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Your search keyword '"Yoshida, Koji"' showing total 685 results
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685 results on '"Yoshida, Koji"'

1. Deterministic Path Search Algorithm on Free-Energy Landscape using Random Grids

Author

Nagai, Tetsuro and Yoshida, Koji

Subjects
Condensed Matter - Statistical Mechanics, Physics - Biological Physics, Physics - Chemical Physics, 82M99
Abstract

Given a multidimensional free-energy or potential-energy landscape, finding reaction paths that connect an initial (or reactant) state and a final (or product) state is important for biophysics and materials science. The likelihood of a path can be evaluated using an objective function, and the most likely reaction path can be found by optimizing its objective function. However, nonlinear optimization on a complex free-energy or potential-energy landscape may lead to suboptimal solutions. In this study, this drawback is avoided using deterministic path-finding methods such as Dijkstra's algorithm on a graph by assigning grids on the coordinate system to graph nodes and relating the objective function of the path to the edge cost between the nodes. Furthermore, the use of random grids is proposed because they more accurately represent paths than regular grids. As a demonstration, the proposed method is successfully applied to find the minimum resistance path on a three-hole potential model, demonstrating that the proposed method is promising., Comment: 26 pages, 9 figures

Published
2024
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3. Associations between readmission and patient-reported measures in acute psychiatric inpatients: a multicenter prospective longitudinal study

Author

Yamaguchi, Sosei, Ojio, Yasutaka, Koike, Junko, Matsunaga, Asami, Ogawa, Makoto, Kikuchi, Akiko, Kawashima, Takahiro, Tachimori, Hisateru, Bernick, Peter, Kimura, Hiroshi, Inagaki, Ataru, Watanabe, Hiroyuki, Kishi, Yoshiki, Yoshida, Koji, Hirooka, Takaaki, Oishi, Satoru, Matsuda, Yasuhiro, and Fujii, Chiyo

Published
2024
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9. Improved data analysis for molecular dynamics in liquid CCl4

Author

Hosokawa, Shinya and Yoshida, Koji

Subjects
Condensed Matter - Disordered Systems and Neural Networks, Condensed Matter - Soft Condensed Matter
Abstract

Previously reported inelastic x-ray scattering spectra of a typical van der Waals molecular liquid CCl4 were reanalyzed by using a generalized Langevin formalism with a memory function including a thermal and two viscoelastic relaxation processes together with a simple sparse modeling. The obtained excitations of longitudinal acoustic phonons show a largely positive deviation from the hydrodynamic value by about 57%, much larger than about 37% by the previously reported damped harmonic oscillator result. Such large values of fast sounds in molecular liquids being larger than about 15-20% of typical liquid metals are interpreted as extra energy-losses for terahertz phonons by vibrational and rotational motions of molecules. The rates of the fast and slow viscoelastic relaxations in the memory function at low Q indicate large values, about 0.5 and 2 ps, which correspond to the vibrational and rotational motions of CCl4 molecules, respectively. These values are larger than those of the typical polar molecular liquid acetone, which may reflect the heavier atomic mass of CCl4. The Q dependences of the viscoelastic relaxation rates are discussed in terms of lifetime and propagating length of the terahertz phonon oscillations. The microscopic kinematic longitudinal viscosity rapidly decreases with Q from a reasonable macroscopic value., Comment: 25 pages, 11 figures

Published
2023

10. A noninvasive urinary microRNA-based assay for the detection of pancreatic cancer from early to late stages: a case control study

Author

Baba, Shogo, Kawasaki, Tadatoshi, Hirano, Satoshi, Nakamura, Toru, Asano, Toshimichi, Okazaki, Ryo, Yoshida, Koji, Kawase, Tomoya, Kurahara, Hiroshi, Oi, Hideyuki, Yokoyama, Masaya, Kita, Junji, Imura, Johji, Kinoshita, Kazuya, Kondo, Shunsuke, Okada, Mao, Satake, Tomoyuki, Igawa, Yukiko Shimoda, Yoshida, Tatsuya, Yamaguchi, Hiroki, Ando, Yoriko, Mizunuma, Mika, Ichikawa, Yuki, Hida, Kyoko, Nishihara, Hiroshi, and Kato, Yasutaka

