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Your search keyword '"Zhao, Guijun"' showing total 42 results
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42 results on '"Zhao, Guijun"'

1. Safety and effectiveness of oral medium to high dose blonanserin in patients with schizophrenia: subgroup analysis from a prospective, multicenter, post-marketing surveillance study in mainland China

Author

Yang, Yuan, Ge, Hongmin, Wang, Xijin, Liu, Xuejun, Li, Keqing, Wang, Gang, Yang, Xiaodong, Deng, Huaili, Sun, Meijuan, Zhang, Ruiling, Chen, Jindong, Cai, Duanfang, Sang, Hong, Liu, Xianglai, Zhan, Guilai, Zhao, Guijun, Li, Haiyun, and Xun, Zhiyuan

Published
2023
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4. Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice

Author

Li, Qing, Chan, Hung, Liu, Wei-Xin, Liu, Chang-An, Zhou, Yunfei, Huang, Dan, Wang, Xueliang, Li, Xiaoxing, Xie, Chuan, Liu, Wing Ying-Zhi, Wang, Xian-Song, Ng, Siu Kin, Gou, Hongyan, Zhao, Liu-Yang, Fong, Winnie, Jiang, Lanping, Lin, Yufeng, Zhao, Guijun, Bai, Feihu, Liu, Xiaodong, Chen, Huarong, Zhang, Lin, Wong, Sunny Hei, Chan, Matthew Tak Vai, Wu, William Ka Kei, and Yu, Jun

Published
2023
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5. Artificial Intelligence–Assisted Colonoscopy for Colorectal Cancer Screening: A Multicenter Randomized Controlled Trial

Author

Xu, Hong, Tang, Raymond S.Y., Lam, Thomas Y.T., Zhao, Guijun, Lau, James Y.W., Liu, Yunpeng, Wu, Qi, Rong, Long, Xu, Weiran, Li, Xue, Wong, Sunny H., Cai, Shuntian, Wang, Jing, Liu, Guanyi, Ma, Tantan, Liang, Xiong, Mak, Joyce W.Y., Xu, Hongzhi, Yuan, Peng, Cao, Tingting, Li, Fudong, Ye, Zhenshi, Shutian, Zhang, and Sung, Joseph J.Y.

Published
2023
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6. Social support status and influencing factors among schizophrenics in remission in Northeast Sichuan

Author

Yang Xin, Zhao Guijun, Xu Qiongying, He Pei, Guo Lirong, Xu Yuanmei, Chen Yanjun, Ran Jijun, and Hu Yan

Subjects
schizophrenia, social support, influencing factors, second round medical insurance reimbursement, Psychology, BF1-990, Psychiatry, RC435-571
Abstract

ObjectiveTo investigate the social support status and influencing factors of schizophrenics in remission in Northeast Sichuan， and to provide ideas for improving their social support.MethodsFrom May to September 2020， a total of 533 patients who met the diagnosis criteria of the International Classification of Diseases， tenth edition （ICD-10） for schizophrenics in remission at the mental health institutions in Guangyuan， Bazhong and Dazhou cities were selected for the survey， and patients were assessed by self-made demographic and clinical data inventory and Social Support Rating Scale （SSRS）. Then the social support status of schizophrenic in remission and influencing factors were analyzed， meantime， the impact of the second round reimbursement policy of medical insurance benefits on their social support was addressed particularly.Results①The SSRS total score， objective support， subjective support， and utilization of support scores of schizophrenics in remission were lower than those of the national norm （t=5.065~30.382， P5 000 yuan （F=15.892）， patient's economic income （t=4.083）， and outpatient or online follow-up （F=3.954）， with statistically significant differences （P

Published
2022
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9. A comparative review of the state and advancement of Site-Specific Crop Management in the UK and China

Author

Zhenhong LI, James TAYLOR, Lynn FREWER, Chunjiang ZHAO, Guijun YANG, Zhenhai LI, Zhigang LIU, Rachel GAULTON, Daniel WICKS, Hugh MORTIMER, Xiao CHENG, Chaoqing YU, Zhanyi SUN

Subjects
remote sensing, decision support, responsible research and innovation, digital soil mapping, Agriculture (General), S1-972
Abstract

Precision agriculture, and more specifically Site-Specific Crop Management (SSCM), has been implemented in some form across nearly all agricultural production systems over the past 25 years. Adoption has been greatest in developed agricultural countries. In this review article, the current situation of SSCM adoption and application is investigated from the perspective of a developed (UK) and developing (China) agricultural economy. The current state-of-the art is reviewed with an emphasis on developments in position system technology and satellite-based remote sensing. This is augmented with observations on the differences between the use of SSCM technologies and methodologies in the UK and China and discussion of the opportunities for (and limitations to) increasing SSCM adoption in developing agricultural economies. A particular emphasis is given to the role of socio-demographic factors and the application of responsible research and innovation (RRI) in translating agri-technologies into China and other developing agricultural economies. Several key research and development areas are identified that need to be addressed to facilitate the delivery of SSCM as a holistic service into areas with low precision agriculture (PA) adoption. This has implications for developed as well as developing agricultural economies.

