, Andrea, additional, Estevez-Loureiro, Rodrigo, additional, Pinon, Miguel A., additional, Salinger, Michael H., additional, Di Virgilio, Antonio, additional, Whisenant, Brian K., additional, Nazif, Tamim M., additional, Kleiman, Neal S., additional, Szerlip, Molly I., additional, Waksman, Ron, additional, Rodés-Cabau, Josep, additional, George, Isaac, additional, DiMaio, J. Michael, additional, Maisano, Francesco, additional, Deeb, G. Michael, additional, Vitanova, Keti, additional, Lange, Rudiger, additional, Borger, Michael A., additional, Hagl, Christian, additional, and Bavaria, Joseph E., additional

Published
2023
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7. SARS-CoV-2-Specific CD8+ T-Cells in Blood but Not in the Lungs of Vaccinated K18-hACE2 Mice after Infection

Author

Ferrantelli, Flavia, primary, Manfredi, Francesco, additional, Chiozzini, Chiara, additional, Leone, Patrizia, additional, Pugliese, Katherina, additional, Spada, Massimo, additional, Di Virgilio, Antonio, additional, Giovannelli, Andrea, additional, Valeri, Mauro, additional, Cara, Andrea, additional, Michelini, Zuleika, additional, Andreotti, Mauro, additional, and Federico, Maurizio, additional

Published
2023
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9. The induction of SARS-CoV-2-specific CD8+ T cell immunity uncouples with the viral spread in K18-hACE2 infected mice

Author

Ferrantelli, Flavia, primary, Manfredi, Francesco, additional, Chiozzini, Chiara, additional, Leone, Patrizia, additional, Pugliese, Katherina, additional, Spada, Massimo, additional, Virgilio, Antonio Di, additional, Giovannelli, Andrea, additional, Valeri, Mauro, additional, Cara, Andrea, additional, Michelini, Zuleika, additional, Andreotti, Mauro, additional, and Federico, Maurizio, additional

Published
2023
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10. A new record of Harlequin Shrimp (Malacostraca: Decapoda: Palaemonidae: Hymenocera picta Dana, 1852) in the southern Mexican Pacific Reefs

Author

Omar Valencia-Mendez, Andres Lopez-Perez, Betel Martinez-Guerrero, Virgilio Antonio-Perez, and Eduardo Ramirez-Chavez

Subjects
caridea, coral reefs, harlequin shrimp, huatulco national park, sea star predator., Ecology, QH540-549.5, General. Including nature conservation, geographical distribution, QH1-199.5
Abstract

The Harlequin Shrimp Hymenocera picta is abundant in the Indo-Pacific and Central Pacific regions, but there are few reports of it from the eastern Pacific. Two pairs of the Harlequin Shrimp were observed feeding on the Sea Star Phataria unifascialis (Gray, 1840) in the reefs of Huatulco National Park, Mexican Pacific. This paper reports the occurrence of H. picta in Mexican Pacific waters and extends its previous distribution by 1,270km north of El Ocotal, Costa Rica in the eastern Pacific equatorial zone. In addition, we evaluate the potential distribution of H. picta along the tropical eastern Pacific using the Maximum-Entropy modelling algorithm.

Published
2017
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11. Different configurations of SARS-CoV-2 spike protein delivered by integrase-defective lentiviral vectors induce persistent functional immune responses, characterized by distinct immunogenicity profiles

Author

Borghi, Martina, primary, Gallinaro, Alessandra, additional, Pirillo, Maria Franca, additional, Canitano, Andrea, additional, Michelini, Zuleika, additional, De Angelis, Maria Laura, additional, Cecchetti, Serena, additional, Tinari, Antonella, additional, Falce, Chiara, additional, Mariotti, Sabrina, additional, Capocefalo, Antonio, additional, Chiantore, Maria Vincenza, additional, Iacobino, Angelo, additional, Di Virgilio, Antonio, additional, van Gils, Marit J., additional, Sanders, Rogier W., additional, Lo Presti, Alessandra, additional, Nisini, Roberto, additional, Negri, Donatella, additional, and Cara, Andrea, additional

Published
2023
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14. New Monoclonal Antibodies Specific for Different Epitopes of the Spike Protein of SARS-CoV-2 and Its Major Variants: Additional Tools for a More Specific COVID-19 Diagnosis

Author

Mariotti, Sabrina, primary, Chiantore, Maria Vincenza, additional, Teloni, Raffaela, additional, Iacobino, Angelo, additional, Capocefalo, Antonio, additional, Michelini, Zuleika, additional, Borghi, Martina, additional, Baggieri, Melissa, additional, Marchi, Antonella, additional, Bucci, Paola, additional, Gioacchini, Silvia, additional, D’Amelio, Raffaele, additional, Brouwer, Philip J. M., additional, Sandini, Silvia, additional, Acchioni, Chiara, additional, Sgarbanti, Marco, additional, Di Virgilio, Antonio, additional, Grasso, Felicia, additional, Cara, Andrea, additional, Negri, Donatella, additional, Magurano, Fabio, additional, Di Bonito, Paola, additional, and Nisini, Roberto, additional

Published
2023
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15. Extracellular vesicle-based anti-HOXB7 CD8+T cell-specific vaccination strengthens antitumor effects induced by vaccination against Her2/neu

Author

Ferrantelli, Flavia, Manfredi, Francesco, Donnini, Micaela, Leone, Patrizia, Pugliese, Katherina, Olivetta, Eleonora, Giovannelli, Andrea, Di Virgilio, Antonio, Federico, Maurizio, and Chiozzini, Chiara

Abstract

We previously developed an innovative strategy to induce CD8+T lymphocyte-immunity through in vivo engineering of extracellular vesicles (EVs). This approach relies on intramuscular injection of DNA expressing antigens of interest fused at a biologically-inactive HIV-1 Nef protein mutant (Nefmut). Nefmutis very efficiently incorporated into EVs, thus conveying large amounts of fusion proteins into EVs released by transfected cells. This platform proved successful against highly immunogenic tumor-specific antigens. Here, we tested whether antigen-specific CD8+T cell immune responses induced by engineered EVs can counteract the growth of tumors expressing two “self” tumor-associated antigens (TAAs): HOXB7 and Her2/neu. FVB/N mice were injected with DNA vectors expressing Nefmutfused to HOXB7 or Her2/neu, singly and in combination, before subcutaneous implantation of breast carcinoma cells co-expressing HOXB7 and Her2/neu. All mice immunized with the combination vaccine remained tumor-free, whereas groups vaccinated with single Nefmut-fused antigens were only partly protected, with stronger antitumor effects in Her2/neu-immunized mice. Double-vaccinated mice also controlled tumor growth upon a later tumor cell re-challenge. Importantly, co-vaccination also contained tumors in a therapeutic immunization setting. These results showed the efficacy of EV-based vaccination against two TAAs, and represent the first demonstration that HOXB7 may be targeted in multi-antigen immunotherapy strategies.