Published
2024
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12. Prospective multicenter surveillance study of branch-duct intraductal papillary mucinous neoplasm of the pancreas; risk of dual carcinogenesis

Author

Ohtsuka, Takao, Maguchi, Hiroyuki, Tokunaga, Shoji, Hijioka, Susumu, Takayama, Yukiko, Koshita, Shinsuke, Hanada, Keiji, Sudo, Kentaro, Uehara, Hiroyuki, Tanno, Satoshi, Tada, Minoru, Kimura, Wataru, Nakamura, Masafumi, Kin, Toshifumi, Kamata, Ken, Masamune, Atsushi, Iwashita, Takuji, Akahoshi, Kazuya, Ueki, Toshiharu, Okamura, Keiya, Kato, Hironari, Kumagi, Teru, Kawabe, Ken, Yoshida, Koji, Mukai, Tsuyoshi, Sakagami, Junichi, Hirono, Seiko, Abue, Makoto, Nakafusa, Tomoki, Morita, Makiko, Shimosegawa, Toru, and Tanaka, Masao

Published
2024
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24. Identification of trypsin-degrading commensals in the large intestine

Author

Li, Youxian, Watanabe, Eiichiro, Kawashima, Yusuke, Plichta, Damian R., Wang, Zhujun, Ujike, Makoto, Ang, Qi Yan, Wu, Runrun, Furuichi, Munehiro, Takeshita, Kozue, Yoshida, Koji, Nishiyama, Keita, Kearney, Sean M., Suda, Wataru, Hattori, Masahira, Sasajima, Satoshi, Matsunaga, Takahiro, Zhang, Xiaoxi, Watanabe, Kazuto, Fujishiro, Jun, Norman, Jason M., Olle, Bernat, Matsuyama, Shutoku, Namkoong, Ho, Uwamino, Yoshifumi, Ishii, Makoto, Fukunaga, Koichi, Hasegawa, Naoki, Ohara, Osamu, Xavier, Ramnik J., Atarashi, Koji, and Honda, Kenya

Published
2022
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30. Biomarker‐Based Approach to α‐Synucleinopathies: Lessons from Neuropathology.

Author

Kovacs, Gabor G., Grinberg, Lea T., Halliday, Glenda, Alafuzoff, Irina, Dugger, Brittany N., Murayama, Shigeo, Forrest, Shelley L., Martinez‐Valbuena, Ivan, Tanaka, Hidetomo, Kon, Tomoya, Yoshida, Koji, Jaunmuktane, Zane, Spina, Salvatore, Nelson, Peter T., Gentleman, Steve, Alegre‐Abarrategui, Javier, Serrano, Geidy E., Paes, Vitor Ribeiro, Takao, Masaki, and Wakabayashi, Koichi

Published
2024
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39. Prevalence and clinicopathological features of primary age‐related tauopathy (PART): A large forensic autopsy study.

