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1. Updated guidance regarding the risk of allergic reactions to COVID-19 vaccines and recommended evaluation and management: A GRADE assessment and international consensus approach.

Author

Greenhawt, Matthew, Dribin, Timothy, Abrams, Elissa, Shaker, Marcus, Chu, Derek, Golden, David, Akin, Cem, Anagnostou, Akterini, ALMuhizi, Faisal, Alqurashi, Waleed, Arkwright, Peter, Baldwin, James, Banerji, Aleena, Bégin, Philippe, Ben-Shoshan, Moshe, Bernstein, Jonathan, Bingemann, Theresa, Bindslev-Jensen, Carsten, Blumenthal, Kim, Byrne, Aideen, Cahill, Julia, Cameron, Scott, Campbell, Dianne, Campbell, Ronna, Cavender, Michael, Chan, Edmond, Chinthrajah, Sharon, Comberiati, Pasquale, Eastman, Jacqueline, Ellis, Anne, Fleischer, David, Fox, Adam, Frischmeyer-Guerrerio, Pamela, Gagnon, Remi, Garvey, Lene, Grayson, Mitchell, Isabwe, Ghislaine, Hartog, Nicholas, Hendron, David, Horner, Caroline, Hourihane, Johnathan, Iglesia, Edward, Kan, Manstein, Kaplan, Blanka, Katelaris, Constance, Kim, Harold, Kelso, John, Khan, David, Lang, David, Ledford, Dennis, Levin, Michael, Lieberman, Jay, Loh, Richard, Mack, Douglas, Mazer, Bruce, Mody, Ketan, Mosnaim, Gisele, Munblit, Daniel, Mustafa, S, Nanda, Anil, Nathan, Richard, Oppenheimer, John, Otani, Iris, Park, Miguel, Pawankar, Ruby, Perrett, Kirsten, Peter, Jonny, Phillips, Elizabeth, Picard, Matthieu, Pitlick, Mitchell, Ramsey, Allison, Rasmussen, Trine, Rathkopf, Melinda, Reddy, Hari, Robertson, Kara, Rodriguez Del Rio, Pablo, Sample, Stephen, Sheshadri, Ajay, Sheik, Javed, Sindher, Sayantani, Spergel, Jonathan, Stone, Cosby, Stukus, David, Tang, Mimi, Tracy, James, Turner, Paul, Vander Leek, Timothy, Wallace, Dana, Wang, Julie, Wasserman, Susan, Weldon, David, Wolfson, Anna, Worm, Margitta, and Yacoub, Mona-Rita

Subjects
COVID-19, SARS-CoV-2, allergic reactions, anaphylaxis, mRNA COVID-19 vaccine, polyethylene glycol, polysorbate 80, repeat allergic reactions, skin testing, vaccination, Humans, COVID-19 Vaccines, GRADE Approach, Consensus, Vaccine Excipients, COVID-19, Hypersensitivity, Immediate, Anaphylaxis, Excipients
Abstract

This guidance updates 2021 GRADE (Grading of Recommendations Assessment, Development and Evaluation) recommendations regarding immediate allergic reactions following coronavirus disease 2019 (COVID-19) vaccines and addresses revaccinating individuals with first-dose allergic reactions and allergy testing to determine revaccination outcomes. Recent meta-analyses assessed the incidence of severe allergic reactions to initial COVID-19 vaccination, risk of mRNA-COVID-19 revaccination after an initial reaction, and diagnostic accuracy of COVID-19 vaccine and vaccine excipient testing in predicting reactions. GRADE methods informed rating the certainty of evidence and strength of recommendations. A modified Delphi panel consisting of experts in allergy, anaphylaxis, vaccinology, infectious diseases, emergency medicine, and primary care from Australia, Canada, Europe, Japan, South Africa, the United Kingdom, and the United States formed the recommendations. We recommend vaccination for persons without COVID-19 vaccine excipient allergy and revaccination after a prior immediate allergic reaction. We suggest against >15-minute postvaccination observation. We recommend against mRNA vaccine or excipient skin testing to predict outcomes. We suggest revaccination of persons with an immediate allergic reaction to the mRNA vaccine or excipients be performed by a person with vaccine allergy expertise in a properly equipped setting. We suggest against premedication, split-dosing, or special precautions because of a comorbid allergic history.

