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318 results on '"Yeung, Sai-Ching J."'

4. Cardiovascular events after cancer immunotherapy as oncologic emergencies: Analyses of 610 head and neck cancer patients treated with immune checkpoint inhibitors

Author

Reyes‐Gibby, Cielito C., primary, Qdaisat, Aiham, additional, Ferrarotto, Renata, additional, Fadol, Anecita, additional, Bischof, Jason J., additional, Coyne, Christopher J., additional, Lipe, Demis N., additional, Hanna, Ehab Y., additional, Shete, Sanjay, additional, Abe, Jun‐Ichi, additional, and Yeung, Sai‐Ching J., additional

Published
2023
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5. Obesity-associated NLRC4 inflammasome activation drives breast cancer progression.

Author

Kolb, Ryan, Phan, Liem, Borcherding, Nicholas, Liu, Yinghong, Yuan, Fang, Janowski, Ann M, Xie, Qing, Markan, Kathleen R, Li, Wei, Potthoff, Matthew J, Fuentes-Mattei, Enrique, Ellies, Lesley G, Knudson, C Michael, Lee, Mong-Hong, Yeung, Sai-Ching J, Cassel, Suzanne L, Sutterwala, Fayyaz S, and Zhang, Weizhou

Subjects
Breast, Lymphocytes, Tumor-Infiltrating, Cell Line, Tumor, Myeloid Cells, Animals, Mice, Inbred C57BL, Humans, Mice, Breast Neoplasms, Mammary Neoplasms, Experimental, Obesity, Disease Progression, Vascular Endothelial Growth Factor A, Calcium-Binding Proteins, Neoplasm Transplantation, Signal Transduction, Female, Apoptosis Regulatory Proteins, Interleukin-1beta, CARD Signaling Adaptor Proteins, Inflammasomes, Breast Cancer, Nutrition, Cancer, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Cardiovascular, Lymphocytes, Tumor-Infiltrating, Cell Line, Tumor, Inbred C57BL, Mammary Neoplasms, Experimental
Abstract

Obesity is associated with an increased risk of developing breast cancer and is also associated with worse clinical prognosis. The mechanistic link between obesity and breast cancer progression remains unclear, and there has been no development of specific treatments to improve the outcome of obese cancer patients. Here we show that obesity-associated NLRC4 inflammasome activation/ interleukin (IL)-1 signalling promotes breast cancer progression. The tumour microenvironment in the context of obesity induces an increase in tumour-infiltrating myeloid cells with an activated NLRC4 inflammasome that in turn activates IL-1β, which drives disease progression through adipocyte-mediated vascular endothelial growth factor A (VEGFA) expression and angiogenesis. Further studies show that treatment of mice with metformin inhibits obesity-associated tumour progression associated with a marked decrease in angiogenesis. This report provides a causal mechanism by which obesity promotes breast cancer progression and lays out a foundation to block NLRC4 inflammasome activation or IL-1β signalling transduction that may be useful for the treatment of obese cancer patients.

Published
2016

6. Cardiovascular events after cancer immunotherapy as oncologic emergencies: Analyses of 610 head and neck cancer patients treated with immune checkpoint inhibitors.

Author

Reyes‐Gibby, Cielito C., Qdaisat, Aiham, Ferrarotto, Renata, Fadol, Anecita, Bischof, Jason J., Coyne, Christopher J., Lipe, Demis N., Hanna, Ehab Y., Shete, Sanjay, Abe, Jun‐Ichi, and Yeung, Sai‐Ching J.

Subjects
IMMUNE checkpoint inhibitors, HEAD & neck cancer, DRUG side effects, CANCER patients, CARDIOTOXICITY, EMERGENCY contraceptives, IPILIMUMAB
Abstract

