9 results on '"Du, Hongxia"'
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2. Advances in the structure design of substrate materials for zinc anode of aqueous zinc ion batteries
- Author
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Yang, Sinian, Du, Hongxia, Li, Yuting, Wu, Xiangsi, Xiao, Bensheng, He, Zhangxing, Zhang, Qiaobao, and Wu, Xianwen
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- 2023
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3. Solubility measurement, correlation and dissolution thermodynamics properties of marbofloxacin in binary solvents
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Liu, Huixian, Wu, Zhiying, Yu, Ping, Dong, Zhipeng, Du, Hongxia, Guo, Hongyong, and Zhang, Yue
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- 2022
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4. Physiological responses of low- and high-cadmium accumulating Robinia pseudoacacia-rhizobium symbioses to cadmium stress.
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Gao, Lan, Wang, Shufeng, Zou, Dongchen, Fan, Xu, Guo, Pan, Du, Hongxia, Zhao, Wancang, Mao, Qiaozhi, Li, Hong, Ma, Ming, and Rennenberg, Heinz
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BLACK locust ,CADMIUM ,COPPER ,SYMBIOSIS ,HEAVY metals ,RHIZOBIUM - Abstract
The role of rhizobia in alleviating cadmium (Cd) stress in woody legumes is still unclear. Therefore, two types of black locust (Robinia pseudoacacia L.) with high and low Cd accumulation abilities were selected from 11 genotypes in China, and the effects of rhizobium (Mesorhizobium huakuii GP1T11) inoculation on the growth, CO 2 and H 2 O gas exchange parameters, Cd accumulation, and the absorption of mineral elements of the high (SX) and low Cd-accumulator (HB) were compared. The results showed that rhizobium-inoculation significantly increased biomass, shoot Cd contents, Cd accumulation, root-to-shoot translocation factor (TF) and the absorption and accumulation of mineral elements in both SX and HB. Rhizobium-inoculation increased chlorophyll a and carotenoid contents, and the intercellular carbon dioxide concentrations in HB plants. Under Cd exposure, the high-accumulator SX exhibited a significant decrease in photosynthetic CO 2 fixation (Pn) and an enhanced accumulation of Cd in leaves, but coped with Cd exposure by increasing chlorophyll synthesis, regulating stomatal aperture (Gs), controlling transpiration (Tr), and increasing the absorption and accumulation of mineral elements. In contrast, the low-accumulator HB was more sensitive to Cd exposure despite preferential accumulation of Cd in roots, with decreased chlorophyll and carotenoid contents, but significantly increased root biomass. Compared to the low-accumulator HB, non-inoculated Cd-exposed SX plants had higher chlorophyll contents, and rhizobium-inoculated Cd-exposed SX plants had higher Pn , Tr , and Gs as well as higher levels of P, K, Fe, Ca, Zn, and Cu. In conclusion, the high- and low-Cd-accumulator exhibited different physiological responses to Cd exposure. Overall, rhizobium-inoculation of black locust promoted the growth and heavy metal absorption, providing an effective strategy for the phytoremediation of heavy metal-contaminated soils by this woody legume. [Display omitted] • The presence of rhizobia significantly enhanced Cd accumulation. • Rhizobium inoculation increased Cd root-to-shoot TF. • Rhizobium inoculation promoted mineral element absorption. • Rhizobium inoculation enhanced the tolerance of low-Cd accumulator to Cd. • Black locust can be a potential woody plant in phytoremediation. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Differentially-expressed genes related to glutathione metabolism and heavy metal transport reveals an adaptive, genotype-specific mechanism to Hg2+ exposure in rice (Oryza sativa L.).
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Wang, Shufeng, Yao, Hesheng, Li, Lingyi, Du, Hongxia, Guo, Pan, Wang, Dingyong, Rennenberg, Heinz, and Ma, Ming
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HEAVY metals ,REGULATOR genes ,GLUTATHIONE ,GENES ,FOOD chains - Abstract
Rice consumption is an essential cause of mercury (Hg) exposure for humans in Asia. However, the mechanism of Hg transport and accumulation in rice plants (Oryza sativa L.) remains unclear. Here, rice genotypes with contrasting Hg uptake and translocation abilities, i.e. H655 (high Hg-accumulator) and H767 (low Hg-accumulator), were selected from 261 genotypes. Through comparative physiological and transcriptome analyses, we investigated the processes responsible for the relationship between Hg accumulation, transport and tolerance. The results showed significant stimulation of antioxidative metabolism, particularly glutathione (GSH) accumulation, and up-regulated expression of regulatory genes of glutathione metabolism for H655, but not for H767. In addition, up-regulated expression of GSH S-transferase (GST) and OsPCS1 in H655 that catalyzes the binding of Hg and GSH, enhances the Hg detoxification capacity, while high-level expression of YSL2 in H655 enhances the transport ability for Hg. Conclusively, Hg accumulation in rice is a consequence of enhanced expression of genes related to Hg binding with GSH and Hg transport. With these results, the present study contributes to the selection of rice genotypes with limited Hg accumulation and to the mitigation of Hg migration in food chains thereby enhancing nutritional safety of Hg-polluted rice fields. [Display omitted] • High and low Hg-accumulators (H655 and H767) were screened from 261 rice genotypes. • Antioxidant capacity of H655 in response to Hg stress was stronger than H767. • Glutathione metabolism responded more exclusively to Hg stress in H655. • Transporter contributed to Hg accumulation difference between H655 and H767. [ABSTRACT FROM AUTHOR]
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- 2023
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6. QiShenYiQi ameliorates salt-induced hypertensive nephropathy by balancing ADRA1D and SIK1 expression in Dahl salt-sensitive rats.
