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The removal of oncology drug wastewater containing Methotraxate (MTX), Iohexol (IOX) and Capacitabine (CPC) by electrooxidation was studied in this study. Anodic oxidation was provided by using mixed metal oxide (MMO) (Ti/IrO2-Ru, Ti/Ru, Ti/IrO2-Ru (EC 300)) and boron doped diamond (BDD) electrodes. In the case of electrooxidation with KMO electrodes, the removal efficiencies of MTX, CPC and IOX were obtained as 56.8%, 35.4% and 52.0%, respectively. On the other hand, the removal efficiencies were 86.1%, 99.0% and 53.4% for MTX, CPC and IOX with the usage of BDD electrode, respectively. Boron doped diamond electrode with its higher overpotential achieved more removal efficiency than MMO electrodes in electrooxidation process. [ABSTRACT FROM AUTHOR]

Objective: Peridural fibrosis after laminectomy is an important surgical problem. Tenoxicam is a nonsteroidal antiinflammatory drug and an oxicam derivative acting by inhibiting the formation of prostaglandin and eicosanoids. Low dose methotrexate which has been used as an antiinflammatory agent rhomatoid arthritis inhibits the synthesis of potentially toxic compounds those accumulate in inflamed tissues. The aim of this study was to evaluate and compare the efficacy of these two independent pharmacological agents in the inhibition of peridural fibrosis. Methods: L3-4-5 bilateral laminectomy with sparing the dura mater integrity was perfomed to 30 male Wistar albino rats. Except the SHAM group, low dose methotraxate (0.2 mg/kg) or tenoxicam (0.5 mg/kg) was administered on the dura mater before the surgical closure. After 42 days, all rats were euthanized and their spinal columns performed laminectomy were removed for the histopathological evaluation. Results: The peridural fibrosis grades of the groups administered low dose methotrexate or tenoxicam were lower than SHAM group grades. They have lower fibroblast counts than SHAM group numerically, although there was no statistically significant difference among groups. Conclusion: Local usage of low dose methotrexate and tenoxicam may be helpful option for prevention of peridural fibrosis after laminectomy procedures in future. [ABSTRACT FROM AUTHOR]