Published
2024
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16. A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells

Author

Orienti, Isabella, Salvati, Valentina, Sette, Giovanni, Zucchetti, Massimo, Bongiorno-Borbone, Lucilla, Peschiaroli, Angelo, Zolla, Lello, Francescangeli, Federica, Ferrari, Mariella, Matteo, Cristina, Bello, Ezia, Di Virgilio, Antonio, Falchi, Mario, De Angelis, Maria Laura, Baiocchi, Marta, Melino, Gerry, De Maria, Ruggero, Zeuner, Ann, and Eramo, Adriana

Published
2019
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17. SARS-CoV-2-Specific CD8 + T-Cells in Blood but Not in the Lungs of Vaccinated K18-hACE2 Mice after Infection.

Author

Ferrantelli, Flavia, Manfredi, Francesco, Chiozzini, Chiara, Leone, Patrizia, Pugliese, Katherina, Spada, Massimo, Di Virgilio, Antonio, Giovannelli, Andrea, Valeri, Mauro, Cara, Andrea, Michelini, Zuleika, Andreotti, Mauro, and Federico, Maurizio

Subjects
T cells, BREAKTHROUGH infections, VIRAL antigens, VACCINATION, RESPIRATORY infections
Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 enters the host by infecting nasal ciliated cells. Then, the virus can spread towards the oropharyngeal cavity and the pulmonary tissues. The antiviral adaptive immunity is promptly induced in response to the virus's detection, with virus-specific T-lymphocytes appearing before antiviral antibodies. Both the breadth and potency of antiviral CD8+ T-cell immunity have a key role in containing viral spread and disease severity. Current anti-SARS-CoV-2 vaccines do not impede the virus's replication in the upper respiratory tract, and there is consensus on the fact that the best potency of the antiviral immune response in both blood and the upper respiratory tract can be reached upon infection in vaccinees (i.e., breakthrough infection). However, whether the antiviral CD8+ T-cells developing in response to the breakthrough infection in the upper respiratory tract diffuse to the lungs is also still largely unknown. To fill the gap, we checked the CD8+ T-cell immunity elicited after infection of K18-hACE2 transgenic mice both at 3 weeks and 3 months after anti-spike vaccination. Virus-specific CD8+ T-cell immunity was monitored in both blood and the lungs before and after infection. By investigating the de novo generation of the CD8+ T-cells specific for SARS-CoV-2 viral proteins, we found that both membrane (M) and/or nucleocapsid (N)-specific CD8+ T-cells were induced at comparable levels in the blood of both unvaccinated and vaccinated mice. Conversely, N-specific CD8+ T-cells were readily found in the lungs of the control mice but were either rare or absent in those of vaccinated mice. These results support the idea that the hybrid cell immunity developing after asymptomatic/mild breakthrough infection strengthens the antiviral cell immunity in the lungs only marginally, implying that the direct exposition of viral antigens is required for the induction of an efficient antiviral cell immunity in the lungs. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Induction of SARS-CoV-2 N-specific CD8+ T cell immunity in lungs by engineered extracellular vesicles associates with strongly impaired viral replication

Author

Manfredi, Francesco, primary, Chiozzini, Chiara, additional, Ferrantelli, Flavia, additional, Leone, Patrizia, additional, Pugliese, Katherina, additional, Spada, Massimo, additional, Virgilio, Antonio di, additional, Giovannelli, Andrea, additional, Valeri, Mauro, additional, Cara, Andrea, additional, Michelini, Zuleika, additional, Andreotti, Mauro, additional, and Federico, Maurizio, additional

Published
2023
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19. Induction of SARS-CoV-2 N-specific CD8+T cell immunity in lungs by engineered extracellular vesicles associates with strongly impaired viral replication

Author

Manfredi, Francesco, primary, Chiozzini, Chiara, additional, Ferrantelli, Flavia, additional, Leone, Patrizia, additional, Pugliese, Katherina, additional, Spada, Massimo, additional, Virgilio, Antonio Di, additional, Giovannelli, Andrea, additional, Valeri, Mauro, additional, Cara, Andrea, additional, Michelini, Zuleika, additional, Andreotti, Mauro, additional, and Federico, Maurizio, additional

Published
2023
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20. Antiviral effect of SARS-CoV-2 N-specific CD8+ T cells induced in lungs by engineered extracellular vesicles.

Author

Manfredi, Francesco, Chiozzini, Chiara, Ferrantelli, Flavia, Leone, Patrizia, Pugliese, Katherina, Spada, Massimo, Di Virgilio, Antonio, Giovannelli, Andrea, Valeri, Mauro, Cara, Andrea, Michelini, Zuleika, Andreotti, Mauro, and Federico, Maurizio

Subjects
T cells, EXTRACELLULAR vesicles, LUNGS, SARS-CoV-2, VIRUS diseases
Abstract

Induction of effective immunity in the lungs should be a requisite for any vaccine designed to control the severe pathogenic effects generated by respiratory infectious agents. We recently provided evidence that the generation of endogenous extracellular vesicles (EVs) engineered for the incorporation of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 Nucleocapsid (N) protein induced immunity in the lungs of K18-hACE2 transgenic mice, which then can survive the lethal virus infection. However, nothing is known about the ability of the N-specific CD8+ T cell immunity in controlling viral replication in the lungs, a major pathogenic signature of severe disease in humans. To fill the gap, we investigated the immunity generated in the lungs by N-engineered EVs in terms of induction of N-specific effectors and resident memory CD8+ T lymphocytes before and after virus challenge carried out three weeks and three months after boosting. At the same time points, viral replication extents in the lungs were evaluated. Three weeks after the second immunization, virus replication was reduced in mice best responding to vaccination by more than 3-logs compared to the control group. The impaired viral replication matched with a reduced induction of Spike-specific CD8+ T lymphocytes. The antiviral effect appeared similarly strong when the viral challenge was carried out 3 months after boosting, and associated with the persistence of N-specific CD8+ T-resident memory lymphocytes. In view of the quite low mutation rate of the N protein, the present vaccine strategy has the potential to control the replication of all emerging variants. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Vector de calidad ambiental normalizado como elemento en la toma de decisiones en una cuenca hídrica