Published
2019
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20. Safety and Effectiveness of Blonanserin in Chinese Patients with Schizophrenia: An Interim Analysis of a 12-Week Open-Label Prospective Multi-Center Post-marketing Surveillance

Author

Wu, Haishan, primary, Wang, Xijin, additional, Liu, Xuejun, additional, Sang, Hong, additional, Bo, Qijing, additional, Yang, Xiaodong, additional, Xun, Zhiyuan, additional, Li, Keqing, additional, Zhang, Ruiling, additional, Sun, Meijuan, additional, Cai, Duanfang, additional, Deng, Huaili, additional, Zhao, Guijun, additional, Li, Juhong, additional, Liu, Xianglai, additional, Zhan, Guilai, additional, and Chen, Jindong, additional

Published
2022
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22. ARTIFICIAL INTELLIGENCE ASSISTED COLONOSCOPY FOR ADENOMA DETECTION IN SCREENING COLONOSCOPY: A MULTI-CENTRE RANDOMIZED CONTROLLED STUDY

Author

Xu, Hong, primary, Tang, Raymond S., additional, Lam, Thomas Y., additional, Zhao, Guijun, additional, Lau, James Y., additional, Liu, Yunpeng, additional, Wu, Qi, additional, Rong, Long, additional, Xu, Weiran, additional, Li, Xue, additional, Wong, Sunny H., additional, Cai, Shuntian, additional, Wang, Jing, additional, Liu, Guanyi, additional, Ma, Tantan, additional, Liang, Xiong, additional, Mak, Joyce W., additional, Xu, Hongzhi, additional, Yuan, Peng, additional, Cao, TingtIng, additional, Zhu, Hong, additional, Ye, Zhenshi, additional, and Sung, Joseph JY., additional

Published
2022
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30. Isolation, primary culture, and morphological characterization of gland epithelium from forest musk deer (Moschus berezovskii)

Author

Lei Meiyan, Cheng-li Zheng, Zhang Chenglu, Tianyuan Ma, Diyan Li, Liang Zhengjie, Zeng Dejun, Jie Hang, Feng Xiaolan, Zhongxian Xu, Zhao Guijun, and Chen Min

Subjects
Moschus berezovskii, Cellular differentiation, Cell Separation, Breeding, Forests, 010502 geochemistry & geophysics, 01 natural sciences, Epithelium, Gas Chromatography-Mass Spectrometry, Fatty Acids, Monounsaturated, chemistry.chemical_compound, Lipid droplet, medicine, Animals, Secretion, Cell Shape, Cells, Cultured, 0105 earth and related environmental sciences, biology, Chemistry, Deer, 0402 animal and dairy science, Animal Structures, Epithelial Cells, 04 agricultural and veterinary sciences, Cell Biology, General Medicine, biology.organism_classification, 040201 dairy & animal science, In vitro, Muscone, Cell biology, medicine.anatomical_structure, Cell culture, Seasons, Developmental Biology
Abstract

Research of epithelial cells in musk gland is lacking. There are no good characterized epithelial cell lines that can provide complementary in vitro models for in vivo research. We successfully cultivated epithelial cells of musk gland for the first time. The protocol described here produces epithelial cell lines from the mature secreting musk gland. Based on morphological observation, epithelial cells of musk gland were isolated and cultured in vitro. After the third passage, the musk gland-derived cells were filled with many lipid droplets and proliferated well. We used gas chromatography and mass spectrometry to explore the chemical composition of lipid droplets in the musk gland-derived cells. The main components of secreted lipid droplet were alkanes, esters, amines, alcohols, ketones, organic acids, and aldehydes. Muscone, which is the main active compound of musk, was not found. This is a new attempt in the field of animal musk to obtain naturally secreted animal musk in vitro by cloning specialized cells. In conclusion, this study provides a reference at the cellular level to further analyze the biology and physiology of the musk gland epithelium and secretion mechanism of musk deer.

