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Your search keyword '"Zhou, Jingru"' showing total 174 results
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174 results on '"Zhou, Jingru"'

8. The mrp-3 gene is involved in haem efflux and detoxification in a blood-feeding nematode.

Author

Tong, Danni, Wu, Fei, Chen, Xueqiu, Du, Zhendong, Zhou, Jingru, Zhang, Jingju, Yang, Yi, Du, Aifang, and Ma, Guangxu

Subjects
RNA interference, MULTIDRUG resistance, CARRIER proteins, SMALL interfering RNA, HAEMONCHUS contortus
Abstract

Background: Haem is essential but toxic for metazoan organisms. Auxotrophic nematodes can acquire sufficient haem from the environment or their hosts in the meanwhile eliminate or detoxify excessive haem through tightly controlled machinery. In previous work, we reported a role of the unique transporter protein HRG-1 in the haem acquisition and homeostasis of parasitic nematodes. However, little is known about the haem efflux and detoxification via ABC transporters, particularly the multiple drug resistance proteins (MRPs). Results: Here, we further elucidate that a member of the mrp family (mrp-3) is involved in haem efflux and detoxification in a blood-feeding model gastrointestinal parasite, Haemonchus contortus. This gene is haem-responsive and dominantly expressed in the intestine and inner membrane of the hypodermis of this parasite. RNA interference of mrp-3 resulted in a disturbance of genes (e.g. hrg-1, hrg-2 and gst-1) that are known to be involved in haem homeostasis and an increased formation of haemozoin in the treated larvae and lethality in vitro, particularly when exposed to exogenous haem. Notably, the nuclear hormone receptor NHR-14 appears to be associated the regulation of mrp-3 expression for haem homeostasis and detoxification. Gene knockdown of nhr-14 and/or mrp-3 increases the sensitivity of treated larvae to exogenous haem and consequently a high death rate (> 80%). Conclusions: These findings demonstrate that MRP-3 and the associated molecules are essential for haematophagous nematodes, suggesting novel intervention targets for these pathogens in humans and animals. [ABSTRACT FROM AUTHOR]

Published
2024
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13. The Impact of Offshore Photovoltaic Utilization on Resources and Environment Using Spatial Information Technology.

Author

Wang, Peng, Zhou, Jingru, Jin, Xinfei, Shi, Jingchao, Chan, Ngai Weng, Tan, Mou Leong, Lin, Xingwen, Ma, Xu, Lin, Xia, Zheng, Kaixuan, Wu, Jiexuan, and Zhang, Fei

Subjects
INFORMATION technology, ENVIRONMENTAL impact analysis, OCEAN zoning, FISHERY resources, FLOW velocity, CHANNEL flow, SUSTAINABLE development
Abstract

In recent years, the rapid development of the photovoltaic (PV) industry has resulted in a saturation of research on onshore PV power plant construction. However, current studies on the impact of marine PVs on the marine environment remain limited and scarce. In order to facilitate the implementation of carbon reduction goals and promote the sustainable development of the offshore PV industry, this study analyzes the environmental impact of PV sea-use resources based on spatial information technology in the western part of Gaotang Island. The findings show that the MIKE21FM model provides relatively accurate simulations of tidal flow and tide level in the marine PV area. Flow velocity in the marine PV area exhibits a decreasing trend, with an average decrease ranging from 0.03 to 0.07 m/s. This decrease minimally affects surrounding navigational channels and large-scale flow fields. The resulting siltation is also deemed less significant, with an annual deposition from 0.03 to 0.06 m/a. Moreover, offshore PV construction resulted in a total intertidal biological loss of 123.45 t. The suspension of sediment during cofferdam construction and removal has a potential effect on zooplankton and fishery resources. Overall, it is proposed that careful planning, prudent site selection, and the execution of countermeasures during marine PV construction will combine to minimize the impact on the marine environment. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Activated Wake Systems in Narcolepsy Type 1

Author

Shan, Ling, primary, Linssen, Suzan, additional, Harteman, Zoe, additional, den Dekker, Fleur, additional, Shuker, Lamis, additional, Balesar, Rawien, additional, Breesuwsma, Nicole, additional, Anink, Jasper, additional, Zhou, Jingru, additional, Lammers, Gert Jan, additional, Swaab, Dick F., additional, and Fronczek, Rolf, additional