Background: Cardio‐oncology and emergency medicine are closely collaborative, as many cardiac events in cancer patients require evaluation and treatment in the emergency department (ED). Immune checkpoint inhibitors (ICIs) have become a common treatment for patients with head and neck cancer (HNC). However, the immune‐related adverse events (irAEs) from ICIs can be clinically significant. Methods: We reviewed and analyzed cardiovascular diagnoses among HNC patients who received ICI during the period April 1, 2016–December 31, 2020 in a large tertiary cancer center. Demographics, clinical and cancer‐related data were abstracted, and billing databases were queried for cardiovascular disease (CVD)‐related diagnosis using International Classification of Disease‐version10 (ICD‐10) codes. We recorded receipt of care at the ED as one of the outcome variables. Results: A total of 610 HNC patients with a median follow‐up time of 12.3 months (median, interquartile range = 5–30 months) comprised our study cohort. Overall, 25.7% of patients had pre‐existing CVD prior to ICI treatment. Of the remaining 453 patients without pre‐existing CVD, 31.5% (n = 143) had at least one CVD‐related diagnosis after ICI initiation. Tachyarrhythmias (91 new events) was the most frequent CVD‐related diagnosis after ICI. The time to diagnosis of myocarditis from initiation of ICI occurred the earliest (median 2.5 months, 1.5–6.8 months), followed by myocardial infarction (3.7, 0.5–9), cardiomyopathy (4.5, 1.6–7.3), and tachyarrhythmias (4.9, 1.2–11.4). Patients with myocarditis and tachyarrhythmias mainly presented to the ED for care. Conclusion: The use of ICI in HNC is still expanding and the spectrum of delayed manifestation of ICI‐induced cardiovascular toxicities is yet to be fully defined in HNC survivors. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Hemoptysis in Cancer Patients

Author

Singer, Emad D., primary, Faiz, Saadia A., additional, Qdaisat, Aiham, additional, Abdeldaem, Karim, additional, Dagher, Jim, additional, Chaftari, Patrick, additional, and Yeung, Sai-Ching J., additional

Published
2023
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10. Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights

Author

Jain, Ashita, primary, Casanova, Diego, additional, Padilla, Alejandra Valdivia, additional, Paniagua Bojorges, Angelica, additional, Kotla, Sivareddy, additional, Ko, Kyung Ae, additional, Samanthapudi, Venkata S. K., additional, Chau, Khanh, additional, Nguyen, Minh T. H., additional, Wen, Jake, additional, Hernandez Gonzalez, Selina L., additional, Rodgers, Shaefali P., additional, Olmsted-Davis, Elizabeth A., additional, Hamilton, Dale J., additional, Reyes-Gibby, Cielito, additional, Yeung, Sai-Ching J., additional, Cooke, John P., additional, Herrmann, Joerg, additional, Chini, Eduardo N., additional, Xu, Xiaolei, additional, Yusuf, Syed Wamique, additional, Yoshimoto, Momoko, additional, Lorenzi, Philip L., additional, Hobbs, Brain, additional, Krishnan, Sunil, additional, Koutroumpakis, Efstratios, additional, Palaskas, Nicolas L., additional, Wang, Guangyu, additional, Deswal, Anita, additional, Lin, Steven H., additional, Abe, Jun-ichi, additional, and Le, Nhat-Tu, additional

Published
2023
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11. Metabolic and Endocrine Oncologic Emergencies

Author

Yeung, Sai-Ching J., Liu, Wenli, Buzdar, Aman U., Series editor, Freedman, Ralph S., Series editor, Manzullo, Ellen F., editor, Gonzalez, Carmen Esther, editor, Escalante, Carmen P., editor, and Yeung, Sai-Ching J., editor

Published
2016
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12. Attempts to Understand Oral Mucositis in Head and Neck Cancer Patients through Omics Studies: A Narrative Review.

Author

San Valentin, Erin Marie D., Do, Kim-Anh, Yeung, Sai-Ching J., and Reyes-Gibby, Cielito C.

Subjects
HEAD & neck cancer, CANCER patients, MUCOSITIS, TRANSCRIPTOMES, SQUAMOUS cell carcinoma, ORAL mucosa
Abstract

Oral mucositis (OM) is a common and clinically impactful side effect of cytotoxic cancer treatment, particularly in patients with head and neck squamous cell carcinoma (HNSCC) who undergo radiotherapy with or without concomitant chemotherapy. The etiology and pathogenic mechanisms of OM are complex, multifaceted and elicit both direct and indirect damage to the mucosa. In this narrative review, we describe studies that use various omics methodologies (genomics, transcriptomics, microbiomics and metabolomics) in attempts to elucidate the biological pathways associated with the development or severity of OM. Integrating different omics into multi-omics approaches carries the potential to discover links among host factors (genomics), host responses (transcriptomics, metabolomics), and the local environment (microbiomics). [ABSTRACT FROM AUTHOR]

Published
2023
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13. An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis

