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Aerosols are complex compounds that greatly affect the global radiation balance and climate system and even human health; in addition, aerosols are currently a large source of uncertainty in the numerical simulation process. The arid and semi-arid areas have fragile ecosystems with abundant dust but lack related high-accuracy aerosol data. To solve these problems, we use the bagging trees ensemble model, based on 1 km aerosol optical depth (AOD) data and multiple environmental covariates, to produce a monthly advanced-performance, full-coverage, and high-resolution (250 m) AOD product (named FEC AOD, fusing environmental covariates AOD) covering the arid and semi-arid areas. Then, based on the FEC AOD products, we analyzed the spatiotemporal AOD pattern and further discussed the interpretation of environmental covariates to AOD. The results show that the bagging trees ensemble model has a good performance, with its verification R2 values always remaining at 0.90 and the R2 being 0.79 for FEC AOD compared with AERONET AOD product. The high-AOD areas are located in the Taklimakan Desert and on the Loess Plateau, and the low-AOD areas are concentrated in southern Qinghai province. The higher the AOD, the stronger the interannual variability. Interestingly, the AOD reflected a dramatic decrease on the Loess Plateau and an evident increase in the south-eastern Taklimakan Desert, while the southern Qinghai province AODs showed almost no significant change between 2000 and 2019. The annual variation characteristics show that the AOD was largest in spring (0.267±0.200) and smallest in autumn (0.147±0.089); the annual AOD variation pattern showed different features, with two peaks in March and August over Gansu province but only one peak in April in other provinces/autonomous regions. Farmlands and construction lands have high AOD levels compared to other land cover types. Meteorological factors demonstrate the maximum interpretation ability of the AODs on all set temporal scales, followed by the terrain factors, while surface properties have the smallest explanatory abilities; the corresponding average contributions are 77.1 %, 59.1 %, and 50.4 %, respectively. The capability of the environmental covariates to explain the AOD varies seasonally in the following sequence: winter (86.6 %) > autumn (80.8 %) > spring (79.9 %) > summer (72.5 %). In this research, we provide a pathbreaking high spatial resolution (250 m) and long time series (2000–2019) FEC AOD dataset covering arid and semi-arid regions to support atmospheric and related studies in northwest China; the full dataset is available at 10.5281/zenodo.5727119 (Chen et al., 2021b). [ABSTRACT FROM AUTHOR]