Author

Juan Pablo Rodríguez Miranda, Virgilio Antonio Miniño Mejía, and Martín Antonio Meléndez Valencia

Subjects
cuenca hidrográfica, calidad ambiental, normalización, variabilidad climática, Communication. Mass media, P87-96, Social sciences (General), H1-99
Abstract

Este artículo considera la variabilidad climática como una variable significativa influyente en la planificación ambiental hídrica estacional de una cuenca hidrográfica. El análisis se hizo mediante el método retrospectivo y exploratorio con tal de obtener la información climática en la normalización de las variables. Se realizó una valoración concurrente (cualitativa y cuantitativa) en términos de la calidad ambiental resultante, ya que puede ser utilizada como marco de referencia para la toma decisiones en futuras inversiones e intervenciones en una cuenca en cualquier lugar del planeta. Se concluye que la integración de la variabilidad climática como aspecto relevante en la variación de escala de tiempo y espacio, así como las variaciones temporales del clima en períodos cortos de tiempo, son de gran influencia en el modelo de toma de decisiones de una cuenca hidrográfica, sobre todo para determinar los valores del vector normalizado de calidad ambiental, dado que la dinámica ambiental es inherente a cada cuenca.

Published
2017
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22. Investigation of antibodies against Chikungunya, Dengue and Zika virus in serum samples from febrile patients and its co-occurrence with malaria in six districts highly endemic for malaria in Mozambique between 2017 – 2018

Author

Sádia Ali, Osvaldo Inlamea, Argentina Muianga, Plácida Maholela, John Oludele, Bibiana Melchior, Virgilio Antonio, Vanessa Monteiro, Telma Isaias, Andarusse Sumail, Inocêncio Chongo, Pascoal Alho, Pirolita Mambo, Norbert Heinrich, and Eduardo Gudo

Abstract

IntroductionArboviruses and malaria are both mosquito-borne diseases, with overlapping symptoms and geographic distribution in tropical settings. However, little information is available on the co-occurrence of arboviruses and malaria in areas highly endemic for malaria in Africa. This study was conducted with the aim to determine the frequency of recent Dengue (DENV), Chikungunya (CHIKV) and Zika (ZIKV) infections and their co-occurrence with malaria in six highly endemic districts for malaria in Mozambique.MethodsBlood samples were collected from febrile outpatients between January 2017 and December 2018 and were then tested for Malaria using RDT. Serum samples from these patients were also tested using commercially available ELISA for the presence of IgM antibodies against CHIKV, ZIKV and DENV, as well as NS1 antigen for DENV. Concurrently, a questionnaire was administered to collect socio-demographic characteristics of patients.ResultsOf the 906 participants enrolled, IgM antibodies against CHIKV, DENV and ZIKV were identified in 134 (14.8%), 64 (7.4%) and 83 (9.2%) individuals, respectively. Malaria was diagnosed in 56 (6.2%) participants, of which 16 (28.6%) were also positive for IgM anti CHIKV, 1 (1.8%) for DENV-NS1, 3 (5.4%) for IgM anti-DENV and 10 (17.8%) for IgM anti-ZIKV. There was a trend towards an increase in the frequency of IgM anti CHIKV positive samples, from 7.0% in 2014 to 14.8% in 2018 and IgM anti-ZIKV positive samples increased from 4.9% in 2015 to 9.2% in 2018.ConclusionThis study showed an increased frequency of arbovirus in Mozambique thus far, as well as a frequent occurrence of arbovirus among malaria positive patients. This highlighted the urgency for the establishment of sentinel surveillance sites for arboviruses and the need for an integrated management of febrile illnesses in places where arboviruses and malaria are both prevalent.AUTHOR SUMMARYArbovirus and malaria share clinical features, which might make the differential diagnosis of acute febrile illnesses significantly difficult, leading to frequent over diagnosis of malaria and under diagnosis of arbovirus in places where both co-occur. In Mozambique and other sub-Saharan countries, epidemiological data on the burden and temporal trend of arbovirus, as well as on co-occurrence with malaria are Chikungunya virus (CHIKV) and Dengue virus (DENV) and its co-occurrence with malaria among 609 febrile patients in six health centres located in five provinces in Mozambique. Recent CHIKV, DENV and ZIKV infection, as measured by presence of IgM antibodies, were found in 14.8%, 7.4% and 9.2% of participants and among 28.6%, 5.4% and 17.8%, of malaria positive patients. These findings suggest that arboviruses are frequent among malaria and non-malaria febrile patients, reinforcing the need for increased awareness of arbovirus in the management of acute febrile illness.

Published
2022

23. 161 - DIPSS Score Validation As a Tool to Estimate Survival and Non-Relapse Mortality after Hematopoietic Stem Cell Transplant in a Brazilian Multicentric Cohort

Author

Moreira Funke, Vaneuza Araujo, Lima, Alberto C M, Hamerschlak, Nelson, Rensi Colturato, Virgílio Antônio, De Souza, Mair Pedro, Vigorito, Afonso Celso, Teixeira, Gustavo Machado, Rocha, Vanderson, Barbosa Mariano, Livia Caroline, Lerner, Decio, Arcuri, Leonardo Javier, Navarro Barros, George Mauricio, Pasquini, Ricardo, Paz, Alessandra, Voltarelli, Clara Leal, Tan, Bin Cheng, Neves, Heliz Regina A., Simione, Anderson João, Silva, Cinthya Corrêa, and Flowers, Mary E.D.