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Du, Hongxia, Xiao, Guangxu, Xue, Zhifeng, Li, Zhixiong, He, Shuang, Du, Xiaoli, Zhou, Zhengchan, Cao, Linghua, Wang, Yule, Yang, Jian, Wang, Xiaoying, and Zhu, Yan
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HYPERTENSIVE crisis , *RATS , *HYPERTENSION , *ANTIHYPERTENSIVE agents , *BLOOD pressure , *REGULATION of blood pressure - Abstract
Hypertension is a leading risk factor for developing kidney disease. Current single-target antihypertensive drugs are not effective for hypertensive nephropathy, in part due to its less understood mechanism of pathogenesis. We recently showed that QiShenYiQi (QSYQ), a component-based cardiovascular Chinese medicine, is also effective for ischemic stroke. Given the important role of the brain-heart-kidney axis in blood pressure control, we hypothesized that QSYQ may contribute to blood pressure regulation and kidney protection in Dahl salt-sensitive hypertensive rats. The therapeutic effects of QSYQ on blood pressure and kidney injury in Dahl salt-sensitive rats fed with high salt for 9 weeks were evaluated by tail-cuff blood pressure monitoring, renal histopathological examination and biochemical indicators in urine and serum. RNA-seq was conducted to identify QSYQ regulated genes in hypertensive kidney, and RT-qPCR, immunohistochemistry, and Western blotting analysis were performed to verify the transcriptomics results and validate the purposed mechanisms. QSYQ treatment significantly decreased blood pressure in Dahl salt-sensitive hypertensive rats, alleviated renal tissue damage, reduced renal interstitial fibrosis and collagen deposition, and improved renal physiological function. RNA-seq and subsequent bioinformatic analysis showed that the expression of ADRA1D and SIK1 genes were among the most prominently altered by QSYQ in salt-sensitive hypertensive rat kidney. RT-qPCR, immunohistochemistry and Western blotting results confirmed that the mRNA and protein expression levels of alpha-1D adrenergic receptor (ADRA1D) in the kidney tissue of the QSYQ-treated rats were markedly down-regulated, while the mRNA and protein levels of salt inducible kinase 1 (SIK1) were significantly increased. QSYQ not only lowered blood pressure, but also alleviated renal damage via reducing the expression of ADRA1D and increasing the expression of SIK1 in the kidney of Dahl salt-sensitive hypertensive rats. [Display omitted] • A first report that a compont-based Chinese medicine QiShenYiQi is effective against hypertension. • QSYQ not only lowers salt-induced high blood pressure, but also ameliorates the sequential kidney injury. • Coordinated ADRA1D downregulation and SIK1 upregulation as a mechanism of renal protection by QSYQ. [ABSTRACT FROM AUTHOR]
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- 2021
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7. Bacteria and archaea involved in anaerobic mercury methylation and methane oxidation in anaerobic sulfate–rich reactors.
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Du, Hongxia, Sun, Tao, Liu, Yang, An, Siwei, Xie, Haiying, Wang, Dingyong, Igarashi, Yasuo, Imanaka, Tadayuki, Luo, Feng, and Ma, Ming
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ANAEROBIC reactors , *METHANOTROPHS , *ARCHAEBACTERIA , *SWINE manure , *DEMETHYLATION , *SULFATE-reducing bacteria , *METHYLATION , *BIOGAS production - Abstract
The identification of dominant microbes in anaerobic mercury (Hg) methylation, methylmercury (MeHg) demethylation, and methane oxidation as sulfate-reducing bacteria, methanogens or, probably, anaerobic methanotrophic archaea (ANMEs) is of great interest. To date, however, the interrelationship of bacteria and archaea involved in these processes remains unclear. Here, we demonstrated the dynamics of microorganisms participating in these processes. Anaerobic fixed-bed reactors were operated with swine manure and sludge to produce methane stably, and then, sulfate (reactor C), sulfate and Hg(II) (reactor H), and sulfate and MeHg (reactor M) were added, and the reactors were operated for 120 d, divided equally into four periods, P1–P4. The bacterial compositions changed nonsignificantly, whereas Methanosaeta in reactors H and M decreased significantly, revealing that it was irrelevant for Hg transformation. The abundances of Syntrophomonadaceae , Methanoculleus , Candidatus Methanogranum and Candidatus Methanoplasma increased continuously with time; these species probably functioned in these processes, but further evidence is needed. Desulfocella and Desulfobacterium dominated first but eventually almost vanished, while the dominant archaeal genera Methanogenium , Methanoculleus and Methanocorpusculum were closely related to ANME–1 and ANME–2. PLS-DA results indicated that both bacteria and archaea in different periods in the three reactors were clustered separately, implying that the microbial compositions in the same periods were similar and changed markedly with time. [Display omitted] • Methanosaeta decreased significantly after adding Hg and was unrelated to Hg transformation. • Desulfocella and Desulfobacterium dominated first but finally almost vanished. • The dominant archaeal genera were closely related to ANME–1 and ANME–2. • Microbes in different periods clustered separately, showing a significant change with time. [ABSTRACT FROM AUTHOR]
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- 2021
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8. Bacterial assemblages imply methylmercury production at the rice-soil system.
