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Most of the existing aerosol cultivation equipments are bulky, simple-structured and poor in functional stability. Based on this, the author developed a set of automatic control high-pressure fine mist cultivation device, designed the PLC automatic control circuit, and simulated and tested the temperature and humidity change curves. The test results verify the simulation model and the overall device runs well, among which the spray atomization process, and the temperature field, humidity field and velocity field under three atomization modes are simulated. Three atomization schemes are analyzed, and in the end the optimal one is selected. In comparison, the side-by-side spray is completely covered; the atomization is more sufficient. The results show that the time when the humidity reaches 90% in the same position is different under different initial humidity conditions. The atomization humidity maintenance time in different environments is approximately the same, and can be maintained for 4 to 5 hours. It can be seen from the comparison of the results that the greater the humidity, the shorter the heat exchange time and the faster the heat exchange.