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Your search keyword '"Wei, Yun-Peng"' showing total 28 results
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28 results on '"Wei, Yun-Peng"'

4. Human Plasma IgG N -Glycome Profiles Reveal a Proinflammatory Phenotype in Chronic Thromboembolic Pulmonary Hypertension

Author

Zhang, Ze-Jian, primary, Wang, Hui-Fang, additional, Lian, Tian-Yu, additional, Zhou, Yu-Ping, additional, Xu, Xi-Qi, additional, Guo, Fan, additional, Wei, Yun-Peng, additional, Li, Jing-Yi, additional, Sun, Kai, additional, Liu, Chao, additional, Pan, Lu-Rong, additional, Ren, Ming, additional, Nie, Lei, additional, Dai, Hai-Long, additional, and Jing, Zhi-Cheng, additional

Published
2023
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5. Clonal Hematopoiesis of Indeterminate Potential in Patients with Chronic Thromboembolic Pulmonary Hypertension

Author

Liu, Chao, primary, Cheng, Chun-Yan, additional, Lian, Tian-Yu, additional, Zhou, Yu-Ping, additional, Yang, Yin-Jian, additional, Zhang, Si-Jin, additional, Wei, Yun-Peng, additional, Zhu, Yong-Jian, additional, Qiu, Lu-Hong, additional, Qiu, Bao-Chen, additional, Ren, Li-Yan, additional, Ma, Jing-Si, additional, Li, Ruo-Nan, additional, Wang, Jia, additional, Shen, Ying-Hui-Zi, additional, Han, Zhi-Yan, additional, Li, Jing-Hui, additional, Zhao, Qin-Hua, additional, Wang, Lan, additional, XU, XI-Qi, additional, Sun, Kai, additional, Wang, Duolao, additional, Zhang, Zejian, additional, and Jing, Zhi-Cheng, additional

Published
2023
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11. Human Plasma Immunoglobulin G N-Glycome Profiles Reveal a Pro-Inflammatory Phenotype in Chronic Thromboembolic Pulmonary Hypertension: A Cross-Sectional Study of Two Independent Cohorts

Author

Zhang, Zejian, primary, Wang, Hui-Fang, additional, Lian, Tian-Yu, additional, Zhou, Yu-Ping, additional, Xu, Xi-Qi, additional, Guo, Fan, additional, Wei, Yun-Peng, additional, Li, Jing-Yi, additional, Sun, Kai, additional, Liu, Chao, additional, Pan, Lu-Rong, additional, Ren, Ming, additional, Nie, Lei, additional, Dai, Hai-Long, additional, and Jing, Zhi-Cheng, additional

Published
2023
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13. Calcium Sensing Receptor Variants Increase Pulmonary Hypertension Susceptibility

Author

Liu, Bingxun, primary, Wei, Yun-Peng, additional, Fan, Xiaohang, additional, Hu, Xiaoyi, additional, Chen, Zeshuai, additional, Liu, Xiaoyuan, additional, Xu, Yan, additional, Wang, Lu, additional, Wang, Tao, additional, Ruiz, Matthieu, additional, Dupuis, Jocelyn, additional, Yuan, Ping, additional, Liu, Jinming, additional, Huang, Songling, additional, Zhu, Liping, additional, Jing, Zhi-Cheng, additional, and Hu, Qinghua, additional

Published
2022
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21. Effects of Carbopol® 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Author

Zheng, Yin, Ouyang, Wu-Qing, Wei, Yun-Peng, Syed, Shahid Faraz, Hao, Chao-Shuang, Wang, Bo-Zhen, and Shang, Yan-Hong

Subjects
Male, integumentary system, topical drug delivery, Administration, Topical, Skin Absorption, Guinea Pigs, nanoemulsion, Administration, Cutaneous, transdermal drug delivery, Permeability, Nanomedicine, Acrylates, Animals, nanoemulsion gel, Emulsions, Gels, Carbopol 934 proportion, Original Research, Skin
Abstract