Published
2023

5. Preparing Patients for Oral Immunotherapy (PPOINT): International Delphi consensus for procedural preparation and consent

Author

Mack, Douglas P., Dribin, Timothy E., Turner, Paul J., Wasserman, Richard L., Hanna, Mariam A., Shaker, Marcus, Tang, Mimi L.K., Rodríguez del Río, Pablo, Sobolewski, Brad, Abrams, Elissa M., Anagnostou, Aikaterini, Arasi, Stefania, Bajowala, Sakina, Bégin, Philippe, Cameron, Scott B., Chan, Edmond S., Chinthrajah, Sharon, Clark, Andrew T., Detjen, Paul, du Toit, George, Ebisawa, Motohiro, Elizur, Arnon, Factor, Jeffrey M., Greiwe, Justin, O’B Hourihane, Jonathan, Hughes, Sarah W., Jones, Douglas H., Muraro, Antonella, Nowak-Wegrzyn, Anna, Patel, Nandinee B., Scurlock, Amy M., Shah, Atul N., Sindher, Sayantani B., Tilles, Stephen, Vickery, Brian P., Wang, Julie, Windom, Hugh H., and Greenhawt, Matthew

Published
2024
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19. WAO consensus on DEfinition of Food Allergy SEverity (DEFASE)

Author

Arasi, Stefania, Nurmatov, Ulugbek, Dunn-Galvin, Audrey, Roberts, Graham, Turner, Paul J., Shinder, Sayantani B., Gupta, Ruchi, Eigenmann, Philippe, Nowak-Wegrzyn, Anna, Ansotegui, Ignacio J., Rivas, Montserrat Fernandez, Petrou, Stavros, Tanno, Luciana K., Vazquez-Ortiz, Marta, Vickery, Brian, Wong, Gary, Alvaro-Lozano, Montserrat, Asaria, Miqdad, Begin, Philippe, Bozzola, Martin, Boyle, Robert, Brough, Helen, Cardona, Victoria, Chinthrajah, R. Sharon, Cianferoni, Antonella, Deschildre, Antoine, Fleischer, David, Gazzani, Flavio, Gerdts, Jennifer, Giannetti, Marilena, Greenhawt, Matthew, Guzmán, Maria Antonieta, Hossny, Elham, Kauppi, Paula, Jones, Carla, Lucidi, Francesco, Monge Ortega, Olga Patricia, Munblit, Daniel, Muraro, Antonella, Pajno, Giovanni, Podestà, Marcia, Rodriguez del Rio, Pablo, Said, Maria, Santos, Alexandra, Shaker, Marcus, Szajewska, Hania, Venter, Carina, Warren, Cristopher, Winders, Tonya, Ebisawa, Motohiro, and Fiocchi, Alessandro

Published
2023
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23. Conclusions

Author

del Río, Pablo, Kiefer, Christoph P., Carrillo-Hermosilla, Javier, Könnölä, Totti, del Río, Pablo, Kiefer, Christoph P., Carrillo-Hermosilla, Javier, and Könnölä, Totti

Published
2021
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29. Introduction

Author

del Río, Pablo, Kiefer, Christoph P., Carrillo-Hermosilla, Javier, Könnölä, Totti, del Río, Pablo, Kiefer, Christoph P., Carrillo-Hermosilla, Javier, and Könnölä, Totti

Published
2021
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32. Managing food allergy: GA2LEN guideline 2022

