Search

Your search keyword '"Yan, Chaoguo"' showing total 194 results
Start Over Author "Yan, Chaoguo" Publication Year Range Last 10 years
194 results on '"Yan, Chaoguo"'

14. Metal-Free Directed C–H Borylation of Indoles at the Sterically Congested C2 Position.

Author

Jiang, Wang, Bai, Jingyi, Lv, Jiahang, Zhao, Yue, Yan, Chaoguo, and Shi, Zhuangzhi

Subjects
BORYLATION, INDOLE compounds, INDOLE, SERVER farms (Computer network management), BENZYL group, INDOLE alkaloids
Abstract

[17] In this context, the development of efficient and mild methods for indole borylation has attracted increasing attention for research on the preparation of complex indoles. Although the use of a 1-adamantanoyl group can provide the desired indole C-H borylation products with high reactivity and selectivity, removing the directing group requires additional steps (Figure 4). Keywords: C-H bond activation; borylation; indoles; BBr 3; site selectivity; metal-free reaction EN C-H bond activation borylation indoles BBr 3 site selectivity metal-free reaction 2220 2226 7 10/31/23 20231127 NES 231127 Graph The indole ring system is one the most common heterocycles, present in many natural products and pharmaceuticals. [22] C2-Borylated indoles are versatile synthetic intermediates used to build 2,3-disubstituted indole skeletons as key intermediates in total syntheses of natural products and pharmaceuticals (Figure 1 A). [Extracted from the article]

Published
2023
Full Text
View/download PDF

22. Pillar[5]arene based water-soluble [3]pseudorotaxane with enhanced fluorescence emission for cell imaging and both type I and II photodynamic cancer therapy.

Author

Zhang, Yue, Wang, Yang, Chen, Tingting, Han, Ying, Yan, Chaoguo, Wang, Jin, Lu, Bing, Ma, Longtao, Ding, Yue, and Yao, Yong

Subjects
CELL imaging, PHOTODYNAMIC therapy, CANCER treatment, FLUORESCENCE
Abstract

Water-soluble [3]pseudorotaxane with enhanced fluorescence emission was successfully constructed and applied in cell imaging and photodynamic cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

50. Ammonium and imidazolium-based amphiphilic tetramethoxy resorcinarenes: Adsorption, micellization, and protein binding

Author

Yan Chaoguo, Liu Dongmei, Jing Wang, and Xia Guo

Subjects
chemistry.chemical_classification, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, Surface tension, Adsorption, Pulmonary surfactant, chemistry, Critical micelle concentration, Amphiphile, Polymer chemistry, Calixarene, Materials Chemistry, Physical and Theoretical Chemistry, Absorption (chemistry), 0210 nano-technology, Spectroscopy, Alkyl
Abstract

To date, the knowledge about the properties of calixarene-based surfactants have been limited although it is hypothesized that the calixarene framework may endow calixarene-based surfactants with unique properties. In the present study, the adsorption and micellization behaviors of amphiphilic calix[4]resorcinarenes and their interactions with proteins were studied by various techniques, including surface tension measurement and fluorescence, UV–vis absorption, and 1H NMR spectroscopy; the amphiphilic calix[4]resorcinarenes were obtained by modifying tetramethoxyresorcinarenes with ammonium and imidazolium groups on the upper rim and alkyl groups on the opposite rim. We found that a tetramethoxyresorcinarene with a very short alkyl chain exhibited good surface activity and the critical micelle concentration (cmc) was much lower than that for the conventional surfactant having a long alkyl chain. Moreover, the cmc and saturated adsorption values (Γmax) decreased but the surface tension (γ) at the cmc (γcmc) and single molecular cross-sectional area (Amin) increased with increasing alkyl chain length. In the presence of proteins, the surface tension remained unchanged at less than stoichiometric tetramethoxyresorcinarene concentrations; however, at higher tetramethoxyresorcinarene concentrations, the surface tension began to decrease drastically, much faster than the case without protein. In addition, the binding of the tetramethoxyresorcinarene to the protein increased the protein activity, and the degree of enhancement in the protein activity was closely related to the protein structure. The molecular simulations further explained the binding modes of the tetramethoxyresorcinarenes to the protein.

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results