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1. Efficient removal of uranium from the kidneys by a picolinate-based pentadentate chelator.

Author

Cao, Dehan, Chen, Bin, Xu, Yigong, Li, Zongyi, Sun, Tingfeng, Hong, Sheng, Zhu, Tianen, Chen, Lei, Li, Ximeng, Wang, Longxiang, Liu, Jiakai, Jin, Yaqi, Wang, Shuao, and Diwu, Juan

Subjects
KIDNEYS, URANIUM, GEOMETRY, LIGAND binding (Biochemistry)
Abstract

In conjunction with theoretical calculations, the in vitro and in vivo uranyl binding capabilities of a bidentate picolinate (Pic) ligand and its pentadentate derivative (H2dpa) are investigated. The planar N3O2-donor configuration of H2dpa matches the typical pentagonal-bipyramid coordination geometry of uranyl, demonstrating a remarkable removal preference for uranyl in the kidneys. [ABSTRACT FROM AUTHOR]

Published
2024
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