Author

Abe, Jun-ichi, primary, Imanishi, Masaki, additional, Li, Shengyu, additional, Zhang, Aijun, additional, Ko, Kyung Ae, additional, Samanthapudi, Venkata S.K., additional, Lee, Ling-Ling, additional, Bojorges, Angelica Paniagua, additional, Gi, Young Jin, additional, Hobbs, Brian P., additional, Deswal, Anita, additional, Herrmann, Joerg, additional, Lin, Steven H., additional, Chini, Eduardo N., additional, Shen, Ying H., additional, Schadler, Keri L., additional, Nguyen, Thi-Hong-Minh, additional, Gupte, Anisha A., additional, Reyes-Gibby, Cielito, additional, Yeung, Sai-Ching J., additional, Abe, Rei J., additional, Olmsted-Davis, Elizabeth A., additional, Krishnan, Sunil, additional, Dantzer, Robert, additional, Palaskas, Nicolas L., additional, Cooke, John P., additional, Pownall, Henry J., additional, Yoshimoto, Momoko, additional, Fujiwara, Keigi, additional, Hamilton, Dale J., additional, Burks, Jared K., additional, Wang, Guangyu, additional, Le, Nhat-Tu, additional, and Kotla, Sivareddy, additional

Published
2023
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17. Efficacy and safety of the combination of metformin, everolimus and exemestane in overweight and obese postmenopausal patients with metastatic, hormone receptor-positive, HER2-negative breast cancer: a phase II study

Author

Yam, Clinton, Esteva, Francisco J., Patel, Miral M., Raghavendra, Akshara S., Ueno, Naoto T., Moulder, Stacy L., Hess, Kenneth R., Shroff, Girish S., Hodge, Silvia, Koenig, Kimberly H., Chavez Mac Gregor, Mariana, Griner, Robin L., Yeung, Sai-Ching J., Hortobagyi, Gabriel N., and Valero, Vicente

Published
2019
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20. Supplementary Video from Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors

Author

Bankson, James A., primary, Walker, Christopher M., primary, Ramirez, Marc S., primary, Stefan, Wolfgang, primary, Fuentes, David, primary, Merritt, Matthew E., primary, Lee, Jaehyuk, primary, Sandulache, Vlad C., primary, Chen, Yunyun, primary, Phan, Liem, primary, Chou, Ping-Chieh, primary, Rao, Arvind, primary, Yeung, Sai-Ching J., primary, Lee, Mong-Hong, primary, Schellingerhout, Dawid, primary, Conrad, Charles A., primary, Malloy, Craig, primary, Sherry, A. Dean, primary, Lai, Stephen Y., primary, and Hazle, John D., primary

Published
2023
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21. Supplementary Table from Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors

Author

Bankson, James A., primary, Walker, Christopher M., primary, Ramirez, Marc S., primary, Stefan, Wolfgang, primary, Fuentes, David, primary, Merritt, Matthew E., primary, Lee, Jaehyuk, primary, Sandulache, Vlad C., primary, Chen, Yunyun, primary, Phan, Liem, primary, Chou, Ping-Chieh, primary, Rao, Arvind, primary, Yeung, Sai-Ching J., primary, Lee, Mong-Hong, primary, Schellingerhout, Dawid, primary, Conrad, Charles A., primary, Malloy, Craig, primary, Sherry, A. Dean, primary, Lai, Stephen Y., primary, and Hazle, John D., primary

Published
2023
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22. Data from Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors

Author

Bankson, James A., primary, Walker, Christopher M., primary, Ramirez, Marc S., primary, Stefan, Wolfgang, primary, Fuentes, David, primary, Merritt, Matthew E., primary, Lee, Jaehyuk, primary, Sandulache, Vlad C., primary, Chen, Yunyun, primary, Phan, Liem, primary, Chou, Ping-Chieh, primary, Rao, Arvind, primary, Yeung, Sai-Ching J., primary, Lee, Mong-Hong, primary, Schellingerhout, Dawid, primary, Conrad, Charles A., primary, Malloy, Craig, primary, Sherry, A. Dean, primary, Lai, Stephen Y., primary, and Hazle, John D., primary

Published
2023
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24. Supplementary Data from Evaluation of Salivary Exosomal Chimeric GOLM1-NAA35 RNA as a Potential Biomarker in Esophageal Carcinoma

