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Your search keyword '"Yoshiyuki Fujisaki"' showing total 4 results
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4 results on '"Yoshiyuki Fujisaki"'

1. Effects of ethyl hexanoate on activities of sympathetic nerves innervating the brown and white adipose tissues, body temperature, and plasma fatty acids

Author

Yoshiko Misonou, Katsuya Nagai, Yuko Horii, Risa Fuyuki, and Yoshiyuki Fujisaki

Subjects
0301 basic medicine, Male, medicine.medical_specialty, Sympathetic Nervous System, Adipose Tissue, White, Adipose tissue, White adipose tissue, Body Temperature, 03 medical and health sciences, 0302 clinical medicine, Adipose Tissue, Brown, Internal medicine, Brown adipose tissue, medicine, Lipolysis, Animals, Rats, Wistar, Caproates, Chemistry, General Neuroscience, Fatty Acids, Thermogenesis, Vagus nerve, Rats, Autonomic nervous system, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, 030217 neurology & neurosurgery, Homeostasis
Abstract

The autonomic nervous system (ANS) is implicated in maintaining homeostasis of the internal environment in mammals. Therefore, changes occurring in the ANS can cause alterations of physiological phenomena. Ethyl hexanoate (EH) is known as the aroma component of apples. To study the action of ethyl hexanoate on physiological phenomena, we examined the effect of an intragastric (IG) injection of 1 mL/kg body weight of 0.1 ppm EH solution on sympathetic nerve activity innervating the brown adipose tissue (BAT) and white adipose tissue (WAT) in anesthetized rats. Consequently, IG administration of EH increased activity of the sympathetic nerves innervating both the BAT and WAT. In addition, the effects of the IG injection on body temperature above the interscapular BAT and plasma free fatty acid (FFA) concentration were also examined in conscious rats. In this attempt IG injection of EH elevated both the body temperature and plasma FFA levels. Furthermore, subdiaphragmatic vagotomy eliminated the effects of EH on sympathetic nerves innervating BAT and WAT. These findings suggest that EH causes excitations of sympathetic nerves innervating BAT and WAT, and enhances thermogenesis and lipolysis via the afferent vagus nerve. Thus, these present findings also suggest the possibility that EH might have anti-obesity effects.

Published
2020

2. Effect of grapefruit and lavender essential oil scents on pancreatic sympathetic nerve activity and plasma glucose in rats

Author

Keiko Maeda, Yoshiyuki Fujisaki, Katsuya Nagai, Yuko Horii, and Jiao Shen

Subjects
Plasma glucose, medicine.medical_specialty, Lavender, Chemistry, Sympathetic nerve activity, General Chemistry, Hypoglycemia, medicine.disease, law.invention, Endocrinology, law, Internal medicine, Olfactory stimulation, medicine, Essential oil, Food Science
Published
2015
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3. EFFECTS OF CHLORELLA PYRENOIDOSA ON SPLENIC SYMPATHETIC NERVE ACTIVITY AND TUMORS INDUCED BY HUMAN COLON CANCER CELLS.

Author

Yuko Horii, Yoshiyuki Fujisaki, Yoshiko Misonou, and Katsuya Nagai

Subjects
*CHLORELLA pyrenoidosa, *IMMUNE system, *COLON cancer, *CANCER cells, *TUMOR growth
Abstract

Chlorella pyrenoidosa and other Chlorella species may be a natural source of immune boosting nutrients. We investigated whether Chlorella pyrenoidosa affects splenic sympathetic nerve activity (splenic-SNA), which is involved in the immune response, and inhibits cancer cell proliferation. We conducted two experiments. Experiment 1 focused on the interaction of Chlorella pyrenoidosa and splenic-SNA. Experiment 2 examined the effects of Chlorella pyrenoidosa on the growth of tumors in nude mice that had been injected with human colon cancer cells (HCT116). We confirmed Chlorella pyrenoidosa suppressed splenic-SNA. In addition, the proliferation of HCT116 cells is suppressed by treated with Chlorella pyrenoidosa. This study is the first to suggest that an effective substance in the treatment of cancer of Chlorella pyrenoidosa may be attributable to suppression of splenic-SNA. [ABSTRACT FROM AUTHOR]

Published
2017

4. INTRADUODENAL INJECTION OF HEAT-KILLED LACTOBACILLUS BREVIS SBC8803 MODULATES AUTONOMIC NEUROTRANSMISSION IN THE GUT: INVOLVEMENT OF VAGAL AFFERENTS AND SEROTONIN RECEPTORS.

Author

Yuko Horii, Yasukazu Nakakita, Yoshiyuki Fujisaki, Hirotaka Kaneda, Tatsuro Shigyo, and Katsuya Nagai

Subjects
*LACTOBACILLUS brevis, *NEURAL transmission, *SEROTONIN receptors, *VAGOTOMY, *INTRAVENOUS injections, *DRUG administration, *LABORATORY rats
Abstract

Previously, we found that intraduodenal administration of heat-killed Lactobacillus brevis SBC8803 (SBC8803) elevates both the efferent gastric vagal nerve activity (efferent GVNA) and the afferent intestinal vagal nerve activity (afferent IVNA) in rats. In this study, the effects of vagotomy and serotonin (5-HT) receptor antagonists on the above changes due to SBC8803 were examined in rats to clarify the mechanism. It was found that the elevation of efferent GVNA induced by SBC8803 was eliminated by subdiaphragmatic vagotomy, and inhibited by intracerebroventricular but not intravenous administration of ketanserin (5-HT2 antagonist), Moreover, both the efferent GVNA and the afferent IVNA elevations were suppressed by intracerebroventricular administration of granisetron (5-HT3 antagonist). Combining this with our previous findings that granisetron can produce the same effects intravenously, these findings suggest the following: 1) the efferent GVNA enhancement requires afferent vagal nerves, central but not peripheral 5-HT2 receptors, and both central and peripheral 5-HT3 receptors, and 2) the afferent IVNA enhancement requires central and peripheral 5-HT3 receptors. Moreover, these results implicate the afferent IVNA in the mechanism of the SBC8803-induced increase in efferent GVNA. [ABSTRACT FROM AUTHOR]

Published
2015

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