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This paper summarized the nursing management of severe eczema in a patient with fracture of the humeral shaft. Key issues of nursing included comprehensive assessment, Traditional Chinese Medicine technology, routine nursing, modified hydropathic compress. Integrative nursing interventions based on the syndrome differentiation are effective to relieve the pain and improve the comfort degree of patients with severe eczema. (本文总结1例右肱骨干骨折患者重度湿疹的护理经验, 包括整体评估、中医适宜技术、常规护理、改良式湿敷巾的应用, 基于中医辨证施护, 制定绿色、安全的中西医结合护理措施, 有效减轻患者痛苦程度, 提高患者舒适度。)

Aqueous lithium‐ion batteries offer promising advantages such as low cost, enhanced safety, high rate capability, and the ability to deliver considerable capacity at 1.8 V, making them ideal candidates for large‐scale reserve power sources for renewable energy. However, the practical application of aqueous lithium‐ion batteries has been hindered by the poor cycle stability of layered cathode materials, including LiCoO2, in neutral aqueous electrolytes. This review examines the working principles, material limitations, and research progress of aqueous lithium‐ion batteries. The types and characteristics of materials used in the cathode of aqueous lithium‐ion batteries are summarized, with a primary focus on the attenuation mechanisms of LiCoO2 when used as the cathode material in aqueous electrolytes. Furthermore, this review explores the advancements in utilizing LiCoO2 in the cathode of aqueous lithium‐ion batteries, as well as the combination with machine learning. By addressing these critical aspects, this review aims to provide a comprehensive understanding of aqueous lithium‐ion batteries and shed light on future development and application prospects. [ABSTRACT FROM AUTHOR]

Objective: Dichlorodiphenyldichloroethylene (DDE), an obesogen accumulating in adipose tissue, is released into circulation with weight loss, although its impact is underexplored among adolescents. We tested the association using an integrative translational approach of epidemiological analysis among adolescents with obesity and in vitro measures exploring the impact of DDE on adipogenesis via preadipocytes. Methods: We included 63 participants from the Teen‐Longitudinal Assessment of Bariatric Surgery (Teen‐LABS) cohort. We assessed 4,4′‐DDE in visceral adipose tissue at surgery and BMI and waist circumference at surgery and 0.5, 1, 3, and 5 years after. We conducted longitudinal analysis to estimate the interaction on weight loss between DDE and time since surgery. In vitro analysis quantified adipogenic differentiation in commercial human preadipocytes exposed to 4,4′‐DDE via fluorescent staining and imaging. Results: A dose–response relationship was observed, with the low‐exposure group having a greater reduction in BMI during the first year compared to higher‐exposure groups and showing smaller regains compared to higher‐exposure groups after the first year. In vitro analysis of preadipocytes treated with 4,4′‐DDE during adipogenic differentiation for 12 days showed a concentration‐dependent increase in lipid accumulation. Conclusions: DDE could contribute to weight trajectory among adolescents undergoing bariatric surgery, potentially mediated via promoted adipogenesis in preadipocytes. [ABSTRACT FROM AUTHOR]

BACKGROUND: Exposure to per- and polyfluoroalkyl substances (PFAS) is ubiquitous and has been associated with an increased risk of several cardiometabolic diseases. However, the metabolic pathways linking PFAS exposure and human disease are unclear. OBJECTIVE: We examined associations of PFAS mixtures with alterations in metabolic pathways in independent cohorts of adolescents and young adults. METHODS: Three hundred twelve overweight/obese adolescents from the Study of Latino Adolescents at Risk (SOLAR) and 137 young adults from the Southern California Children's Health Study (CHS) were included in the analysis. Plasma PFAS and the metabolome were determined using liquid-chromatography/high-resolution mass spectrometry. A metabolome-wide association study was performed on log- transformed metabolites using Bayesian regression with a g-prior specification and g-computation for modeling exposure mixtures to estimate the impact of exposure to a mixture of six ubiquitous PFAS (PFOS, PFHxS, PFHpS, PFOA, PFNA, and PFDA). Pathway enrichment analysis was performed using Mummichog and Gene Set Enrichment Analysis. Significance across cohorts was determined using weighted Z-tests. RESULTS: In the SOLAR and CHS cohorts, PFAS exposure was associated with alterations in tyrosine metabolism (meta- analysis p = 0.00002) and de novo fatty acid biosynthesis (p = 0.03), among others. For example, when increasing all PFAS in the mixture from low (~ 30th percentile) to high (~ 70th percentile), thyroxine (T4), a thyroid hormone related to tyrosine metabolism, increased by 0.72 standard deviations (SDs; equivalent to a standardized mean difference) in the SOLAR cohort (95% Bayesian credible interval (BCI): 0.00, 1.20) and 1.60 SD in the CHS cohort (95% BCI: 0.39, 2.80). Similarly, when going from low to high PFAS exposure, arachidonic acid increased by 0.81 SD in the SOLAR cohort (95% BCI: 0.37, 1.30) and 0.67 SD in the CHS cohort (95% BCI: 0.00, 1.50). In general, no individual PFAS appeared to drive the observed associations. DISCUSSION: Exposure to PFAS is associated with alterations in amino acid metabolism and lipid metabolism in adolescents and young adults. https:// doi.org/10.1289/EHP11372, Introduction Per- and polyfluoroalkyl substances (PFAS) make up a prevalent class of persistent organic pollutants with endocrine and metabolism disrupting properties. (1,2) PFAS are used in a broad range of [...]