Author

Lin, Yusheng, primary, Dong, Hongmei, primary, Deng, Weilun, primary, Lin, Wan, primary, Li, Kai, primary, Xiong, Xiao, primary, Guo, Yi, primary, Zhou, Fuyou, primary, Ma, Changchun, primary, Chen, Yuping, primary, Ren, Hongzheng, primary, Yang, Haijun, primary, Dai, Ningtao, primary, Ma, Lang, primary, Meltzer, Stephen J., primary, Yeung, Sai-Ching J., primary, and Zhang, Hao, primary

Published
2023
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26. Supplementary Table Legend from Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma

Author

Phan, Liem M., primary, Fuentes-Mattei, Enrique, primary, Wu, Weixin, primary, Velazquez-Torres, Guermarie, primary, Sircar, Kanishka, primary, Wood, Christopher G., primary, Hai, Tao, primary, Jimenez, Camilo, primary, Cote, Gilbert J., primary, Ozsari, Levent, primary, Hofmann, Marie-Claude, primary, Zheng, Siyuan, primary, Verhaak, Roeland, primary, Pagliaro, Lance, primary, Cortez, Maria Angelica, primary, Lee, Mong-Hong, primary, Yeung, Sai-Ching J., primary, and Habra, Mouhammed Amir, primary

Published
2023
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28. Data from Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma

Author

Phan, Liem M., primary, Fuentes-Mattei, Enrique, primary, Wu, Weixin, primary, Velazquez-Torres, Guermarie, primary, Sircar, Kanishka, primary, Wood, Christopher G., primary, Hai, Tao, primary, Jimenez, Camilo, primary, Cote, Gilbert J., primary, Ozsari, Levent, primary, Hofmann, Marie-Claude, primary, Zheng, Siyuan, primary, Verhaak, Roeland, primary, Pagliaro, Lance, primary, Cortez, Maria Angelica, primary, Lee, Mong-Hong, primary, Yeung, Sai-Ching J., primary, and Habra, Mouhammed Amir, primary

Published
2023
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30. Supplementary Tables S1-S12 from Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma

Author

Phan, Liem M., primary, Fuentes-Mattei, Enrique, primary, Wu, Weixin, primary, Velazquez-Torres, Guermarie, primary, Sircar, Kanishka, primary, Wood, Christopher G., primary, Hai, Tao, primary, Jimenez, Camilo, primary, Cote, Gilbert J., primary, Ozsari, Levent, primary, Hofmann, Marie-Claude, primary, Zheng, Siyuan, primary, Verhaak, Roeland, primary, Pagliaro, Lance, primary, Cortez, Maria Angelica, primary, Lee, Mong-Hong, primary, Yeung, Sai-Ching J., primary, and Habra, Mouhammed Amir, primary

Published
2023
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31. Supplementary Figures S1-S6 from Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma

Author

Phan, Liem M., primary, Fuentes-Mattei, Enrique, primary, Wu, Weixin, primary, Velazquez-Torres, Guermarie, primary, Sircar, Kanishka, primary, Wood, Christopher G., primary, Hai, Tao, primary, Jimenez, Camilo, primary, Cote, Gilbert J., primary, Ozsari, Levent, primary, Hofmann, Marie-Claude, primary, Zheng, Siyuan, primary, Verhaak, Roeland, primary, Pagliaro, Lance, primary, Cortez, Maria Angelica, primary, Lee, Mong-Hong, primary, Yeung, Sai-Ching J., primary, and Habra, Mouhammed Amir, primary

Published
2023
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35. Radiation therapy induces immunosenescence mediated by p90RSK

Author

Imanishi, Masaki, primary, Cheng, Haizi, additional, Kotla, Sivareddy, additional, Deswal, Anita, additional, Le, Nhat-Tu, additional, Chini, Eduardo, additional, Ko, Kyung Ae, additional, Samanthapudi, Venkata S. K., additional, Lee, Ling-Ling, additional, Herrmann, Joerg, additional, Xu, Xiaolei, additional, Reyes-Gibby, Cielito, additional, Yeung, Sai-Ching J., additional, Schadler, Keri L., additional, Yusuf, Syed Wamique, additional, Liao, Zhongxing, additional, Nurieva, Roza, additional, Amir, El-ad David, additional, Burks, Jared K., additional, Palaskas, Nicolas L., additional, Cooke, John P., additional, Lin, Steven H., additional, Kobayashi, Michihiro, additional, Yoshimoto, Momoko, additional, and Abe, Jun-ichi, additional

Published
2022
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40. Neoantigen‐based cancer vaccination using chimeric RNA‐loaded dendritic cell‐derived extracellular vesicles

