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17 results on '"Zhong, Jixing"'

2. Single-cell atlas of domestic pig cerebral cortex and hypothalamus

Author

Zhu, Jiacheng, Chen, Fang, Luo, Lihua, Wu, Weiying, Dai, Jinxia, Zhong, Jixing, Lin, Xiumei, Chai, Chaochao, Ding, Peiwen, Liang, Langchao, Wang, Shiyou, Ding, Xiangning, Chen, Yin, Wang, Haoyu, Qiu, Jiaying, Wang, Feiyue, Sun, Chengcheng, Zeng, Yuying, Fang, Jian, Jiang, Xiaosen, Liu, Ping, Tang, Gen, Qiu, Xin, Zhang, Xingliang, Ruan, Yetian, Jiang, Sanjie, Li, Jiankang, Zhu, Shida, Xu, Xun, Li, Fang, Liu, Zhongmin, Cao, Gang, and Chen, Dongsheng

Published
2021
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3. Single-cell brain atlas of Parkinson's disease mouse model

Author

Zhong, Jixing, Tang, Gen, Zhu, Jiacheng, Wu, Weiying, Li, Ge, Lin, Xiumei, Liang, Langchao, Chai, Chaochao, Zeng, Yuying, Wang, Feiyue, Luo, Lihua, Li, Jiankang, Chen, Fang, Huang, Zhen, Zhang, Xiuqing, Zhang, Yu, Liu, Hongde, Qiu, Xin, Tang, Shengping, and Chen, Dongsheng

Published
2021
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4. Establishment of porcine and human expanded potential stem cells

Author

Gao, Xuefei, Nowak-Imialek, Monika, Chen, Xi, Chen, Dongsheng, Herrmann, Doris, Ruan, Degong, Chen, Andy Chun Hang, Eckersley-Maslin, Melanie A., Ahmad, Shakil, Lee, Yin Lau, Kobayashi, Toshihiro, Ryan, David, Zhong, Jixing, Zhu, Jiacheng, Wu, Jian, Lan, Guocheng, Petkov, Stoyan, Yang, Jian, Antunes, Liliana, Campos, Lia S., Fu, Beiyuan, Wang, Shengpeng, Yong, Yu, Wang, Xiaomin, Xue, Song-Guo, Ge, Liangpeng, Liu, Zuohua, Huang, Yong, Nie, Tao, Li, Peng, Wu, Donghai, Pei, Duanqing, Zhang, Yi, Lu, Liming, Yang, Fengtang, Kimber, Susan J., Reik, Wolf, Zou, Xiangang, Shang, Zhouchun, Lai, Liangxue, Surani, Azim, Tam, Patrick P. L., Ahmed, Asif, Yeung, William Shu Biu, Teichmann, Sarah A., Niemann, Heiner, and Liu, Pentao

Published
2019
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6. Zhong, Jixing

Author

Zhong, Jixing and Zhong, Jixing

Published
2023

7. Single cell chromatin accessibility of the developmental cephalochordate

Author

Chen, Dongsheng, primary, Huang, Zhen, additional, Ding, Xiangning, additional, Xu, Zaoxu, additional, Zhong, Jixing, additional, Liang, Langchao, additional, Xu, Luohao, additional, Cai, Chaochao, additional, Wang, Haoyu, additional, Qiu, Jiaying, additional, Zhu, Jiacheng, additional, Wang, Xiaoling, additional, Xiang, Rong, additional, Wu, Weiying, additional, Ding, Peiwen, additional, Wang, Feiyue, additional, Feng, Qikai, additional, Zhou, Si, additional, Yuan, Yuting, additional, Wu, Wendi, additional, Yan, Yanan, additional, Zhou, Yitao, additional, Chen, Duo, additional, Li, Guang, additional, Zhu, Shida, additional, Chen, Fang, additional, Zhang, Qiujin, additional, Wu, Jihong, additional, and Xu, Xun, additional

Published
2020
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8. Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson’s disease mouse brain

Author

Zhong, Jixing, primary, Tang, Gen, additional, Zhu, Jiacheng, additional, Qiu, Xin, additional, Wu, Weiying, additional, Li, Ge, additional, Lin, Xiumei, additional, Liang, Langchao, additional, Chai, Chaochao, additional, Zeng, Yuying, additional, Wang, Feiyue, additional, Luo, Lihua, additional, Li, Jiankang, additional, Chen, Fang, additional, Huang, Zhen, additional, Xu, Xun, additional, Tang, Shengping, additional, Zhu, Shida, additional, and Chen, Dongsheng, additional

Published
2020
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9. Single cell atlas of trisomy 21 cerebral cortex