Published
2022
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25. Aortic valve versus root surgery after failed transcatheter aortic valve replacement

Author

Vitanova, Keti, primary, Zaid, Syed, additional, Tang, Gilbert H.L., additional, Kaneko, Tsuyoshi, additional, Bapat, Vinayak N., additional, Modine, Thomas, additional, Denti, Paolo, additional, Saha, Shekhar, additional, Hagl, Christian, additional, Kiefer, Philipp, additional, Holzhey, David, additional, Noack, Thilo, additional, Borger, Michael A., additional, Desai, Nimesh D., additional, Bavaria, Joseph E., additional, Voisine, MDPierre, additional, Mohammadi, Siamak, additional, Rodés-Cabau, Josep, additional, Harrington, Katherine B., additional, Squiers, John J., additional, Szerlip, Molly I., additional, DiMaio, J. Michael, additional, Mack, Michael J., additional, Rovin, Joshua, additional, Gennari, Marco, additional, Fukuhara, Shinichi, additional, Deeb, G. Michael, additional, Sengupta, Aditya, additional, Demers, Philippe, additional, Ibrahim, Reda, additional, Wyler von Ballmoos, Moritz, additional, Atkins, Marvin D., additional, Kleiman, Neal S., additional, Reardon, Michael J., additional, Maisano, Francesco, additional, Bhadra, Oliver D., additional, Conradi, Lenard, additional, Shults, Christian, additional, Satler, Lowell F., additional, Waksman, Ron, additional, Pirelli, Luigi, additional, Brinster, Derek R., additional, Algadheeb, Muhanad, additional, Chu, Michael W.A., additional, Bagur, Rodrigo, additional, Ramlawi, Basel, additional, Grubb, Kendra J., additional, Robinson, Newell B., additional, Wang, Lin, additional, Petrossian, George A., additional, Leroux, Lionel, additional, Doty, John R., additional, Whisenant, Brian K., additional, Kempfert, Joerg, additional, Unbehaun, Axel, additional, Rahim, Hussein, additional, Nazif, Tamim M., additional, George, Isaac, additional, Geirsson, Arnar, additional, Forrest, John K., additional, Vincent, Flavien, additional, Van Belle, Eric, additional, Koussa, Mohamad, additional, Goldberg, Joshua B., additional, Ahmad, Hasan A., additional, Ben Ali, Walid, additional, Andreas, Martin, additional, Werner, Paul, additional, Goel, Kashish, additional, Shah, Ashish S., additional, Gelpi, Guido, additional, Ruel, Marc, additional, Al-Atassi, Talal, additional, Van Mieghem, Nicholas M., additional, Hokken, Thijmen W., additional, D'Onofrio, Augusto, additional, Tessari, Chiara, additional, Hirji, Sameer, additional, Shah, Pinak B., additional, Belluschi, Igor, additional, Garatti, Andrea, additional, Bruschi, Giuseppe, additional, Ouzounian, Maral, additional, Pizano, Alejandro, additional, Di Eusanio, Marco, additional, Capestro, Filippo, additional, Taramasso, Maurizio, additional, Colli, Andrea, additional, Estevez-Loureiro, Rodrigo, additional, Pinon, Miguel A., additional, Salinger, Michael H., additional, Di Virgilio, Antonio, additional, Nguyen, Tom C., additional, and Lange, Rudiger, additional

Published
2022
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26. Strong SARS-CoV-2 N-Specific CD8+ T Immunity Induced by Engineered Extracellular Vesicles Associates with Protection from Lethal Infection in Mice

Author

Ferrantelli, Flavia, primary, Chiozzini, Chiara, additional, Manfredi, Francesco, additional, Leone, Patrizia, additional, Spada, Massimo, additional, Di Virgilio, Antonio, additional, Giovannelli, Andrea, additional, Sanchez, Massimo, additional, Cara, Andrea, additional, Michelini, Zuleika, additional, and Federico, Maurizio, additional

Published
2022
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27. Current Practices on Prophylaxis of Graft Versus Host Disease (GVHD) in Latin America (LA): Interim Results of a WBMT Survey

Author

Galeano, Sebastian, Funke, Vaneuza Araújo Moreira, Seber, Adriana, Vigorito, Afonso C, Miranda, Eliana C M, Americo, Andre Dias, Antolinez, Valentine Jimenez, Arana, Luara, Arrais, Celso, Azevedo, Wellington, Barriga, Francisco J, Barros, George Mauricio Navarro, Basquiera, Prof. Ana Lisa, Berro, Mariano, Bonfim, Carmem, Bouzas, Luis Fernando, Brandao, Laila Rigolin Fortunato, Brun, Caroline Pellicioli, Chiattone, Ricardo Rabello, Collazo, Maylu, Colturato, Virgílio Antônio Rensi, Daudt, Liane Esteves, Duarte, Fernando, Fatobene, Giancarlo, Feliciano, Joao Victor, Fernandes, Juliana Folloni, Ferrando, Martin, Frutos, Cristobal A, Fuente, Lucia, Garcia, Julia Lopes, Gomez, Andres, Gomez, David, Gonzalez, Maria Guadalupe, Jaimovich, Gregorio, Karduss, Amado, Soares, Rodolfo Daniel de Almeida, Loth, Gisele, Luzardo, JOel Badell, Macedo, Maria Cristina Martins de Almeida, Medina, Lauro Fabian Amador, Melo, Andresa, Monteiro, Tatiana Dias Marconi, Moreira, Maria Cláudia Rodrigues, Moreno, Adrienne, Pages, Carolina, Paton, Eduardo, Paz, Alessandra, Puga, Barbara, Rojas, Nicolas, Passos, Roselene, Ruiz-Argüelles, Guillermo José, Salvino, Marco Aurélio, Sapelli, Jaqueline, Solano, Julio César, Gallardo-Pérez, Moisés M, Stevenazzi, Mariana, Teixeira, Gustavo Machado, Zanette, Antonella, Rocha, Vanderson, Hamerschlak, Prof. Nelson, Villela, Luiz, Vitriu, Adriana Verónica, Flowers, Mary E.D., Muhsen, Ibrahim N., and Aljurf, Mahmoud

Published
2024
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28. Comparative Outcomes for HLA-Matched Siblings, Mismatched, and Haploidentical Donors in Myelodisplastic Syndromes: Report from the Latin American Register

