Search

Your search keyword '"Wadley, Glenn D."' showing total 177 results
Start Over Author "Wadley, Glenn D." Publication Year Range Last 10 years
177 results on '"Wadley, Glenn D."'

6. Total testosterone is not associated with muscle mass, function or exercise adaptations in pre-menopausal females

Author

Alexander, Sarah E, primary, Gatto, Briana, additional, Knowles, Olivia E, additional, Williams, Ross M, additional, Fiebig, Kinga N, additional, Jansons, Paul, additional, Della Gatta, Paul A, additional, Garnham, Andrew, additional, Eynon, Nir, additional, Wadley, Glenn D, additional, Aisbett, Brad, additional, Hiam, Danielle, additional, and Lamon, Severine, additional

Published
2024
Full Text
View/download PDF

13. A Comparison of Sodium Citrate and Sodium Bicarbonate Ingestion: Blood Alkalosis and Gastrointestinal Symptoms.

Author

Urwin, Charles S., Snow, Rodney J., Condo, Dominique, Snipe, Rhiannon M.J., Wadley, Glenn D., Convit, Lilia, and Carr, Amelia J.

Subjects
SODIUM bicarbonate, ALKALOSIS, CONFIDENCE intervals, GASTROINTESTINAL diseases, CITRATES, MANN Whitney U Test, TREATMENT effectiveness, RANDOMIZED controlled trials, DIETARY supplements, DESCRIPTIVE statistics, BLIND experiment, CROSSOVER trials, DATA analysis software, SYMPTOMS, EVALUATION
Abstract

This study compared the recommended dose of sodium citrate (SC, 500 mg/kg body mass) and sodium bicarbonate (SB, 300 mg/kg body mass) for blood alkalosis (blood [HCO3−]) and gastrointestinal symptoms (GIS; number and severity). Sixteen healthy individuals ingested the supplements in a randomized, crossover design. Gelatin capsules were ingested over 15 min alongside a carbohydrate-rich meal, after which participants remained seated for forearm venous blood sample collection and completion of GIS questionnaires every 30 min for 300 min. Time-course and session value (i.e., peak and time to peak) comparisons of SC and SB supplementation were performed using linear mixed models. Peak blood [HCO3−] was similar for SC (mean 34.2, 95% confidence intervals [33.4, 35.0] mmol/L) and SB (mean 33.6, 95% confidence intervals [32.8, 34.5] mmol/L, p =.308), as was delta blood [HCO3−] (SC = 7.9 mmol/L; SB = 7.3 mmol/L, p =.478). Blood [HCO3−] was ≥6 mmol/L above baseline from 180 to 240 min postingestion for SC, significantly later than for SB (120–180 min; p <.001). GIS were mostly minor, and peaked 80–90 min postingestion for SC, and 35–50 min postingestion for SB. There were no significant differences for the number or severity of GIS reported (p >.05 for all parameters). In summary, the recommended doses of SC and SB induce similar blood alkalosis and GIS, but with a different time course. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

14. A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetes-induced cardiac pathology

Author

Weeks, Kate L., primary, Kiriazis, Helen, additional, Wadley, Glenn D., additional, Masterman, Emma I., additional, Sergienko, Nicola M., additional, Raaijmakers, Antonia J. A., additional, Trewin, Adam J., additional, Harmawan, Claudia A., additional, Yildiz, Gunes S., additional, Liu, Yingying, additional, Drew, Brian G., additional, Gregorevic, Paul, additional, Delbridge, Lea M. D., additional, McMullen, Julie R., additional, and Bernardo, Bianca C., additional

Published
2023
Full Text
View/download PDF

23. Factors Influencing Blood Alkalosis and Other Physiological Responses, Gastrointestinal Symptoms, and Exercise Performance Following Sodium Citrate Supplementation: A Review.

Author

Urwin, Charles S., Snow, Rodney J., Condo, Dominique, Snipe, Rhiannon, Wadley, Glenn D., and Carr, Amelia J.

Subjects
STATISTICAL significance, ALKALOSIS, ERGOGENIC aids, CITRATES, GASTROINTESTINAL diseases, DIETARY supplements, BODY movement, EXERCISE, EXERCISE intensity, BODY mass index, SYMPTOMS
Abstract