Author

Zhang, Jingxuan, primary, Wang, Shiyou, additional, Xu, Zaoxu, additional, Ding, Xiangning, additional, Li, Chen, additional, Zhang, Yonghong, additional, Chen, Yin, additional, Zhong, Jixing, additional, Liang, Langchao, additional, Chai, Chaochao, additional, Wang, Xiaoling, additional, Xiang, Rong, additional, Zhu, Jiacheng, additional, Lin, Xiumei, additional, Ding, Peiwen, additional, Zhang, Qiang, additional, Wang, Mingyue, additional, Feng, Qikai, additional, Zhang, Zhijun, additional, Guo, Guangling, additional, Xue, Shen, additional, Jin, Lin, additional, He, Zhikai, additional, Yan, Li, additional, Xiao, Bing, additional, Zhang, Changjun, additional, Xu, Yan, additional, Li, Wei, additional, Zhang, Yichi, additional, Wu, Weiying, additional, Jiang, Sanjie, additional, Xia, Jun, additional, Gao, Ya, additional, Wang, Lei, additional, Dong, Shichen, additional, Liu, Si, additional, Zhu, Shida, additional, Chen, Fang, additional, Chen, Dongsheng, additional, and Xu, Xun, additional

Published
2020
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10. Single cell atlas of domestic pig brain illuminates the conservation and divergence of cell types at spatial and species levels

Author

Chen, Dongsheng, primary, Zhu, Jiacheng, additional, Zhong, Jixing, additional, Chen, Fang, additional, Lin, Xiumei, additional, Dai, Jinxia, additional, Chen, Yin, additional, Wang, Shiyou, additional, Ding, Xiangning, additional, Wang, Haoyu, additional, Qiu, Jiaying, additional, Wang, Feiyue, additional, Wu, Weiying, additional, Liu, Ping, additional, Tang, Gen, additional, Qiu, Xin, additional, Ruan, Yetian, additional, Li, Jiankang, additional, Zhu, Shida, additional, Xu, Xun, additional, Li, Fang, additional, Liu, Zhongmin, additional, and Cao, Gang, additional

Published
2019
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12. Single cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina

Author

Zhong, Jixing, primary, Chen, Dongsheng, additional, Hu, Fangyuan, additional, Chen, Fang, additional, Xu, Zaoxu, additional, Fang, Jian, additional, Xu, Jianjiang, additional, Wang, Shiyou, additional, Liang, Langchao, additional, Chai, Chaochao, additional, Ding, Xiangning, additional, Zhu, Jiacheng, additional, Ding, Peiwen, additional, Xia, Jun, additional, Jiang, Sanjie, additional, Li, Wei, additional, Gao, Ya, additional, Zhang, Jianguo, additional, Li, Jiankang, additional, Xu, Ping, additional, Gao, Fengjuan, additional, Wang, Dandan, additional, Zhang, Daowei, additional, Huang, Jie, additional, Qu, Shoufang, additional, Zhang, Shenghai, additional, Wu, Jihong, additional, and Sun, Xinghuai, additional

Published
2019
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13. Single cell RNA sequencing reveals cellular diversity of trisomy 21 retina

Author

Wu, Jihong, primary, Ding, Xiangning, additional, Hu, Fangyuan, additional, Xu, Zaoxu, additional, Zhang, Shenghai, additional, Liang, Langchao, additional, Chai, Chaochao, additional, Zhong, Jixing, additional, Wang, Shiyou, additional, Lin, Xiumei, additional, Chen, Yin, additional, Feng, Qikai, additional, Zhu, Jiacheng, additional, Jiang, Sanjie, additional, Xia, Jun, additional, Li, Wei, additional, Gao, Ya, additional, Li, Jiankang, additional, Zhang, Jingxuan, additional, He, Zhikai, additional, Xue, Shen, additional, Guo, Guanglin, additional, Xu, Ping, additional, Gao, Fengjuan, additional, Wang, Dandan, additional, Zhang, Daowei, additional, Chen, Dongsheng, additional, Sun, Xinghuai, additional, and Chen, Fang, additional

Published
2019
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14. FabriEVEs: A dedicated platform for endogenous viral elements in fishes, amphibians, birds, reptiles and invertebrates

Author

Zhong, Jixing, primary, Zhu, Jiacheng, additional, Xu, Zaoxu, additional, Zou, Geng, additional, Zhao, JunWei, additional, Jiang, SanJie, additional, Zhang, Wei, additional, Xia, Jun, additional, Yang, Lin, additional, Li, Fang, additional, Gao, Ya, additional, Chen, Fang, additional, Wu, Yiquan, additional, and Chen, Dongsheng, additional

Published
2019
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15. Single-cell RNA-seq reveals dynamic transcriptome profiling in human early neural differentiation

