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With the rapid development of modern computer technology, control technology and communication technology, it has become a practical problem to optimize the monitoring mode of BOP sub-items, to seek more reasonable and effective, more economical and convenient, more stable and reliable engineering application solutions that reflect the mature automation technology today and to uniformly monitor and design these sub-items. In particular, it has been mature in thermal power plant applying auxiliary control network technology in auxiliary workshops, and the technology has been widely used in chemical industry, metallurgy and other industries. BOP sub-items are networked on the basis of the current monitoring mode, and without affecting the project progress. Realizing of moderate centralized control will improve the level of automatic operation and management of nuclear power plant, and meet the requirements of informatization management of the plant.

B lymphocyte-induced maturation protein-1 (Blimp-1) ensures B-cell differentiation into the plasma cell stage, and its instability constitutes a crucial oncogenic element in certain aggressive cases of activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL). However, the underlying degradation mechanisms and their possible therapeutic relevance remain unexplored. Here, we show that N-terminal misfolding mutations in ABC-DLBCL render Blimp-1 protein susceptible to proteasome-mediated degradation but spare its transcription-regulating activity. Mechanistically, whereas wild-type Blimp-1 metabolism is triggered in the nucleus through PML-mediated sumoylation, the degradation of lymphoma-associated mutants is accelerated by subversion of this pathway to Hrd1-mediated cytoplasmic sequestration and ubiquitination. Screening experiments identifies the heat shock protein 70 (HSP70) that selects Blimp-1 mutants for Hrd1 association, and HSP70 inhibition restores their nuclear accumulation and oncorepressor activities without disrupting normal B-cell maturation. Therefore, HSP70-Hrd1 axis represents a potential therapeutic target for restoring the oncorepressor activity of unstable lymphoma-associated Blimp-1 mutants., The transcriptional repressor Blimp-1 has an important role in B-cell differentiation. Here the authors show that lymphoma-associated Blimp-1 mutants are selectively recognized by HSP70-Hrd1, which leads to their accelerated degradation and propose HSP70 inhibition as a therapeutic approach for certain lymphomas.