Author

Duarte, Fernando, de Jesus dos Santos Sousa, Talyta Ellen, Funke, Vaneuza Araújo Moreira, Duarte, Isabella Araújo, Hamerschlak, Prof. Nelson, Villela, Neysimelia, Macedo, Maria Cristina Martins de Almeida, Vigorito, Afonso C, Soares, Rodolfo Daniel de Almeida, Diaz, Lilián, Neto, Abrahão Elias Hallack, Bettarello, Gustavo, de Gusmão, Breno Moreno, Salvino, Marco Aurélio, Calixto, Rodolfo Froes, Moreira, Maria Cláudia Rodrigues, Teixeira, Gustavo Machado, Paton, Eduardo, Rocha, Vanderson, Enrico, Alicia, Bonfim, Carmem, Chiattone, Ricardo Rabello, Simioni, Anderson João, Arrais, Celso, Coelho, Erika, and Colturato, Virgílio Antônio Rensi

Published
2024
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30. Safety and efficiency modifications of SIV-based integrase-defective lentiviral vectors for immunization

Author

Bona, Roberta, primary, Michelini, Zuleika, additional, Mazzei, Chiara, additional, Gallinaro, Alessandra, additional, Canitano, Andrea, additional, Borghi, Martina, additional, Vescio, Maria Fenicia, additional, Di Virgilio, Antonio, additional, Pirillo, Maria Franca, additional, Klotman, Mary E., additional, Negri, Donatella, additional, and Cara, Andrea, additional

Published
2021
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31. Aporte de fuentes de aguas superficiales en la parte este del Lago Enríquillo y el impacto de esas aguas en el crecimiento del lago

Author

Virgilio Antonio Miniño Mejía, Yolanda León, Cándido Quintana, and Aída Rosario

Subjects
Lago Enríquillo, lagos, República Dominicana., Communication. Mass media, P87-96, Social sciences (General), H1-99
Abstract

El lago Enriquillo es el más grande de las Antillas con una extensión superficial de aproximadamente 265 km² (actual-mente se aproxima a los 400 km2). La salinidad del lago había sido hasta hace poco tiempo mucho mayor que la del mar, pero el aumento de su nivel de aguas ha bajado la salinidad del mismo considerablemente hasta unas 20 partes por mil. Está situado a aproximadamente 44 metros bajo el nivel del mar. Su crecimiento desproporcionado ha causado alarma en la comunidad científica internacional, pues es algo sin precedentes hasta donde se conoce. Durante su historia el lago Enriquillo ha experimentado oscila-ciones en el nivel de sus aguas, pero durante esta última crecida, a partir del año 2004, este crecimiento ha sido muy rápido y continuo, lo cual ha provocado cierta incertidumbre entre los científicos que han trabajado la geología, la hidrología y la hidrogeología del área, pues no se ha podido determinar la causa exacta de este fenómeno.

Published
2015
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32. Caracterización de la morfología de la semilla de Pinus Occidentalis Swartz

Author

Virgilio Antonio Miniño Mejía, Luis Enrique Rodríguez de Francisco, Omar Paíno Perdomo, Yolanda León, and Liz Paulino

Subjects
morfología(botanica), pinos, pinus occidentalis awartz., Communication. Mass media, P87-96, Social sciences (General), H1-99
Abstract

La gran biodiversidad de especies de plantas en la isla La Española, hace conveniente la elaboración de trabajos que permitan identificar las familias, géneros y especies, a partir de diversos caracteres, como los anatómicos. En la República Dominicana se carece de investigaciones sobre las semillas de las especies endémicas. Es importante profundizar en estudios morfológicos y anatómicos de las semillas de nuestras especies y emplearlas con diferentes fines, como orientación taxonómica, conocer más sobre su ecología, entre otros. En nuestro trabajo tratamos de utilizar un carácter relevante de Pinus occidentalis, como es su semilla. El presente estudio nos permite conocer sobre la superficie de la semilla de Pinus occidentalis, pues la morfología de la semilla juega un papel importante en la dispersión de la especie.

Published
2014
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33. Isolation and Characterization of Mouse Monoclonal Antibodies That Neutralize SARS-CoV-2 and Its Variants of Concern Alpha, Beta, Gamma and Delta by Binding Conformational Epitopes of Glycosylated RBD With High Potency

Author

Mariotti, Sabrina, primary, Capocefalo, Antonio, additional, Chiantore, Maria Vincenza, additional, Iacobino, Angelo, additional, Teloni, Raffaela, additional, De Angelis, Maria Laura, additional, Gallinaro, Alessandra, additional, Pirillo, Maria Franca, additional, Borghi, Martina, additional, Canitano, Andrea, additional, Michelini, Zuleika, additional, Baggieri, Melissa, additional, Marchi, Antonella, additional, Bucci, Paola, additional, McKay, Paul F., additional, Acchioni, Chiara, additional, Sandini, Silvia, additional, Sgarbanti, Marco, additional, Tosini, Fabio, additional, Di Virgilio, Antonio, additional, Venturi, Giulietta, additional, Marino, Francesco, additional, Esposito, Valeria, additional, Di Bonito, Paola, additional, Magurano, Fabio, additional, Cara, Andrea, additional, Negri, Donatella, additional, and Nisini, Roberto, additional

Published
2021
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34. Surgical Explantation After TAVR Failure

