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Tüketici sözleşmelerinden olan mesafeli sözleşme, tüketici ile satıcı/sağlayıcının eş zamanlı fiziksel varlığı olmadan, uzaktan iletişim araçları kullanılmak suretiyle akdettikleri sözleşmedir. Mesafeli sözleşme bir sözleşme tipini ifade etmemektedir. Mesafeli sözleşme, sözleşmenin nasıl akdedildiği ile ilgili olup, bu sözleşme kurulurken uzaktan iletişim araçları kullanılmaktadır. Bu nedenle çeşitli sözleşme tipleri mesafeli sözleşme olarak kurulabilir. Hangi sözleşme tipinin mesafeli olarak kurulabileceği ise mesafeli sözleşmenin kapsamını ifade eder. Ancak mesafeli sözleşme olarak kurulabilecek çok fazla sözleşme tipi bulunmaktadır. Mesafeli olarak kurulabilen sözleşme tipi isimli veya isimsiz sözleşme olabilir. Bu nedenle düzenlemelerde hangi sözleşme tiplerinin mesafeli olarak kurulamayacağına yer verilmektedir. Çalışmamızda öncelikle mesafeli sözleşme kavramına yer verilmektedir. Ardından bu sözleşmenin kapsamı çeşitli düzenlemelere göre ele alınmaktadır. Ayrıca isimli sözleşmelerden olan satış sözleşmesinin mesafeli olarak kurulması ile isimsiz sözleşme olan abonelik sözleşmesinin mesafeli olarak kurulması mesafeli sözleşmenin kapsamında olan sözleşmelere örnek olarak incelenmektedir., The distance contract one of the consumer contracts is the contract concluded by the consumer and the seller/provider using the means of remote communication without the simultaneous physical presence. The distance contract does not refer to a contract type. The distance contract is related to how the contract is concluded and remote communication tools are used when establishing this contract. Therefore, various types of contracts can be established as distance contracts. The distinction between which type of contract can be established is the extent of the distance contract. However, there are many types of contracts that can be established as distance contracts. The type of contract that can be established as a distance can be a contract with the typical or atypical contract. For this reason, it is stated in the regulations which types of contracts cannot be established distant. In our study, the concept of distance contract is given first. The scope of this agreement is then examined. The scope of the contract is handled according to various regulations. In addition, the distinction between the establishment of the contract of sale and the establishment of atypical contract contract, which are within the scope of the distance contract, are examined as examples.

PubMedID: 28864648 Objective. To arrive at consensus for candidate outcomes for disease activity assessment in largevessel vasculitis (LVV) in clinical trials. Methods.A Delphi survey including 99 items was circulated among international experts for 3 rounds. Results. Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. Conclusion. This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes. Copyright © 2017. All rights reserved. National Institute of Arthritis and Musculoskeletal and Skin Diseases: U01 AR51874 04, U54 AR057319 National Center for Research Resources: U54 RR019497 Sponsored by the Vasculitis Clinical Research Consortium, which has received support from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319 and U01 AR51874 04), the National Center for Research Resources (U54 RR019497), and the Office of Rare Diseases Research. Additional support for the work of the OMERACT Vasculitis Working Group was received through a Patient-Centered Outcomes Research Institute Pilot Project Grant. S.Z. Aydin, MD, Associate Professor, Division of Rheumatology, The Ottawa Hospital Research Institute, University of Ottawa; H. Direskeneli, MD, Professor of Rheumatology, Division of Rheumatology, Marmara University Faculty of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology, and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Section of Rheumatology, University of Pennsylvania, White Building, 5th Floor Penn, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu Accepted for publication June 3, 2017.

Aim: To analyze the effect of TLR-9 (-1486 T>C) and TLR-9 (C>T) gene polymorphisms both at TLR-9 levels and together with their sepsis parameters. In this regard, the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used in order to detect TLR-9 gene polymorphisms, whereas the ELISA technique was used to analyze TLR-9 serum levels in 80 sepsis patients and 100 healthy individuals. Materials and Methods: The study group consisted of 80 patients with a diagnosis of sepsis and 100 healthy individuals. TLR-9 C>T polymorphism was identified by PCR-RFLP. Results: There was no substantial difference observed between sepsis and control groups in terms of TLR-9 (-1486 T>C) and TLR-9 (C>T) genotype and allele distribution. When serum TLR-9 levels were compared to TLR-9 (-1486 T>C) and TLR-9 (C>T) genotype and allele distribution, there was a statistically substantial decrease in TLR-9 serum levels of both TLR-9 (-1486 T>C) TT and TLR-9 (C>T) TT individuals in the sepsis group (p=0.011 and p=0.036, respectively). Conclusion: There is no relation between sepsis and both TLR-9 (C>T) and TLR-9(-1486 T>C) polymorphisms; however, there is a relation between sepsis and decreased serum TLR-9 levels of both TLR-9 (-1486 T>C) TT and TLR-9 (C>T) TT polymorphisms due to sepsisassociated immunosuppression.