Search

Your search keyword '"Wang, Zhengjian"' showing total 22 results
Start Over Author "Wang, Zhengjian" Publication Year Range Last 10 years
22 results on '"Wang, Zhengjian"'

5. Investigation of Chip Morphology in Elliptical Vibration Micro-Turning of Silk Fibroin.

Author

Wang, Zhengjian, Luo, Xichun, Sun, Jining, Xie, Wenkun, Piao, Yinchuan, Jiang, Yonghang, and Chen, Xiuyuan

Subjects
SILK fibroin, DRUG delivery systems, FREQUENCIES of oscillating systems, INDUSTRIAL diamonds, DRUG efficacy
Abstract

Silk fibroin, known for its biocompatibility and biodegradability, holds significant promise for biomedical applications, particularly in drug delivery systems. The precise fabrication of silk fibroin particles, specifically those ranging from tens of nanometres to hundreds of microns, is critical for these uses. This study introduces elliptical vibration micro-turning as a method for producing silk fibroin particles in the form of cutting chips to serve as carriers for drug delivery systems. A hybrid finite element and smoothed particle hydrodynamics (FE-SPH) model was used to investigate how vibration parameters, such as frequency and amplitude, influence chip formation and morphology. This research is essential for determining the size and shape of silk fibroin particles, which are crucial for their effectiveness in drug delivery systems. The results demonstrate the superior capability of elliptical vibration micro-turning for producing shorter, spiral-shaped chips in the size range of tens of microns, in contrast to the long, continuous chips with zig-zag folds and segmented edges generated by conventional micro-turning. The unique zig-zag shapes result from the interplay between the high flexibility and hierarchical structure of silk fibroin and the controlled cutting environment provided by the diamond tool. Additionally, higher vibration frequencies and lower vertical amplitudes promote chip curling, facilitate breakage, and improve chip control, while reducing cutting forces. Experimental trials further validate the accuracy of the hybrid model. This study represents a significant advancement in the processing of silk fibroin film, offering a complementary approach to fabricating short, spiral-shaped silk fibroin particles with a high surface-area-to-volume ratio compared to traditional spheroids, which holds great potential for enhancing drug-loading efficiency in high-precision drug delivery systems. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

10. Intestinal Mucosal Immune Barrier: A Powerful Firewall Against Severe Acute Pancreatitis-Associated Acute Lung Injury via the Gut-Lung Axis

Author

Li,Fan, Wang,Zhengjian, Cao,Yinan, Pei,Boliang, Luo,Xinyu, Liu,Jin, Ge,Peng, Luo,Yalan, Ma,Shurong, Chen,Hailong, Li,Fan, Wang,Zhengjian, Cao,Yinan, Pei,Boliang, Luo,Xinyu, Liu,Jin, Ge,Peng, Luo,Yalan, Ma,Shurong, and Chen,Hailong

Abstract

Fan Li,1– 3,* Zhengjian Wang,4,* Yinan Cao,1– 3 Boliang Pei,1– 3 Xinyu Luo,1– 3 Jin Liu,1– 3 Peng Ge,1– 3 Yalan Luo,1– 3 Shurong Ma,1,3 Hailong Chen1– 3 1Department of General Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 2Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 3Laboratory of Integrative Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 4Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shurong Ma; Hailong Chen, Department of General Surgery, the First Affiliated Hospital of Dalian Medical University, Zhongshan Road 222, Dalian, Liaoning, 116011, People’s Republic of China, Tel +86-411-83635963, Fax +86-411-83622844, Email shurongma94@163.com; chenhailong@dmu.edu.cnAbstract: The pathogenesis of severe acute pancreatitis-associated acute lung injury (SAP-ALI), which is the leading cause of mortality among hospitalized patients in the intensive care unit, remains incompletely elucidated. The intestinal mucosal immune barrier is a crucial component of the intestinal epithelial barrier, and its aberrant activation contributes to the induction of sustained pro-inflammatory immune responses, paradoxical intercellular communication, and bacterial translocation. In this review, we firstly provide a comprehensive overview of the composition of the intestinal mucosal immune barrier and its pivotal roles in the pathogenesis of SAP-ALI. Secondly, the mechanisms of its crosstalk with gut microbiota, which is called gut-lung axis, and its effect on SAP-ALI were summarized. Finally, a number of drugs that could enhance the

Published
2024

14. Mechanisms of Qingyi Decoction in Severe Acute Pancreatitis-Associated Acute Lung Injury via Gut Microbiota: Targeting the Short-Chain Fatty Acids-Mediated AMPK/NF-κB/NLRP3 Pathway

Author

Wang, Zhengjian, primary, Liu, Jin, additional, Li, Fan, additional, Ma, Shurong, additional, Zhao, Liang, additional, Ge, Peng, additional, Wen, Haiyun, additional, Zhang, Yibo, additional, Liu, Xiaojun, additional, Luo, Yalan, additional, Yao, Jiaqi, additional, Zhang, Guixin, additional, and Chen, Hailong, additional

Published
2023
Full Text
View/download PDF

22. An Optimized Trivalent Chromium Conversion Coating Process for AA2024-T351 Alloy

Author

Qi, Jiantao, Gao, Lei, Li, Y., Wang, Zhengjian, Thompson, George, and Skeldon, Peter

Subjects
Corrosion protection, Electrochemical noise, Coating process, AA2024 alloy, Electrochemical Impedance
Abstract

In this work, a trivalent chromium conversion coating applied on AA2024-T351 alloy has been optimized for corrosion protection in sodium chloride solutions. Scanning electron microscopy, energy dispersive X-ray spectroscopy and electrochemical measurements were employed to characterize the coating. An immersion post-treatment of the coated alloy in 40 ºC deionized water for 120 s considerably enhanced the corrosion protection properties, compared with a post treatment at 20 °C, or the absence of a post-treatment. Electrochemical noise measurements, combined with real time imaging, and potentiodynamic polarization experiments indicated a conversion treatment for 300 or 600 s provides optimal corrosion protection. Relatively long conversion treatments decreased the corrosion protection due to an increase in coating defects and cracks, especially around the second-phase particles.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results