Author

Bapat, Vinayak N., primary, Zaid, Syed, additional, Fukuhara, Shinichi, additional, Saha, Shekhar, additional, Vitanova, Keti, additional, Kiefer, Philipp, additional, Squiers, John J., additional, Voisine, Pierre, additional, Pirelli, Luigi, additional, von Ballmoos, Moritz Wyler, additional, Chu, Michael W.A., additional, Rodés-Cabau, Josep, additional, DiMaio, J. Michael, additional, Borger, Michael A., additional, Lange, Rudiger, additional, Hagl, Christian, additional, Denti, Paolo, additional, Modine, Thomas, additional, Kaneko, Tsuyoshi, additional, Tang, Gilbert H.L., additional, Sengupta, Aditya, additional, Holzhey, David, additional, Noack, Thilo, additional, Harrington, Katherine B., additional, Mohammadi, Siamak, additional, Brinster, Derek R., additional, Atkins, Marvin D., additional, Algadheeb, Muhanad, additional, Bagur, Rodrigo, additional, Desai, Nimesh D., additional, Bhadra, Oliver D., additional, Conradi, Lenard, additional, Shults, Christian, additional, Satler, Lowell F., additional, Ramlawi, Basel, additional, Robinson, Newell B., additional, Wang, Lin, additional, Petrossian, George A., additional, Andreas, Martin, additional, Werner, Paul, additional, Garatti, Andrea, additional, Vincent, Flavien, additional, Van Belle, Eric, additional, Juthier, Francis, additional, Leroux, Lionel, additional, Doty, John R., additional, Goldberg, Joshua B., additional, Ahmad, Hasan A., additional, Goel, Kashish, additional, Shah, Ashish S., additional, Geirsson, Arnar, additional, Forrest, John K., additional, Grubb, Kendra J., additional, Hirji, Sameer, additional, Shah, Pinak B., additional, Bruschi, Giuseppe, additional, Gelpi, Guido, additional, Belluschi, Igor, additional, Ouzounian, Maral, additional, Ruel, Marc, additional, Al-Atassi, Talal, additional, Kempfert, Joerg, additional, Unbehaun, Axel, additional, Van Mieghem, Nicholas M., additional, Hokken, Thijmen W., additional, Ben Ali, Walid, additional, Ibrahim, Reda, additional, Demers, Philippe, additional, Pizano, Alejandro, additional, Di Eusanio, Marco, additional, Capestro, Filippo, additional, Estevez-Loureiro, Rodrigo, additional, Pinon, Miguel A., additional, Salinger, Michael H., additional, Rovin, Joshua, additional, D'Onofrio, Augusto, additional, Tessari, Chiara, additional, Di Virgilio, Antonio, additional, Taramasso, Maurizio, additional, Gennari, Marco, additional, Colli, Andrea, additional, Whisenant, Brian K., additional, Nazif, Tamim M., additional, Kleiman, Neal S., additional, Szerlip, Molly Y., additional, Waksman, Ron, additional, George, Isaac, additional, Nguyen, Tom C., additional, Maisano, Francesco, additional, Deeb, G. Michael, additional, Bavaria, Joseph E., additional, Reardon, Michael J., additional, Mack, Michael J., additional, Bapat, Vinayak N., additional, Brinkman, William T., additional, George, Timothy J., additional, Potluri, Srinivasa, additional, Ryan, William H., additional, Schaffer, Justin M., additional, Smith, Robert L., additional, Szerlip, Molly, additional, Nazif, Tamim, additional, Rahim, Hussein, additional, Grubb, Kendra, additional, Atkins, Marvin, additional, Goel, Sachin, additional, Kleiman, Neal, additional, Reardon, Michael, additional, Wyler von Ballmoos, Moritz, additional, Doty, John, additional, Whisenant, Brian, additional, Salinger, Michael, additional, Satler, Lowell, additional, Schults, Christian, additional, Fisher, Susan, additional, Alexis, Sophia L., additional, Kliger, Chad A., additional, Rutkin, Bruce, additional, Yu, Pey-Jen, additional, Petrossian, George, additional, Robinson, Newell, additional, Deeb, Michael, additional, Oakley, Jessica, additional, Bavaria, Joseph, additional, Desai, Nimesh, additional, Walsh, Lisa, additional, Nguyen, Tom, additional, Ahmad, Hasan, additional, Goldberg, Joshua, additional, Spielvogel, David, additional, Forrest, John, additional, Chu, Michael, additional, Cartier, Raymond, additional, Rodes-Cabau, Josep, additional, Abois, Alain-Philippe, additional, Boodhwani, Munir, additional, Dick, Alexander, additional, Glover, Christopher, additional, Labinaz, Marino, additional, Lam, Buu-Khanh, additional, Delhaye, Cedric, additional, Delsaux, Adeline, additional, Denimal, Tom, additional, Gaul, Anaïs, additional, Koussa, Mohammad, additional, Pamart, Thibault, additional, Sonnabend, Svetlana, additional, Krane, Markus, additional, Munsterer, Andrea, additional, Borger, Michael, additional, Kiefer, Philippe, additional, Bhadra, Oliver, additional, Conradi, Len, additional, Merlanti, Bruno, additional, Russo, Claudio F., additional, Romagnoni, Claudia, additional, Van Mieghem, Nicholas, additional, and Pinnon, Miguel, additional

Published
2021
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36. Impacto de las aguas superficiales en el aumento del nivel de las aguas del Lago Enriquillo

Author

Virgilio Antonio Miniño Mejía, Cándido Quintana, and Yolanda M. León

Subjects
Hydrology, Irrigation, business.industry, Extreme events, Livestock, General Medicine, business, Subsoil, Surface water, Geology
Abstract

A partir del 2014 el lago Enriquillo, localizado en el suroeste de la República Dominicana, empezó a evidenciar un continuo crecimiento en el nivel de sus aguas llegando, de 265 km2 hasta alrededor de 375 km2. Esto duró hasta el 2013 cuando se empezó a observar un decrecimiento paulatino hasta el momento. Durante todo este tiempo se han venido llevando a cabo investigaciones para determinar la causa, o causas, que dieron lugar a este fenómeno. Aunque se han planteado varias hipótesis sobre dicha crecida aún no existe un consenso generalizado sobre la crecida del lago. Lo que se plantea en este trabajo de investigación es que, exceptuando el aporte de aguas superficiales a través de eventos extremos, la mayor cantidad de agua que drena en el lago Enriquillo es a través del subsuelo, ya que la mayoría de los ríos y canales alrededor del lago han estado secos durante los últimos dos años. Gran parte del agua que fluye desde las sierras de Neyba y Bahoruco, desde el Norte y Sur respectivamente, es utilizada para riego y ganadería, en menor escala. El lago Enriquillo no recibe aporte de aguas superficiales desde la parte Oeste, y en cuanto al Este solo drena de manera continua el canal Cristóbal, el cual tiene un flujo que en gran medida depende del manejo de una compuerta y del uso para agricultura.

