Search

Additional file 1: Supplementary Figure 1. GO Enrichment pathway associated with cellular component, and biological process. Supplementary Figure 2. The differentially expression of 10 plasma protein candidates among three groups. Supplementary Figure 3. The differentially expression of 14 serum amino acids among three groups. Supplementary Figure 4. The differentially expression of 15 bile acids among three groups. Supplementary Figure 5. The differentially expression of six classic tumor markers among three groups. Supplementary Figure 6. Proteins and amnio acids related to NSCLC stage. Supplementary Figure 7. Single index with AUC>0.7 for NSCLC screening. Supplementary Figure 8. Single index with AUC>0.7 in differentiating NSCLC and BPD. Supplementary Figure 9.The process and the result of binary logistic regression with backward elimination methods. Supplementary Table 1. Screened differentially expressed proteins and corresponding validation proteins. Supplementary Table 2. Performance of single predictor in NSCLC screening. Supplementary Table 3. Performance of single predictor in NSCLC diagnosis. Supplementary Table 4. Screening model by stepwise binary logistic regression analysis in training samples. Supplementary Table 5. Performance analysis of 3 models in screening NSCLC. Supplementary Table 6. Testing of 3 models in screening NSCLC. Supplementary Table 7. Diagnosis model by stepwise binary logistic regression analysis in training samples. Supplementary Table 8. Performance analysis of 3 models in differentiating NSCLC and BPD. Supplementary Table 9. Testing of 3 models in differentiating NSCLC and BPD. Supplementary Table 10. The concentration units of these candidates.

Additional file 1: Table S1. The sequences of primers, siRNA and mimics or inhibitor used in this study.

Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of the disease, NPP still presents a major diagnostic and therapeutic challenge. High mobility group box 1 (HMGB1) mediates inflammatory and immune reactions in nervous system and emerging evidence reveals that HMGB1 plays an essential role in neuroinflammation through receptors such as Toll-like receptors (TLR), receptor for advanced glycation end products (RAGE), C-X-X motif chemokines receptor 4 (CXCR4), and N-methyl-D-aspartate (NMDA) receptor. In this review, we present evidence from studies that address the role of HMGB1 in NPP. First, we review studies aimed at determining the role of HMGB1 in NPP and discuss the possible mechanisms underlying HMGB1-mediated NPP progression where receptors for HMGB1 are involved. Then we review studies that address HMGB1 as a potential therapeutic target for NPP.

Inflamm-aging is a challenging and promising new branch of aging-related research fields that includes areas such as immunosenescence. Increasing evidence indicates that inflamm-aging is intensively associated with many aging diseases, such as Alzheimer’s disease, atherosclerosis, heart disease, type II diabetes, and cancer. Mounting studies have focused on the role of inflamm-aging in disease progression and many advances have been made in the last decade. However, the underlying mechanisms by which inflamm-aging affects pathological changes and disease development are still unclear. Here, we review studies of inflamm-aging that explore the concept, pathological features, mechanisms, intervention, and the therapeutic strategies of inflamm-aging in disease progression.

Lung cancer is the major cause of cancer death worldwide. Novel, recently discovered classes of noncoding RNAs (ncRNAs) have diverse functional and regulatory activities and increasing evidence suggests crucial roles for deregulated ncRNAs in the onset and progression of cancer, including lung cancer. Exosomes are small extracellular membrane vesicles of endocytic origin that are released by many cells and are found in most body fluids. Tumor-derived exosomes mediate tumorigenesis by facilitating tumor growth and metastasis. MicroRNAs (miRNAs) are a subclass of ncRNAs that are present in exosomes. miRNAs are taken up by neighboring or distant cells and modulate various functions of recipient cells. Here, we review exosome-derived ncRNAs with a focus on miRNAs and their role in lung cancer biology.