Nanoemulsions (NEs) are used as transdermal drug delivery systems for systematic therapeutic purposes. We hypothesized that the skin permeation profile of an NE could be modulated by incorporating it into a hydrogel containing differing proportions of thickening agent. The objectives of this study were as follows: 1) to determine the stability and skin irritability of NE gels (NGs) containing 1%, 2%, and 3% (w/w) Carbopol® 934 (CP934) (termed NG1, NG2, and NG3, respectively); 2) to compare the skin permeation profiles and drug deposition patterns of the NGs; and 3) to visualize the drug delivery routes of the NGs. Terbinafine and citral were incorporated into the NGs as model drugs. Ex vivo skin permeation tests indicated that the percutaneous flux rates of terbinafine decreased in the order NE (215 μg/cm2) > NG1 (213 μg/cm2) > NG2 (123 μg/cm2) > NG3 (74.3 μg/cm2). The flux rates of citral decreased in the order NE (1,026 μg/cm2) > NG1 (1,021 μg/cm2) > NG2 (541 μg/cm2) > NG3 (353 μg/cm2). The NGs accumulated greater amounts of the drugs in the stratum corneum and less in the epidermis/dermis than did the NE (P

Published
2016

23. Comprehensive analysis of the clinical significance and prospective molecular mechanisms of differentially expressed autophagy-related genes in thyroid cancer

Author

Lin, Peng, primary, He, Yun, additional, Wen, Dong-Yue, additional, Li, Xiao-Jiao, additional, Zeng, Jing-Jing, additional, Mo, Wei-Jia, additional, Li, Qing, additional, Peng, Jin-Bo, additional, Wu, Yu-Quan, additional, Pan, Deng-Hua, additional, Li, Hai-Yuan, additional, Mo, Qiu-Yan, additional, Wei, Yun-Peng, additional, Yang, Hong, additional, and Chen, Gang, additional

Published
2018
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26. Effects of Carbopol® 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Author

Zheng,Yin, Ouyang,Wu-Qing, Wei,Yun-Peng, Syed,Shahid, Hao,Chao-Shuang, Wang,Bo-Zhen, Shang,Yan-Hong, Zheng,Yin, Ouyang,Wu-Qing, Wei,Yun-Peng, Syed,Shahid, Hao,Chao-Shuang, Wang,Bo-Zhen, and Shang,Yan-Hong

Abstract

Yin Zheng,1 Wu-Qing Ouyang,1 Yun-Peng Wei,1 Shahid Faraz Syed,2,3 Chao-Shuang Hao,1 Bo-Zhen Wang,4 Yan-Hong Shang1,5 1Department of Basic Veterinary Sciences, College of Veterinary Medicine, 2Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi; 3Faculty of Veterinary and Animal Sciences, Lasbella University of Agriculture Water and Marine Sciences, Uthal Baluchistan, Pakistan; 4College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, 5College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China Abstract: Nanoemulsions (NEs) are used as transdermal drug delivery systems for systematic therapeutic purposes. We hypothesized that the skin permeation profile of an NE could be modulated by incorporating it into a hydrogel containing differing proportions of thickening agent. The objectives of this study were as follows: 1) to determine the stability and skin irritability of NE gels (NGs) containing 1%, 2%, and 3% (w/w) Carbopol® 934 (CP934) (termed NG1, NG2, and NG3, respectively); 2) to compare the skin permeation profiles and drug deposition patterns of the NGs; and 3) to visualize the drug delivery routes of the NGs. Terbinafine and citral were incorporated into the NGs as model drugs. Ex vivo skin permeation tests indicated that the percutaneous flux rates of terbinafine decreased in the order NE (215 µg/cm2) > NG1 (213 µg/cm2) > NG2 (123 µg/cm2) > NG3 (74.3 µg/cm2). The flux rates of citral decreased in the order NE (1,026 µg/cm2) > NG1 (1,021 µg/cm2) > NG2 (541 µg/cm2) > NG3 (353 µg/cm2). The NGs accumulated greater amounts of the drugs in the stratum corneum and less in the epidermis/dermis than did the NE (P<0.05)

Published
2016

27. Identification of Noncoding Functional Regulatory Variants of STIM1 Gene in Idiopathic Pulmonary Arterial Hypertension.

Author

Liu B, Wen CJ, Zhou G, Wei YP, Wu Z, Zhang T, Zhou Y, Qiu S, Wang T, Ruiz M, Dupuis J, Yuan P, Liu J, Zhu L, Jing ZC, and Hu Q

Subjects
Humans, Male, Female, Case-Control Studies, Middle Aged, Adult, Neoplasm Proteins genetics, Myocytes, Smooth Muscle metabolism, Familial Primary Pulmonary Hypertension genetics, Familial Primary Pulmonary Hypertension physiopathology, Genetic Predisposition to Disease, Muscle, Smooth, Vascular metabolism, Gene Expression Regulation, Cell Proliferation genetics, Polymorphism, Single Nucleotide, Stromal Interaction Molecule 1 genetics, Stromal Interaction Molecule 1 metabolism, Pulmonary Artery
Abstract