Published
2023
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21. Smoking quantity determines disease activity and function in Chinese patients with ankylosing spondylitis

Author

Zhang, Hui, Wan, Wei, Liu, Jing, Dai, Shengming, Zou, Yaohong, Qian, Qiaoxia, Ding, Yue, Xu, Xia, Ji, Hengdong, He, Hongjun, Zhu, Qi, Yang, Chengde, Ye, Shuang, Jiang, Lindi, Tang, Jianping, Tong, Qiang, He, Dongyi, Zhao, Dongbao, Li, Yuan, Ma, Yanyun, Zhou, Jingru, Mei, Zhendong, Chen, Xiangxiang, Yuan, Ziyu, Zhang, Juan, Wang, Xiaofeng, Yang, Yajun, Jin, Li, Gao, Ying, Zhou, Xiaodong, Reveille, John D., Zou, Hejian, and Wang, Jiucun

Published
2018
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22. Activated wake systems in narcolepsy type 1

Author

Shan, Ling, Linssen, Suzan, Harteman, Zoe, den Dekker, Fleur, Shuker, Lamis, Balesar, Rawien, Breesuwsma, Nicole, Anink, Jasper, Zhou, Jingru, Lammers, Gert Jan, Swaab, Dick F, Fronczek, Rolf, Shan, Ling, Linssen, Suzan, Harteman, Zoe, den Dekker, Fleur, Shuker, Lamis, Balesar, Rawien, Breesuwsma, Nicole, Anink, Jasper, Zhou, Jingru, Lammers, Gert Jan, Swaab, Dick F, and Fronczek, Rolf

Abstract

OBJECTIVE: Narcolepsy type 1 (NT1) is assumed to be caused solely by a lack of hypocretin (orexin) neurotransmission. Recently, however, we found an 88% reduction in corticotropin-releasing hormone (CRH)-positive neurons in the paraventricular nucleus (PVN). We assessed the remaining CRH neurons in NT1 to determine whether they co-express vasopressin (AVP) to reflect upregulation. We also systematically assessed other wake-systems, since current NT1 treatments target histamine, dopamine and norepinephrine pathways.METHODS: In postmortem tissue of people with NT1 and matched controls we immunohistochemically stained and quantified neuronal populations expressing: CRH and AVP in the PVN, and CRH in the Barrington nucleus; the key neuronal histamine-synthesizing enzyme, histidine decarboxylase (HDC) in the hypothalamic tuberomammillary nucleus (TMN); the rate-limited-synthesizing enzyme, tyrosine hydroxylase (TH), for dopamine in the mid-brain and for norepinephrine in the locus coeruleus (LC).RESULTS: In NT1, there was: a 234% increase in the percentage of CRH cells co-expressing AVP, while there was an unchanged integrated optical density of CRH staining in the Barrington nucleus; a 36% increased number of histamine neurons expressing HDC, while the number of typical human TMN neuronal profiles was unchanged; a tendency towards an increased density of TH-positive neurons in the substantia nigra compacta; while the density of TH-positive LC neurons was unchanged.INTERPRETATION: Our findings suggest an upregulation of activity by histamine neurons and remaining CRH neurons in NT1. This may explain earlier reports of normal basal plasma cortisol levels but lower levels after dexamethasone suppression. Alternatively, CRH neurons co-expressing AVP neurons are less vulnerable. This article is protected by copyright. All rights reserved.

Published
2023

26. Clinical patterns and characteristics of ankylosing spondylitis in China

Author

Qian, Qiaoxia, Xu, Xia, He, Hongjun, Ji, Hengdong, Zhang, Hui, Ding, Yue, Dai, Sheng-Ming, Zou, Yaohong, Zhu, Qi, Yang, Chengde, Ye, Shuang, Jiang, Lindi, Tang, Jian-Ping, Tong, Qiang, He, Dongyi, Zhao, Dongbao, Li, Yuan, Ma, Yanyun, Zhou, Jingru, Yuan, Ziyu, Zhang, Juan, Jin, Li, Zhou, Xiaodong, Reveille, John D., Zou, Hejian, and Wang, Jiucun

Published
2017
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