Published
2018

38. LA SUCCESSIONE PER CAUSA DI MORTE

Author

Pasquale, Stanzione, Gabriella Autorino Stanzione, Meoli, Bruno, Federica, Resta, Angelo, Saturno, Giovanni, Sciancalepore, Salvatore, Sica, Virgilio, D'Antonio, and Claudia, Troisi

Published
2021

40. Impact of Treatment Prior to Allogeneic Transplantation of Hematopoietic Stem Cells in Patients with Myelodysplastic Syndrome: Results of the Latin American Bone Marrow Transplant Registry

Author

Duarte, Fernando Barroso, Moura, Anna Thawanny Gadelha, Funke, Vaneuza Araújo Moreira, Colturato, Virgílio Antônio Rensi, Hamerschlak, Nelson, Vilela, Neysimélia Costa, Lopes, Luiz Fernando, de Almeida Macedo, Maria Cristina Martins, Vigorito, Afonso Celso, de Almeida Soares, Rodolfo Daniel, Paz, Alessandra, Stevenazzi, Mariana, Diaz, Lilián, Neto, Abrahao Elias Hallack, Bettarello, Gustavo, de Gusmão, Breno Moreno, Salvino, Marco Aurélio, Calixto, Rodolfo Froes, Moreira, Maria Cláudia Rodrigues, Teixeira, Gustavo Machado, da Silva, Cinthya Corrêa, Simioni, Anderson João, and Lemes, Romélia Pinheiro Gonçalves

Published
2020
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41. Integrase-Defective Lentiviral Vector Is an Efficient Vaccine Platform for Cancer Immunotherapy

Author

Morante, Valeria, primary, Borghi, Martina, additional, Farina, Iole, additional, Michelini, Zuleika, additional, Grasso, Felicia, additional, Gallinaro, Alessandra, additional, Cecchetti, Serena, additional, Di Virgilio, Antonio, additional, Canitano, Andrea, additional, Pirillo, Maria Franca, additional, Bona, Roberta, additional, Cara, Andrea, additional, and Negri, Donatella, additional

Published
2021
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42. Estudio sobre la capacidad de absorción de nutrientes de cuatro genotipos de arroz (Oryza sativa L.) en función de concentraciones variables de mercurio total (HgT)

Author

González Viloria, Virgilio Antonio, Gutiérrez Rodríguez, Nahyle Sohan, and Peroza Sierra, José Antonio

Subjects
Mercurio, Soils, Oryza sativa, Mercury, Nutrients, Absorción, Nutrientes, Suelos, Mojana, Absorption
Abstract

El arroz (Oryza sativa L.) es considerado uno de los principales cultivos de gran importancia en el mundo por ser el alimento básico en muchas culturas culinarias. En los últimos años ha presentado problemas de contaminación con Hg, al estar este metal en constante flujo: suelo-aire-agua, sobre todo en la región de La Mojana donde los suelos son contaminados por efecto de lavado y arrastre de las aguas provenientes de la ciénaga de Ayapel y la cuenca del rio San Jorge. El objetivo de esta investigación fue cuantificar las cantidades de HgT y nutrientes absorbidos por la planta en función de seis [Hg] en el suelo (86, 500, 1000, 2500, 5000, y 10000 μg Hg kg-1 de suelo) de cuatro variedades de arroz sembradas en dos texturas diferentes: ArL (F-2000 y F-473) y FArL (F-67 y F-68). El estudio fue hecho en materas con 18 kg con suelos de la región de La Mojana bajo condiciones controladas, se investigaron seis tratamientos con cuatro repeticiones las variedades F-2000 y F-473 y tres repeticiones las variedades F-67 y F-68. Los tratamientos se distribuyeron en un diseño de bloques completos al azar (1x2x6). Al final del ciclo se evaluó: HgT/planta, Hg en raíces y granos pilados y cantidad de nutriente absorbido por planta, en cada una de las variedades. Para la evaluación de medias se utilizó la prueba de Tukey al 5% de probabilidades, comparando el factor de interacción [Hg] en el suelo e interacción entre variedades. El ANAVA de HgT/planta presento diferencias estadísticas (p

Published
2020

43. Representatividad del grupo Teatro Ensayo Gestus en la praxis teatral guayaquileña en el período 1988-2015

Author

Valero Montalván, Virgilio Antonio and Cortez Galecio, Cristian Arnulfo

Subjects
Estudios del arte, Praxis teatral, Historia teatro Guayaquil, Teatro Ensayo Gestus, Crítica teatral
Abstract

A partir de una aproximación histórica al Teatro en Guayaquil, este trabajo categoriza al grupo ecuatoriano Teatro Ensayo Gestus dentro un esbozo de cartografía del movimiento escénico guayaquileño. Por ello, se analizó la representatividad del grupo con base en su actividad, organización, trayectoria, las poéticas de sus producciones y la mirada crítica de gestores y artistas nacionales e internacionales desde 1988 hasta el 2015. En correspondencia, la presente investigación evidenció que el Teatro Ensayo Gestus ha aportado al movimiento escénico ecuatoriano un espacio que les ha permitido desarrollar capacidades en el teatro; no solamente por el deseo de montar obras, sino que desde su diario quehacer abrió la posibilidad de obtener un desarrollo grupal e individual que ha brindado expectativas diferentes y que ha contribuido al crecimiento cultural en Guayaquil. Se demostró que la obra de Gestus aboga por un teatro educativo, progresista y profesional que ha brindado un crecimiento al espectador, alternativas nuevas que a través de la escena se han traducido en nuevas perspectivas de su conocimiento. Como efecto inmediato, ha producido un cambio social a partir de un cambio individual y se ha trazado en sus proyectos la necesidad de llegar a una masa de público adulto e infantil, que tiene poco o ningún acceso al teatro, con obras de contenido y lenguaje directo y calidad en su entrega. Based on a historical approach to the Theater in Guayaquil, this work categorizes the Ecuadorian group Teatro Ensayo Gestus within a cartographic outline of the scenic movement of Guayaquil. Analyzing the representativeness of the group based on its activity, organization, career, the poetics of its productions and the critical view of national and international managers and artists from 1988 to 2015, the present investigation shows that the Group has contributed to the Ecuadorian theater movement a space that has allowed them to develop capacities in the theater, not only for the desire to create plays, but from their daily work opened the possibility of obtaining a group and individual development that has offered different expectations and has contributed to the cultural growth in Guayaquil. It shows that the work of Gestus stand up an educational theater, progressive and professional, has provided a growth to the viewer, new alternatives that through the scene have been translated into new perspectives of their knowledge, producing a social change from an individual change and has route in their projects the need to reach a mass of adult and children, who has little or no access to theater, with plays of content, direct language and quality in the perform. Magíster en Estudios del Arte Cuenca

Published
2019

45. 403 - In the Molecular Classification Era, Can We Still Use IPSS-R in HSCT of MDS Patients?