This review aimed to identify factors associated with (a) physiological responses, (b) gastrointestinal (GI) symptoms, and (c) exercise performance following sodium citrate supplementation. A literature search identified 33 articles. Observations of physiological responses and GI symptoms were categorized by dose (< 500, 500, and > 500 mg/kg body mass [BM]) and by timing of postingestion measurements (in minutes). Exercise performance following sodium citrate supplementation was compared with placebo using statistical significance, percentage change, and effect size. Performance observations were categorized by exercise duration (very short < 60 s, short ≥ 60 and ≤ 420 s, and longer > 420 s) and intensity (very high > 100% VO2max and high 90–100% VO2max). Ingestion of 500 mg/kg BM sodium citrate induced blood alkalosis more frequently than < 500 mg/kg BM, and with similar frequency to >500 mg/kg BM. The GI symptoms were minimized when a 500 mg/kg BM dose was ingested in capsules rather than in solution. Significant improvements in performance following sodium citrate supplementation were reported in all observations of short-duration and very high–intensity exercise with a 500 mg/kg BM dose. However, the efficacy of supplementation for short-duration, high-intensity exercise is less clear, given that only 25% of observations reported significant improvements in performance following sodium citrate supplementation. Based on the current literature, the authors recommend ingestion of 500 mg/kg BM sodium citrate in capsules to induce alkalosis and minimize GI symptoms. Supplementation was of most benefit to performance of short-duration exercise of very high intensity; further investigation is required to determine the importance of ingestion duration and timing. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

24. Impaired postprandial adipose tissue microvascular blood flow responses to a mixed-nutrient meal in first-degree relatives of adults with type 2 diabetes

Author

Roberts-Thomson, Katherine M., primary, Hu, Donghua, additional, Russell, Ryan D., additional, Greenaway, Timothy, additional, Betik, Andrew C., additional, Parker, Lewan, additional, Kaur, Gunveen, additional, Richards, Stephen M., additional, Premilovac, Dino, additional, Wadley, Glenn D., additional, and Keske, Michelle A., additional

Published
2022
Full Text
View/download PDF

27. Additional file 1 of Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle

Author

Trewin, Adam J., Silver, Jessica, Dillon, Hayley T., Della Gatta, Paul A., Parker, Lewan, Hiam, Danielle S., Lee, Yin Peng, Richardson, Mark, Wadley, Glenn D., and Lamon, Séverine

Abstract

Additional file 1: Figure S1: Expression of lncRNA TUG1 transcript variants in male and female human skeletal muscle. Figure S2: Optimisation of Tug1 knockdown in C2C12 myocytes and uncropped western blot images. Figure S3: Mitochondrial morphology in myotubes with Tug1 knockdown, supplement to Fig. 3. Figure S4: Tug1 knockdown in cells used for mitochondrial respiration experiments, related to Fig. 4. Figure S5: Supporting data for transcriptomic responses to EPS and Tug1 KD, related to Figs. 6 and 7. Individual data are available at DOI: 10.6084/m9.figshare.20175770 [24].

Published
2022
Full Text
View/download PDF

29. Impaired postprandial skeletal muscle vascular responses to a mixed meal challenge in normoglycaemic people with a parent with type 2 diabetes

Author

Russell, Ryan D., primary, Roberts-Thomson, Katherine M., additional, Hu, Donghua, additional, Greenaway, Timothy, additional, Betik, Andrew C., additional, Parker, Lewan, additional, Sharman, James E., additional, Richards, Stephen M., additional, Rattigan, Stephen, additional, Premilovac, Dino, additional, Wadley, Glenn D., additional, and Keske, Michelle A., additional

Published
2021
Full Text
View/download PDF

40. High-glucose mixed-nutrient meal ingestion impairs skeletal muscle microvascular blood flow in healthy young men

Author

Parker, Lewan, Morrison, Dale J., Beti, Andrew C., Roberts-Thomson, Katherine, Kaur, Gunveen, Wadley, Glenn D., Sha, Christopher S., Kesk, Michelle A., Parker, Lewan, Morrison, Dale J., Beti, Andrew C., Roberts-Thomson, Katherine, Kaur, Gunveen, Wadley, Glenn D., Sha, Christopher S., and Kesk, Michelle A.

Abstract

Oral glucose ingestion leads to impaired muscle microvascular blood flow (MBF), which may contribute to acute hyperglycemia-induced insulin resistance. We investigated whether incorporating lipids and protein into a high-glucose load would prevent postprandial MBF dysfunction. Ten healthy young men (age, 27 yr [24, 30], mean with lower and upper bounds of the 95% confidence interval; height, 180 cm [174, 185]; weight, 77 kg [70, 84]) ingested a high-glucose (1.1 g/kg glucose) mixed-nutrient meal (10 kcal/kg; 45% carbohydrate, 20% protein, and 35% fat) in the morning after an overnight fast. Femoral arterial blood flow was measured via Doppler ultrasound, and thigh MBF was measured via contrast-enhanced ultrasound, before meal ingestion and 1 h and 2 h postprandially. Blood glucose and plasma insulin were measured at baseline and every 15 min throughout the 2-h postprandial period. Compared with baseline, thigh muscle microvascular blood volume, velocity, and flow were significantly impaired at 60 min postprandial (−25%, −27%, and −46%, respectively; all P < 0.05) and to a greater extent at 120 min postprandial (−37%, −46%, and −64%; all P < 0.01). Heart rate and femoral arterial diameter, blood velocity, and blood flow were significantly increased at 60 min and 120 min postprandial (all P < 0.05). Higher blood glucose area under the curve was correlated with greater MBF dysfunction ( R2 = 0.742; P < 0.001). Ingestion of a high-glucose mixed-nutrient meal impairs MBF in healthy individuals for up to 2 h postprandial