Background: STIM1 (stromal interaction molecule 1) regulates store-operated calcium entry and is involved in pulmonary artery vasoconstriction and pulmonary artery smooth muscle cell proliferation, leading to pulmonary arterial hypertension (PAH)., Methods: Bioinformatics analysis and a 2-stage matched case-control study were conducted to screen for noncoding variants that may potentially affect STIM1 transcriptional regulation in 242 patients with idiopathic PAH and 414 healthy controls. Luciferase reporter assay, real-time quantitative polymerase chain reaction, western blot, 5-ethynyl-2'-deoxyuridine (EdU) assay, and intracellular Ca 2+ measurement were performed to study the mechanistic roles of those STIM1 noncoding variants in PAH., Results: Five noncoding variants (rs3794050, rs7934581, rs3750996, rs1561876, and rs3750994) were identified and genotyped using Sanger sequencing. Rs3794050, rs7934581, and rs1561876 were associated with idiopathic PAH (recessive model, all P <0.05). Bioinformatics analysis showed that these 3 noncoding variants possibly affect the enhancer function of STIM1 or the microRNA (miRNA) binding to STIM1 . Functional validation performed in HEK293 and pulmonary artery smooth muscle cells demonstrated that the noncoding variant rs1561876-G ( STIM1 mutant) had significantly stronger transcriptional activity than the wild-type counterpart, rs1561876-A, by affecting the transcriptional regulatory function of both hsa-miRNA-3140-5p and hsa-miRNA-4766-5p. rs1561876-G enhanced intracellular Ca 2+ signaling in human pulmonary artery smooth muscle cells secondary to calcium-sensing receptor activation and promoted proliferation of pulmonary artery smooth muscle cells under both normoxia and hypoxia conditions, suggesting a possible contribution to PAH development., Conclusions: The potential clinical implications of the 3 noncoding variants of STIM1 , rs3794050, rs7934581, and rs1561876, are 2-fold, as they may help predict the risk and prognosis of idiopathic PAH and guide investigations on novel therapeutic pathway(s)., Competing Interests: None.

Published
2024
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28. Effects of Carbopol ® 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study.

Author

Zheng Y, Ouyang WQ, Wei YP, Syed SF, Hao CS, Wang BZ, and Shang YH

Subjects
Administration, Cutaneous, Administration, Topical, Animals, Emulsions, Gels, Guinea Pigs, Male, Permeability, Skin cytology, Skin Absorption, Acrylates chemistry, Acrylates metabolism, Nanomedicine, Skin metabolism
Abstract

Nanoemulsions (NEs) are used as transdermal drug delivery systems for systematic therapeutic purposes. We hypothesized that the skin permeation profile of an NE could be modulated by incorporating it into a hydrogel containing differing proportions of thickening agent. The objectives of this study were as follows: 1) to determine the stability and skin irritability of NE gels (NGs) containing 1%, 2%, and 3% (w/w) Carbopol ® 934 (CP934) (termed NG1, NG2, and NG3, respectively); 2) to compare the skin permeation profiles and drug deposition patterns of the NGs; and 3) to visualize the drug delivery routes of the NGs. Terbinafine and citral were incorporated into the NGs as model drugs. Ex vivo skin permeation tests indicated that the percutaneous flux rates of terbinafine decreased in the order NE (215 μg/cm 2 ) > NG1 (213 μg/cm 2 ) > NG2 (123 μg/cm 2 ) > NG3 (74.3 μg/cm 2 ). The flux rates of citral decreased in the order NE (1,026 μg/cm 2 ) > NG1 (1,021 μg/cm 2 ) > NG2 (541 μg/cm 2 ) > NG3 (353 μg/cm 2 ). The NGs accumulated greater amounts of the drugs in the stratum corneum and less in the epidermis/dermis than did the NE ( P <0.05) over a period of 12 h. Laser scanning confocal microscopy indicated that the NGs altered the main drug delivery routes from skin appendages to intercellular paths. Histological images suggested that perturbations to the skin structure, specifically the size of the epidermal intercellular spaces and the separation distance of dermal collagen bundles, could be significantly minimized by increasing the proportion of CP934. These results suggest that adjustments of the CP934 proportions can be used to modulate the skin permeation profiles of NGs for specific therapeutic purposes., Competing Interests: The authors report no conflicts of interest in this work.

Published
2016
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