Author

Shang, Zhouchun, Chen, Dongsheng, Wang, Quanlei, Wang, Shengpeng, Deng, Qiuting, Wu, Liang, Liu, Chuanyu, Ding, Xiangning, Wang, Shiyou, Zhong, Jixing, Zhang, Doudou, Cai, Xiaodong, Zhu, Shida, Yang, Huanming, Liu, Longqi, Fink, J Lynn, Chen, Fang, Liu, Xiaoqing, Gao, Zhengliang, Xu, Xun, Shang, Zhouchun, Chen, Dongsheng, Wang, Quanlei, Wang, Shengpeng, Deng, Qiuting, Wu, Liang, Liu, Chuanyu, Ding, Xiangning, Wang, Shiyou, Zhong, Jixing, Zhang, Doudou, Cai, Xiaodong, Zhu, Shida, Yang, Huanming, Liu, Longqi, Fink, J Lynn, Chen, Fang, Liu, Xiaoqing, Gao, Zhengliang, and Xu, Xun

Abstract

Background: Investigating cell fate decision and subpopulation specification in the context of the neural lineage is fundamental to understanding neurogenesis and neurodegenerative diseases. The differentiation process of neural-tube-like rosettes in vitro is representative of neural tube structures, which are composed of radially organized, columnar epithelial cells and give rise to functional neural cells. However, the underlying regulatory network of cell fate commitment during early neural differentiation remains elusive. Results: In this study, we investigated the genome-wide transcriptome profile of single cells from six consecutive reprogramming and neural differentiation time points and identified cellular subpopulations present at each differentiation stage. Based on the inferred reconstructed trajectory and the characteristics of subpopulations contributing the most toward commitment to the central nervous system lineage at each stage during differentiation, we identified putative novel transcription factors in regulating neural differentiation. In addition, we dissected the dynamics of chromatin accessibility at the neural differentiation stages and revealed active cis-regulatory elements for transcription factors known to have a key role in neural differentiation as well as for those that we suggest are also involved. Further, communication network analysis demonstrated that cellular interactions most frequently occurred in the embryoid body stage and that each cell subpopulation possessed a distinctive spectrum of ligands and receptors associated with neural differentiation that could reflect the identity of each subpopulation. Conclusions: Our study provides a comprehensive and integrative study of the transcriptomics and epigenetics of human early neural differentiation, which paves the way for a deeper understanding of the regulatory mechanisms driving the differentiation of the neural lineage.

Published
2018

16. Genetic variability and functional implication of HPV16 from cervical intraepithelial neoplasia in Shanghai women.

Author

Zhao, Junwei, Zhu, Jiacheng, Guo, Junhan, Zhu, Tailin, Zhong, Jixing, Liu, Min, Ruan, Yetian, Liao, Shujie, and Li, Fang

Subjects
CERVICAL intraepithelial neoplasia, BINDING sites, AMINO acids
Abstract

Human papillomavirus (HPV)16 gene mutation is usually associated with persistent HPV infection and cervical intraepithelial neoplasia (CIN). However, the functional implications of HPV16 mutations remain poorly understood.145 LCR/E6/E7 of the HPV16 isolates were amplified and sequenced, and HPV16 integration status was detected. In total, 89 SNPs (68 in the LCR, 13 in E6, 8 in E7) were discovered, 11 of which were nonsynonymous mutations (8 in E6, 3 in E7). The H85Y and E120D variants in E6 were significantly reduced in the high‐grade squamous intraepithelial lesion (HSIL) group compared to the T," a potential binding site for TATA‐binding protein, is the most common in LCR variants. A4 (Asian) was associated with an increased risk of HSIL compared to A1–3(P =.009). The H85/E120 in E6 and N29 in HPV16 E7 might play a critical role in carcinogenesis by disrupting p53 and Rb degradation due to affecting their interaction, respectively. In a word, the findings in this study provide preventative and therapeutic interventions of HPV16 ‐related cervical lesions/cancer. Highlight: The variants analysis of HPV16 E6, E7 and LCR gene from clinical samples, try reconstructing the phylogenetic relationship of the mutation and understand the effect of variants on carcinogenesis.The H85/E120 in E6 and N29 in HPV16 E7 might play a critical role in carcinogenesis by disrupting p53 and Rb degradation due to affecting their interaction, respectively. [ABSTRACT FROM AUTHOR]

Published
2020
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17. Single-cell RNA-seq reveals dynamic transcriptome profiling in human early neural differentiation

Author

Shang, Zhouchun, primary, Chen, Dongsheng, additional, Wang, Quanlei, additional, Wang, Shengpeng, additional, Deng, Qiuting, additional, Wu, Liang, additional, Liu, Chuanyu, additional, Ding, Xiangning, additional, Wang, Shiyou, additional, Zhong, Jixing, additional, Zhang, Doudou, additional, Cai, Xiaodong, additional, Zhu, Shida, additional, Yang, Huanming, additional, Liu, Longqi, additional, Fink, J Lynn, additional, Chen, Fang, additional, Liu, Xiaoqing, additional, Gao, Zhengliang, additional, and Xu, Xun, additional

Published
2018
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