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A new γ-lactone compound, trichonafurin A (1), was obtained from the culture of Trichoderma atroviride ZW-7, an endophyte of the marine brown alga Sargassum thunbergii. Its structure was unambiguously assigned by detailed interpretation of 1D/2D NMR and HRESIMS data. Trichonafurin A (1) exhibited moderate cytotoxicity against HeLa and HepG2 cell lines with IC50 values of 20.2 and 32.1 μM, respectively. [ABSTRACT FROM AUTHOR]

A new carotane sesquiterpene, trichocarotin N (1), was isolated from a culture of the marine-derived fungus Trichoderma virens QD-11. The structure of this compound was established by detailed analysis of 1D/2D NMR and HRESIMS data. Trichocarotin N (1) exhibited moderate cytotoxicity against HeLa and MCF-7 cancer cell lines, with IC50 values of 32.4 and 41.6 μM, respectively. A new carotane sesquiterpene, trichocarotin N (1), was isolated from a culture of the marine-derived fungus Trichoderma virens QD-11. The structure of this compound was established by detailed analysis of 1D/2D NMR and HRESIMS data. Trichocarotin N (1) exhibited moderate cytotoxicity against HeLa and MCF-7 cancer cell lines, with IC50 values of 32.4 and 41.6 μM, respectively. [ABSTRACT FROM AUTHOR]

A new norsesquiterpene and four known bisabolanes were obtained from the organic extract of Trichoderma atroviride TD-8 isolated from ocean sediments. Their structures were assigned by detailed interpretation of 1D/2D NMR and HRESIMS data, and they were determined to be nor-bisabolan-1,11-diol (1), (3R,6R,7R)-1,10-bisaboladien-3-ol (2), (3R,6R,7S)-1,10-bisaboladien-3,6-diol (3), (3R,6S,7R,10R)-1-bisabolen3,10,11-triol (4), (3R,6R,7S,10R)-1-bisabolen-3,10,11-triol (5). Nor-bisabolan-1,11-diol (1) exhibited moderate cytotoxicity against HeLa and HCT-8 cell lines with IC50 values of 28.6 and 30.3 μM, respectively. [ABSTRACT FROM AUTHOR]