1. Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose-Coated Magnetic Nanoparticles.
- Author
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Medříková Z, Novohradsky V, Zajac J, Vrána O, Kasparkova J, Bakandritsos A, Petr M, Zbořil R, and Brabec V
- Subjects
- Antineoplastic Agents chemistry, Antineoplastic Agents pharmacokinetics, Antineoplastic Agents pharmacology, Carboxymethylcellulose Sodium pharmacokinetics, Cell Line, Tumor, Cisplatin administration & dosage, Cisplatin pharmacokinetics, Drug Delivery Systems, Humans, Antineoplastic Agents administration & dosage, Carboxymethylcellulose Sodium chemistry, Cisplatin chemistry, Cisplatin pharmacology, Folic Acid chemistry, Magnetite Nanoparticles chemistry, Platinum chemistry
- Abstract
The fabrication of nanoparticles using different formulations, and which can be used for the delivery of chemotherapeutics, has recently attracted considerable attention. We describe herein an innovative approach that may ultimately allow for the selective delivery of anticancer drugs to tumor cells by using an external magnet. A conventional antitumor drug, cisplatin, has been incorporated into new carboxymethylcellulose-stabilized magnetite nanoparticles conjugated with the fluorescent marker Alexa Fluor 488 or folic acid as targeting agent. The magnetic nanocarriers possess exceptionally high biocompatibility and colloidal stability. These cisplatin-loaded nanoparticles overcome the resistance mechanisms typical of free cisplatin. Moreover, experiments aimed at the localization of the nanoparticles driven by an external magnet in a medium that mimics physiological conditions confirmed that this localization can inhibit tumor cell growth site-specifically., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2016
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