Author

Yoshida, Koji, Hata, Yukiko, Ichimata, Shojiro, Tanaka, Ryo, and Nishida, Naoki

Abstract

INTRODUCTION: Primary age‐related tauopathy (PART), often regarded as a minimally symptomatic pathology of old age, lacks comprehensive cohorts across various age groups. METHODS: We examined PART prevalence and clinicopathologic features in 1589 forensic autopsy cases (≥40 years old, mean age ± SD 70.2 ± 14.2 years). RESULTS: PART cases meeting criteria for argyrophilic grain diseases (AGD) were AGD+PART (n = 181). The remaining PART cases (n = 719, 45.2%) were classified as comorbid conditions (PART‐C, n = 90) or no comorbid conditions (pure PART, n = 629). Compared to controls (n = 208), Alzheimer's disease (n = 133), and AGD+PART, PART prevalence peaked in the individuals in their 60s (65.5%) and declined in the 80s (21.5%). No significant clinical background differences were found (excluding controls). However, PART‐C in patients inclusive of age 80 had a higher suicide rate than pure PART (p < 0.05), and AGD+PART showed more dementia (p < 0.01) and suicide (p < 0.05) than pure PART. DISCUSSION: Our results advocate a reevaluation of the PART concept and its diagnostic criteria. Highlights: We investigated 1589 forensic autopsy cases to investigate the features of primary age‐related tauopathy (PART).PART peaked in people in their 60s in our study.Many PART cases over 80s had comorbid pathologies in addition to neurofibrillary tangles pathology.Argyrophilic grain disease and Lewy pathology significantly affected dementia and suicide rates in PART.Our results suggest that the diagnostic criteria of PART need to be reconsidered. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Distinctive Deposition Patterns of Sporadic Transthyretin-Derived Amyloidosis in the Atria: A Forensic Autopsy-Based Study.

Author

Ichimata, Shojiro, Hata, Yukiko, Yoshida, Koji, Hirono, Keiichi, and Nishida, Naoki

Subjects
ATRIAL natriuretic peptides, HEART atrium, CARDIAC amyloidosis, LEFT heart atrium, ATRIUMS (Architecture)
Abstract

Left-to-right differences in the histopathologic patterns of transthyretin-derived amyloid (ATTR) deposition in the atria of older adults have not yet been investigated. Hence, this study evaluated heart specimens from 325 serial autopsy subjects. The amount of ATTR deposits in the seven cardiac regions, including both sides of atria and atrial appendages, was evaluated semiquantitatively. Using digital pathology, we quantitatively evaluated the immunohistochemical deposition burden of ATTR in the myocardium. We identified 20 sporadic ATTR cardiac amyloidosis cases (nine males). All patients had ATTR deposition in the left atrial regions of the myocardium. In the semiquantitative analysis, 14 of the 20 cases showed more severe ATTR deposition on the left atrial regions than on the right side, with statistically significant differences in the pathology grading (p < 0.01 for both the atrium and atrial appendage). Quantitative analysis further supported the difference. Moreover, six had ATTR deposition in the epineurium and/or neural fibers of the atria. Cluster analysis revealed that ATTR deposition in the myocardium was significantly more severe in males than in females. The heterogeneous distribution of amyloid deposits between atria revealed in this study may impair the orderly transmission of the cardiac conduction system and induce arrhythmias, which may be further aggravated by additional neuropathy in the advanced phase. This impairment could be more severe among males. These findings emphasize that atrial evaluation is important for individuals with sporadic ATTR cardiac amyloidosis, particularly for early detection. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Multiple system atrophy with amyloid-β predominant Alzheimer’s disease neuropathologic change

Author

Kon, Tomoya, primary, Ichimata, Shojiro, additional, Di Luca, Daniel G, additional, Martinez-Valbuena, Ivan, additional, Kim, Ain, additional, Yoshida, Koji, additional, Alruwaita, Abdullah A, additional, Kleiner, Galit, additional, Strafella, Antonio P, additional, Forrest, Shelley L, additional, Sato, Christine, additional, Rogaeva, Ekaterina, additional, Fox, Susan H, additional, Lang, Anthony E, additional, and Kovacs, Gabor G, additional

Published
2024
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49. Clinicopathological Appearance of Epidermal Growth-Factor-Containing Fibulin-like Extracellular Matrix Protein 1 Deposition in the Lower Gastrointestinal Tract: An Autopsy-Based Study.