Author

Bansal, Priya, Berni–Canani, Roberto, Blumchen, Katharina, Bonertz, Andreas, Bourgoin-Heck, Melisande, Ceylon, Ozlem, Divaret-Chauveau, Amandine, Fleischer, David, Gomez, Maximiliano, Groetch, Marion, Hernandez, Domingo Barber, Hjorth, Betina, Hussey, Lydia Collins, Knulst, André C., Leung, Agnes, Mack, Douglas, Mahler, Vera, Mori, Francesca, Namazova-Baranova, Leyla, Palosuo, Kati, Parisi, Claudio Alberto Salvador, Pastorino, Antonio Carlos, Rudzeviciene, Odilija, Said, Maria, Sawiec, Piotr, Sicherer, Scott, Sato, Sakura, Zubchenko, Svitlana, Muraro, Antonella, de Silva, Debra, Halken, Susanne, Worm, Margitta, Khaleva, Ekaterina, Arasi, Stefania, Dunn-Galvin, Audrey, Nwaru, Bright I., De Jong, Nicolette W., Rodríguez Del Río, Pablo, Turner, Paul J., Smith, Pete, Begin, Philippe, Angier, Elizabeth, Arshad, Hasan, Ballmer-Weber, Barbara, Beyer, Kirsten, Bindslev-Jensen, Carsten, Cianferoni, Antonella, Demoulin, Céline, Deschildre, Antoine, Ebisawa, Motohiro, Fernandez-Rivas, Maria Montserrat, Fiocchi, Alessandro, Flokstra-de Blok, Bertine, Gerdts, Jennifer, Gradman, Josefine, Grimshaw, Kate, Jones, Carla, Lau, Susanne, Loh, Richard, Alvaro Lozano, Montserrat, Makela, Mika, Marchisotto, Mary Jane, Meyer, Rosan, Mills, Clare, Nilsson, Caroline, Nowak-Wegrzyn, Anna, Nurmatov, Ulugbek, Pajno, Giovanni, Podestà, Marcia, Poulsen, Lars K., Sampson, Hugh A., Sanchez, Angel, Schnadt, Sabine, Szajewska, Hania, Van Ree, Ronald, Venter, Carina, Vlieg-Boerstra, Berber, Warner, Amena, Wong, Gary, Wood, Robert, Zuberbier, Torsten, and Roberts, Graham

Published
2022
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36. Increased miR‐21‐3p levels in extracellular vesicles of children with food anaphylaxis.

Author

Nuñez‐Borque, Emilio, Rodriguez del Rio, Pablo, Di Paolo, Virginia, Fernández‐Bravo, Sergio, Galardi, Angela, Bazire, Raphaëlle, Ibáñez‐Sandín, María Dolores, Benito‐Martín, Alberto, Di Giannatale, Angela, and Esteban, Vanesa

Subjects
*PLATELET-derived growth factor, *PIGMENT epithelium-derived factor, *TUMOR necrosis factor receptors, *RETINOIC acid receptors, *T helper cells
Abstract

This article discusses the role of microRNAs (miRNAs) carried by extracellular vesicles (EVs) in the context of anaphylaxis, a severe allergic reaction. The study focuses on children with food-mediated anaphylaxis and examines the levels of miR-21-3p and miR-487b-3p in EVs during the acute phase of the reaction compared to the basal phase. The results show an increase in miR-21-3p levels in EVs during anaphylaxis, suggesting its potential as a mediator of the condition. The study also highlights the involvement of miR-21-3p and miR-375-3p in immune and cardiovascular processes related to anaphylaxis. These findings contribute to a better understanding of the molecular mechanisms underlying anaphylaxis and may inform future research on targeted therapies. [Extracted from the article]

Published
2024
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42. Summing Up

Author

Mir-Artigues, Pere, del Río, Pablo, Caldés, Natàlia, Mir-Artigues, Pere, del Río, Pablo, and Caldés, Natàlia

Published
2019
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44. Introduction

Author

Mir-Artigues, Pere, del Río, Pablo, Caldés, Natàlia, Mir-Artigues, Pere, del Río, Pablo, and Caldés, Natàlia

Published
2019
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50. Core Outcome Set for IgE ‐mediated food allergy clinical trials and observational studies of interventions: International Delphi consensus study ‘ COMFA ’