Author

Duarte, Fernando Barroso, dos Santos Sousa, Talyta Ellen de Jesus, Moreira Funke, Vaneuza Araujo, Rensi Colturato, Virgílio Antônio, Hamerschlak, Prof. Nelson, Villela, Neysimelia, de Almeida Macedo, Maria Cristina Martins, Vigorito, Afonso Celso, de Almeida Soares, Rodolfo Daniel, Paz, Alessandra, Diaz, Lilián, Stevenazzi, Mariana, Hallack Neto, Abrahão Elias, Bettarello, Gustavo, de Gusmão, Breno Moreno, Salvino, Marco Aurélio, Calixto, Rodolfo Froes, Rodrigues Moreira, Maria Cláudia, Teixeira, Gustavo Machado, Silva, Cinthya Corrêa, Paton, Eduardo, Rocha, Vanderson, Enrico, Alicia, Bonfim, Carmem, Chiattone, Ricardo Rabello, Simioni, Anderson João, Arrais, Celso, and Coelho, Erika

Published
2023
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46. Development and Preclinical Evaluation of an Integrase Defective Lentiviral Vector Vaccine Expressing the HIVACAT T Cell Immunogen in Mice

Author

Gallinaro, Alessandra, primary, Borghi, Martina, additional, Pirillo, Maria Franca, additional, Cecchetti, Serena, additional, Bona, Roberta, additional, Canitano, Andrea, additional, Michelini, Zuleika, additional, Di Virgilio, Antonio, additional, Olvera, Alex, additional, Brander, Christian, additional, Negri, Donatella, additional, and Cara, Andrea, additional

Published
2020
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48. Hazard identification of pyrogenic synthetic amorphous silica (NM-203) after sub-chronic oral exposure in rat: A multitarget approach

Author

Tassinari, Roberta, primary, Di Felice, Gabriella, additional, Butteroni, Cinzia, additional, Barletta, Bianca, additional, Corinti, Silvia, additional, Cubadda, Francesco, additional, Aureli, Federica, additional, Raggi, Andrea, additional, Narciso, Laura, additional, Tait, Sabrina, additional, Valeri, Mauro, additional, Martinelli, Andrea, additional, Di Virgilio, Antonio, additional, Pacchierotti, Francesca, additional, Cordelli, Eugenia, additional, Eleuteri, Patrizia, additional, Villani, Paola, additional, Fessard, Valerie, additional, and Maranghi, Francesca, additional

Published
2020
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49. Additional file 1: of A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells

Author

Orienti, Isabella, Salvati, Valentina, Sette, Giovanni, Zucchetti, Massimo, Bongiorno-Borbone, Lucilla, Peschiaroli, Angelo, Zolla, Lello, Francescangeli, Federica, Ferrari, Mariella, Matteo, Cristina, Bello, Ezia, Virgilio, Antonio Di, Falchi, Mario, Angelis, Maria De, Baiocchi, Marta, Melino, Gerry, Maria, Ruggero De, Zeuner, Ann, and Eramo, Adriana

Subjects
carbohydrates (lipids)
Abstract

Figure S1. Metabolites plasma concentrations (MPR and oxo-4-HPR) determined in mice after single oral treatment of 4 doses of Bio-nFeR: 10, 50, 100 and 200 mg/Kg. The analysis was performed after 0, 24, 48 h. Figure S2. Evaluation of the 50% inhibitory concentration (IC50) of BionFeR and NCI-FeR formulation was done on a representative lung cancer stem cell line (LCSC). The cells were exposed to the indicated drug doses (0–30 μM) and cell viability was evaluated by CellTiter-Glo after 72 h. Figure S3. A) Sphingomyelin-Ceramide (SM-CER) and Sphingomyelin- Dihydro-Ceramide (SM-DH-CER) content in lung (LC), melanoma (MEL) and colon (CRC) tumors treated with Bio-nFeR at single 100–150 mg/Kg administration were quantified through Ultra High Performance Liquid Chromatography (UHPLC), normalized to control and plotted as fold change. B) Quantification of Glucosyl-Ceramide (GLC-CER) and Glucosyl-Dihydro-Ceramide (GLC-DH-CER) in the same samples as in A, normalized to control and plotted as fold change. Figure S4. Cancer stem cell marker expression in CSC-culture conditions and in CSC-derived xenografts. A) Flow cytometry analysis of Aldefluor in (left panels) and CD44v6 (middle and right panels) in the indicated CSC and xenograft samples. B) Immunoblot analysis of CSC antigens c-Kit and SOX-2 in the indicated control (−) or BionFeR treated (+) melanoma xenografts. β-actin blot was used for equal loading control. Figure S5. Growth curves of lung CSC-derived xenografts in control mice or mice treated with Bio-nFeR or NCI-FeR at 100 mg/kg dose for the indicated times. Mean ± standard error is shown. *P

Published
2019
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50. Representatividad del grupo Teatro Ensayo Gestus en la praxis teatral guayaquileña en el período 1988-2015

Author

Cortez Galecio, Cristian Arnulfo, Valero Montalván, Virgilio Antonio, Cortez Galecio, Cristian Arnulfo, and Valero Montalván, Virgilio Antonio

Abstract

Based on a historical approach to the Theater in Guayaquil, this work categorizes the Ecuadorian group Teatro Ensayo Gestus within a cartographic outline of the scenic movement of Guayaquil. Analyzing the representativeness of the group based on its activity, organization, career, the poetics of its productions and the critical view of national and international managers and artists from 1988 to 2015, the present investigation shows that the Group has contributed to the Ecuadorian theater movement a space that has allowed them to develop capacities in the theater, not only for the desire to create plays, but from their daily work opened the possibility of obtaining a group and individual development that has offered different expectations and has contributed to the cultural growth in Guayaquil. It shows that the work of Gestus stand up an educational theater, progressive and professional, has provided a growth to the viewer, new alternatives that through the scene have been translated into new perspectives of their knowledge, producing a social change from an individual change and has route in their projects the need to reach a mass of adult and children, who has little or no access to theater, with plays of content, direct language and quality in the perform.

Published
2019

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