Search

Myeloid-derived suppressor cells (MDSCs) mobilize and migrate from bone marrow to peripheral tissues or immune organs, which is associated with poor prognosis in sepsis. Intervention of MDSCs might be a potential target for the effective treatment of sepsis. In the present study, we demonstrated that IL-1R1 blockade with either recombinant human IL-1R antagonist Anakinra or IL-1R1 deficiency had a protective effect on the liver injury in septic mice. The possible mechanism was that Anakinra treatment and IL-1R1 knockout inhibited the migration of MDSCs to the liver in sepsis, thus attenuating the immune suppression of MDSCs on effector T cells characterized with the decrease in proportion of CD4+ and CD8+ T cells. Furthermore, the switch from pro-inflammatory M1 macrophage to anti-inflammatory M2 phenotype and the ability of bacterial clearance in the liver of septic mice were enhanced obviously by Anakinra and IL-1R1 deficiency, which contributes to the attenuated liver injury. Taken together, these findings provide new ideas for revealing the relationship between IL-1R1 and MDSCs in sepsis, thereby providing a potentially effective target for ameliorating septic liver injury. • The blockade of IL-1R1 signaling showed a protective effect on the liver injury of septic mice. • IL-1R1 signaling blockade reduced the proportion of MDSCs in liver of septic mice. • The IL-1R1 blockade attenuated the immune suppression of MDSCs on T cells by inhibiting the migration of MDSCs to the liver. • The IL-1R1 blockade enhanced the ability of bacterial clearance in the liver of septic mice. The IL-1R1 blockade attenuated liver injury by promoting the switch of macrophages from M1 to M2 phenotype. [ABSTRACT FROM AUTHOR]