Search

Seven hexahydrodispiro[indole-3,3′-indolizine-2′,3″-piperidine]-2(1 H),4″-dione compounds were synthesized by a catalyst-free 1,3-dipolar cycloaddition reaction in a one-pot three-component system containing 3,5-diarylidene-1-benzylpiperidin-4-one, isatin and l -pipecolic acid. The structures of these compounds were characterized by nuclear magnetic resonance, high-resolution mass spectrometry and X-ray data analysis. These chemical entities were evaluated for their cytotoxicity (brine shrimp assay), and five compounds were found potential in this bioassay. Compound 2e was the most prominent target against Artemia salina with an LC50 value of 7.27 μg/mL. [ABSTRACT FROM AUTHOR]

ABSTRACT Fluorescent nanoparticles with multiplex distinct emission signatures and high brightness by a single wavelength excitation are substantially needed in multiplex bioassays and imaging. In this study, we synthesized fluorescent polymeric nanoparticles incorporated with three polymerizable organic dyes via a one-pot miniemulsion. By altering the doping ratio of three tandem dyes, the nanoparticles display abundant multiple fluorescence such as blue, cyan, green, orange, pink, red etc., together with distinguishable emission signatures under a single wavelength excitation, which were arising from the effective fluorescence resonance energy transfer (FRET) between the three energy-matched dyes. Meanwhile, a large Stokes shift (up to 250 nm) can be generated by taking place multiple FRET cascade mechanism between donor and acceptor fluorophores in nanoparticles, which also suggests broad applications in biological labeling and imaging. Moreover, these nanoparticles are uniform in size, highly bright, excellently photostable, and shown prominent longterm stability. Overall, the novel multicolor fluorescent polymeric nanoparticles augur well for their potential applications in multiplexed bioanalysis and emitting displays. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41492. [ABSTRACT FROM AUTHOR]

A non-catalytic condensation of Ni II β-aminonorcorrole with aryl aldehydes is shown to produce a family of pyrromethane dimers that undergo deaminative cyclization to yield pyridine-fused bis(norcorrole)s comprising two antiaromatic macrocycles communicating by an aromatic moiety. The new compounds were characterized by spectroscopic, structural, and electrochemical methods supported by DFT calculations, all of which revealed unexpected antiaromaticity enhancement in the fused system., (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)