Author

Demidova, Anastasia, Drewitz, Karl Philipp, Kimkool, Parisut, Banjanin, Nikolina, Barzylovich, Vladyslava, Botjes, Erna, Capper, India, Castor, Mary Anne R., Comberiati, Pasquale, Cook, Emma E., Costa, Joana, Chu, Derek K., Epstein, Michelle M., Galvin, Audrey Dunn, Giovannini, Mattia, Girard, Frédéric, Golding, Michael A., Greenhawt, Matthew, Ierodiakonou, Despo, Jones, Christina J., Khaleva, Ekaterina, Knibb, Rebecca C., Macit‐Çelebi, Melahat Sedanur, Mack, Douglas P., Mafra, Isabel, Marchisotto, Mary Jane, Mijakoski, Dragan, Nekliudov, Nikita, Özdemir, Cevdet, Patel, Nandinee, Pazukhina, Ekaterina, Protudjer, Jennifer L. P., Rodríguez del Rio, Pablo, Roomet, Jelena, Sammut, Patrick, Schoos, Ann‐Marie Malby, Schopfer, Anita Fossaluzza, Schultz, Fallon, Seylanova, Nina, Skypala, Isabel, Sørensen, Martin, Stoleski, Sasho, Stylianou, Eva, Upton, Julia, van de Veen, Willem, Genuneit, Jon, Boyle, Robert J., Apfelbacher, Christian, Munblit, Daniel, Adel‐Patient, Karine, Demidova, Anastasia, Drewitz, Karl Philipp, Kimkool, Parisut, Banjanin, Nikolina, Barzylovich, Vladyslava, Botjes, Erna, Capper, India, Castor, Mary Anne R., Comberiati, Pasquale, Cook, Emma E., Costa, Joana, Chu, Derek K., Epstein, Michelle M., Galvin, Audrey Dunn, Giovannini, Mattia, Girard, Frédéric, Golding, Michael A., Greenhawt, Matthew, Ierodiakonou, Despo, Jones, Christina J., Khaleva, Ekaterina, Knibb, Rebecca C., Macit‐Çelebi, Melahat Sedanur, Mack, Douglas P., Mafra, Isabel, Marchisotto, Mary Jane, Mijakoski, Dragan, Nekliudov, Nikita, Özdemir, Cevdet, Patel, Nandinee, Pazukhina, Ekaterina, Protudjer, Jennifer L. P., Rodríguez del Rio, Pablo, Roomet, Jelena, Sammut, Patrick, Schoos, Ann‐Marie Malby, Schopfer, Anita Fossaluzza, Schultz, Fallon, Seylanova, Nina, Skypala, Isabel, Sørensen, Martin, Stoleski, Sasho, Stylianou, Eva, Upton, Julia, van de Veen, Willem, Genuneit, Jon, Boyle, Robert J., Apfelbacher, Christian, Munblit, Daniel, and Adel‐Patient, Karine

Abstract

Background: IgE‐mediated food allergy (FA) is a global health concern with substantial individual and societal implications. While diverse intervention strategies have been researched, inconsistencies in reported outcomes limit evaluations of FA treatments. To streamline evaluations and promote consistent reporting, the Core Outcome Measures for Food Allergy (COMFA) initiative aimed to establish a Core Outcome Set (COS) for FA clinical trials and observational studies of interventions. Methods: The project involved a review of published clinical trials, trial protocols and qualitative literature. Outcomes found as a result of review were categorized and classified, informing a two‐round online‐modified Delphi process followed by hybrid consensus meeting to finalize the COS. Results: The literature review, taxonomy mapping and iterative discussions with diverse COMFA group yielded an initial list of 39 outcomes. The iterative online and in‐person meetings reduced the list to 13 outcomes for voting in the formal Delphi process. One more outcome was added based on participant suggestions after the first Delphi round. A total of 778 participants from 52 countries participated, with 442 participating in both Delphi rounds. No outcome met a priori criteria for inclusion, and one was excluded as a result of the Delphi. Thirteen outcomes were brought to the hybrid consensus meeting as a result of Delphi and two outcomes, ‘allergic symptoms’ and ‘quality of life’ achieved consensus for inclusion as ‘core’ outcomes. Conclusion: In addition to the mandatory reporting of adverse events for FA clinical trials or observational studies of interventions, allergic symptoms and quality of life should be measured as core outcomes. Future work by COMFA will define how best to measure these core outcomes.

Published
2024

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