Published
2020

43. Exercise improves metabolic function and alters the microbiome in rats with gestational diabetes

Author

Mahizir, Dayana, Briffa, Jessica F., Wood, Jennifer L., Anevska, Kristina, Hill-Yardin, Elisa L., Jefferies, Andrew J., Gravina, Sogand, Mazzarino, Gisella, Franks, Ashley E., Moritz, Karen M., Wadley, Glenn D., Wlodek, Mary E., Mahizir, Dayana, Briffa, Jessica F., Wood, Jennifer L., Anevska, Kristina, Hill-Yardin, Elisa L., Jefferies, Andrew J., Gravina, Sogand, Mazzarino, Gisella, Franks, Ashley E., Moritz, Karen M., Wadley, Glenn D., and Wlodek, Mary E.

Published
2020

44. Skeletal muscle AMPK is not activated during 2 h of moderate intensity exercise at ∼65%

Author

McConell, Glenn K., Wadley, Glenn D., Le plastrier, Kieran, and Linden, Kelly C.

Subjects
endurance, Male, training, trained, AMP-Activated Protein Kinases, Cross-Sectional Studies, AMPK activity, Humans, Longitudinal Studies, signalling, Muscle, Skeletal, metabolism, Exercise, Research Paper, Acetyl-CoA Carboxylase
Abstract

Key points AMP‐activated protein kinase (AMPK) is considered a major regulator of skeletal muscle metabolism during exercise.However, we previously showed that, although AMPK activity increases by 8–10‐fold during ∼120 min of exercise at ∼65% V˙O2peak in untrained individuals, there is no increase in these individuals after only 10 days of exercise training (longitudinal study).In a cross‐sectional study, we show that there is also a lack of activation of skeletal muscle AMPK during 120 min of cycling exercise at 65% V˙O2peak in endurance‐trained individuals.These findings indicate that AMPK is not an important regulator of exercise metabolism during 120 min of exercise at 65% V˙O2peak in endurance trained men.It is important that more energy is directed towards examining other potential regulators of exercise metabolism. Abstract AMP‐activated protein kinase (AMPK) is considered a major regulator of skeletal muscle metabolism during exercise. Indeed, AMPK is activated during exercise and activation of AMPK by 5‐aminoimidazole‐4‐carboxyamide‐ribonucleoside (AICAR) increases skeletal muscle glucose uptake and fat oxidation. However, we have previously shown that, although AMPK activity increases by 8–10‐fold during ∼120 min of exercise at ∼65% V˙O2peak in untrained individuals, there is no increase in these individuals after only 10 days of exercise training (longitudinal study). In a cross‐sectional study, we examined whether there is also a lack of activation of skeletal muscle AMPK during 120 min of cycling exercise at 65% V˙O2peak in endurance‐trained individuals. Eleven untrained (UT; V˙O2peak = 37.9 ± 5.6 ml.kg−1 min−1) and seven endurance trained (ET; V˙O2peak = 61.8 ± 2.2 ml.kg−1 min−1) males completed 120 min of cycling exercise at 66 ± 4% V˙O2peak (UT: 100 ± 21 W; ET: 190 ± 15 W). Muscle biopsies were obtained at rest and following 30 and 120 min of exercise. Muscle glycogen was significantly (P, Key points AMP‐activated protein kinase (AMPK) is considered a major regulator of skeletal muscle metabolism during exercise.However, we previously showed that, although AMPK activity increases by 8–10‐fold during ∼120 min of exercise at ∼65% V˙O2peak in untrained individuals, there is no increase in these individuals after only 10 days of exercise training (longitudinal study).In a cross‐sectional study, we show that there is also a lack of activation of skeletal muscle AMPK during 120 min of cycling exercise at 65% V˙O2peak in endurance‐trained individuals.These findings indicate that AMPK is not an important regulator of exercise metabolism during 120 min of exercise at 65% V˙O2peak in endurance trained men.It is important that more energy is directed towards examining other potential regulators of exercise metabolism.

Published
2018

45. Exercise improves metabolic function and alters the microbiome in rats with gestational diabetes

Author

Mahizir, Dayana, primary, Briffa, Jessica F., additional, Wood, Jennifer L., additional, Anevska, Kristina, additional, Hill‐Yardin, Elisa L., additional, Jefferies, Andrew J., additional, Gravina, Sogand, additional, Mazzarino, Gisella, additional, Franks, Ashley E., additional, Moritz, Karen M., additional, Wadley, Glenn D., additional, and Wlodek, Mary E., additional

Published
2019
Full Text
View/download PDF

49. Non-coding RNAs regulating cardiac muscle mass

Author

Wadley, Glenn D., Lamon, Séverine, Alexander, Sarah E., McMullen, Julie R., Bernardo, Bianca C., Wadley, Glenn D., Lamon, Séverine, Alexander, Sarah E., McMullen, Julie R., and Bernardo, Bianca C.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results