Author

Ichimata, Shojiro, Hata, Yukiko, Yoshida, Koji, and Nishida, Naoki

Subjects
GASTROINTESTINAL system, SMALL intestine, SUBMUCOUS plexus, COLON (Anatomy), EXTRACELLULAR matrix proteins, CLINICAL pathology, AMYLOID, BIREFRINGENCE
Abstract

This study examined the patterns of epidermal growth-factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) deposition in the small intestine and colon to evaluate the association between the histopathological severity of EFEMP1 deposition and constipation and determine the colocalization of amyloid transthyretin (ATTR) and EFEMP1 deposits. In 40 older cases (≥80 years of age), EFEMP1 deposition in the small intestine initiated in the submucosal and subserous vessels, subserous interstitium, and serosa (early stage), progressing to the muscularis propria and peri-Auerbach plexus area (intermediate stage), and finally spreading diffusely to other areas, excluding the mucosa and muscularis mucosa (advanced stage). The colon had a similar pattern of progression. During the middle-to-advanced stages, amyloid formation was observed in some vascular and serous deposits. A subgroup of cases was identified in which EFEMP1 deposition was the only presumed cause of constipation. Additionally, we demonstrated the colocalization of ATTR and EFEMP1 deposition. Apple-green birefringence was detected under polarized light only in approximately one-half of the cases in the small intestine and one-third of the cases in the colon. These findings strongly suggest that EFEMP1 deposits are correlated with pathological conditions of the lower gastrointestinal tract. As the histopathological diagnosis using Congo red-stained specimens is challenging, the combined use of elastic fiber staining and EFEMP1 immunohistochemistry is recommended to identify EFEMP1 deposition. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Randomized phase I/II study of vascular endothelial growth factor receptor peptide vaccines for patients with hepatocellular carcinoma.

Author

Yoshimaru, Yoko, Nagaoka, Katsuya, Tanaka, Kentaro, Narahara, Satoshi, Inada, Hiroki, Kurano, Sotaro, Tokunaga, Takayuki, Iio, Etsuko, Watanabe, Takehisa, Setoyama, Hiroko, Tateyama, Masakuni, Yoshida, Koji, Tsunoda, Takuya, Nakamura, Yusuke, Tanaka, Motohiko, Sasaki, Yutaka, and Tanaka, Yasuhito

Subjects
VASCULAR endothelial growth factor receptors, CHEMOEMBOLIZATION, PEPTIDE vaccines, HEPATOCELLULAR carcinoma, CYTOTOXIC T cells
Abstract

Aim: We evaluated the safety and efficacy of vascular endothelial growth factor receptor (VEGFR)‐targeted peptide vaccines for the immunization of patients with unresectable hepatocellular carcinoma (HCC) who had responded to transarterial chemoembolization. Methods: Twenty‐two patients were randomized 1:1 to receive VEGFR‐targeted peptides or placebo. The primary end‐point was the safety assessment of the immunization. The secondary end‐points were evaluation of immunological responses and clinical outcomes. Results: No severe adverse events were induced by the study agents. Among the 12 patients in the vaccine group, a VEGFR1‐specific cytotoxic T lymphocyte (CTL) response was induced in eight (66.7%) patients and a VEGFR2‐specific CTL response was induced in 10 (83.3%). The median progression‐free survival (PFS) and overall survival (OS) rates were 4.8 and 52.0 months, respectively, in the vaccine group, and 2.7 and 21.8 months, respectively, in the placebo group. No statistically significant differences were found between the two groups (PFS p = 0.925, OS p = 0.190). When divided into two groups according to immunoreactivity, the median PFS of patients with and without a strong immune response to VEGFR1 were 7.4 and 2.7 months, and that to VEGFR2 were 10.6 and 2.7 months, respectively; there were significant differences according to the immune response. Conclusions: Immunotherapy with peptide vaccines targeting VEGFR1 and VEGFR2 was well tolerated with no serious adverse events. It also effectively induced peptide‐specific CTLs in patients with unresectable HCC. [ABSTRACT FROM AUTHOR]

Published
2024
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