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The formed bionic "Fe/Mo bimetallene" can effectively promote the separation and transfer of photo-generated carriers by multi-electron redox reactions. [Display omitted] The "FeMo cofactors" in biological nitrogenase play a decisive role in nitrogen reduction. Herein, a novel bionic Fe/Mo bimetallene was applied in photocatalytic nitrogen reduction. The surface coating Fe/Mo bimetallene of Bi 2 Mo 0.3 W 0.7 O 6 (BMWO) nanocrystals could effectively promote the separation and transportation of photogenerated carriers by multi–electron redox reactions and deliver 2.8 times longer photo–carrier lifetime. Consequently, the nitrogen fixation activity of Fe/Mo bimetallene–coated BMWO nanocrystal photocatalyst was obviously enhanced (218.93 μmol g–1h−1), which was about 4.8 times that of unmodified BMWO nanocrystals. This work provides a novel approach to design bionic Fe/Mo bimetallene–modified inorganic semiconductor photocatalysts for nitrogen reduction. [ABSTRACT FROM AUTHOR]

A good understanding of the power system resilience is necessary for optimizing the investment strategies and supporting the emergency rescue, but the existing quantitative estimation results based on real outage events are still lacked due to the data limitations. Therefore, this study first establishes a unified framework to measure the power system resilience under different natural disasters, by integrating the electricity performance curve with the dynamic inoperability input-output model. Then, a database of 285 Chinese historical big power outage events caused by natural disasters is established, and the city-level power system resilience values are estimated. Finally, a benefit analysis is conducted for improving the power system resilience. Our major findings are that: (1) Electricity system recoveries quickest from hail (23.05 h), while restores slowest from snowstorm (117.31 h). (2) China's city electricity system is the most resilient to the thunderstorm, while is the least resilient to the earthquake. (3) Enhancing the power system resilience will significantly reduce the requirements for rescue resources, and the saved emergency rescue cost ranges from 0.57 million yuan to 12.08 million yuan with 1% reduction of initial inoperability. • Power system resilience under natural disasters is estimated • A database of disaster induced power outages is established • The sectoral interdependency is considered in the resilience estimation • The cost-benefit analysis is conducted for the resilience enhancement • Statistical analysis of the historical outage events is conducted [ABSTRACT FROM AUTHOR]

In recent years, the strategy for tumor therapy has changed from focusing on the direct killing effect of different types of therapeutic agents on cancer cells to the new mainstream of multi-mode and -pathway combined interventions in the microenvironment of the developing tumor. Flavonoids, with unique tricyclic structures, have diverse and extensive immunomodulatory and anti-cancer activities in the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are the most abundant immunosuppressive cells in the TME. The regulation of macrophages to fight cancer is a promising immunotherapeutic strategy. This study covers the most comprehensive cognition of flavonoids in regulating TAMs so far. Far more than a simple list of studies, we try to dig out evidence of crosstalk at the molecular level between flavonoids and TAMs from literature, in order to discuss the most relevant chemical structure and its possible relationship with the multimodal pharmacological activity, as well as systematically build a structure-activity relationship between flavonoids and TAMs. Additionally, we point out the advantages of the macro-control of flavonoids in the TME and discuss the potential clinical implications as well as areas for future research of flavonoids in regulating TAMs. These results will provide hopeful directions for the research of antitumor drugs, while providing new ideas for the pharmaceutical industry to develop more effective forms of flavonoids. [Display omitted] • The most comprehensive cognition of flavonoids in regulating TAMs so far. • Flavonoids regulate macrophage recruitment, reprogramming, and activity. • Chemical structure determining the activity and efficacy between flavonoids and TAMs. • The multi-target effect of flavonoids makes them affect the TME. [ABSTRACT FROM AUTHOR]