Published
2018

34. Mucosal microbiome dysbiosis in gastric carcinogenesis

Author

Coker, Olabisi Oluwabukola, primary, Dai, Zhenwei, additional, Nie, Yongzhan, additional, Zhao, Guijun, additional, Cao, Lei, additional, Nakatsu, Geicho, additional, Wu, William KK, additional, Wong, Sunny Hei, additional, Chen, Zigui, additional, Sung, Joseph J Y, additional, and Yu, Jun, additional

Published
2017
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38. The musk chemical composition and microbiota of Chinese forest musk deer males

Author

Li, Diyan, primary, Chen, Binlong, additional, Zhang, Long, additional, Gaur, Uma, additional, Ma, Tianyuan, additional, Jie, Hang, additional, Zhao, Guijun, additional, Wu, Nan, additional, Xu, Zhongxian, additional, Xu, Huailiang, additional, Yao, Yongfang, additional, Lian, Ting, additional, Fan, Xiaolan, additional, Yang, Deying, additional, Yang, Mingyao, additional, Zhu, Qing, additional, and Satkoski Trask, Jessica, additional

Published
2016
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41. Mucosal microbiome dysbiosis in gastric carcinogenesis

Author

Coker, Olabisi Oluwabukola, Dai, Zhenwei, Nie, Yongzhan, Zhao, Guijun, Cao, Lei, Nakatsu, Geicho, Wu, William KK, Wong, Sunny Hei, Chen, Zigui, Sung, Joseph J Y, and Yu, Jun

Abstract

ObjectivesWe aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis.DesignWe performed 16S rRNA gene analysis of gastric mucosal samples from 81 cases including superficial gastritis (SG), atrophic gastritis (AG), intestinal metaplasia (IM) and gastric cancer (GC) from Xi’an, China, to determine mucosal microbiome dysbiosis across stages of GC. We validated the results in mucosal samples of 126 cases from Inner Mongolia, China.ResultsWe observed significant mucosa microbial dysbiosis in IM and GC subjects, with significant enrichment of 21 and depletion of 10 bacterial taxa in GC compared with SG (q<0.05). Microbial network analysis showed increasing correlation strengths among them with disease progression (p<0.001). Five GC-enriched bacterial taxa whose species identifications correspond to Peptostreptococcus stomatis, Streptococcus anginosus, Parvimonas micra, Slackia exiguaand Dialister pneumosinteshad significant centralities in the GC ecological network (p<0.05) and classified GC from SG with an area under the receiver-operating curve (AUC) of 0.82. Moreover, stronger interactions among gastric microbes were observed in Helicobacter pylori-negative samples compared with H. pylori-positive samples in SG and IM. The fold changes of selected bacteria, and strengths of their interactions were successfully validated in the Inner Mongolian cohort, in which the five bacterial markers distinguished GC from SG with an AUC of 0.81.ConclusionsIn addition to microbial compositional changes, we identified differences in bacterial interactions across stages of gastric carcinogenesis. The significant enrichments and network centralities suggest potentially important roles of P. stomatis, D. pneumosintes, S. exigua, P. micraand S. anginosusin GC progression.

Published
2018
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42. Correction of RNA splicing defect in β 654 -thalassemia mice using CRISPR/Cas9 gene-editing technology.

Author

Lu D, Gong X, Fang Y, Guo X, Chen Y, Yang F, Zhao G, Ma Q, Zeng Y, and Zeng F

Abstract

β654-thalassemia is a prominent Chinese subtype of b-thalassemia, representing 17% of all cases of β-thalassemia in China. The molecular mechanism underlying this subtype involves the IVS-2-654 C→T mutation leading to aberrant β-globin RNA splicing. This results in an additional 73-nucleotide exon between exons 2 and 3 and leads to a severe thalassemia syndrome. Herein, we explored a CRISPR/Cas9 genome editing approach to eliminate the additional 73- nucleotide by targeting both the IVS-2-654 C→T and a cryptic acceptor splice site at IVS-2-579 in order to correct aberrant b-globin RNA splicing and ameliorate the clinical β-thalassemia syndrome in β654 mice. Gene-edited mice were generated by microinjection of sgRNA and Cas9 mRNA into one-cell embryos of β654 or control mice: 83.3% of live-born mice were gene-edited, 70% of which produced correctly spliced RNA. No off-target events were observed. The clinical symptoms, including hematologic parameters and tissue pathology of all of the edited β654 founders and their offspring were significantly improved compared to those of the non-edited β654 mice, consistent with the restoration of wild-type b-globin RNA expression. Notably, the survival rate of gene-edited heterozygous β654 mice increased significantly, and liveborn homozygous β654 mice were observed. Our study demonstrated a new and effective gene-editing approach that may provide groundwork for the exploration of β654-thalassemia therapy in the future.

Published
2022
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