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Your search keyword '"Zhang, Yu-cai"' showing total 34 results
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34 results on '"Zhang, Yu-cai"'

20. Chinese guidelines for the diagnosis and treatment of hand, foot and mouth disease (2018 edition)

Author

Li, Xing-Wang, Ni, Xin, Qian, Su-Yun, Wang, Quan, Jiang, Rong-Meng, Xu, Wen-Bo, Zhang, Yu-Cai, Yu, Guang-Jun, Chen, Qiang, Shang, Yun-Xiao, Zhao, Cheng-Song, Yu, Hui, Zhang, Ting, Liu, Gang, Deng, Hui-Ling, Gao, Jie, Ran, Xian-Gui, Yang, Qiao-Zhi, Xu, Bian-Li, Huang, Xue-Yong, Wu, Xing-Dong, Bao, Yi-Xiao, Chen, Yi-Ping, Chen, Zhi-Hai, Liu, Qing-Quan, Lu, Guo-Ping, Liu, Chun-Feng, Wang, Rong-Bing, Zhang, Guo-Liang, Gu, Fang, Xu, Hong-Mei, Li, Ying, and Yang, Tao

Published
2018
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23. EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway

Author

Zhang, Yu Cai, Peiyong Chen, Hui Xu, Shanglai Li, Bingru Zhao, Yixuan Fan, Feng Wang, and Yanli

Subjects
EZH2, Hu sheep, proliferation, apoptosis, gonadotropin secretion, pituitary cells
Abstract

Pituitary gonadotropins perform essential functions in mammalian reproduction by stimulating gametogenesis and steroidogenesis in the ovaries and testicles. EZH2 is a histone methyltransferase that inhibits proliferation and aggravates apoptosis in stem cells subjected to pathological stimuli. However, the expression and molecular mechanisms of EZH2 in pituitary cells in vitro have not been extensively studied. In this study, the relative abundances of EZH2 mRNA (p < 0.01) and protein (p < 0.05) expression were larger in the pituitary cells of Hu sheep with relatively greater fecundity (GF) compared to those with lesser fecundity (LF). Loss-of-function examinations demonstrated that EZH2 gene knockdown led to an earlier induction of apoptosis in sheep pituitary cells (PCs). The relative abundance of CASP3, CASP9, and BAX was increased (p < 0.01), while BCL2’s abundance was less decreased (p < 0.01) in PCs where there was EZH2 gene knockdown. Additionally, cell proliferation (p < 0.01) and viability (p < 0.01) were decreased in EZH2-knockdown sheep PCs, and the cell cycle was blocked compared to a negative control (NC). Notably, EZH2 gene knockdown led to reduced abundances of gonadotropin subunit gene transcripts (FSHβ, p < 0.05) and reduced FSH release (p < 0.01) from PCs. EZH2 gene knockdown led to reduced phosphorylation of AKT, ERK, and mTOR (p < 0.01). The results suggest that EZH2 regulates pituitary cell proliferation, apoptosis, and FSH secretion through modulation of the AKT/ERK signaling pathway, providing a foundation for further study of pituitary cell functions.

Published
2023
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24. Risk factors of delirium in a paediatric intensive care unit: A prospective case series study.

Author

Xu, Ting‐Ting, Zhang, Yu‐Cai, Ye, Xiao‐Fei, Fu, Cong‐Hui, Li, Yan, Ju, Min‐Jie, Liu, Ji, Yang, Xiao‐Ya, and Zhang, Wei‐Ying

Subjects
*INTENSIVE care units, *STATISTICS, *SCIENTIFIC observation, *HUMAN research subjects, *CONFIDENCE intervals, *CRITICALLY ill, *MULTIVARIATE analysis, *PATIENTS, *PEDIATRICS, *DISEASE incidence, *MANN Whitney U Test, *FISHER exact test, *RISK assessment, *BENZODIAZEPINES, *INFORMED consent (Medical law), *T-test (Statistics), *PEARSON correlation (Statistics), *DELIRIUM, *DESCRIPTIVE statistics, *RESEARCH funding, *LOGISTIC regression analysis, *ODDS ratio, *DATA analysis software, *LONGITUDINAL method, *TRANQUILIZING drugs, *CHILDREN
Abstract

Background: Delirium is one of the most common complications in critically ill children. Once delirium occurs, it will cause physical and psychological distress in children and increase the length of their ICU stay and hospitalization costs. Understanding the risk factors for delirium in critically ill children can help develop targeted nursing interventions to reduce the incidence of delirium. Aims: To investigate the incidence and the risk factors of delirium in the paediatric intensive care unit (PICU). Study design: We performed a prospective observational study in critically ill patients in the PICU between February and July 2020. Delirium was diagnosed by the Cornell Assessment of Paediatric Delirium (CAPD) and the Richmond Agitation Sedation Scale and analysed via univariate analysis and multivariate logistic regression to determine the independent risk factors of delirium in critically ill children. Results: The study enrolled 315 patients ranging in age from 1–202 (65.3–54.3) months, with 56.2% (n = 177) being male. The incidence of delirium was 29.2% (n = 92) according to CAPD criteria. Among them, 33 cases (35.9%) were of hyperactive delirium, 16 cases (17.4%) were of hypoactive delirium, and 43 cases (46.7%) were of mixed delirium. By using stepwise logistic regression, the independent risk factors of delirium included mechanical ventilation (odds ratio [OR], 11.470; 95% confidence interval [CI], 4.283–30.721), nervous system disease (OR, 5.596; 95%CI, 2.445 to 12.809), developmental delay (OR, 5.157; 95% CI, 1.990–13.363), benzodiazepine (OR, 3.359; 95% CI 1.278–8.832), number of catheters (OR, 1.918; 95% CI, 1.425 to 2.582), and age (OR, 0.985; 95% confidence interval CI, 0.976–0.993). Conclusions: Delirium is a common complication in the PICU. The independent risk factors include mechanical ventilation, nervous system disease, developmental delay, benzodiazepines, higher number of catheters, and younger age. This study may help develop intervention strategies to reduce the incidence of delirium in critically ill children by targeting modifiable risk factors. Relevance to Clinical Practice: Recommendations for practice include paying attention to high‐risk children in the ICU who are prone to delirium, removing influencing factors as soon as possible, and providing targeted nursing interventions. [ABSTRACT FROM AUTHOR]

Published
2023
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