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This paper will examine the economic and geographical analysis of companies in the manufacturing industry, located in the South Bohemia region. The theoretical concept chosen to examine this paper will be the Global Production Networks (GPN). This is used for the comparison of states and firms in the world economy. A decision was made to select a quantitative approach of studying selected GPNs. The subject area is to, analyse the economic activity and their results of 11 groups of companies according to their position in the GPN in reference to their hierarchy, ownership, function and size. Three data indicators will be used to support this analysis, Returns on Assets (ROA), Wages to Turnover (WTT) and Capital Expenditures to Turnover (CTT). This paper will find out which company type produces the best results and which can positively affect local development. This paper will also explore if there is any pattern on location, company category and its economical results. Key words: global production networks, manufacturing industry, South Bohemia, economical structure