Author

Xiong, Xiao, primary, Ke, Xiurong, additional, Wang, Lu, additional, Lin, Yusheng, additional, Wang, Shuhong, additional, Yao, Zhimeng, additional, Li, Kai, additional, Luo, Yichen, additional, Liu, Fan, additional, Pan, Yunlong, additional, Yeung, Sai‐Ching J., additional, Helfrich, Wijnand, additional, and Zhang, Hao, additional

Published
2022
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43. Oncologic emergencies and urgencies: A comprehensive review

Author

Gould Rothberg, Bonnie E., primary, Quest, Tammie E., additional, Yeung, Sai‐Ching J., additional, Pelosof, Lorraine C., additional, Gerber, David E., additional, Seltzer, Justin A., additional, Bischof, Jason J., additional, Thomas, Charles R., additional, Akhter, Nausheen, additional, Mamtani, Mira, additional, Stutman, Robin E., additional, Baugh, Christopher W., additional, Anantharaman, Venkataraman, additional, Pettit, Nicholas R., additional, Klotz, Adam D., additional, Gibbs, Michael A., additional, and Kyriacou, Demetrios N., additional

Published
2022
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47. Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications

Author

Banerjee, Priyanka, primary, Olmsted-Davis, Elizabeth A., additional, Deswal, Anita, additional, Nguyen, Minh T. H., additional, Koutroumpakis, Efstratios, additional, Palaskas, Nicholas L., additional, Lin, Steven H., additional, Kotla, Sivareddy, additional, Reyes-Gibby, Cielito, additional, Yeung, Sai-Ching J., additional, Yusuf, Syed Wamique, additional, Yoshimoto, Momoko, additional, Kobayashi, Michihiro, additional, Yu, Bing, additional, Schadler, Keri, additional, Herrmann, Joerg, additional, Cooke, John P., additional, Jain, Abhishek, additional, Chini, Eduardo, additional, Le, Nhat-Tu, additional, and Abe, Jun-Ichi, additional

Published
2022
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48. The role of procalcitonin in identifying high‐risk cancer patients with febrile neutropenia: A useful alternative to the multinational association for supportive care in cancer score

Author

Chaftari, Patrick, primary, Chaftari, Anne‐Marie, additional, Hachem, Ray, additional, Yeung, Sai‐Ching J., additional, Dagher, Hiba, additional, Jiang, Ying, additional, Malek, Alexandre E., additional, Dailey Garnes, Natalie, additional, Mulanovich, Victor E., additional, and Raad, Issam, additional

Published
2021
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50. Examining pain among non‐Hispanic Black and non‐Hispanic White patients with cancer visiting emergency departments: CONCERN (Comprehensive Oncologic Emergencies Research Network).

Author

Hudson, Matthew F., Strassels, Scott A., Durham, Danielle D., Siddique, Sunny, Adler, David, Yeung, Sai‐Ching J., Bernstein, Steven L., Baugh, Christopher W., Coyne, Christopher J., Grudzen, Corita R., Henning, Daniel J., Klotz, Adam, Madsen, Troy E., Pallin, Daniel J., Rico, Juan F., Ryan, Richard J., Shapiro, Nathan I., Swor, Robert, Venkat, Arvind, and Wilson, Jason

Subjects
CANCER pain, RESEARCH, STATISTICS, NARCOTICS, HEALTH services accessibility, HOSPITAL emergency services, ACQUISITION of data methodology, PAIN measurement, CONFIDENCE intervals, ANALGESICS, BLACK people, SELF-evaluation, HEALTH status indicators, RACE, QUANTITATIVE research, PATIENTS, MANN Whitney U Test, CANCER patients, PEARSON correlation (Statistics), T-test (Statistics), MEDICAL records, EMERGENCY medical services, CHI-squared test, DESCRIPTIVE statistics, WHITE people, LOGISTIC regression analysis, DATA analysis software, ODDS ratio, SOCIODEMOGRAPHIC factors, PAIN management, SECONDARY analysis, LONGITUDINAL method
Abstract

The article examines pain among non-Hispanic Black and non-Hispanic white patients with cancer visiting emergency departments (ED) with Comprehensive Oncologic Emergencies Research Network (CONCERN). Topics include encourage research into any racial or socioeconomic gaps in the treatment of pain in ED cancer patients; and patient self report and compared using Pearson chi-square with assessed cell residuals.

Published
2022
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