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Your search keyword '"Xu, Hong-Xi"' showing total 258 results
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258 results on '"Xu, Hong-Xi"'

18. Autophagy Regulators in Cancer

Author

Zhang, Juan, primary, Xiang, Qian, additional, Wu, Man, additional, Lao, Yuan-Zhi, additional, Xian, Yan-Fang, additional, Xu, Hong-Xi, additional, and Lin, Zhi-Xiu, additional

Published
2023
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21. Ginsenoside Rg1 mitigates cerebral ischaemia/reperfusion injury in mice by inhibiting autophagy through activation of mTOR signalling

Author

Xi, Zhi-chao, Ren, Han-gui, Ai, Lin, Wang, Yuan, Liu, Meng-fan, Qiu, Yu-fei, Feng, Ji-ling, Fu, Wang, Bi, Qian-qian, Wang, Feng, and Xu, Hong-xi

Abstract

Reperfusion injury, which is distinct from ischaemic injury, occurs when blood flow is restored in previously ischaemic brain tissue, further compromising neurons and other cells and worsening the injury. There is currently a lack of pharmaceutical agents and therapeutic interventions that specifically mitigate cerebral ischaemia/reperfusion (I/R) injury. Ginsenoside Rg1 (Rg1), a protopanaxatriol-type saponin isolated from Panax ginsengC. A. Meyer, has been found to protect against cerebral I/R injury, but its intricate protective mechanisms remain to be elucidated. Numerous studies have shown that autophagy plays a crucial role in protecting brain tissue during the I/R process and is emerging as a promising therapeutic strategy for effective treatment. In this study, we investigated whether Rg1 protected against I/R damage in vitro and in vivo by regulating autophagy. Both MCAO and OGD/R models were established. SK-N-AS and SH-SY5Y cells were subjected to OGD followed by reperfusion with Rg1 (4–32 μM). MCAO mice were injected with Rg1 (30 mg·kg−1·d−1. i.p.) for 3 days before and on the day of surgery. Rg1 treatment significantly mitigated ischaemia/reperfusion injury both in vitro and in vivo. Furthermore, we demonstrated that the induction of autophagy contributed to I/R injury, which was effectively inhibited by Rg1 in both in vitro and in vivo models of cerebral I/R injury. Rg1 inhibited autophagy through multiple steps, including impeding autophagy initiation, inducing lysosomal dysfunction and inhibiting cathepsin enzyme activities. We revealed that mTOR activation was pivotal in mediating the inhibitory effect of Rg1 on autophagy. Treatment with Torin-1, an autophagy inducer and mTOR-specific inhibitor, significantly reversed the impact of Rg1 on autophagy, decreasing its protective efficacy against I/R injury both in vitro and in vivo. In conclusion, our results suggest that Rg1 may serve as a promising drug candidate against cerebral I/R injury by inhibiting autophagy through activation of mTOR signalling.

Published
2024
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22. A novel method for age identification of mountain‐cultivated ginseng.

Author

Zhang, Gong‐Min, Huang, Qing, Chen, Gan, Yuan, Man, Zheng, Chang‐Wu, Zhang, Hong‐Mei, and Xu, Hong‐Xi

Abstract

Panax ginseng, a slow‐growing perennial herb, is the most praised and popular traditional medicinal herb. Mountain‐cultivated ginseng (MCG) and cultivated ginseng (CG) both belong to Panax ginseng C. A. Meyer. The market price and medical effects of this popular health product are closely related to its age. It is widely acknowledged that CG is typically harvested after 4–6 years of growth, but MCG is often collected after 10 years. Until now, the age identification of MCG or mountain wild ginseng (MWG) has remained a major challenge. In this study, we established a novel and rapid method for staining xylem vessels with phloroglucinol and identifying the "annual growth rings" of ginseng by utilizing a stereoscope, which serves as a reliable indicator of the age of MCG. Statistical analysis of the ring radius and the ring density of MCG aged from 1 to 20 years shows that the secondary xylem of MCG increases rapidly in the first 3 years but then gradually slows down from 4 to 10 years, and minor fluctuation is observed in the next 10 years. Meanwhile, the space between the growth rings (ring density) becomes increasingly small with age. This straightforward staining approach can reveal the age of MCG with remarkable clarity and can distinguish MCG from CG. Research Highlights: A novel rapid staining method for Panax ginseng was established.The age of mountain‐cultivated ginseng (MCG) can be identified by microscopic techniques.MCG and cultivated ginseng (CG) can be discriminated by microstructure characteristics. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Synergistic Anti‐Tumor Effect of Toosendanin and Paclitaxel on Triple‐Negative Breast Cancer via Regulating ADORA2A‐EMT Related Signaling.

Author

Zhang, Juan, Xu, Hong‐Xi, Wu, Yu‐Lin, Cho, William Chi Shing, Xian, Yan‐Fang, and Lin, Zhi‐Xiu

Abstract

Triple negative breast cancer (TNBC) is an aggressive cancer with very poor prognosis. Combination therapy has proven to be a promising strategy for enhancing TNBC treatment efficacy. Toosendanin (TSN), a plant‐derived triterpenoid, has shown pleiotropic effects against a variety of tumors. Herein, it is evaluated whether TSN can enhance the efficacy of paclitaxel (PTX), a common chemotherapeutic agent, against TNBC. It is found that TSN and PTX synergistically suppress the proliferation of TNBC cell lines such as MDA‐MB‐231 and BT‐549, and the combined treatment also inhibits the colony formation and induces cell apoptosis. Furthermore, this combination shows more marked migratory inhibition when compared to PTX alone. Mechanistic study shows that the ADORA2A pathway in TNBC is down‐regulated by the combination treatment via mediating epithelial‐to‐mesenchymal transition (EMT) process. In addition, the combined treatment of TSN and PTX significantly attenuates the tumor growth when compared to PTX monotherapy in a mouse model bearing 4T1 tumor. The results suggest that combination of TSN and PTX is superior to PTX alone, suggesting that it may be a promising alternative adjuvant chemotherapy strategy for patients with TNBC, especially those with metastatic TNBC. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Additional file 1 of Brucein D augments the chemosensitivity of gemcitabine in pancreatic cancer via inhibiting the Nrf2 pathway

Author

Zhang, Juan, Xu, Hong-Xi, Cho, William Chi Shing, Cheuk, Wah, Li, Yang, Huang, Qiong-Hui, Yang, Wen, Xian, Yan-Fang, and Lin, Zhi-Xiu

Abstract

Additional file 1: Figure S1. Nrf2 is overexpressed in PDAC and in GEM treated PDAC cells. Figure S2. Toxicological evaluation of BD combined with GEM in KPC mouse model. Figure S3. BD inhibits the Nrf2 activity. Figure S4. knockdown of Nrf2 enhances the chemosensitivity of GEM in PDAC. Figure S5. Activation of Nrf2 enhances the chemosensitivity of GEM in PDAC cells.

Published
2022
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45. Additional file 1 of Prevalence of mental health problems in frontline healthcare workers after the first outbreak of COVID-19 in China: a cross-sectional study

Author

Guo, Wen-Ping, Min, Qing, Gu, Wei-Wei, Yu, Liang, Xiao, Xiao, Yi, Wei-Bing, Li, Hong-Liang, Huang, Bei, Li, Jun-Li, Dai, Ya-Jun, Xia, Jian, Liu, Jie, Li, Bei, Zhou, Ben-Hong, Minglun Li, Xu, Hong-Xi, Wang, Xuan-Bin, and Shi, Wen-Yuan

Abstract

Additional file 1: Table S1. Sex, occupation and geographic data of nonrespondents.

Published
2021
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