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Guo, Pan, Rennenberg, Heinz, Du, Hongxia, Wang, Tao, Gao, Lan, Flemetakis, Emmanouil, Hänsch, Robert, Ma, Ming, and Wang, Dingyong
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METHYLMERCURY , *PLANT development , *MICROBIAL diversity , *RHIZOSPHERE , *PLANT health , *MERCURY vapor , *MERCURY - Abstract
[Display omitted] • Methylators were dominating in rice rhizosphere, rather than the bulk soil. • Hg-promoted methylators are key taxa in the rhizosphere at the flowering stage. • In planta demethylation and methylation in rice roots are possible. • Desulfovibrionaceae may play an important role in Hg detoxification of rice. The plant microbiota can affect plant health and fitness by promoting methylmercury (MeHg) production in paddy soil. Although most well-known mercury (Hg) methylators are observed in the soil, it remains unclear how rice rhizosphere assemblages alter MeHg production. Here, we used network analyses of microbial diversity to identify bulk soil (BS), rhizosphere (RS) and root bacterial networks during rice development at Hg gradients. Hg gradients greatly impacted the niche-sharing of taxa significantly relating to MeHg/THg, while plant development had little effect. In RS networks, Hg gradients increased the proportion of MeHg-related nodes in total nodes from 37.88% to 45.76%, but plant development enhanced from 48.59% to 50.41%. The module hub and connector in RS networks included taxa positively (Nitrososphaeracea, Vicinamibacteraceae and Oxalobacteraceae) and negatively (Gracilibacteraceae) correlating with MeHg/THg at the blooming stage. In BS networks, Deinococcaceae and Paludibacteraceae were positively related to MeHg/THg, and constituted the connector at the reviving stage and the module hub at the blooming stage. Soil with an Hg concentration of 30 mg kg−1 increased the complexity and connectivity of root microbial networks, although microbial community structure in roots was less affected by Hg gradients and plant development. As most frequent connector in root microbial networks, Desulfovibrionaceae did not significantly correlate with MeHg/THg, but was likely to play an important role in the response to Hg stress. [ABSTRACT FROM AUTHOR]
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- 2023
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9. Recovery of post-stroke cognitive and motor deficiencies by Shuxuening injection via regulating hippocampal BDNF-mediated Neurotrophin/Trk Signaling.
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Li, Zhixiong, Wang, Huanyi, Xiao, Guangxu, Du, Hongxia, He, Shuang, Feng, Yuxin, Zhang, Boli, and Zhu, Yan
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INJECTIONS , *ISCHEMIC stroke , *LABORATORY mice , *HIPPOCAMPUS (Brain) , *ARTERIAL occlusions - Abstract
A mild ischemic stroke may cause both debilitating locomotor and cognitive decline, for which the mechanism is not fully understood, and no therapies are currently available. In this study, a nonfatal stroke model was constructed in mice by a modified middle cerebral artery occlusion (MCAO) procedure, allowing an extended recovery period up to 28 days. The extended MCAO model successfully mimicked phenotypes of a recovery phase post-stroke, including locomotor motor and cognitive deficiencies, which were effectively improved after Shuxuening injection (SXNI) treatment. Tissue slices staining showed that SXNI repaired brain injury and reduced neuronal apoptosis, especially in the hippocampus CA3 region. Transcriptomics sequencing study revealed 565 differentially expressed genes (DEGs) in the ischemic brain after SXNI treatment. Integrated network pharmacological analysis identified Neurotrophin/Trk Signaling was the most relevant pathway, which involves 15 key genes. Related DEGs were further validated by RT-PCR. Western-blot analysis showed that SXNI reversed the abnormal expression of BDNF, TrkB, Mek3 and Jnk1after stroke. ELISA found that SXNI increased brain level of p-Erk and Creb. At sub-brain level, the expression of BDNF and TrkB was decreased and GFAP was increased on the hippocampal CA3 region in the post-stroke recovery phase and this abnormality was improved by SXNI. In vitro experiments also found that oxygen glucose deprivation reduced the expression of BDNF and TrkB, which was reversed by SXNI. In summary, we conclude that SXNI facilitates the recovery of cognitive and locomotor dysfunction by modulating Neurotrophin/Trk Signaling in a mouse model for the recovery phase of post-ischemic stroke. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2021
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